Synthetic phenolic antioxidant contamination in farmland soils induced by mulching films: Distribution and transformation pathways.

The occurrence and distribution of synthetic phenolic antioxidants (SPAs) originating from mulch film in farmland soils, along with their transformation characteristics and pathways, remain largely unknown. This study is the first to investigate nineteen SPAs and four transformation products (TPs) in farmland soils across China. In film-mulching soils, concentrations of SPAs (median, range: 83.

Effects of Algal-Derived -Glucan on the Growth Performance, Intestinal Health, and Resistance of Ricefield Eel ().

Ricefield eel is an important economic fish in China. However, large-scale intensive breeding has increased the incidence of diseases in eels. In this study, we conducted an 8-week feeding trial to investigate the effects of -glucan on the growth performance, intestinal health, and resistance of ().

Knowledge translation initiatives at the Transitional Pain Service: insights from healthcare provider outreach and patient education.

Evidence-based treatment of chronic pain requires a multidisciplinary approach grounded in the biopsychosocial model. Implementing this approach within health systems relies on its acceptance by both healthcare providers and patients. While pioneering multidisciplinary pain clinics can serve as a model for implementation, a systematic effort is needed to share knowledge effectively and broadly.

Insulator-metal transition in VO film on sapphire studied by broadband dielectric spectroscopy.

Vanadium dioxide ([Formula: see text]) is a favorable material platform of modern optoelectronics, since it manifests the reversible temperature-induced insulator-metal transition (IMT) with an abrupt and rapid changes in the conductivity and optical properties. It makes possible applications of such a phase-change material in the ultra-fast optoelectronics and terahertz (THz) technology. Despite the considerable interest to this material, data on its broadband electrodynamic response in different states are still missing in the literature.

Chlorine-substituted transformation products generated during chlorination of the organophosphorus insecticide disulfoton induce anti-acetylcholine esterase activity.

Global concern regarding transformation products (TPs) derived from contaminants, including pesticides, in the environment and during water treatment has been growing markedly. In the present study, we investigated the anti-acetylcholinesterase (AChE) activity of an aqueous solution of the organophosphorus insecticide disulfoton, a toxicological endpoint for determining the acceptable daily intake of disulfoton, both in the presence and the absence of metabolism during chlorination. Disulfoton rapidly reacted with free chlorine and completely disappeared within 0.

Estimation of surface doses in the presence of an air gap under a bolus for a 6 MV clinical photon beam - a phantom study.

Goal of the present study was to develop and build a phantom that replicates the air gaps under a gel bolus and to estimate the surface dose (D) under normal incidence with a 6 MV photon beam. For this, an acrylic phantom with 10 plates, each including five open slots (one in the centre and four off axis) with a size of 2 cm × 2 cm at depths of 0.54 cm, 0.

The usage of the paris classification system in urine cytology in the diagnosis of non-muscle-invasive bladder cancer: a retrospective single-center study.

Purpose: This retrospective single-center study aimed to determine the correlation between The Paris System (TPS) urine cytology classification, cystoscopy findings, and non-muscle-invasive bladder cancer diagnosis. In addition, we sought to identify factors that might explain the abnormal cytology classification in cases in which no malignancy was detected.

Methods: A Total of 855 patients evaluated with urine cytology between 2017 and 2020 at Kuopio University Hospital were included.

Age and Sex-Based Differences in Therapy Preferences Among Patients with Cancer: Evidence from a Novel Therapy Preference Scale.

Patients' preferences are crucial to formulating personalized treatment plans. We developed a self-reported questionnaire, Therapy Preference Scale (TPS), to examine treatment preferences of patients with cancer. TPS has 30 questions-19 on patients' preferences on safety, quality of life, and treatment effectiveness, 8 questions on importance of various treatment characteristics, and 3 on patients' preferred intent of therapy, expenses, and life expectancy gain.

Dose verification of 2 targets simultaneously for single-isocenter stereotactic radiation therapy and radiosurgery plans.

Most of conventional 2-dimensional (2D) methods verify dose of multiple targets separately one-by-one for Single-isocenter Multiple-target (SIMT) brain plans, which are inefficient and sub-optimal. This study presented a practical method to verify the dose of 2 targets simultaneously for improved efficiency and accuracy. Fifteen Stereotactic Radiation Therapy (SRT) and sixteen Stereotactic Radiosurgery (SRS) plans were used for this study.

