The Evolution of Uroflowmetry and Bladder Diary and the Emerging Trend of Using Home Devices From Hospital to Home.

Although uroflowmetry and bladder diaries are widely used for noninvasive evaluation of lower urinary tract symptoms, they still have limitations in diagnostic capability and users' convenience. The aim of this paper is to discuss potential solutions by reviewing (1) the evolution and current clinical use of uroflowmetry and bladder diary, including clinical guidelines, daily practice applications, and their historical development; (2) a growing trend toward using home devices with various technologies; and (3) a comprehensive comparison of the strengths and weaknesses of these home devices. In our opinion, the following points can be highlighted: (1) the emerging trend of using home devices can enhance diagnostic capabilities through repeated measurements and the convenience of at-home testing and (2) home devices, which provide both frequency-volume and uroflowmetry information, have the potential to transform the management of lower urinary tract symptoms.

Use of Electronic Health Records to Identify Factors Related to Skin Changes in Terminal Patients.

Objective: To investigate the incidence of skin changes at life's end (SCALE) among hospice patients and identify associated factors.

Methods: The authors conducted a retrospective chart review of demographic data, medical history, Braden Scale assessment scores, Charlson Comorbidity Index, symptom records, and medical treatments of patients admitted to a local teaching hospital's hospice unit between May 2019 and April 2021.

Results: Most (79%) of the 300 hospice patients included in the study had cancer.

Transthyretin variants impact blood-nerve barrier and neuroinflammation in amyloidotic neuropathy.

Hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) is a neurodegenerative disease caused by mutations in the gene encoding transthyretin (TTR). Despite amyloid deposition being pathognomonic for diagnosis, this pathology in nervous tissues cannot fully account for nerve degeneration, implying additional pathophysiology for neurodegeneration, which, however, has not yet been fully elucidated. In this study, neuroinflammation in ATTRv-PN was investigated by examining nerve morphometry, the blood-nerve barrier, and macrophage infiltration in the sural nerves of ATTRv-PN patients and the sciatic nerves of a complementary mouse system, i.

Systematic review of 99 extremity bone malignancy survival prediction models.

Background: Various prediction models have been developed for extremity metastasis and sarcoma. This systematic review aims to evaluate extremity metastasis and sarcoma models using the utility prediction model (UPM) evaluation framework.

Methods: We followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and systematically searched PubMed, Embase, and Cochrane to identify articles presenting original prediction models with 1-year survival outcome for extremity metastasis and 5-year survival outcome for sarcoma.

Degrees of Death: The Hierarchy of Capital Punishments Between Strangulation and Decapitation in Qing China.

This article unravels the classification of individuals which operated through the dualism between two execution methods, strangulation and decapitation, during the Qing dynasty. The fundamental difference lay in whether the method of execution preserved the integrity of the corpse. As this factor entailed important moral and metaphysical consequences, there is an uncrossable boundary between the two situations.

Bisdemethoxycurcumin and Curcumin Alleviate Inflammatory Bowel Disease by Maintaining Intestinal Epithelial Integrity and Regulating Gut Microbiota in Mice.

Curcuminoids, found in turmeric ( L.), include curcumin (CUR), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC). Although CUR and DMC are well-studied, the anti-inflammatory effects of BDMC remain less explored.

Comparison of different microbiome analysis pipelines to validate their reproducibility of gastric mucosal microbiome composition.

Microbiome analysis has become a crucial tool for basic and translational research due to its potential for translation into clinical practice. However, there is ongoing controversy regarding the comparability of different bioinformatic analysis platforms and a lack of recognized standards, which might have an impact on the translational potential of results. This study investigates how the performance of different microbiome analysis platforms impacts the final results of mucosal microbiome signatures.

Measurement of multidifferential cross sections for dijet production in proton-proton collisions at .

A measurement of the dijet production cross section is reported based on proton-proton collision data collected in 2016 at by the CMS experiment at the CERN LHC, corresponding to an integrated luminosity of up to 36.3 . Jets are reconstructed with the anti- algorithm for distance parameters of and 0.

Oleanolic acid inhibits aldo-keto reductase family 1 member B10-induced cancer stemness and avoids cisplatin-based chemotherapy resistance via the Snail signaling pathway in oral squamous cell carcinoma cell lines.

Background/purpose: Oral squamous cell carcinoma (OSCC) is a common malignancy often associated with poor prognosis due to chemoresistance. In this study, we investigated whether arecoline, a major alkaloid in betel nuts, can stimulate aldo-keto reductase family 1 member B10 (AKR1B10) levels in OSCC, promoting cancer stemness and leading to resistance to cisplatin (CDDP)-based chemotherapy.

Materials And Methods: Gain- and Loss- of AKR1B10 functions were analyzed using WB and q-PCR of OSCC cells.

Soft coral Lobophytum crassum extract inhibits migration and induces apoptosis capabilities in human oral squamous cell carcinoma cells.

