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RSC Adv
January 2021
MicroNano System Research Center, College of Information and Computer, Key Laboratory of Advanced Transducers and Intelligent Control System of the Ministry of Education and Shanxi Province, Taiyuan University of Technology Taiyuan 030024 China
Herein, a pH and redox dual-responsive drug delivery system (CDs-Pt(iv)-PEG) was developed based on fluorescence carbon dots (CDs). In this system, cisplatin(iv) prodrug (Pt(iv)) was selected as a model drug to reduce toxic side effects. The aldehyde-functionalized monomethoxy polyethylene glycol (mPEG-CHO) was conjugated to CDs-Pt(iv) to form pH sensitive benzoic imine bond.
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