Physician Health in the Times of COVID-19.

Background And Objectives: A virtual registry study evaluating real world evidence on physicians' use of prophylactic regimens for protection against SARS-CoV-2. This paper summarizes the interim results.

Methods: Asymptomatic physicians at risk of acquiring SARS-CoV-2 responded to online questions at baseline and 7 weeks post-baseline.

Cerebrospinal Fluid - A Clinicopathologic Analysis.

Context And Objective: This study aims to emphasize the importance of an appropriate CSF examination in patients of suspected CNS disease and the necessity of correlating it with the clinico-radiologic findings which will help in early diagnosis of CNS diseases and guide the further management of the disease.

Design: In this 2 year study, 215 CSF samples from patients with clinically suspected diseases of the CNS were studied. The CSF samples were analyzed for gross examination, protein, sugar, adenosine deaminase (ADA) levels, microscopic examination and microbiologic examination.

Satisfying Doubters and Critics: Dealing with the Peer Review.

Although peer review process intends to improve the quality of published scientific literature, many authors find the process intimidating and overbearing. Responding to reviewers' comments in a hasty and inappropriate manner is self-defeating. Authors need to answer the reviewers in an objective manner providing additional description, rational arguments and relevant evidence.

Comparsion of Intravenous Lignocaine, Tramadol and Keterolac for Attenuation of Propofol Injection Pain.

Introduction: Propofol possesses many characteristics of an ideal intravenous anaesthetic agent, providing a smooth induction and a rapid recovery. However, it has been reported to evoke considerable pain on injection in 10-100% of patients. The cause of pain upon intravenous injection of propofol remains a mystery.

The study of complications of vivax malaria in comparison with falciparum malaria in Mumbai.

Introduction: Severe malaria due to P. vivax infection is increasingly observed now a days. Organ failure in vivax malaria is caused by mechanisms of inflammation as well as sequestration.

Hypomagnesemia in critically ill medical patients.

Background: Hypomagnesemia is an important but underdiagnosed electrolyte abnormality in critically ill patients. There are many studies to find the prevalence of hypomagnesemia and its effects on mortality and morbidity in these patients. Most of these studies have been carried out in intensive care units caring for patients with medical and surgical conditions and postoperative patients or those in respiratory intensive care unit, or critically ill cancer patients.

Moyamoya disease with hypertension in a young adult.

A 13 year old boy presented with recurrent TIAs and was found to have high blood pressure. On investigations he was detected to be Moyamoya disease. Hypertension is known to be associated with Moyamoya disease; the cause being renal artery stenosis.

Splenic mass and isolated gastric varices: a rare presentation of a neuroendocrine tumor of the pancreas.

Context: Splenic involvement in neuroendocrine pancreatic tumors is well known but rarely presents as a primary splenic mass.

Case Report: A rare case of a neuroendocrine tumor involving the tail of the pancreas, splenic hilum and splenic flexure of the colon, forming a conglomerate mass and presenting as isolated gastric varices is described. A 75-year-old male presented with hematemesis and melena.

Role of carotid intima-media thickness in assessment of atherosclerosis: an autopsy study.

Background: The non-invasive technique of measuring carotid artery intima-media thickness has generated considerable interest as a marker of atherosclerosis, particularly in predicting clinical coronary events and coronary artery disease. In the present study, a postmortem comparative analysis of intima-media thickness of carotid artery with coronary artery atherosclerosis has been carried out. To date no such morphological tissue studies are available from our country.

Chronic thromboembolic pulmonary hypertension--diagnosed on spiral CT angiography.

Chronic thromboembolic pulmonary hypertension (CTEPH) is a part of the spectrum of venous thromboembolism in which pulmonary thrombus fails to resolve, resulting in occlusion of the major pulmonary artery. Diagnosis of this disease is important as it is potentially curable by pulmonary thromboendarterectomy. A case of CTEPH diagnosed non-invasively on spiral computerized (CT) pulmonary angiography is reported.

A cost-effectiveness analysis of three antimalarial treatments for acute, uncomplicated Plasmodium falciparum malaria in Mumbai, India.

Background: Malaria is a major public health problem representing 2.3% of the overall global disease burden. The cost of treatment of malaria continues to rise as older drugs and insecticides become less effective and are replaced by more effective, but also more expensive products.

Upper lobe fibrosis in ulcerative colitis.

We report a case of ulcerative colitis where chest radiograph and high-resolution computed tomography (HRCT) of the lungs revealed bilateral upper lobe fibrosis, which was misdiagnosed and treated as pulmonary tuberculosis. The diagnosis of ulcerative colitis was confirmed by sigmoidoscopy and rectal biopsy.

Idiopathic hypereosinophilic syndrome manifesting as pulmonary oedema.

Idiopathic hypereosinophilic syndrome is a progressive and fatal disease if not treated effectively. We report this case since hypereosinophilia is an uncommon cause of pulmonary oedema.

Pharmacoeconomics.

Today, spiraling costs of medical care coupled with limited resources have led to an explosive increase in the number of pharmacoeconomic analyses being carried out. The first step in a pharmacoeconomic analysis is to measure the costs and benefits of the therapeutic regimens being compared. Then one compares these costs and benefits by calculating a cost: benefit ratio for each regimen.

Bilateral renal angiomyolipomas in association with end stage renal disease without features of tuberous sclerosis.

We report a case of end stage renal disease in association with bilateral renal angiomyolipomas (RAML). There were no features suggestive of tubercous sclerosis (TS). Renal angiomyolipomas were detected incidentally, patient being asymptomatic for the same.

A study of insulin resistance in subjects with acanthosis nigricans.

Aim: To study the prevalence of insulin resistance (IR) and its sequelae in patients with acanthosis.

Methodology: Thirty six patients (28 females; eight males) with biopsy proven acanthosis nigricans and eight controls were evaluated for insulin sensitivity (IS) by estimating (a) the glucose and insulin responses to a 75 gm glucose load (Oral glucose tolerance test-OGTT), (b) the glucose disposal rate (GDR) during an intravenous insulin tolerance test (ITT). Serum androgen levels (testosterone--Te, androstenedione--ASD, Dehydro-epiandrosterone sulphate--DHEAS) were estimated in the basal state and 60 min after a bolus of insulin.

Primary fourth ventricular hemorrhage.

A case of primary fourth ventricular hemorrhage with spontaneous recovery is reported. To the best of our knowledge, there is no previous report of this rare clinical entity.

Neuropathy in rheumatoid arthritis.

Background: Paucity of Indian literature on rheumatoid neuropathy creates a lacuna in the critical evaluation and discussion of the subject. We did this study to find out the incidence and pattern of neuropathy and to correlate it with disease parameters and other extra-articular involvement.

Material And Methods: We studied 31 patients of rheumatoid arthritis (RA) classified by ACR criteria.