Effects of Four Sulfonate-Containing Additives and Hydroxyethyl Cellulose on the Properties of Electrolytic Copper Foils.

Ultrathin electrolytic copper foils with a thickness of 6 μm were prepared by a test machine using copper sulfate electrolyte with gelatin, hydroxyethyl cellulose (HEC), and sulfonic acid-containing organics as additives. The effects of four sulfonic acid-containing organic additives, sodium 3-mercaptopropanesulfonate (MPS), bis-(sodium sulfopropyl)-disulfide (SPS), sodium 3-[[(dimethylamino)thioxomethyl]thio]propanesulfonate (DPS), and sodium 3-((4,5-dihydrothiazol-2-yl)thio)propane-1-sulfonate (TPS), on the physical property of copper foils were investigated. The results show that all these additives can effectively improve the gloss and tensile strength of electrolytic copper foil, and the texture coefficients of Cu(111) selectivity increase.

Effects of Dietary Tea Polyphenols on the Growth, Antioxidant Status, Immune Function, and Intestinal Microbiota of Largemouth Bass ().

This research aimed to explore the impact of tea polyphenol (TP) supplementation on the development, antioxidant properties, immune responses, and gut wellness in largemouth bass (, LMB). Four diets with varying levels of TPs (0.00%, 0.

Non-Drug and Non-Invasive Therapeutic Options in Alzheimer's Disease.

Despite the massive efforts of modern medicine to stop the evolution of Alzheimer's disease (AD), it affects an increasing number of people, changing individual lives and imposing itself as a burden on families and the health systems. Considering that the vast majority of conventional drug therapies did not lead to the expected results, this review will discuss the newly developing therapies as an alternative in the effort to stop or slow AD. Focused Ultrasound (FUS) and its derived Transcranial Pulse Stimulation (TPS) are non-invasive therapeutic approaches.

Optimizing UroVysion Fluorescence Hybridization Reflex Testing in Atypical Urothelial Cell Diagnosis: A Comprehensive Cytomorphological Analysis.

Objective: Urinary cytology is a key diagnostic tool for evaluating suspected urinary tract carcinoma, primarily high-grade urothelial carcinoma. The Paris System for Reporting Urinary Cytology (TPS), introduced in 2016, aimed to standardize reporting, though challenges with subjectivity and variability in diagnosing Atypical Urothelial Cells (AUCs) persist.

Methods: This retrospective study explored the correlation between cytomorphological features in "atypical" diagnosis and UroVysion fluorescence hybridization (U-FISH) results.

Proton minibeam (pMBRT) radiation therapy: experimental validation of Monte Carlo dose calculation in the RayStation TPS.

Proton minibeam radiation therapy (pMBRT) dose profile is characterized by highly heterogeneous dose in the plane perpendicular to the beam direction and rapidly changing depth dose profiles. Typically, dose measurements are benchmarked against in-house Monte Carlo simulation tools. It is essential to have a treatment planning system (TPS) that can accurately predict pMBRT doses in tissue and be available via commercial platform for preclinical and clinical use.

HMGB1 assists the predictive value of tumor PD-L1 expression for the efficacy of anti-PD-1/PD-L1 antibody in NSCLC.

Background: The expression of anti-programmed cell death ligand-1 (PD-L1) in tumors is widely used as a biomarker to predict the therapeutic efficacy of anti-programmed cell death-1(PD-1)/PD-L1 antibodies. However, the predictive accuracy of this method is limited. High-mobility group box 1 (HMGB1) is known to modulate cancer immunity.

Expression Analysis and Functional Validation of DcTPSb1 in Terpene Synthesis of .

Terpenes are critical components of the floral fragrance component in , synthesized by terpene synthase (TPS). Analysis of the genome and transcriptional data revealed that the gene was significantly up-regulated during flowering periods, showing a strong correlation with the accumulation of aromatic monoterpenes in the floral components of . Consequently, the gene was selected for further analysis.

Crystalline Covalent Triazine Frameworks and 2D Triazine Polymers: Synthesis and Applications.

ConspectusCovalent triazine frameworks (CTFs) are a novel class of nitrogen-rich conjugated porous organic materials constructed by robust and functional triazine linkages, which possess unique structures and excellent physicochemical properties. They have demonstrated broad application prospects in gas/molecular adsorption and separation, catalysis, energy conversion and storage, etc. In particular, crystalline CTFs with well-defined periodic molecular network structures and regular pore channels can maximize the utilization of the features of CTFs and promote a deep understanding of the structure-property relationship.

