2 results match your criteria: "Taiwan National Research Institute of Chinese Medicine[Affiliation]"

Activation of AMP-activated protein kinase α1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis.

Hum Mol Genet

February 2015

Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan Division of Neuroscience, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan National Research Institute of Chinese Medicine, Taipei 112, Taiwan

TAR DNA-binding protein-43 (TDP-43) is a nuclear RNA-binding protein involved in many cellular pathways. TDP-43-positive inclusions are a hallmark of amyotrophic lateral sclerosis (ALS). The major clinical presentation of ALS is muscle weakness due to the degeneration of motor neurons.

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A liquid chromatographic method coupled with microdialysis was used to determine the protein-unbound (-)-epigallocatechin-3-gallate (EGCG) in rat blood. EGCG and dialysates were separated using a Merck RP-18e column maintained at ambient temperature, and a mobile phase comprised of acetonitrile-10 mM monopotassium phosphate (pH 3.82) (20:80, v/v) with a flow rate of 1.

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