Identification of RN7SK LncRNA as a novel biomarker in Alzheimer's disease using bioinformatics and expression analysis.

Alzheimer's disease (AD) is a degenerative illness that accounts for the common type of dementia among adults over the age of 65. Despite extensive studies on the pathogenesis of the disease, early diagnosis of AD is still debatable. In this research, we performed bioinformatics approaches on the AD-related E-MTAB 6094 dataset to uncover new potential biomarkers for AD diagnosis.

Identifying the facilitators of Iran's alcoholic beverage black market and presenting solutions for harm reduction: a qualitative document analysis.

Background: Despite Iran's prohibition politics regarding alcoholic beverages consumption, marketing, and trading, there is a flourishing black market. Often, alcohol producers on this black market do not adhere alcohol production standards, resulting in a lot of deaths and significant consequences each year. Accordingly, this study was carried out to identify facilitators for the growth of the black market for alcoholic beverages in Iran and provide solutions for harm reduction.

Nursing students' perception of the clinical learning environment and its impact on academic adjustment: a cross-sectional descriptive study.

Background: Academic adjustment significantly influences the progress of nursing students. Understanding clinical education environments can profoundly affect students' academic adjustment. This study aims to determine nursing students' perception of the clinical learning environment and its relationship to academic adjustment.

The ability of clostridium novyi-NT spores to induce apoptosis via the mitochondrial pathway in mice with HPV-positive cervical cancer tumors derived from the TC-1 cell line.

Background: A precise observation is that the cervix's solid tumors possess hypoxic regions where the oxygen concentration drops below 1.5%. Hypoxia negatively impacts the host's immune system and significantly diminishes the effectiveness of several treatments, including radiotherapy and chemotherapy.

Assessing patient satisfaction with hemodialysis and peritoneal dialysis care and associated factors in Iran.

Purpose: With the increasing demand for dialysis, there is a growing emphasis on patient-centered care. This study investigated patients' satisfaction levels with peritoneal dialysis (PD) and hemodialysis (HD) care in Iran.

Methods: A cross-sectional multicenter study was conducted among 346 patients with chronic kidney disease (CKD) covered by the Iran Health Insurance Organization who received dialysis services from October to December 2022 across the country.

Preparation and Evaluation of the Effectiveness of an Anti-Wrinkle Cream Containing Equisetum arvense and Soybean Extracts.

Background: Skin aging is a multifaceted condition marked by the development of wrinkles, reduced suppleness, and uneven pigmentation. Both endogenous and exogenous factors contribute to skin aging. Studies have examined the possible anti-aging advantages of horsetail and soybean extracts, which are abundant in antioxidants.

The Black Cloud of Endometriosis on different aspects of the Life of Women with Endometriosis: a qualitative study in Iran.

Aim: To explore the perception of the impact of endometriosis on various aspects in affected women with endometriosis.

Method: Data was gathered through in-depth and semi-structured individual interviews using open questions to comprehend women's experiences with endometriosis and their health-promoting lifestyle. The Conventional Qualitative Content Analysis approach was utilized, and sampling continued until data saturation.

Modulating exosomal communication between macrophages and melanoma cancer cells via cyclodextrin-based nanosponges loaded with doxorubicin.

The cellular components of the tumor microenvironment (TME) comprise cancer cells and nonmalignant cells including stromal and immune cells. Exosomes are extracellular vesicles secreted by various types of cells that play a crucial role in intercellular communications within TME. The main goal of this study was to elucidate how exosomes of macrophage cells treated with doxorubicin (DOX) and DOX-loaded cyclodextrin-based nanosponges (DOX-CDNSs), affect melanoma cancer cell proliferation.

Comparison of X-Ray Attenuation Performance, Antimicrobial Properties, and Cytotoxicity of Silicone-Based Matrices Containing BiO, PbO, or BiO/PbO Nanoparticles.

Background: Application of the nanomaterials to preparing X-ray shields and successfully treating multiresistant microorganisms has attracted great attention in modern life.

Objective: This study aimed to prepare flexible silicone-based matrices containing BiO, PbO, or BiO/PbO nanoparticles and select a cost-effective, cytocompatible, and antibacterial/antifungal X-ray shield in clinical radiography.

Material And Methods: In this experimental study, we prepared the nanoparticles by the modified biosynthesis method and fabricated the X-ray shields containing 20 wt% of the nanoparticles.

The impact of professional oral health care on the oral health of older people: a systematic review and meta-analysis.

