239 results match your criteria: "Taizhou Institute of Health Sciences[Affiliation]"
Genetic Loci Associated with Nail Plate Morphology in East Asian Populations.
J Invest Dermatol
October 2024
CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, China. Electronic address:
Brain Iron in signature regions relating to cognitive aging in older adults: the Taizhou Imaging Study.
Alzheimers Res Ther
October 2024
Department of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, No. 12 Middle Wulumuqi Road, Shanghai, 200040, China.
Article Synopsis
- Recent MRI studies show that extra iron in the brain can make Alzheimer's disease (AD) worse and speed up memory problems in older people.
- Researchers looked at 770 older adults to see how brain iron and shrinkage are related to thinking skills over time.
- They found that higher levels of brain iron were linked to worse cognitive scores, meaning that more iron can be a sign that memory and thinking skills might decline faster.
Longitudinal association of peripheral blood DNA methylation with liver fat content: distinguishing between predictors and biomarkers.
Lipids Health Dis
September 2024
Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, NO. 180 Fenglin Road, Shanghai, 200032, China.
Background: Alterations in DNA methylation (DNAm) have been observed in patients with fatty liver, but whether they are cause or consequence remains unknown. The study aimed to investigate longitudinal association of epigenome-wide DNAm with liver fat content (LFC) in Chinese participants, and explore their temporal relationships.
Methods: Data were obtained from 2 waves over a four-year time period of the Shanghai Changfeng Study (discovery, n = 407 and replication, n = 126).
The Cancer Incidence and Trends From 2011 to 2018 in Ma'anshan, China: A Registry-Based Observational Study.
Cancer Control
September 2024
School of Public Health, Fudan University, Shanghai, China.
Article Synopsis
- The study examines cancer incidence trends in Ma'anshan, China from 2011 to 2018, noting a rising cancer burden without prior data available for the area.
- The research analyzed cancer registry data to determine age-standardized incidence rates and average annual percentage changes, finding 13,508 cases in males and 9,558 in females over the study period.
- Results revealed a decline in upper gastrointestinal cancers, while breast, colorectal, and thyroid cancers increased, suggesting a shift in the cancer spectrum in Ma'anshan compared to the national rates.
Point-based risk score for the risk stratification and prediction of hepatocellular carcinoma: a population-based random survival forest modeling study.
EClinicalMedicine
September 2024
State Key Laboratory of Genetic Engineering, Human Phenome Institute, and School of Life Sciences, Fudan University, Shanghai, China.
Background: The precise associations between common clinical biomarkers and hepatocellular carcinoma (HCC) risk remain unclear but hold valuable insights for HCC risk stratification and prediction.
Methods: We examined the linear and nonlinear associations between the baseline levels of 32 circulating biomarkers and HCC risk in the England cohort of UK Biobank (UKBB) (n = 397,702). The participants were enrolled between 2006 and 2010 and followed up to 31st October 2022.
Impact of accelerated biological aging and genetic variation on esophageal adenocarcinoma: Joint and interaction effect in a prospective cohort.
Int J Cancer
January 2025
State Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, and School of Life Science, Fudan University, Shanghai, China.
Accelerated biological aging may be associated with increased risk of esophageal adenocarcinoma (EAC). However, its relationship with genetic variation, and its effect on improving risk population stratification, remains unknown. We performed an exposome association study to determine potential associated factors associated with EAC.
View Article and Find Full Text PDFInvestigating the link between gut microbiome and bone mineral density: The role of genetic factors.
Bone
November 2024
Department of Biostatistics, School of Public Health, Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China; Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China. Electronic address:
Article Synopsis
- * Analyzing fecal microbiome samples from 605 individuals aged 55-65, the research identified specific bacteria linked to osteoporosis and assessed their interactions with genetic risk factors.
- * Key findings revealed that certain bacteria like Clostridium leptum were more common in osteoporosis patients, while others showed varied effects on bone mineral density based on genetic risk levels.
Quantitative gait markers and the TUG time in chronic kidney disease.
Heliyon
August 2024
Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China.
Background: Poor gait performance results in more fall incidents among people with chronic kidney disease (CKD). It is unknown what specific quantitative gait markers contribute to high fall risk in CKD and the size of their mediation effects.
Methods: We included 634 participants from the Taizhou Imaging Study who had complete gait and laboratory data.
Unraveling the role of BMI and blood markers in the relationship between plant-based diets and osteoporosis: A prospective cohort study.
Prev Med
October 2024
State Key Laboratory of Genetic Engineering, Zhangjiang Fudan International Innovation Center, School of Life Sciences, Human Phenome Institute, Fudan University, Shanghai, China; Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China; Yiwu Research Institute of Fudan University, Yiwu, Zhejiang, China. Electronic address:
Article Synopsis
- Some people are worried that eating a plant-based diet could be bad for bone health, but there hasn't been enough research on it.
- A big study with over 200,000 people found that those following certain plant-based diets had a higher risk of developing osteoporosis, a condition that weakens bones.
