Distress and coping mechanisms among people with diabetes: cross-sectional assessment from an NCD screening clinic of a tertiary care hospital in North India.

Background: Of the numerous complications encountered by people with diabetes (PWD), the effect on mental health is concerning. Within mental health, diabetes distress (DD) occurs when a patient has unfavourable emotional stress while managing their condition, which can be managed by coping strategies but are less studied together in Indian settings. So, the present study aimed to determine the proportion of DD and associated factors and coping skills among the PWD.

Encorafenib, cetuximab and chemotherapy in BRAF-mutant colorectal cancer: a randomized phase 3 trial.

Encorafenib + cetuximab (EC) is approved for previously treated BRAF V600E-mutant metastatic colorectal cancer (mCRC) based on the BEACON phase 3 study. Historically, first-line treatment of BRAF V600E-mutant mCRC with chemotherapy regimens has had limited efficacy. The phase 3 BREAKWATER study investigated EC+mFOLFOX6 versus standard of care (SOC) in patients with previously untreated BRAF V600E mCRC.

Effects of different water and fertilizer treatments on the matrix properties and plant growth of tailings waste.

Vegetation ecological restoration technology is widely regarded as an environmentally sustainable and green technology for the remediation of mineral waste. The appropriate ratio of amendments can improve the substrate environment for plant growth and increase the efficiency of ecological restoration. Herbs and shrubs are preferred for vegetation restoration in abandoned mines because of their rapid establishment and easy management.

Kinematic Alignment Compared with Mechanical Alignment Techniques Results in Greater Peak Three-Dimensional Knee Joint Moments During Stair Negotiation.

Background: This study investigated the influence of surgical alignment techniques on knee joint biomechanics during stair negotiation tasks. Our hypothesis was that a more personalized joint alignment would result in reduced medial knee loading biomechanics to negotiate the stairs.

Methods: There were 28 adults (14 mechanical alignments [MA], 14 kinematic alignment [KA]) who underwent total knee arthroplasty (TKA) at least one year post-operatively and performed five stair ascent and descent trials at their preferred velocities.

Structures and mRNP remodeling mechanism of the TREX-2 complex.

mRNAs are packaged with proteins into messenger ribonucleoprotein complexes (mRNPs) in the nucleus. mRNP assembly and export are of fundamental importance for all eukaryotic gene expression. Before export to the cytoplasm, mRNPs undergo dynamic remodeling governed by the DEAD-box helicase DDX39B (yeast Sub2).

A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance.

Distinguishing tumor maintenance genes from initiation, progression, and passenger genes is critical for developing effective therapies. We employed a functional genomic approach using the Lazy Piggy transposon to identify tumor maintenance genes in vivo and applied this to sonic hedgehog (SHH) medulloblastoma (MB). Combining Lazy Piggy screening in mice and transcriptomic profiling of human MB, we identified the voltage-gated potassium channel KCNB2 as a candidate maintenance driver.

Mixotrophic denitrification using thiocyanate as an electron donor: Role of thiocyanate under different C/N conditions.

Thiocyanate (SCN) is a highly toxic reducing inorganic compound commonly found in various nitrogen-rich wastewater and is also a promising electron donor for mixotrophic denitrification. However, its extent of involvement in mixotrophic denitrification under conditions of carbon limitation or excess remains unclear. In this study, five reactors were constructed to investigate the participation and microbial mechanisms of SCN in mixotrophic denitrification under high C/N and low C/N conditions.

In situ remediation of oil-contaminated soils by ozonation: Experimental study and numerical modeling.

