304 results match your criteria: "Tachikawa Hospital[Affiliation]"

Background: Sensitization to mucus plugs, and bacterial colonization may coexist and relate to a refractory phenotype during follow-up in asthma with bronchiectasis and allergic bronchopulmonary aspergillosis (ABPA).

Objective: This study aimed to clarify the features of -sensitized refractory asthma with bronchiectasis and determine the refractory phenotype in this population and ABPA.

Methods: This study included cases of the oldest available -specific IgE data and chest computed tomography images from a nationwide survey of refractory asthma with bronchiectasis.

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While the skin is a common target organ for sarcoidosis, cutaneous granulomatous vasculitis is rare among patients with sarcoidosis. Due to the lack of detailed studies on cutaneous sarcoid vasculitis, both dermatologists and pathologists remain unfamiliar with this rare but important vasculitic disorder. We clinicopathologically evaluated eight cases with biopsy-proven cutaneous vasculitis and cutaneous sarcoidosis and analyzed morphologic changes in the process of vasculitis for both small vessels and muscular vessels in detail.

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Article Synopsis
  • The study aimed to evaluate the effectiveness of anti-VEGF therapy on visual acuity in patients with diabetic macular edema (DME) over two years.
  • The research involved analyzing data from 1,780 eyes treated from 2015 to 2019, documenting changes in best-corrected visual acuity (BCVA) and treatment methods.
  • Results showed a significant improvement in BCVA, with 73.3% of eyes maintaining good vision, highlighting anti-VEGF therapy as the preferred first-line treatment for DME.
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Clinical relevance of proteinuria selectivity index and fractional excretion of sodium in patients with nephrotic syndrome.

Sci Rep

October 2024

Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.

Article Synopsis
  • The study investigates the potential of the Proteinuria Selectivity Index (PSI) and fractional excretion of sodium (FENa) as tools for classifying nephrotic syndrome and predicting treatment responses.
  • It involved a retrospective analysis of 611 patients who underwent kidney biopsies, categorizing their conditions and determining optimal cutoffs for PSI and FENa to predict complete remission.
  • The findings indicate that both low PSI and FENa are associated with a higher likelihood of achieving complete remission, suggesting their clinical relevance in nephrotic syndrome management.
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Longitudinal observation of distal tibial degeneration in varus ankle osteoarthritis using plain radiograph.

Foot Ankle Surg

September 2024

Tachikawa Hospital, 4-2-22 Nishiki-cho, Tachikawa-shi, Tokyo 190-8531, Japan. Electronic address:

Background: This study aimed to explore the natural history of distal tibial deformity in varus ankle osteoarthritis and to identify risk factors for its progression.

Methods: This retrospective longitudinal observational study included 97 ankles with moderate to severe varus ankle osteoarthritis, monitored for > 2 years. Radiographic assessments were conducted on weightbearing plain radiographs at the initial and final visit.

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Macular edema is a known side effect of taxane-based anticancer drugs. We retrospectively investigated data from 11 centers between January 2016 and December 2021. Among 14,260 patients, 30 (0.

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Article Synopsis
  • The study by the Epilepsy Subcommittee of the Japanese Society of General Hospital Psychiatry aimed to identify challenges that psychiatrists face when treating epilepsy and transitioning patients from pediatric to adult care.
  • A survey was conducted with 1,980 psychiatrists, out of which 545 responded, revealing that a significant majority (89.2%) felt hesitant about treating epilepsy and managing the transition of patients.
  • Factors like years of experience, board certification in epilepsy, and workplace support from specialists were associated with reduced hesitancy and increased confidence in providing quality care for epilepsy patients.*
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The human foot is a complex structure comprising 26 bones, whose coordinated movements facilitate proper deformation of the foot, ensuring stable and efficient locomotion. Despite their critical role, the kinematics of foot bones during movement remain largely unexplored, primarily due to the absence of non-invasive methods for measuring foot bone kinematics. This study addresses this gap by proposing a neural network model for estimating foot bone movements using surface markers.

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A 78-year-old Japanese man presented to the emergency department with a sore throat and fever that worsened over 3 weeks. A tonsil biopsy led to the diagnosis of pleomorphic mantle cell lymphoma (MCL) that had infiltrated the right adrenal gland, inferior vena cava, and right atrium (RA). Although the patient's cardiac tumor had high mobility, his hemodynamic state was stable, and he did not present with fatal arrhythmia.

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Lower limb kinematic changes during gait after hallux valgus surgery: A prospective observational study.

Clin Biomech (Bristol)

August 2024

Department of Orthopaedic Surgery, International University of Health and Welfare (IUHW) Mita Hospital, 1-4-3 Mita, Minato-ku, Tokyo 108-8329, Japan; Department of Orthopaedic Surgery, School of Medicine, International University of Health and Welfare (IUHW), 4-3 Kouzunomori, Narita City, Chiba 286-8686, Japan; Department of Orthopaedic Surgery, International University of Health and Welfare (IUHW) Shioya Hospital, 77 Tomita, Yaita City, Tochigi 329-2145, Japan.

Background: Patients with hallux valgus are known to alter lower limb joint kinematics during gait. However, little information is available about gait changes following hallux valgus surgery. We aimed to longitudinally investigate lower limb kinematic changes at the mid and terminal stances of gait after hallux valgus surgery.