Background/purpose: The extract of the soft coral has shown an anti-cancer activity in various cancer cells. However, its effect on the oral squamous cell carcinoma cell (OSCC) lines remains unclear. The purpose of this study is to investigate the anti-cancer effects of the extract of (C127) on the OSCC cells.

Significant association of oral health-related quality of life with mental depression in middle-aged and older Taiwanese adults.

Background/purpose: With the gradual aging of the population, oral health has emerged as a critical concern alongside mental well-being. This study endeavored to investigate the relationship between oral health-related quality of life (OHRQoL) and mental depression in middle-aged and older population.

Materials And Methods: Based on the Taiwan Longitudinal Study on Aging in 2015, 7631 participants were enrolled.

Integrating digital technologies in dental technician education: A comparative study of national examination in Asian countries.

Background/purpose: The integration of digital technologies in dental technician education revolutionized the profession in Asian countries. Despite the growing adoption of digital methods, national examinations predominantly relied on traditional techniques. This study aimed to conduct a comparative analysis of national examination standards and digital course integration in dental technician education among 5 countries including Japan, Taiwan, South Korea, the Philippines, and China.

High-precision and non-invasive measurement of crestal bone level by optical coherence tomography.

Background/purpose: Identifying crestal bone level (CBL) on the buccal and lingual aspects poses challenges in conventional dental radiographs. Given that optical coherence tomography (OCT) has the capability to non-invasively provide in-depth information about the periodontium, this in vitro study aimed to assess whether OCT can effectively identify periodontal landmarks and measure CBL in the presence of gingiva.

Materials And Methods: An in-house handheld scanning probe connected to a 1310-nm swept-source OCT (SS-OCT) system, along with self-developed algorithms were employed to measure the CBL in dental models with artificial gingiva.

Enhancement of titanium surfaces using different acid solutions at room temperature to improve bone cell responses.

Background/purpose: Early osseointegration of titanium (Ti) dental implants relies on the surface topography. Surface modification of Ti seeks to enhance bone regeneration around implants. Acid etching is the simple, less technique sensitive and cost-effective technique for surface treatment.

The investigation of thermal behavior and temperature analysis of three types of contemporary gutta-percha points.

Background/purpose: The impact of thermal behavior on the clinical performance of gutta-percha points (GP) is unclear. This study aimed to investigate the thermal behavior of three different types of GP and their temperature changes (TC) in a simulated clinical environment.

Materials And Methods: The GP tested were Conform Fit® Gutta-Percha Points (CF), Autofit™ Feathered Tip Gutta Percha (AF), and Gutta Percha Root Canal Points (GC).

Bone morphogenetic protein-4 induced matrix turnover and osteogenic differentiation-related molecules of stem cells from apical papilla and its associated ALK/Smad signaling.

Background/purpose: Revascularization procedures are used over apexification to treat teeth with necrotic pulp tissues and incomplete root formation. Clinically, inducing proliferation, migration, matrix deposition, and differentiation of stem cells from apical papilla (SCAPs) are critical for pulp regeneration. The study aimed to elucidate the impact of bone morphogenetic protein-4 (BMP-4) on plasminogen activation molecules and the osteogenic/odontogenic differentiation of SCAPs, as well as understand the related signaling mechanisms.

Investigation of the cushioning mechanism of a novel dental implant system with composite hydrogel.

Background/purpose: Dental implants can restore both function and aesthetics in edentulous areas. However, the absence of cushioning mechanical behavior in implants may limit their clinical performance and reduce the long-term survival rates. This study aimed to establish an implant cushion mechanism that mimicked the natural periodontal ligament, utilizing the properties of composite hydrogels.

Biomineralization reaction from nanosized calcium silicate: A new method for reducing dentin hypersensitivity.

Background/purpose: This study assessed the ability of experimental materials consisting of dicalcium silicate (DCS) and tricalcium silicate (TCS) with nanosized particles to form intratubular crystals under phosphate-buffered saline (PBS) and the effect on dentin permeability reduction.

Materials And Methods: By isolating the cervical part of the extracted premolars, 195 specimens were obtained. Two experimental materials (DCS/TCS and TCS) were applied to the dentin surface by brushing and stored in PBS (n = 65).

investigation of human salivary microbial growth with lysogeny broth for translational research-A pilot study.

Background/purpose: Salivary microbiome has become a surrogate indicator of oral disease due to its collective reservoirs and convenience in sampling. However, failed clinical trials often lead to wastes of resources, indicating a need for preclinical models. In this pilot study, we aimed to compare the salivary microbiome by metagenomics analysis before and after lysogeny broth culture for prospective translational studies.

Calf circumference and serum albumin level are the reliable biomarkers for predicting the chewing ability and nutritional status of the elderly people.

Background/purpose: The relationship among chewing ability, food texture selection, and nutritional status in the elderly is well-known. This study tried to find the reliable biomarkers to predict the chewing ability and nutritional status of the elderly people.

Materials And Methods: Sixty-eight elderly subjects (mean age, 80.