Effect of Ni-Doping on the Optical, Structural, and Electrochemical Properties of Ag Nanoclusters.

Atomically precise metal nanoclusters (NCs) can be compositionally controlled at the single-atom level, but understanding structure-property correlations is required for tailoring specific optical properties. Here, the impact of Ni atom doping on the optical, structural, and electrochemical properties of atomically precise 1,3-benzene dithiol (BDT) protected Ag NCs is studied. The Ni-doped Ag (NiAg(BDT)) NCs, are synthesized using a co-reduction method and characterized using electrospray ionization mass spectrometry (ESI MS), ion mobility spectrometry (IMS), and X-ray photoelectron spectroscopy (XPS).

Incompletely Observed Nonparametric Factorial Designs With Repeated Measurements: A Wild Bootstrap Approach.

In many life science experiments or medical studies, subjects are repeatedly observed and measurements are collected in factorial designs with multivariate data. The analysis of such multivariate data is typically based on multivariate analysis of variance (MANOVA) or mixed models, requiring complete data, and certain assumption on the underlying parametric distribution such as continuity or a specific covariance structure, for example, compound symmetry. However, these methods are usually not applicable when discrete data or even ordered categorical data are present.

Ultrafast optical induction of magnetic order at a quantum critical point.

Time-resolved ultrafast spectroscopy has emerged as a promising tool to dynamically induce and manipulate non-trivial electronic states of matter out-of-equilibrium. Here we theoretically investigate light pulse driven dynamics in a Kondo lattice system close to quantum criticality. Based on a time-dependent auxiliary fermion mean-field calculation we show that light can dehybridize the local Kondo screening and induce oscillating magnetic order out of a previously paramagnetic state.

Photon Upconversion of Defect-Bound Excitons in hBN-Encapsulated MoS Monolayer.

Atomic defects associated with vacancies in two-dimensional transition metal dichalcogenide monolayers efficiently trap charged carriers and strongly localize excitons. Defects in semiconducting monolayers are seldomly utilized for enhancing optical phenomena, although they may provide resonant intermediate states within the energy band gap for applications with multiphoton excitations, like highly efficient and thermally robust photon upconversion. In an MoS monolayer encapsulated by hBN with high defect and resident electron densities, we observe an upconversion of localized exciton (X) emission with a huge energy gain of up to 290 meV.

Proof-of-principle of 3D-printed track-end detectors for dosimetry in proton therapy.

Background: Dosimetric equipment in particle therapy (PT) is associated with high costs. There is a lack of versatile, tissue-equivalent detectors suitable for in-vivo dosimetry. Faraday-cup (FC) type detectors are sensitive to stopped protons, that is, to track-ends (TEs).

Solvent-Directed Social Chiral Self-Sorting in PdL Coordination Cages.

A family of Pd cages prepared from ligands based on an axially chiral diamino-[1,1'-biazulene] motif (serving as a unique azulene-based surrogate of the ubiquitous BINOL moiety) is reported. We show that preparing a cage starting from the racemate of a shorter bis-monodentate ligand derivative, equipped with pyridine donor groups, leads to integrative ("social") chiral self-sorting, exclusively yielding the product, but only in a selection of solvents. This phenomenon is driven by individual solvent molecules acting as hydrogen bonding tethers between the amino groups of neighboring ligands, thereby locking the final coordination cage in a single isomeric form.

Design of optimal concentrations for in vitro cytotoxicity experiments.

Concentration-dependent cytotoxicity experiments are frequently used in toxicology. Although it has been reported that an adequate choice of concentrations improves the quality of the statistical inference substantially, a recent literature review of three major toxicological journals has shown that the corresponding methods are rarely used in toxicological practice. In this study the performance of different sets of concentrations, also called designs, are analyzed, while the overall goal is to promote the advantages of optimal design procedures and to present a user-friendly guideline for planning new cytotoxicity concentration-response experiments.

No Socioeconomic Inequalities in Mortality among Catholic Monks: A Quasi-Experiment Providing Evidence for the Fundamental Cause Theory.

We propose a novel approach to test the fundamental cause theory (FCT) by analyzing the association between socioeconomic status (SES), as measured by the order titles "brothers" and "padres," and mortality in 2,421 German Catholic monks born between 1840 and 1959. This quasi-experiment allows us to study the effect of SES on mortality in a population with largely standardized living conditions. Mortality analyses based on Kaplan-Meier product limit estimation show that there were no statistically significant survival differences between the high and lower SES monks.

Baseline Inflammation but not Exercise Modality Impacts Exercise-induced Kynurenine Pathway Modulation in Persons With Multiple Sclerosis: Secondary Results From a Randomized Controlled Trial.

Background: The kynurenine pathway (KP) is an important hub in neuroimmune crosstalk that is dysregulated in persons with multiple sclerosis (pwMS) and modulated by exercise in a modality-specific manner.

Objectives: To compare changes in the KP metabolite profile of pwMS (1) following combined treatments including either high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT) during a 3-week multimodal rehabilitation, (2) to evaluate exercise response in relation to baseline systemic inflammation, and (3) to investigate associations of kynurenines with physical capacity and clinical outcomes.

Methods: For this secondary analysis of a randomized controlled trial, serum concentrations of kynurenines at baseline and after 3 weeks were determined using targeted metabolomics (LC-MS/MS).

Where does the processing of size meet the processing of space?

