268 results match your criteria: "Taipei Veterans General Hospital Yuanshan & Su-Ao Branch[Affiliation]"

: The prevalence of diabetes is increasing worldwide, particularly in the Pacific Ocean island nations. Although machine learning (ML) models and data mining approaches have been applied to diabetes research, there was no study utilizing ML models to predict diabetes incidence in Taiwan. We aimed to predict the onset of diabetes in order to raise health awareness, thereby promoting any necessary lifestyle modifications and help mitigate disease burden.

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Background: Myopia has been a rising problem globally. Early-onset myopia significantly increases the risk of high myopia later in life. Despite the proven benefits of increased outdoor time, optimal strategies for preventing early-onset myopia in premyopic children need further investigation.

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Effects of Heat-Killed Probiotic Strains on Biofilm Formation, Transcription of Virulence-Associated Genes, and Prevention of UTIs in Mice.

Probiotics Antimicrob Proteins

November 2024

Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, No.145 Xingda Rd., South Dist., Taichung, 40227, Taiwan.

Article Synopsis
  • Urinary tract infections (UTIs) are complicated by antibiotic-resistant uropathogens, and this study evaluated the effectiveness of 18 heat-killed probiotics and their supernatants in reducing biofilm formation and dispersing existing biofilms against these pathogens.
  • Fourteen probiotic strains significantly inhibited UPEC biofilm formation by 20-80% and reduced existing biofilms by 10-60%, while eight strains also effectively targeted Methicillin-resistant E. coli (MREC).
  • The study concluded that certain heat-killed probiotics could promote biofilm dispersion and lower urinary bacterial load in an animal model, indicating their potential as a treatment for UTIs.
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We employed an untargeted proteo-metabolomic approach to profile circulating biomarkers in plasma samples from the I-Lan Longitudinal Aging Study, aiming to identify biomarkers and pathways associated with physio-cognitive decline syndrome (PCDS). In 115 propensity score-matched PCDS case-control pairs, pathway analyses implicated dysregulation of fatty acid metabolism and inflammation in PCDS pathogenesis. Sex-specific associations were observed, with disruptions in central carbon metabolism (elevated PKM, MDH1, and GAPDH; decreased MINPP1) and tyrosine metabolism (decreased MIF, DBH; increased thyroxine) characterizing in men.

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Article Synopsis
  • The study investigates the risk of developing Parkinson's disease (PD) in patients with bipolar disorder (BD) and major depression, using data from Taiwan’s National Health Insurance Research Database.
  • Results indicate that both BD and major depression patients have a higher risk of developing PD than controls, with BD patients having a significantly greater risk (51% higher than those with major depression).
  • The research suggests a complex relationship between psychotropic medication and the risk of neurodegenerative diseases, emphasizing the need for further studies to improve treatment strategies for patients with BD.
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Muscle function outweighs appendicular lean mass in predicting adverse outcomes: Evidence from Asian longitudinal studies.

J Nutr Health Aging

December 2024

Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan; Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Hsinchu, Taiwan; Taipei Municipal Gan-Dau Hospital (Managed by Taipei Veterans General Hospital), Taipei, Taiwan. Electronic address:

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Sex-dependent interplay of phosphate and inflammation on muscle strength irrespective of muscle mass in middle-aged and older adults.

Exp Gerontol

November 2024

Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Center for Geriatric and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan; Taipei Municipal Gan-Dau Hospital (managed by Taipei Veterans General Hospital), Taipei, Taiwan. Electronic address:

Background: Elevated circulatory phosphate levels are linked to age-related muscle dysfunction, yet the mechanisms remain unclear. This study investigated the hypothesis that inflammation plays a role in connecting elevated phosphate levels to muscular dysfunction in middle-aged and older individuals and explored potential sex-based differences in these associations.

Methods: The study, based on the I-Lan Longitudinal Aging Study Cohort, analyzed individuals' serum phosphate and hsCRP levels.

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Background: Limited knowledge exists regarding the interrelations between sleep quality and resilience within the demographic of healthy, community-residing middle-aged and older adults, with a particular dearth of information regarding sex-specific associations. This study aimed to examine the sex-specific associations between sleep quality, resilience, and biomarkers in community-dwelling middle-aged and older adults.