Integrated metabolome and transcriptome analysis provides insights into the mechanisms of terpenoid biosynthesis in tea plants (Camellia sinensis).

Volatile terpenoids are major substances responsible for the floral and fruity scents of teas. However, little is known about the regulatory mechanisms of terpenoid biosynthesis pathways in tea plants. 'Zhenfeng Yesheng tea' (ZFYS), a distinctive tea tree germplasm resource in Guizhou province, is known for its unique flavor characterized by a mellow taste and a floral aroma.

Prognostic and clinical heterogeneity of PD1 and PD-L1- immunohistochemical scores in endometrial cancers.

Introduction: PD1/PD-L1 inhibition (ICi) has recently become a new standard of care for patients with advanced MMR-deficient (MMRd) endometrial cancers. Nevertheless, response to immunotherapy is more complex than the presence of a single biomarker and therefore it remains challenging to predict patients response to ICi beyond MMRd tumors. Elevated PD-L1 expression (CPS ≥ 1) is often used as a prognostic marker as well as a predictive biomarker of response to ICi in different tumor types.

Heterogeneous head phantom for validating treatment planning system in boron neutron capture therapy.

In clinical boron neutron capture therapy (BNCT), the distribution of dose to a heterogeneous medium that is predicted by a treatment planning system (TPS) should be experimentally validated. A head phantom specifically developed for this purpose is described and demonstrated herein. The cylindrical phantom exhibits distinct regions made from four materials (polymethyl methacrylate, calcium phosphate, air, and boric acid) to approximate a head structure with explicitly defined skin, skull, and brain tissue with a cavity and tumor within.

Identification of Dufulin photolysis and hydrolysis products in water using a C stable isotope assisted HPLC-HRMS strategy.

Dufulin is an efficient antiviral agent for plants, however, data on its environmental fate, particularly concerning its transformation products (TPs), remain scarce. The TPs formed during abiotic degradation may pose significant environmental risks due to potential toxicity. Therefore, this study systematically investigated the hydrolysis and photolysis kinetics of Dufulin in aqueous solutions across various pH conditions.

PD-L1 expression in PitNETs: Correlations with the 2022 WHO classification.

Introduction: and research question: Prognostic factors to predict the behavior of pituitary neuroendocrine tumors (PitNET) are scarce. PD-L1 expression was associated with prognosis in other neuroendocrine neoplasms and we analyzed PD-L1 expression in PitNET, according to the 2022 WHO classification.

Material And Methods: A retrospective analysis was performed.

Linear Accelerator (LINAC) Radiosurgical Management of Brain Arteriovenous Malformations: An Experience From a Tertiary Care Center.

Introduction: Brain arteriovenous malformations (AVM) are complex vascular pathologies with a significant risk of hemorrhage. Stereotactic radiosurgery (SRS) is an effective treatment modality for AVM, initially popularized on the Gamma Knife (Elekta AB, Stockholm, Sweden) platform, and now benefits from the modern advances in linear accelerator (LINAC)-based platforms. This study evaluates the outcomes of LINAC-based SRS/hypofractionated stereotactic radiotherapy (hFSRT) for cerebral AVMs.

Efficacy and Safety of Immunotherapy Combined with Anlotinib as FirstLine Treatment in Older NSCLC Patients with PD-L1 Expression<50.

Background: Non-small cell lung cancer (NSCLC) predominantly affects older adults; these patients have significant comorbidities, making them unsuitable for chemotherapy. This study aimed to evaluate the efficacy and safety of immune checkpoint inhibitor (ICI) along with anlotinib combination therapy as a first-line treatment in older NSCLC patients with programmed death ligand-1(PD-L1) expression＜50%.

Methods: We conducted a retrospective observational study including 73 patients with advanced NSCLC treated at Nanjing Brain Hospital.

Characterization and evaluation methods of fused deposition modeling and stereolithography additive manufacturing for clinical linear accelerator photon and electron radiotherapy applications.

Purpose: To propose comprehensive characterization methods of additive manufacturing (AM) materials for MV photon and MeV electron radiotherapy.

Methodology: This study investigated 15 AM materials using CT machines. Geometrical accuracy, tissue-equivalence, uniformity, and fabrication parameters were considered.