Previous studies revealed an S-R compatibility effect between physical stimulus size and response location, with faster left (right) responses to small (large) stimuli, respectively, as compared to the reverse assignments. Here, we investigated the locus of interactions between the processing of size and spatial locations. In Experiment 1, we explored whether stimulus size and stimulus location interact at a perceptual level of processing when responses lack spatiality.

H and C NMR and FTIR Spectroscopic Analysis of Formic Acid Dissociation Dynamics in Water.

The formation and transport of ionic charges in formic acid-water (HCOOH-HO) mixtures with initial water mole fractions ranging from X = 0 to 1 were investigated using C and H NMR, FTIR spectroscopy, viscosity, conductivity, and pH measurements. The maximum molar concentration of ions (HO and HCOO), along with the relative differences between theoretical and experimental densities, spin-lattice relaxation times (), activation energies (), viscosity (η), and conductivity (σ), were identified within the range of X ≈ 0.5-0.

Targeted Polariton Flow Through Tailored Photonic Defects.

In non-Hermitian open quantum systems, such as polariton condensates, the local tailoring of gains and losses opens up an interesting possibility to realize functional optical elements. Here, we demonstrate that deliberately introducing losses via a photonic defect, realized by reducing the quality factor of a DBR mirror locally within an ultrahigh-quality microcavity, may be utilized to create directed polariton currents towards the defect. We discuss the role of polariton-polariton interactions in the process and how to tailor the effective decay time of a polariton condensate by coupling it to the defect.

Multitasking practice eliminates modality-based interference by separating task representations in sensory brain regions.

The debate on the neural basis of multitasking costs evolves around neural overlap between concurrently performed tasks. Recent evidence suggests that training-related reductions in representational overlap in fronto-parietal brain regions predict multitasking improvements. Cognitive theories assume that overlap of task representations may lead to unintended information exchange between tasks (i.

Counteracting the loss of release for indomethacin-copovidone ASDs.

This work revisits the changing release behavior of indomethacin(IND)-copovidone amorphous solid dispersions (ASDs) when increasing their drug load (DL). While showing congruent release behavior at DL 0.1, ASDs with DLs of 0.

Verbal stimuli allow for symmetrical S-R priming effects between size and space.

The spatial-size association of response codes (SSARC) effect refers to the observation that left responses are faster and more accurate to small stimuli whereas right responses are faster and more accurate to large stimuli, as compared to the reverse assignment. The underlying spatial-size associations are strongly asymmetrical with physical size/location stimuli and vocal location/size responses and allow for regular but not reciprocal SSARC effects. Recent evidence, however, points towards an important role of stimulus mode in the emergence of reciprocal compatibility effects.

Acute exercise boosts NAD metabolism of human peripheral blood mononuclear cells.

Nicotinamide adenine dinucleotide (NAD) coenzymes are the central electron carriers in biological energy metabolism. Low NAD levels are proposed as a hallmark of ageing and several diseases, which has given rise to therapeutic strategies that aim to tackle these conditions by boosting NAD levels. As a lifestyle factor with preventive and therapeutic effects, exercise increases NAD levels across various tissues, but so far human trials are mostly focused on skeletal muscle.

Using interpretable machine learning methods to identify the relative importance of lifestyle factors for overweight and obesity in adults: pooled evidence from CHNS and NHANES.

Background: Overweight and obesity pose a huge burden on individuals and society. While the relationship between lifestyle factors and overweight and obesity is well-established, the relative contribution of specific lifestyle factors remains unclear. To address this gap in the literature, this study utilizes interpretable machine learning methods to identify the relative importance of specific lifestyle factors as predictors of overweight and obesity in adults.

Social Comparison, Social Indispensability, or Both? On the Psychological Mechanisms Underlying Effort Gains in Swimming Relays.

Members of swimming relays often show effort gains in relays (i.e., more effort and faster swimming times in the relay vs.

London dispersion driven compaction of coordination cages in the gas-phase - a combined ion mobility and theoretical study.

Large self-assembled systems (such as metallosupramolecular rings and cages) can be difficult to structurally characterize, in particular when they show a highly dynamic behavior. In the gas-phase, Ion Mobility Spectrometry (IMS), in tandem with Electrospray Ionization Mass Spectrometry (ESI MS), can yield valuable insights into the size, shape and dynamics of such supramolecular assemblies. However, the detailed relationship between experimental IMS data and the actual gas-phase structure is still poorly understood for soft and flexible self-assemblies.

Phenazinium- and Malachite Green-Based Pd(II) Cages: Chiroptical Discrimination of Nucleoside Triphosphates.

Organic chromophores have been successfully implemented into supramolecular systems to bestow them with distinct photophysical properties for various applications, ranging from solar energy conversion, photochemical reactions or as receptors for guest molecules with optical readout. We had previously introduced first members of the large family of coal-tar dyes (methylene blue, crystal violet and rhodamine) as integral components of coordination cages. Here, we add two new chromophores, malachite green (MGP) and a purple phenazinium dye (PHP), serving as backbones of bis-monodentate banana-shaped ligands with pyridine donors.

Ethanol Production Using and In Situ Extraction in a Capillary Microreactor.

The bacterium is investigated as a model organism for the cultivation and separation of ethanol as a product by in situ extraction in continuous flow microreactors. The considered microreactor is the Coiled Flow Inverter (CFI), which consists of a capillary coiled onto a support structure. Like other microreactors, the CFI benefits from a high surface-to-volume ratio, which enhances mass and heat transfer.