326,008 results match your criteria: "Taiwan; National Taiwan University Children's Hospital[Affiliation]"

Background & Aims: Atezolizumab/bevacizumab (A/B) is now a standard first-line treatment for advanced hepatocellular carcinoma (HCC), but the optimal second-line regimen is not known. We evaluated real-world treatment patterns and outcomes to investigate factors associated with post-progression survival (PPS).

Methods: In this multicenter, international, retrospective study, we examined clinical characteristics and outcomes of patients with advanced HCC who progressed on first-line A/B.

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Introduction: -mutant NSCLC is associated with low mutation burden and low levels of PD-L1 expression. We conducted a phase 2 trial to determine the efficacy of durvalumab, tremelimumab, and platinum-pemetrexed in mutant NSCLC after progression with EGFR tyrosine kinase inhibitors (TKIs).

Methods: Participants were treated with induction durvalumab, tremelimumab, and platinum-pemetrexed, followed by durvalumab-pemetrexed maintenance.

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Understanding factors influencing the spatio-temporal patterns of apex predators is prerequisite for their conservation. We studied space use and diel activity of tigers () in response to prey availability and anthropogenic activities with trail cameras in Nepal during December 2022-March 2023. We used hierarchical occupancy models to evaluate how prey availability (space use of prey species) and anthropogenic activities (number of humans and livestock) contributed to the tigers' space use, while accounting for landscape effects on their detection probability.

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Is Well-being Associated with Burnout? From a Multi-center Cross-sectional Study in Taiwan.

J Occup Environ Med

January 2025

Department of Digital Mental Health, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

Article Synopsis
  • The study examines the relationship between well-being and burnout among 242 Taiwanese workers, using validated assessment tools for both well-being and burnout.
  • Positive Emotion and Engagement were found to significantly correlate with personal burnout, while Positive Emotion, Engagement, and Relationships were linked to work-related burnout.
  • The findings suggest that improving workplace well-being can help reduce burnout, with different aspects of well-being influencing burnout in distinct ways.
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Artificial light sources, particularly blue light, have raised concerns about their impact on biological health and behavior. In this study, we explored the effects of blue light on the locomotion and cognitive functions of early adult Drosophila melanogaster. Our experiments were conducted in a custom-designed behavioral arena to assess how blue light influences these parameters.

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Background: This study compared the ventilatory variables and computed tomography (CT) features of patients with coronavirus disease 2019 (COVID-19) versus those of patients with pulmonary non-COVID-19-related acute respiratory distress syndrome (ARDS) during the early phase of ARDS.

Methods: This prospective, observational cohort study of ARDS patients in Taiwan was performed between February 2017 and June 2018 as well as between October 2020 and January 2024. Analysis was performed on clinical characteristics, including consecutive ventilatory variables during the first week after ARDS diagnosis.

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Background: Psoriatic arthritis (PsA) is a common comorbidity in patients with psoriasis (PsO) that leads to significant disease burden. Biologic therapies targeting the interleukin (IL)-23/IL-17 axis have been widely used for PsO, but their comparative effectiveness in preventing PsA remains unclear.

Objective: The study objective was to compare the occurrence of developing incidental PsA among PsO patients treated with interleukin-23 inhibitors (IL23is) or interleukin-17 inhibitors (IL17is).

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Unlabelled: Rural communities face healthcare challenges. This study assessed a multicomponent intervention to improve hospital visits and anti-osteoporosis medication (AOM) treatment rates. A total of 567 patients were randomized into three groups.

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Dual modality feature fused neural network integrating binding site information for drug target affinity prediction.

NPJ Digit Med

January 2025

State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.

Accurately predicting binding affinities between drugs and targets is crucial for drug discovery but remains challenging due to the complexity of modeling interactions between small drug and large targets. This study proposes DMFF-DTA, a dual-modality neural network model integrates sequence and graph structure information from drugs and proteins for drug-target affinity prediction. The model introduces a binding site-focused graph construction approach to extract binding information, enabling more balanced and efficient modeling of drug-target interactions.

