Human endometrial stem cell-derived small extracellular vesicles enhance neurite outgrowth and peripheral nerve regeneration through activating the PI3K/AKT signaling pathway.

Nowadays, extracellular vesicles (EVs) such as exosomes participate in cell-cell communication and gain attention as a new approach for cell-free therapies. Recently, various studies have demonstrated the therapeutic ability of exosomes, while the biological effect of human endometrial stem cell (hEnSC)-derived small EVs such as exosomes is still unclear. Herein, we obtained small EVs from hEnSC and indicated that these small EVs activate the vital cell signaling pathway and progress neurite outgrowth in PC-12 cell lines.

Psychotropic medications: a descriptive study of prescription trends in Tabriz, Iran, 2021-2022.

Introduction: Mental disorders, such as anxiety and depression, significantly impacted global populations in 2019 and 2020, with COVID-19 causing a surge in prevalence. They affect 13.4% of the people worldwide, and 21% of Iranians have experienced them.

Recent advances in the application of engineered exosomes from mesenchymal stem cells for regenerative medicine.

Exosomes, cell-derived vesicles produced by cells, are fascinating and drawing growing interest in biomedical exploration due to their exceptional properties. There is intriguing evidence that exosomes are involved in major biological processes, including diseases and regeneration. Exosomes from mesenchymal stem cells (MSCs) have shown promising outcomes in regenerative medicine.

Antiviral and antibacterial peptides: Mechanisms of action.

Antimicrobial peptides (AMPs) present promising alternatives for addressing bacterial and viral multidrug resistance due to their distinctive properties. Understanding the mechanisms of these compounds is essential for achieving this objective. Therefore, this comprehensive review aims to highlight primary natural sources of AMPs and elucidate various aspects of the modes of action of antiviral and antibacterial peptides (ABPs).

MOFs-based adsorbents for the removal of tetracycline from water and food samples.

Tetracyclines (TCs) are widely employed for the prevention and treatment of diseases in animals besides being deployed to promote animal growth and weight gain. Such practices result in trace amounts of TCs occurrence in water and foodstuffs of animal origin, including eggs and milk, thus posing severe health risks to humans. To ensure the food and water safety and to avoid exposure to humans, the removal of TC residues from food and water has recently garnered a considerable attention.

Simultaneous blockade of the CD73/EGFR axis inhibits tumor growth.

Targeting the influencing factors in tumor growth and expansion in the tumor microenvironment is one of the key approaches to cancer immunotherapy. Various factors in the tumor microenvironment can in cooperation stimulate tumor growth, suppress anti-tumor immune responses, promote drug resistance, and ultimately enhance tumor recurrence. Therefore, due to the dependence and close cooperation of these axes, their combined targeting can have a greater effect compared to their individual targeting.

Overlooked and underserved: how healthcare fails men in the pursuit of equity.

Purpose Of Review: Men face distinctive health-related challenges as a result of biological, behavioral, and sociocultural factors. In addition, the modern healthcare system does not offer men equal opportunities and options to ensure sex-specific access and delivery to health services. Men's health concerns are, indeed, often not addressed or even forgotten.

Ultrastructural characteristics of leishmania (L.)tropica (Wright, 1903) and cell-parasite relationships in cutaneous leishmaniasis. Light and electron microscopic study.

A light and electron microscopic study of skin biopsies taken from 9 patients with ulcerative leishmaniasis of both sexes aged from 14 to 26 years in the territory of the Republic of Azerbaijan was carried out. Based on clinical, morphological and electron microscopic parameters, all patients were diagnosed with ulcerative cutaneous anthroponotic leishmaniasis (Leishmania (L.) tropica).

Efficacy of uterine flushing with human chorionic gonadotropin (hCG) on pregnancy rates in primary unexplained infertility: a randomized controlled trial.

Background: There are limited and controversial findings concerning ovulation induction using intrauterine and intramuscular human chorionic gonadotropin (hCG) injection compared to intramuscular hCG alone. The study aimed to examine the impact of intrauterine hCG injection, which is used to induce ovulation, on the efficacy of the intrauterine insemination (IUI) technique in patients with unexplained infertility.

Methods: A randomized controlled clinical trial was conducted involving 80 subjects with unexplained primary infertility at the infertility clinic of Al-Zahra Hospital in northwest Iran.

Role of exosomes in dental and craniofacial regeneration - A review.

Background: The treatment of congenital deformities, traumatic injuries, infectious diseases, and tumors in the craniomaxillofacial (CMF) region is complex due to the intricate nature of the tissues involved. Conventional treatments such as bone grafts and cell transplantation face limitations, including the need for multiple surgeries, complications, and safety concerns.

Objective: This paper aims to provide a comprehensive analysis of the role of exosomes (EXOs) in CMF and dental tissue regeneration and to explore their potential applications in regenerative dental medicine.

MicroRNAs as diagnostic biomarkers in diabetes male infertility: a systematic review.