Methods: This cross-sectional study was conducted using data from the 2022 Gan-Dau Healthy Longevity Plan survey initiated by the locality-based community hospital, Taipei Municipal Gan-Dau Hospital (TMGDH).

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The distinct impacts of sarcopenic and dynapenic obesity on mortality in middle-aged and older adults based on different adiposity metrics: Results from I-Lan Longitudinal Aging Study.

Clin Nutr

August 2024

Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan; Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan.

Background & Aims: Sarcopenic obesity (SO) and dynapenic obesity (DO) represent two manifestations of excessive fat accumulation concurrent with compromised muscle mass and function, thereby necessitating an examination of their implications for health. This study aims to investigate the relationship between SO/DO and mortality, taking into account various adiposity measures and existing sarcopenia criteria, with further stratified analyses based on age and gender.

Methods: The study sample comprised 1779 older adults residing in the community from the I-Lan Longitudinal Aging Study (ILAS).

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Activin A as a potential biomarker for preserved ratio impaired spirometry (PRISm) and clinical outcomes in community-dwelling adults.

Arch Gerontol Geriatr

November 2024

School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan; Taipei Municipal Gan-Dau Hospital (Managed by Taipei Veterans General Hospital), Taipei, Taiwan.

Introduction: This study endeavors to decipher the association between Activin A and PRISm, thereby addressing the potential of Activin A as a serum biomarker for early detection and long-term clinical outcome prediction of PRISm and subsequent all-cause mortality.

Methods: The study sample comprised middle-aged and older adults from the I-Lan Longitudinal Aging Study. Pulmonary function including forced vital capacity (FVC) and forced expiratory volume in one second (FEV) were measured.

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Background: The relationship between inflammation and covert cerebral small vessel disease (SVD) with regards to sex difference has received limited attention in research. We aim to unravel the intricate associations between inflammation and covert SVD, while also scrutinizing potential sex-based differences in these connections.

Methods: Non-stroke/dementia-free study population was from the I-Lan longitudinal Aging Study.

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Rotenone (RTN) induces neurotoxicity and motor dysfunction in rats, mirroring the pathophysiological traits of Parkinson's disease (PD), including striatal oxidative stress, mitochondrial dysfunction, and changes in neural structure. This makes RTN a valuable model for PD research. Berberine (BBR), an isoquinoline alkaloid recognized for its antioxidative, anti-inflammatory, and neuroprotective properties, was evaluated for its ability to counteract RTN-induced impairments.

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Follistatin-respiratory connection predicting all-cause mortality among community-dwelling middle-to-old age individuals: Results from the I-Lan Longitudinal Study.

J Nutr Health Aging

August 2024

Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan; Taipei Municipal Gan-Dau Hospital (Managed by Taipei Veterans General Hospital), Taipei, Taiwan.

Objectives: The link between aging and pulmonary function decline is well-established, but the underlying mechanisms have yet to be fully revealed. Serum follistatin, a myokine implicated in muscle degeneration, may play a role in age-related pulmonary changes. This study aims to investigate the relationship between serum follistatin levels and pulmonary function decline in community-dwelling older adults, and evaluate their combined association with all-cause mortality.

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Safeguarding vitality and cognition: The role of sarcopenia in intrinsic capacity decline among octogenarians from multiple cohorts.

J Nutr Health Aging

June 2024

Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan; Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan. Electronic address:

Article Synopsis
  • The study explores the relationship between sarcopenia (muscle loss) and declines in intrinsic capacity (IC) among older adults, particularly focusing on octogenarians in Taiwan.
  • Data from 599 individuals revealed high prevalence rates of possible sarcopenia (64.6%) and sarcopenia (32.1%) using different diagnostic criteria, with those affected showing significant declines in vitality and cognitive function.
  • The findings emphasize the need for regular screening and management of sarcopenia to support healthy aging in older populations, particularly in preserving vitality and cognitive capacity.
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Background: The effectiveness of isolated resistance training (RT) on cognitive function among older adults with schizophrenia is insufficiently investigated. This study investigated the effectiveness of 12-weeks POWER rehabilitation, a novel RT regimen, on cognitive function among older patients with schizophrenia and frailty.

