A non-hormonal reversible contraceptive targeting GSK3α, a protein kinase, essential for epididymal sperm maturation.

Background And Objectives: Epididymal transit renders key competence to mammalian spermatozoa for fertilizing eggs. Generally, the two paralogs of glycogen synthase kinase 3, GSK3α and GSK3β, functionally overlap except in testis and sperm. We showed that GSK3α is essential for epididymal sperm maturation and fertilization.

Assessing the Causes of Acceptance or Refusal of Breast Cosmetic Procedures Among Saudi Women When They Get to Age of Menopause: A Cross Sectional Study-Saudi Arabia.

Introduction: Cosmetic breast surgery encompasses a variety of procedures aimed at enhancing breast appearance and is increasingly popular globally. Despite this trend, the acceptance of such surgeries among Saudi women approaching menopause remains understudied. This research aims to explore the attitudes and perceptions toward cosmetic breast surgery in this demographic, considering cultural and religious influences in Saudi Arabia.

Prevalence of in sheep and goats in northwestern Saudi Arabia with notes on potential vectors.

The prevalence of spp. infecting sheep and goats were investigated in two cities and surroundings in northwest Saudi Arabia. Blood samples from 403 sheep and goats from Madina ( = 201) and Tabuk ( = 202) cities (177 from sheep and 226 from goats) were investigated.

Lipopeptides from Bacillus atrophaeus MCM61 and melatonin suppress gray mold-induced oxidative stress in cut roses (Rosa hybrida L.) and improve vase life.

Application of melatonin and lipopeptides (LPs) derived from Bacillus strains is considered an efficient strategy to control plant diseases at both pre and postharvest stages. However, the combined application of melatonin and LPs has not been studied yet. Therefore, the present study presents the synergistic effect of melatonin and LPs produced by Bacillus atrophaeus strain MCM61 against gray mold disease and its impact on quality parameters and vase life of cut roses.

Assessment of Cardiotoxicity Incidence in Patients Receiving HER-2-Targeted Therapies for Breast Cancer in Saudi Arabia.

Background: HER2-targeting therapies may increase the risk of decreased left ventricular ejection fraction (LVEF), potentially leading to heart failure. The growing number of breast cancer survivors due to HER2-targeted treatments necessitates long-term cardiotoxicity management.

Method: This retrospective study included HER2-positive breast cancer patients aged 18 or older who received at least 1 dose of HER2-targeting treatment between 2016 and 2020.

Minimizing Blood Loss Using Tranexamic Acid in Patients Undergoing Liposuction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background: Liposuction has become the most sought-after aesthetic surgery across the globe, increasing the demand for more developments in patient safety protocols. Evidence of the efficacy of tranexamic acid (TXA) in reducing intraoperative blood loss with minimal complications have led to its widespread applications across various surgical operations. However, the role and effectiveness of TXA in liposuction is not fully understood.

Developing novel hybrid bilayer nanofibers based on polylactic acid with impregnation of chamomile essential oil and gallic acid-stabilized silver nanoparticles.

This study presents fabrication and characterization of novel chamomile essential oil (CMO)/gallic acid-stabilized silver nanoparticles (gallic acid-nanosilver, GNS), embedded into polylactic acid (PLA)-based hybrid bilayer nanofibers (NFs). Where CMO was impregnated into polyvinyl alcohol (PVA)-polyethylene glycol (PEG) solution and electrospun simultaneously with PLA to obtain PLA/PVA-PEG-CMO NFs (PLA/CMO A2). Meanwhile, GNS were added to PVA-PEG-CMO and electrospun to obtain PLA/PVA-PEG-CMO-GNS NFs (PLA/CMO-GNS A3).

Assessment of Health Science Students' Knowledge of Ocular Chemical Injuries and Proper Immediate Action: A Cross-Sectional Study at King Khalid University.

Introduction Chemical injuries are considered to be one of the true ocular emergencies that require years of visual rehabilitation in addition to immediate medical intervention to maintain eyesight. Thus, it is imperative that medical professionals and the general public are both aware of the damage and how to treat it. Objective The current study's objectives were to determine what influences students' understanding of ocular first aid in trauma scenarios and to evaluate the degree of knowledge among health university students at King Khalid University.

The Efficacy and Safety of Inclisiran for Low-Density Lipoprotein (LDL) in Patients With Atherosclerotic Cardiovascular Disease (ASCVD): A Systematic Review of Randomized Controlled Trials.

This systematic review synthesizes current evidence to evaluate the safety and efficacy of inclisiran for lowering low-density lipoprotein cholesterol (LDL-C). A thorough search was conducted across four main databases - PubMed, Web of Science, SCOPUS, and Science Direct - for relevant studies published in the literature within the last five years (2020-2024). We included seven studies with a total of 6831 participants, of which 4661 (68.

Jacq. mediated green synthesis of silver nanoparticles: synthesis, characterization, and biological activities supported by molecular docking.