- The study showed that how much someone weighs (BMI) and some blood markers can affect this risk, so it's important for people on plant-based diets to manage their weight to help protect their bones.
Nonlinear relationships of circulating polyunsaturated fatty acids with the complications of liver cirrhosis: A prospective, longitudinal cohort study.
Clin Nutr
September 2024
Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China; Department of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety (Fudan University), Ministry of Education, Fudan University, Shanghai, China; Fudan University Taizhou Institute of Health Sciences, Taizhou, China. Electronic address:
Background & Aims: The role of circulating polyunsaturated fatty acids (PUFAs) in preventing liver cirrhosis complications remains unclear.
Methods: Between 2006 and 2010, 273,834 UK Biobank participants with plasma PUFA quantification data were enrolled and followed up until October 31, 2022. Plasma PUFAs were quantified using a high-throughput nuclear magnetic resonance-based metabolic profiling platform.
Proteogenomic Analysis Identifies a Causal Association between Plasma Apolipoprotein B Levels and Liver Cancer Risk.
J Proteome Res
September 2024
State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University, Shanghai 200433, China.
Article Synopsis
- Liver cancer is linked to specific protein changes in the bloodstream, revealing potential biomarkers through plasma proteomic profiling.
- Researchers used advanced mass spectrometry to analyze plasma from different groups, discovering 193 proteins with significant expression differences.
- Notably, apolipoprotein B (APOB) showed a strong negative correlation with liver cancer risk, suggesting that higher levels of APOB could reduce the risk of developing the disease, potentially mediated by hepatic fat content.
Serum Branched-Chain Amino Acids and Long-Term Complications of Liver Cirrhosis: Evidence from a Population-Based Prospective Study.
Nutrients
July 2024
Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai 200437, China.
Background And Aims: The role of serum branched-chain amino acids (BCAAs) in long-term liver cirrhosis complication events remains unclear. We aimed to evaluate the associations between serum BCAAs and the risk of liver-related events.
Methods: We included a total of 64,005 participants without liver cirrhosis complication events at baseline from the UK Biobank.
GWAS-based polygenic risk scoring for predicting cerebral artery dissection in the Chinese population.
BMC Neurol
July 2024
Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Article Synopsis
- The study investigates the genetic factors contributing to cerebral artery dissection (CeAD), a serious but rare disease, focusing on the Chinese population through genome-wide association studies (GWAS) and polygenic risk scores (PRS).
- A total of 210 CeAD patients and 280 controls were analyzed, identifying 13 significant SNPs related to CeAD, with implications for understanding its pathophysiology and identifying potential new genetic associations.
- The research finds that the identified genes are involved in critical biological processes and outlines a predictive model for CeAD using genetic data, age, and sex, which could help in risk assessment and management.
A multi-ancestry GWAS meta-analysis of facial features and its application in predicting archaic human features.
J Genet Genomics
July 2024
CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, Yunnan 650223, China. Electronic address:
Article Synopsis
- Facial morphology is a complex genetic trait that is important for evolutionary studies, but fossil evidence for ancient humans like Neanderthals and Denisovans is limited.
- A large-scale study of 9674 East Asians and 10,115 Europeans identified 71 genetic loci linked to facial features and developed a predictive tool called the facial polygenic score (FPS).
- By applying the FPS to ancient DNA, researchers found that Neanderthals and Denisovans likely had similar facial features, contributing to our understanding of human evolutionary history.
Characteristics of auto-quantified tumor-infiltrating lymphocytes and the prognostic value in adenocarcinoma of the esophagogastric junction, gastric adenocarcinoma, and esophageal squamous cell carcinoma.
Aging (Albany NY)
July 2024
Department of Epidemiology and Ministry of Education Key Laboratory of Public Health Safety, School of Public Health, Fudan University, Shanghai, China.
Background: Adenocarcinoma of the esophagogastric junction (AEGJ) with a specific pathological profile and poor prognosis has limited therapeutic options. Previous studies have found that TILs exhibit distinct characteristics in different tumors and are correlated with tumor prognosis. We established cellular training sets to obtain auto-quantified TILs in pathological images.
View Article and Find Full Text PDFPotential mediation effect of insulin resistance on the association between iron metabolism indicators and non-alcoholic fatty liver disease.
J Dig Dis
May 2024
Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
Article Synopsis
- - The study investigates the connection between iron metabolism and insulin resistance (IR) in relation to non-alcoholic fatty liver disease (NAFLD) and its progression to non-alcoholic steatohepatitis (NASH).
- - Data from the National Health and Nutritional Examination Survey (NHANES) was analyzed, revealing that higher serum ferritin and total iron-binding capacity (TIBC) are linked to an increased risk of NAFLD and NASH, particularly in participants with IR.
- - The findings suggest that IR plays a significant role in the relationship between elevated serum ferritin levels and the development of NAFLD and NASH, accounting for a large portion of the risk.