The goal of the present work is to quantify the performance of ozonation as a method for the in situ remediation of soils polluted at varying degree with different types of hydrocarbons, and assess its applicability, in terms of remediation efficiency, cost factors, and environmental impacts. Ozonation tests are conducted on dry soil beds, for three specific cases: sandy soil contaminated with low, moderate and high concentration of a non-aqueous phase liquid (NAPL) consisting of equal concentrations of n-decane, n-dodecane, and n-hexadecane; sandy soil polluted with diesel fuel; oil-drilling cuttings (ODC). The transient changes of the concentration of the total organic carbon (TOC), total petroleum hydrocarbons (TPH), polycyclic aromatic hydrocarbons (PAHs), and soluble chemical oxygen demand (SCOD) in soil and carbon dioxide (CO), carbon monoxide (CO), volatile organic compounds (VOCs), and ozone (O) in exhaust gases are recorded.

Demographic patterns in horseback riding head and neck injuries within the United States: A NEISS database study.

Objective: Our primary objective was to identify and describe demographic trends in head and neck injuries incurred while participating in horseback riding.

Study Design: Cross-sectional analysis.

Setting: National Database.

Quantitative and Visual Benefits of Data-Driven Motion Correction on Oncologic PET/CT: A Prospective Cross-sectional Study.

Rationale And Objective: Conventional positron emission tomography (PET) respiratory gating utilizes a fraction of acquired PET counts (i.e., optimal gate [OG]), whereas elastic motion correction with deblurring (EMCD) utilizes all PET counts to reconstruct motion-corrected images without increasing image noise.

ARCH: Large-scale knowledge graph via aggregated narrative codified health records analysis.

Objective: Electronic health record (EHR) systems contain a wealth of clinical data stored as both codified data and free-text narrative notes (NLP). The complexity of EHR presents challenges in feature representation, information extraction, and uncertainty quantification. To address these challenges, we proposed an efficient Aggregated naRrative Codified Health (ARCH) records analysis to generate a large-scale knowledge graph (KG) for a comprehensive set of EHR codified and narrative features.

Heterotrophic denitrification enhancement via effective organic matter degradation driven by suitable iron dosage in sediment.

The control of internal pollution was important throughout the restoration of the lake, especially the removal of sediment internal nitrogen. Experiments involving incubation were conducted in this study to investigate the effects of iron remediation on nitrogen in both water and sediment. Adding iron with varying dosage had different effects on the nutrients content and other properties of water and sediment in remediation.

Design and early progress of the Comparison of Anticoagulation and anti-Platelet Therapies for Intracranial Vascular Atherostenosis (CAPTIVA) trial.

Background: The usual antithrombotic treatment for symptomatic intracranial atherosclerotic stenosis (ICAS) consists of dual treatment with clopidogrel and aspirin for 90 days followed by aspirin alone but the risk of recurrent stroke remains high up to 12 months. The Comparison of Anticoagulation and anti-Platelet Therapies for Intracranial Vascular Atherostenosis (CAPTIVA) trial was designed to determine whether other combinations of dual antithrombotic therapy are superior to clopidogrel and aspirin.

Methods: CAPTIVA is an ongoing, prospective, double-blinded, three-arm clinical trial at over 100 sites in the United States and Canada that will randomize 1683 high-risk subjects with a symptomatic infarct attributed to 70-99% stenosis of a major intracranial artery to 12 months of treatment with (1) ticagrelor (180 mg loading dose, then 90 mg twice daily), (2) low-dose rivaroxaban (2.

Assembly and Annotation of the Tetraploid Salsola tragus (Russian thistle) Genome.

This report presents two phased chromosome-scale genome assemblies of allotetraploid Salsola tragus (2n=4x=36) and fills the current genomics resource gap for this species. Flow cytometry estimated 1C genome size was 1.319 Gbp.

Emerging Roles of TRIM56 in Antiviral Innate Immunity.

The tripartite-motif protein 56 (TRIM56) is a RING-type E3 ubiquitin ligase whose functions were recently beginning to be unveiled. While the physiological role(s) of TRIM56 remains unclear, emerging evidence suggests this protein participates in host innate defense mechanisms that guard against viral infections. Interestingly, TRIM56 has been shown to pose a barrier to viruses of distinct families by utilizing its different domains.