This study uses the aerial parts of total extract (PMTE) to synthesize silver nanoparticles (AgNPs) in an environmentally friendly manner. TEM, SEM, FTIR, X-ray powder diffraction (XRD), Zeta potential, UV, and FTIR were used to characterize the green silver nanoparticles (PM-AgNPs). PM-AgNPs were evaluated as anticancer agents compared to (PMTE) against breast (MCF-7), lung (A549), and ovary adenocarcinoma (SKOV3) human tumour cells.

A model combining BI-RADS® descriptors from pre-treatment B-mode breast ultrasound with clinicopathological tumor features shows promise in the prediction of residual disease after neoadjuvant chemotherapy.

Purpose: To create a simple model using standard BI-RADS® descriptors from pre-treatment B-mode ultrasound (US) combined with clinicopathological tumor features, and to assess the potential of the model to predict the presence of residual tumor after neoadjuvant chemotherapy (NAC) in breast cancer (BC) patients.

Method: 245 female BC patients receiving NAC between January 2017 and December 2019 were included in this retrospective study. Two breast imaging fellows independently evaluated representative B-mode tumor images from baseline US.

Comprehensive Systematic Review of Breast Implant Illness: Symptoms, Management, and Long-Term Outcomes.

Background: Breast augmentation using silicone implants is common, with over 300,000 annual US surgeries. It was initially approved in 1962, there were safety concerns with the use of silicone implants, leading to a 1992-2006 FDA moratorium. Recently, Breast Implant Illness (BII) was described as a cluster of symptoms associated with silicone implants, with a lack of diagnostic criteria, which increased the likelihood of implant removal and a variety of treatment options.

Conservation tillage: a way to improve yield and soil properties and decrease global warming potential in spring wheat agroecosystems.

Climate change is one of the main challenges, and it poses a tough challenge to the agriculture industry globally. Additionally, greenhouse gas (GHG) emissions are the main contributor to climate change; however, croplands are a prominent source of GHG emissions. Yet this complex challenge can be mitigated through climate-smart agricultural practices.

The impact of antibiotic use in gastrointestinal tumors treated with immune checkpoint inhibitors: systematic review and meta-analysis.

Background: Immune checkpoint inhibitors (ICI) have improved overall survival in patients with different cancer types. However, treatment efficacy varies between patients depending on several factors. Recent research suggested that antibiotic-induced dysbiosis can impair ICI efficacy.

Prevalence of Adverse Respiratory Symptoms Among E-Cigarette Users in Saudi Arabia - A Cross-Sectional Study.

Electronic cigarettes, frequently referred to as e-cigarettes, have emerged as a controversial and rapidly growing phenomenon in the realm of tobacco and nicotine consumption worldwide. This study reports the prevalence of respiratory symptoms among e-cigarette users. This study also helps to understand the potential harmful effects and importance of quitting e-cigarette smoking.

Thermodynamic, chemical, and electrochemical studies of Aloe ferox Mill extract as a naturally developing copper corrosion inhibitor in HCl solution.

Copper can be susceptible to corrosion in acidic cleaning solutions for desalination system, especially if the solution is highly concentrated or if the cleaning process involves extended exposure to the acid. In the current work, Aloe ferox Mill (AFM extract) can be used as a natural origin corrosion inhibitor for copper in 1.0 M HCl solution.

The Relationship Between Breast Density and Breast Cancer Surgical Outcomes: A Systematic Review.

This study aims to investigate the relationship between mammographic breast density and the surgical outcomes of breast cancer. PubMed, SCOPUS, Web of Science, Science Direct, and the Wiley Library were systematically searched for relevant literature. Rayyan QRCI was employed throughout this comprehensive process.

A systematic review on malaria and dengue vaccines for the effective management of these mosquito borne diseases: Improving public health.

Insect vector-borne diseases (VBDs) pose significant global health challenges, particularly in tropical and subtropical regions. The WHO has launched the "Global Vector Control Response (GVCR) 2017-2030" to address these diseases, emphasizing a comprehensive approach to vector control. This systematic review investigates the potential of malaria and dengue vaccines in controlling mosquito-borne VBDs, aiming to alleviate disease burdens and enhance public health.

Numerical investigation of sand erosion rate in a horizontal axis wind turbine.

Renewable energy represents an important alternative solution for many energy problems nowadays and a tool for a healthier environment by reducing carbon footprints resulting from burning fossil fuels. However, more work needs to be done towards maximizing the energy produced from renewable energy methods and making sure that the infrastructure used stays in service for a longer duration. Sand erosion phenomena is responsible for the degradation of the wind turbine blades and hence the decrease in their performance and life.

Cystic Lung Changes, Bronchiectasis, and a Heterozygous-Primary Ciliary Dyskinesia-Associated Variant in the DNAH5 Gene: A Diagnostic Challenge.

BACKGROUND Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disease that can present at different ages with different phenotypes. Missed and delayed diagnoses are fairly common. Many variants in the DNAH5 gene have been described that confirm the diagnosis of PCD.

Knowledge and Attitude Regarding Cutaneous Leishmaniasis Among Adult Population in Tabuk, Saudi Arabia.

Background Cutaneous leishmaniasis (CL) is a major health problem in Saudi Arabia. It is caused by the protozoa Leishmania. The vector is female sand flies.