Introduction: In recent years, Professional Oral Health Care (POHC) has received serious attention for improving Oral Health Indicators (OHIs) in older people. Therefore, the present study aims to evaluate the impact of POHC on the oral health of older people through a systematic review and meta-analysis of existing studies and evidence.

Methods: Published articles until August 1, 2023, were searched in databases such as Scopus, PubMed, and Web of Science.

Association of maxillofacial injuries with traumatic brain injuries in paediatric patients: a case-control study.

Background: Traumatic brain injuries (TBIs) are among the most challenging conditions to accurately diagnose in children, and many TBIs are underdiagnosed. Patients with maxillofacial injury may be at risk for TBI. The objective of this study was to analyse the association between maxillofacial injuries and TBI among paediatric patients.

Challenges of smoking cessation in users of non-invasive stimulation technologies in Iran: a parallel convergent mixed-methods study.

Objectives: In recent years, non-invasive stimulation technologies such as repetitive transcranial magnetic stimulation, transcranial direct current stimulation, bioresonance and auriculotherapy have been used for smoking cessation. Individuals may face various challenges throughout the quitting process. This study aimed to explore the challenges of smoking cessation for users of non-invasive stimulation technologies in Iran.

Exosome-driven nano-immunotherapy: revolutionizing colorectal cancer treatment.

Colorectal cancer (CRC) ranks as the third most common cancer worldwide and remains a major cause of cancer-related deaths, necessitating the development of innovative therapeutic approaches beyond conventional treatment modalities. Conventional therapies, such as radiation, chemotherapy, and surgery, are hindered by challenges like imprecise targeting, substantial toxicity, and the development of resistance. Exosome-driven nano-immunotherapy has emerged as a groundbreaking approach that leverages the natural properties of exosomes-cell-derived vesicles known for their role in intercellular communication-to deliver therapeutic agents with high precision and specificity.

A Systematic Review and Meta-Analysis to Evaluate the Effects of Chitosan on Obesity Indicators.

Chitosan, a commonly used dietary supplement, is believed to have the potential to decrease body weight by binding to dietary fats and decreasing their absorption. However, due to conflicting results from various studies, this review aimed to investigate the effects of chitosan supplementation on obesity indicators in adults. To find appropriate randomized clinical trials (RCTs), a thorough search was conducted across electronic databases like PubMed/Medline, Scopus, and ISI Web of Science.

Shortened NIHSS for Rapid Stroke Assessment in Emergency Care Settings.

Objectives: The National Institutes of Health Stroke Scale (NIHSS) is widely used to assess ischemic stroke severity, but its full 11-item version can be time-consuming. This study evaluates the NIHSS-8, a shortened version, for its efficacy compared with NIHSS-11 in an emergency department setting.

Methods: A cohort study was conducted from May 2018 to May 2019 at Imam Reza Hospital, Tabriz, Iran.

Application of core-shell magnetic metal-organic framework in developing dispersive micro solid phase extraction combined with dispersive liquid-liquid microextraction for the extraction and enrichment of some pesticides in orange blossom, Aloysia Citrodora, and fennel herbal infusions.

This paper introduces an innovative technique for extracting pesticides from herbal infusions using a core-shell magnetic adsorbent (i.e., Cu-BTC@FeO) where achieving a notable enrichment factor for the target pesticides by coupling with a dispersive liquid-liquid microextraction method.

Investigating the resilience of kidneys in rats exposed to chronic partial sleep deprivation and circadian rhythm disruption as disruptive interventions.

Sleep is a vital biological function that significantly influences overall health. While sleep deprivation (SD) and circadian rhythm disruption are known to negatively impact various organs, their specific effects on kidney function remain understudied. This study aimed to investigate the impact of chronic partial sleep deprivation and circadian rhythm disruption on renal function in rats, providing insights into the relationship between sleep disturbances and kidney health.

Aripiprazole-loaded niosome/chitosan-gold nanoparticles for breast cancer chemo-photo therapy.

Introduction: Breast cancer, a formidable global health challenge for women, necessitates innovative therapeutic strategies with enhanced efficacy and minimal side effects. Aripiprazole (ARI), a widely used schizophrenia medication, exhibits promising potential in the treatment of breast cancer. As cancer therapy evolves towards a combination approach, multimodal nano-based delivery systems, such as ARI-loaded niosomes (NIOs) combined with Chitosan-Au nanoparticles for chemo-photothermal therapy, show promise over traditional chemotherapy alone by enhancing targeted efficacy and minimizing side effects.