Viral Transcript and Tumor Immune Microenvironment-Based Transcriptomic Profiling of HPV-Associated Head and Neck Squamous Cell Carcinoma Identifies Subtypes Associated with Prognosis.

Human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HPV-positive HNSCC) has distinct biological characteristics from HPV-negative HNSCC. Using an AI-based analytical platform on meta cohorts, we profiled expression patterns of viral transcripts and HPV viral genome integration, and classified the tumor microenvironment (TME). Unsupervised clustering analysis revealed five distinct and novel TME subtypes across patients (immune-enriched, highly immune and B-cell enriched, fibrotic, immune-desert, and immune-enriched luminal).

Enhancement of Fertilizer Efficiency Through Chinese Milk Vetch and Rice Straw Incorporation.

The incorporation of rice straw (RS) and Chinese milk vetch (CMV) with reduced chemical fertilizers (CFs) is a viable solution to reduce the dependency on CF. However, limited research has been conducted to investigate the impact of CMV and RS with reduced CF on rice production. A field trial was conducted from 2018 to 2021 with six treatments: CK (no fertilizer), F100 (100% NPK fertilizer (CF)), MSF100 (100% CF+CMV and RS incorporation), MSF80 (80% CF+CMV+RS), MSF60 (60% CF+CMV+RS), and MSF40 (40% CF+CMV+RS).

Structure of Plant Populations in Constructed Wetlands and Their Ability for Water Purification.

In constructed wetlands (CWs) with multiple plant communities, population structure may change over time and these variations may ultimately influence water quality. However, in CWs with multiple plant communities, it is still unclear how population structure may change over time and how these variations ultimately influence water quality. Here, we established a CW featuring multiple plant species within a polder to investigate the variation in plant population structure and wastewater treatment effect for drainage water over the course of one year.

Improving Cooking Skills, Lifestyle Behaviors, and Clinical Outcomes for Adults at Risk for Cardiometabolic Disease: Protocol for a Randomized Teaching Kitchen Multisite Trial (TK-MT).

Background/objectives: This protocol describes a study to investigate the feasibility and preliminary efficacy of a novel Teaching Kitchen Multisite Trial (TK-MT) for adults with cardiometabolic abnormalities. The TK-MT protocol describes a hybrid lifestyle intervention combining in-person and virtual instruction in culinary skills, nutrition education, movement, and mindfulness with community support and behavior change strategies. This 18-month-long randomized controlled trial aims to evaluate the feasibility of implementing a 12-month, 24 class program, assess preliminary study efficacy, and identify barriers and facilitators to implementation.

Magnesium Depletion Score and Mortality in Individuals with Metabolic Dysfunction Associated Steatotic Liver Disease over a Median Follow-Up of 26 Years.

Unlabelled: Metabolic dysfunction associated steatotic liver disease (MASLD) has been associated with increased risks of all-cause and cardiovascular disease (CVD) mortality. Identification of modifiable risk factors that may contribute to higher risks of mortality could facilitate targeted and intensive intervention strategies in this population. This study aims to examine whether the magnesium depletion score (MDS) is associated with all-cause and CVD mortality among individuals with MASLD or metabolic and alcohol associated liver disease (MetALD).

Pathogen Detection and Resistome Analysis in Healthy Shelter Dogs Using Whole Metagenome Sequencing.

According to the Humane Society, 25 to 40 percent of pet dogs in the United States are adopted from animal shelters. Shelter dogs can harbor bacterial, viral, fungal, and protozoal pathogens, posing risks to canine and human health. These bacterial pathogens may also carry antibiotic resistance genes (ARGs), serving as a reservoir for antimicrobial resistance (AMR) transmission.

Plasma Endothelin-1 Levels: Non-Predictors of Alzheimer's Disease Reveal Age Correlation in African American Women.

Alzheimer's disease (AD) and related dementias (ADRD) disproportionately impact racial and ethnic minorities. Contributing biological factors that explain this disparity have been elusive. Moreover, non-invasive biomarkers for early detection of AD are needed.