Methods: Thirty-two older adults with schizophrenia and frailty were enrolled and randomized to receive either a 12-week, twice weekly POWER rehabilitation, or without add-on training.

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Background: Sleep disturbance and impulsivity are key components of mood vulnerability in bipolar disorder (BD), but few studies have assessed the association between these two symptoms among patients with BD.

Methods: Forty-seven euthymic patients with bipolar I disorder (BDI) or bipolar II disorder (BDII) and 58 age- and sex-matched healthy controls were enrolled in this cross-sectional study. Trait impulsivity was measured using the Barratt Impulsiveness Scale Version 11 (BIS-11), which yielded 3 second-order factors: attention, motor, and non-planning.

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Article Synopsis
  • The study investigated frailty as a common issue in older adults, focusing on how it affects mortality and how it differs between sexes.
  • Frailty prevalence was nearly equal in men (5.3%) and women (5.8%), but frail individuals tended to be older and less educated with various body composition differences observed between the sexes.
  • Importantly, frailty was found to be a significant predictor of mortality only in men, indicating that frailty impacts men's health more severely than women's in this healthy elderly population.
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Intrinsic capacity and multimorbidity predicting incident disability-Insights from the I-Lan Longitudinal Aging Study.

Arch Gerontol Geriatr

June 2024

Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Geriatric Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan; Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan; Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan.

Objectives: This longitudinal cohort study aimed to examine the effect of intrinsic capacity (IC) and multimorbidity on the development of new disabilities.

Methods: The study utilized data from 1,009 participants without disabilities from the I-Lan Longitudinal Aging Study. Multivariable logistic regressions were employed to assess the predictive capability of IC (ranging from 0 to 100) and multimorbidity for incident disability over a 7-year follow-up period.

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Background: With the increasing number of individuals with dementia, families have hired an increasing number of live-in migrant caregivers (LIMCs). Currently, limited evidence is available regarding the influence of long-term care resource utilization on the hiring of LIMCs for caring for individuals with dementia in Taiwan.

Methods: We recruited individuals with dementia who did not hire LIMCs and their primary family caregivers from nine hospitals in Taiwan as baseline.

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Introduction: The neuroanatomical changes driving both cognitive and mobility impairments, an emerging preclinical dementia syndrome, are not fully understood. We examined gray-matter volumes (GMVs) and structural covariance networks (SCNs) abnormalities in community-based older people preceding the conversion to physio-cognitive decline syndrome (PCDS).

Methods: Voxel-wise brain GMV and established SCNs were compared between PCDS and non-PCDS converters.

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A national survey on health-related quality of life for people with dementia in residential long-term care institutions.

J Formos Med Assoc

July 2024

School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Division of General Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; Brain Research Center, National Yang-Ming Chiao Tung University, Taipei, Taiwan. Electronic address:

Background: Health-related quality of life (HRQoL) is an essential outcome parameter in geriatric research; however, the available evidence is mixed regarding the factors associated with HRQoL among people with dementia. We aimed to identify factors that contribute to HRQoL among people with dementia in residential long-term care (LTC) institutions.

Methods: We randomly selected 299 of 1607 registered residential LTC institutions in Taiwan.

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The existence of intrinsic capacity (IC) subtypes and their distinct impacts on age-related outcomes remain unexplored. This study sought to investigate IC impairment trajectories across domains and their associations with the risk of age-related outcomes, including falls, functional limitations, reduced quality of life (QoL) and mortality at 4- and 8-year follow-ups. The study sample comprised 1,782 older adults residing in the community from the Taiwan Longitudinal Study on Ageing (TLSA).

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Background: It is essential to assist individuals with a mental illness who have achieved clinical recovery in their personal recovery. Understanding the relationship between self-stigma and social support and the effects on perceived recovery can be valuable for clinical professionals in helping patients lead meaningful lives.

Aim: To examine the serial mediating roles of social support and perceived hope in self-stigma and the effects on perceived recovery.

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Objective: This study aimed to evaluate the efficacy of integrated multidomain interventions and primary health care on intrinsic capacity (IC) and related biomarkers.

Design: An ancillary analysis from the Taiwan Integrated Geriatric Care (TIGER) study: a randomized controlled trial.

Setting And Participants: A total of 398 community-dwelling older adults aged ≥65 years with ≥3 chronic conditions.

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