A comprehensive genetic variant reference for the Chinese population.
Sci Bull (Beijing)
December 2024
Faculty of Computing, Harbin Institute of Technology, Harbin 150001, China; Zhengzhou Research Institute, Harbin Institute of Technology, Zhengzhou 450000, China; School of Medicine and Health, Harbin Institute of Technology, Harbin 150001, China. Electronic address:
Sleep Pattern, Genetic Susceptibility, and Abdominal Aortic Aneurysm in UK Biobank Participants: Large-Scale Cohort Study.
JACC Adv
June 2024
Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Article Synopsis
- Abdominal aortic aneurysm (AAA) significantly contributes to cardiovascular deaths, prompting research into its connections with sleep patterns and genetic predisposition.
- A study involving 344,855 participants assessed various sleep factors and their correlation with AAA risk over an average follow-up of nearly 12.6 years.
- Results indicated that healthier sleep patterns lower the risk of AAA, especially in individuals with high genetic risk, highlighting the importance of good sleep for cardiovascular health.
Healthy lifestyles are associated with alleviating the single-nucleotide polymorphism-based genetic risks of ischaemic stroke, intracerebral haemorrhage and myocardial infarction.
Stroke Vasc Neurol
June 2024
State Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, and National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, Shanghai, China
Background: Both genetic and lifestyle factors contribute to myocardial infarction (MI) and stroke, including ischaemic stroke (IS) and intracerebral haemorrhage (ICH). We explored how and the extent to which a healthy lifestyle, by considering a comprehensive list, could counteract the genetic risk of those diseases, respectively.
Methods: 315 044 participants free of stroke and MI at baseline were identified from the UK Biobank.
Associations of sleep behaviors and genetic risk with risk of incident osteoporosis: A prospective cohort study of 293,164 participants.
Bone
September 2024
School of Public Health, the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China; Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China. Electronic address:
Article Synopsis
- This study aimed to investigate how unhealthy sleep behaviors impact the risk of developing osteoporosis (OP) over time, using data from the UK Biobank with a follow-up of nearly 14 years.
- The results showed that poor sleep habits, such as irregular sleep duration and insomnia, were linked to a significantly higher risk of OP, with insomnia being particularly impactful.
- Additionally, the study evaluated the genetic risk factors for OP and calculated the extent to which unhealthy sleep behaviors contribute to the incidence of this condition.
Protein truncating variants in mitochondrial-related nuclear genes and the risk of chronic liver disease.
BMC Med
June 2024
State Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, and School of Life Sciences, Fudan University, No. 2005 Songhu Road, Shanghai, 200438, China.
Article Synopsis
- Mitochondrial dysfunction is a key feature in liver diseases, yet the role of protein truncating variants (PTVs) in mitochondrial-related genes and their effect on liver disease risk is not well understood.
- The study involved analyzing PTVs from over 440,000 participants to assess their correlation with liver dysfunction and related health outcomes.
- Results showed that 96.1% of participants had at least one PTV, with significant associations found between these variants and increased risks for liver fibrosis, cancer, and mortality, underscoring the need for early identification and potential intervention strategies.
Reply: Regarding the use of decision curve analysis in predicting long-term complications of liver cirrhosis.
Hepatology
January 2025
Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China.
Association of Sleep Pattern and Genetic Susceptibility with Obstructive Sleep Apnea: A Prospective Analysis of the UK Biobank.
Nat Sci Sleep
May 2024
Bio-Med Big Data Center, CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Science, Shanghai, 200031, People's Republic of China.
Purpose: The prevalence of obstructive sleep apnea (OSA) is high worldwide. This study aimed to quantify the relationship between the incidence of OSA and sleep patterns and genetic susceptibility.
Methods: A total of 355,133 white British participants enrolled in the UK Biobank between 2006 and 2010 with follow-up data until September 2021 were recruited.
Longitudinal analysis of epigenome-wide DNA methylation reveals novel loci associated with BMI change in East Asians.
Clin Epigenetics
May 2024
CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Background: Obesity is a global public health concern linked to chronic diseases such as cardiovascular disease and type 2 diabetes (T2D). Emerging evidence suggests that epigenetic modifications, particularly DNA methylation, may contribute to obesity. However, the molecular mechanism underlying the longitudinal change of BMI has not been well-explored, especially in East Asian populations.
View Article and Find Full Text PDFLipid metabolism mediates the association between body mass index change and bone mineral density: The Taizhou imaging study.
Prev Med
July 2024
School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China; Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China. Electronic address:
Article Synopsis
- Limited research shows that changes in body mass index (BMI) can affect osteoporosis, particularly through lipid metabolism, in a study of 820 Chinese participants aged 55-65 years.
- The findings indicate that an increase in BMI is associated with a lower risk of osteoporosis and osteopenia, with various serum metabolites linked to these changes, particularly HDL and VLDL cholesterol.
- The study concludes that gaining weight may help reduce osteoporosis risk in older adults, highlighting the role of lipid metabolism in bone health.