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We conducted a genome-wide association study on income among individuals of European descent (N = 668,288) to investigate the relationship between socio-economic status and health disparities. We identified 162 genomic loci associated with a common genetic factor underlying various income measures, all with small effect sizes (the Income Factor). Our polygenic index captures 1-5% of income variance, with only one fourth due to direct genetic effects.

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Soliton solutions of the (2 + 1)-dimensional Jaulent-Miodek evolution equation via effective analytical techniques.

Sci Rep

January 2025

Department of Mathematics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, 602105, India.

In this study, we investigate the [Formula: see text]-D Jaulent-Miodek (JM) equation, which is significant due to its energy-based Schrödinger potential and applications in fields such as optics, soliton theory, signal processing, geophysics, fluid dynamics, and plasma physics. Given its broad utility, a rigorous mathematical analysis of the JM equation is essential. The primary objective of this work is to derive exact soliton solutions using the Modified Sub-Equation (MSE) and Modified Auxiliary Equation (MAE) techniques.

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Osteoarthritis (OA) is a degenerative joint disease with a complex aetiology, which includes inflammation, cellular growth dysregulation and extracellular matrix (ECM) degradation. This study investigated the therapeutic potential of a small-molecule compound, 2-amino-4-(3,4,5-trimethoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile (CN7:1h) in modulating these critical biochemical pathways in OA. Cellular models and rat models of OA were used to explore the impact of CN7:1h on the nuclear factor kappa light chain enhancer of activated B cells (NF-κB) and mechanistic target of rapamycin (mTOR) signalling pathways.

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Cholecystocutaneous fistula: A rare case in an elderly female with a massive abdominal mass.

Arab J Gastroenterol

January 2025

Department of Emergency Medicine, Cathay General Hospital, Taipei 106, Taiwan; School of Medicine, National Tsing Hua University, Hsinchu, Taiwan. Electronic address:

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Rigler's triad of gallstone ileus.

Arab J Gastroenterol

January 2025

Department of Pathology, Chung Shan Medical University Hospital, Taichung, Taiwan; Department of Pathology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan. Electronic address:

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Risk of mortality among adolescents and young adults following hospitalization from an intentional overdose.

Am J Emerg Med

January 2025

Department of Emergency Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Department of Biomedical Engineering, National Taiwan University, Taipei City, Taiwan; International Bachelor Program in Electrical and Communication Engineering, Yuan Ze University, Taoyuan, Taiwan. Electronic address:

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Humic substances modulate bacterial communities and mitigate adverse effects of temperature stress in coral reef organisms.

J Appl Microbiol

January 2025

Centre for Environmental and Marine Studies (CESAM) and Department of Biology, University of Aveiro, Aveiro, Portugal.

Aims: In the present study, we tested if terrestrially-derived humic substances (HS) could mitigate the adverse effects of elevated temperature and UVB radiation on the bacterial communities of two hard corals (Montipora digitata and Montipora capricornis), one soft coral (Sarcophyton glaucum), sediment and water. We also examined the impact of temperature, UVB radiation and HS supplementation on coral photosynthetic activity, a proxy for coral bleaching.

Methods And Results: We performed a multifactorial experiment using a randomized-controlled microcosm setup.

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Metabolic-associated fatty liver disease (MAFLD) has emerged as a leading chronic liver disease. This condition is characterized by an abnormal accumulation of fat within liver and can progress from simple steatosis to more severe stages involving chronic inflammation and oxidative stress. In this study, we investigated the potential therapeutic effects and underlying mechanism of novel bioactive peptides (EWYF and EWFY) on Western diet-induced MAFLD in C57BL/6J mice.

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The Evolution of Uroflowmetry and Bladder Diary and the Emerging Trend of Using Home Devices From Hospital to Home.

