6 results match your criteria: "Taizhou Affiliated Hospital of Nanjing University of Chinese Medicine[Affiliation]"
Causal Pathways Between Breast Cancer and Cardiovascular Disease Through Mediator Factors: A Two-Step Mendelian Randomization Analysis.
Int J Womens Health
November 2024
Taizhou Affiliated Hospital of Nanjing University of Chinese Medicine, Taizhou, People's Republic of China.
Background: The causal relationship of breast cancer (BC) with cardiovascular disease (CVD) and the underlying mediating pathways remains elusive. Our study endeavors to investigate the causal association between BC and CVD, with a focus on identifying potential metabolic mediators and elucidating their mediation effects in this causality.
Methods: In this study, we conducted two-sample Mendelian randomization (MR) to estimate the causal effect of BC (overall BC, ER+ BC, ER- BC) from the Breast Cancer Association Consortium (BCAC) on CVD including coronary heart disease (CHD), hypertensive heart disease (HHD), ischaemic heart disease (IHD), and heart failure (HF) from the FinnGen consortium.
Photo-Thermally Controllable Tumor Metabolic Modulation to Assist T Cell Activation for Boosting Immunotherapy.
Int J Nanomedicine
November 2024
Department of Ophthalmology, the Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, 225300, People's Republic of China.
Article Synopsis
- * A novel photo-thermal-controlled drug delivery system was created to inhibit tumor glycolysis and enhance T cell activation, using a drug encapsulated in modified nanoparticles that respond to specific light wavelengths.
- * This approach effectively reduces tumor growth and immune evasion by decreasing lactate and PD-L1 levels, ultimately improving the efficiency of immunotherapy treatments.
Research on the Therapeutic Effect of Qizhu Anti Cancer Recipe on Colorectal Cancer Based on RNA Sequencing Analysis.
Comb Chem High Throughput Screen
November 2024
School of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China
Background: Colorectal cancer is one of the common malignant tumors in clinical practice, and traditional Chinese medicine, as an important adjuvant treatment method, plays important roles in the treatment of malignant tumors.
Objective: This study aims to explore the mechanism of action of the Qizhu anti-cancer recipe on colorectal cancer through transcriptome sequencing.
Methods: The control group and Qizhu anti-cancer recipe group were established separately, and sequencing of the cells of the two groups was performed using the Illumina sequencing platform.
A cause-effect relationship between uterine diseases and breast cancer: A bidirectional Mendelian randomization study.
Heliyon
September 2024
Taizhou Affiliated Hospital of Nanjing University of Chinese Medicine, Taizhou, Jiangsu, 225300, China.
Article Synopsis
- The study investigates the relationship between uterine diseases (such as endometriosis and endometrial cancer) and breast cancer using Mendelian randomization to identify causal links.
- Results show significant genetic associations, indicating that certain uterine diseases increase the risk of breast cancer, while genetic predispositions to breast cancer can elevate risks for certain uterine conditions.
- Sensitivity analyses support the consistency of these findings, and further exploration of associated genetic variants reveals involvement in biological processes like cellular senescence.
Objective: To investigate the association between liver enzymes and ovarian cancer (OC), and to validate their potential as biomarkers and their mechanisms in OC. Methods Genome-wide association studies for OC and levels of enzymes such as Alkaline phosphatase (ALP), Aspartate aminotransferase (AST), Alanine aminotransferase, and gamma-glutamyltransferase were analyzed. Univariate and multivariate Mendelian randomization (MR), complemented by the Steiger test, identified enzymes with a potential causal relationship to OC.
View Article and Find Full Text PDFAutophagy plays a pro-apoptotic role in arsenic trioxide-induced cell death of liver cancer.
J Integr Med
May 2024
Oncology Department of Traditional Chinese Medicine, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China. Electronic address:
Objective: The effects of arsenic trioxide (AsO) on hepatocellular carcinoma have been documented widely. Autophagy plays dual roles in the survival and death of cancer cells. Therefore, we investigated the exact role of autophagy in AsO-induced apoptosis in liver cancer cells.
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