This study conducts an in-depth review of the correlation between testis tissue changes and circulating microRNAs (miRNA) in diabetes-induced male reproductive complications, drawing upon both animal and clinical studies. The original articles published in English that specifically investigate miRNAs linked to male infertility in humans or animals with either type I or ΙΙ diabetes mellitus were included. The relevant articles were gathered from the PubMed, Google Scholar, Cochrane Library, and ScienceDirect databases.

Serum vitamin D levels and their correlation with pro-inflammatory prostaglandins in Acute myeloid leukemia: a cross-sectional analysis.

Background This study investigated the association between prostaglandins, vitamin D levels, and their potential role in acute myeloid leukemia (AML). Previous research has shown prostaglandins' stimulatory effects and vitamin D's inhibitory effects in various malignancies. Methods This cross-sectional study evaluated 54 AML patients at Shahid Ghazi Center of Imam Reza Hospital in Tabriz.

Prevalence of cataracts in Iran based on the Persian eye cohort study.

The PERSIAN eye cohort study is a population-based study that evaluates the overall prevalence of cataracts and their subtypes (nuclear sclerosis, cortical, and PSC) in Iran. In this study, from January 2015 to September 2021, 16,016 participants over 35 years of age from four provinces who were selected by random cluster sampling were examined. Demographic information, education, socioeconomic status, and place of residence were collected through interviews.

Distribution of fungal agents in the respiratory system of patients with underlying lung diseases; molecular identification and antifungal susceptibility profiles.

Background And Objectives: Airway fungal infection is a severe clinical problem, especially in patients with compromised immune functions. Here, we examined the distribution and antifungal susceptibility profiles of fungal agents isolated from respiratory tract of symptomatic patients hospitalized in pulmonary units.

Materials And Methods: This descriptive cross-sectional study took place from 2023 to 2024, involving 360 patients.

Alzheimer's disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges.

Background: Alzheimer's disease (AD) is a chronic, progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired reasoning. It is the leading cause of dementia in older adults, marked by the pathological accumulation of amyloid-beta plaques and neurofibrillary tangles. These pathological changes lead to widespread neuronal damage, significantly impacting daily functioning and quality of life.

Effectiveness of different gums on modulating of glycemic indices in adults: a systematic review and meta-analysis.

Background: Functional foods have been widely used as the anti-diabetic agents worldwide. Existing studies presented conflicting results of anti-hyperglycemic properties of gums. This systematic review and meta-analysis study evaluated the existing trials and determined the efficacy of different gums on glycemic indices.

Futile care in COVID-19: how ICU nurses' resilience impacts turnover intention? A cross-sectional descriptive study.

Background: Futile care is a set of actions without creating a reasonable chance of benefiting critically ill patients. In the COVID-19 pandemic, there is a need to discuss futile care perception. This may cause unbearable pressure for nurses in terms of resilience and turnover intention.

The relationship between healthy eating index and Mediterranean diet adherence score with inflammatory indices and disease severity: a case-control study of hospitalized COVID-19 patients.

Background: Recent studies have focused on the connection between nutrition, inflammation, and infectious diseases. This study was conducted to investigate the relationship between the Mediterranean diet adherence score (MDS) and the healthy eating index (HEI) with some clinical findings of patients with COVID-19.

Methods: This case-control study was conducted in 29 Bahman hospital of Tabriz, Iran, from June to December 2022.

Effect of postpartum clinical guideline on maternal outcomes in iranian women: a randomized controlled clinical trial.

Background: The postpartum period is a vital time for women, infants, spouses, parents, caregivers and families. Considering the importance of postpartum care and the necessity of using comprehensive and up-to-date clinical guidelines in Iran, this study was designed to implement a indigenized clinical guideline in Iran on maternal outcomes, including maternal functioning, postpartum depression and postpartum specific anxiety (primary outcomes) as well as infant care, maternal health problems, experiencing violence, feeding method and contraception use (secondary outcomes).

Methods: This randomized controlled trial was conducted with 272 postpartum women in Taleghani and Alzahra hospitals in Tabriz in 2023.

Spot test with smartphone digital image analysis for determination of methadone in exhaled breath condensate.

In this work, we explored the potential of the spot test combined with image analysis using smartphones as a rapid, simple, low-cost, and environmentally friendly method for identifying methadone concentration. Herein, a carbon-gold nanocomposite has been used to generate color variation at different concentrations of methadone. The data obtained from the digital image colorimetric method was compared with those from the UV-Vis spectroscopy as a standard technique.

Retraction notice to "Multifaceted role of polyphenols in the treatment and management of neurodegenerative diseases"[Chemosphere 307 (2022) 136020].

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal).

Identification of RN7SK LncRNA as a novel biomarker in Alzheimer's disease using bioinformatics and expression analysis.

Alzheimer's disease (AD) is a degenerative illness that accounts for the common type of dementia among adults over the age of 65. Despite extensive studies on the pathogenesis of the disease, early diagnosis of AD is still debatable. In this research, we performed bioinformatics approaches on the AD-related E-MTAB 6094 dataset to uncover new potential biomarkers for AD diagnosis.