Interact J Med Res

January 2025

Division of Urology, Department of Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.

Although uroflowmetry and bladder diaries are widely used for noninvasive evaluation of lower urinary tract symptoms, they still have limitations in diagnostic capability and users' convenience. The aim of this paper is to discuss potential solutions by reviewing (1) the evolution and current clinical use of uroflowmetry and bladder diary, including clinical guidelines, daily practice applications, and their historical development; (2) a growing trend toward using home devices with various technologies; and (3) a comprehensive comparison of the strengths and weaknesses of these home devices. In our opinion, the following points can be highlighted: (1) the emerging trend of using home devices can enhance diagnostic capabilities through repeated measurements and the convenience of at-home testing and (2) home devices, which provide both frequency-volume and uroflowmetry information, have the potential to transform the management of lower urinary tract symptoms.

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This study explores the selective oxidative scission of bicyclo[2.2.2]octenones derived from masked -benzoquinones (MOBs).

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Use of Electronic Health Records to Identify Factors Related to Skin Changes in Terminal Patients.

Adv Skin Wound Care

January 2025

Chia-Jung Chan, MS, RN, is Head Nurse, Taipei Medical University Hospital, Taipei, Taiwan. Yeu-Hui Chuang, PhD, RN, is Professor, School of Nursing, College of Nursing, Taipei Medical University, and Researcher, Research Center in Nursing Clinical Practice, Wan Fang Hospital, Taipei Medical University; Tsai-Wei Huang, PhD, RN, is Professor, School of Nursing, College of Nursing. Taipei Medical University, and Researcher, Research Center in Nursing Clinical Practice, Wan Fang Hospital, Taipei Medical University; Made Satya Nugraha Gautama, S.Kep, Ns, is Lecturer, Department of Nursing, Faculty of Medicine, Universitas Pendidikan Ganesha, Bali, Indonesia.

Objective: To investigate the incidence of skin changes at life's end (SCALE) among hospice patients and identify associated factors.

Methods: The authors conducted a retrospective chart review of demographic data, medical history, Braden Scale assessment scores, Charlson Comorbidity Index, symptom records, and medical treatments of patients admitted to a local teaching hospital's hospice unit between May 2019 and April 2021.

Results: Most (79%) of the 300 hospice patients included in the study had cancer.

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Prognostic factors in severe dengue patients: A multi-center retrospective cohort study.

PLoS Negl Trop Dis

January 2025

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, School of Medicine, College of Medicine, Center for Tropical Medicine and Infectious Disease Research, Kaohsiung Medical University, Kaohsiung, Taiwan (R.O.C.).

Background/purpose: Early detection of severe dengue (SD) and appropriate management are crucial in reducing the case fatality rate. The objective of this study was to investigate the clinical characteristics of SD and identify independent risk factors associated with mortality among SD patients.

Methods: A retrospective study was conducted at two medical center hospitals between 2002 and 2019, involving patients aged ≧18 years with laboratory-confirmed SD.

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Hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) is a neurodegenerative disease caused by mutations in the gene encoding transthyretin (TTR). Despite amyloid deposition being pathognomonic for diagnosis, this pathology in nervous tissues cannot fully account for nerve degeneration, implying additional pathophysiology for neurodegeneration, which, however, has not yet been fully elucidated. In this study, neuroinflammation in ATTRv-PN was investigated by examining nerve morphometry, the blood-nerve barrier, and macrophage infiltration in the sural nerves of ATTRv-PN patients and the sciatic nerves of a complementary mouse system, i.

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Objectives: The usefulness of methotrexate-polyglutamates (MTX-PGs) concentration for management of rheumatoid arthritis has been debated. We aimed to clarify the association of MTX-PGs concentration with efficacy and safety in MTX-naïve patients initiating MTX in a prospective interventional clinical trial.

Methods: The MIRACLE trial enrolled 300 MTX-naïve patients.

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