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Acute uterine irritation provokes colonic motility via transient receptor potential A(1)-dependent spinal NR2B phosphorylation in rats.

Anesthesiology

February 2014

From the Department of Medicine (H.-Y.P, Y.-P.C.), Mackay Medical College, New Taipei, Taiwan; Division of Thoracic Surgery, Department of Health (C.-M.Y.), Taichung Hospital, Executive Yuan, Taichung, Taiwan; Department of Anesthesiology (J.-K.C.), Mackay Memorial Hospital, New Taipei, Taiwan; School of Medicine (T.R.), Fu-Jen Catholic University, New Taipei, Taiwan; Department of Obstetrics and Gynecology (G.-D.C.), Chung-Shan Medical University Hospital, Chung-Shan Medical University, Taichung, Taiwan; Department of Physiology, School of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, and Department of Medicine, Mackay Medical College (M.-C.H.); Department of Veterinary Medicine, College of Veterinary Medicine, National Chung-Hsing University, Taichung, Taiwan, and Department of Medicine, Mackay Medical College (C.-Y.L.); and Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan, and Department of Biotechnology, Asia University, Taichung, Taiwan, and Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University (T.-B.L.), Taipei, Taiwan. Drs. Peng and Lin contributed equally to this work.

Background: Patients with inflammatory gynecological/obstetrical problems often complain of irritable bowel syndrome. The authors examined whether acute uterus irritation reflexively provokes colonic motility in rat preparations.

Methods: A modified colon manometry and striated abdominal muscle electromyogram activity in response to mustard oil (MO) instillation into the uterine horn were continuously recorded in anesthetized rats.

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