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Article Synopsis
  • The study investigates clinical risk factors that affect the ineligibility for endoscopic resection (ER) of metachronous remnant gastric cancer (MRGC) in patients with a history of proximal gastrectomy (PG).
  • Out of 203 patients, 32 instances of MRGC were identified, with 62.5% classified as eligible for ER; the majority of non-ER cases were linked to lesions in the pseudofornix, which was found to be a significant risk factor.
  • Visibility during endoscopic examinations was notably better in areas outside the pseudofornix, highlighting the need for better preparation to clear food residues in this area to increase the chances of successful ER.
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Introduction: Precise prediction of hospital stay duration is essential for maximizing resource utilization during surgery. Existing lumbar spinal stenosis (LSS) surgery prediction models lack accuracy and generalizability. Machine learning can improve accuracy by considering preoperative factors.

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Article Synopsis
  • The text discusses a previously underestimated pathogen that is part of normal skin flora but is now recognized for causing severe infections, especially in immunocompromised patients.
  • Identifying this pathogen at the species level poses challenges in clinical microbiology, which limits understanding of its role in infectious diseases.
  • A rare case study is presented involving a patient with severe neutropenia who developed multiple subcutaneous abscesses, with the pathogen identified through genotyping, emphasizing its significance in severe skin infections.
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Information about influences of vortioxetine on pregnant women and neonates during perinatal period is almost unknown. The case was a 28-year-old Japanese woman in her first pregnancy, treated for depression with vortioxetine (20 mg daily) among other medications. At 36 weeks of gestation, she was admitted for premature rupture of the membranes and delivered a girl with no apparent congenital anomalies.

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Article Synopsis
  • A 28-year-old woman with untreated high blood pressure for 5 years was hospitalized due to breathing issues, coughing up blood, and eye problems.
  • Imaging revealed lung plaques and she experienced kidney damage, low platelets, and anemia.
  • After 8 weeks of antihypertensive treatment, her kidney function improved, leading to a diagnosis of malignant nephrosclerosis linked to a hypertensive crisis.
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Identification of a rare MET variant in three siblings with extramammary Paget disease.

Clin Exp Dermatol

July 2024

Department of Dermatology, Tachikawa Hospital, Federation of National Public Service Personnel Mutual Aid Associations, Tokyo, Japan.

Article Synopsis
  • Extramammary Paget disease (EMPD) is a skin cancer primarily found in the genital and underarm areas of older adults, with limited studies on its genetics, especially in familial cases.* -
  • This report presents the first known familial cases of EMPD involving three siblings, who all showed a specific genetic variant in the MET gene linked to the disease.* -
  • Further research is needed to better understand the impact of MET gene variants on the development of EMPD, particularly in families with multiple affected members.*
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While our understanding of the molecular basis of mixed phenotype acute leukemia (MPAL) has progressed over the decades, our knowledge is limited and the prognosis remains poor. Investigating cases of familial leukemia can provide insights into the role of genetic and environmental factors in leukemogenesis. Although familial cases and associated mutations have been identified in some leukemias, familial occurrence of MPAL has never been reported.

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Article Synopsis
  • - The study investigates long COVID symptoms among 935 patients in Japan, categorizing them into five distinct clusters based on various symptom presentations and their impact on quality of life (QOL).
  • - The clusters include: numerous symptoms affecting multiple organs, minimal symptoms, taste and smell disorders, fatigue with psychological symptoms, and fatigue with respiratory issues, showcasing a diverse range of long COVID experiences.
  • - Findings highlight the need for personalized treatment approaches, as the severely affected patients (mostly elderly in cluster 1) experienced the greatest decline in QOL, while other clusters showed different symptom trends and demographic profiles.
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Background: Abdominal surgical infectious complications (ASIC) after gastrectomy for gastric cancer impair patients' survival and quality of life. JCOG0912 was conducted to compare laparoscopy-assisted distal gastrectomy with open distal gastrectomy for clinical stage IA or IB gastric cancer. The present study aimed to identify risk factors for ASIC using prospectively collected data.

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Regeneration of Panniculus Carnosus Muscle in Fetal Mice Is Characterized by the Presence of Actin Cables.

Biomedicines

December 2023

Department of Plastic and Reconstructive Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Mammalian skin, including human and mouse skin, does not regenerate completely after injury; it is repaired, leaving a scar. However, it is known that skin wounds up to a certain stage of embryonic development can regenerate. The mechanism behind the transition from regeneration to scar formation is not fully understood.

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Morphological features of the non-affected side of the hindfoot in patients with unilateral varus ankle osteoarthritis.

Ann Anat

February 2024

Department of Orthopaedics Surgery, School of Medicine,  Keio University, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan; Department of Clinical Biomechanics,  Keio University, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.

Background: The innate shape characteristics of the hindfoot bones alter the loading conditions of the foot and thus may be associated with an increased risk of developing varus ankle osteoarthritis (OA). This study aimed to clarify the innate morphological patterns of the hindfoot bones that may be associated with ankle OA by analyzing the differences between the bone morphology of the non-affected side of patients with unilateral varus ankle OA and that of healthy participants.

Methods: In this case-control study, computed tomography images were used to develop three-dimensional models of three hindfoot bones (distal tibia with fibula, talus, and calcaneus) from 23 non-affected sides of patients with radiography-diagnosed unilateral ankle OA and 22 healthy control participants.

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Background: A previous report confirmed the safety of laparoscopy-assisted total and proximal gastrectomies (LATG and LAPG) (JCOG1401). This report demonstrates the 5-year relapse-free survival (RFS) and overall survival (OS) after long-term follow-up to confirm the efficacy of these surgical methods as key secondary endpoints for cStage I gastric cancer.

Methods: This study enrolled patients who had histologically proven gastric adenocarcinoma and were diagnosed with clinical T1N0, T1N(+), or T2N0 tumors according to the 14th edition of the Japanese Classification of Gastric Carcinoma (3rd English edition).

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