Adipokine levels and T786C polymorphism of eNOS gene promoter correlation in patients with arterial hypertension.

Genetic factors contribute to the development of metabolic syndrome and subsequent arterial hypertension (AH). The study of the T786C polymorphism of the endothelial nitric oxide synthase (eNOS) gene in arterial hypertension is important as its correlation with adipokine imbalance is a novelty area to find associations between hypertension development, obesity, and heredity. The purpose of the current study was to investigate serum adipokines levels, depending on the T786C polymorphism of the eNOS in patients with arterial hypertension.

Clinical significance of positron emission tomography-computed tomography in the classification of thymic tumors.

Objectives: This study aimed to explore the possibility of positron emission tomography/computed tomography (PET-CT) in identifying histological classification of thymic tumors.

Methods: Patients diagnosed as thymic tumors and accepted PET-CT scans were included. Thymic tumors were classified into three subgroups: low risk thymoma (A, AB and B1), high risk thymoma (B2, B3) and thymic carcinoma (TC).

Electricity-Efficient On-Demand Photothermal Activation for Tunable Thermochromic Windows.

Thermochromic (TC) windows with passively controlled sunlight regulation have demonstrated significant building energy conservations. Realizing the active control of the TC window can expand its popularity while remaining an intractable challenge. Herein, a low-power-dissipative strategy that endows TC windows with an actively tunable transmittance is presented through the electro-induced tunable photothermal conversions (ETPCs).

Methylation Profiles Differ According to Clinical Characteristics in Well-Differentiated Neuroendocrine Tumors of the Lung.

Neuroendocrine tumors (NET) of the lung constitute a rare entity of primary lung malignancies that often exhibit an indolent clinical course. Epigenetics-related differences have been described previously for lung NET, but the clinical significance remains unclear. In this study, we performed genome-wide methylation analysis using the Infinium MethylationEPIC BeadChip technology on FFPE tissues from lung NET treated at two academic centers.

A Z-Scheme Heterojunction g-CN/WO for Efficient Photodegradation of Tetracycline Hydrochloride and Rhodamine B.

The construction of heterojunctions can effectively inhibit the rapid recombination of photogenerated electrons and holes in photocatalysts and offers great potential for pollutant degradation. In this study, a Z-scheme heterojunction g-CN/WO photocatalyst was synthesized using a combination of hydrothermal and calcination methods. The photocatalytic degradation performance was tested under visible light; the degradation efficiency of Rh B reached 97.

Green Synthesis and Characterization of Silver Nanoparticles from Leaf Extract: Evaluation of Their Antioxidant, Anti-Inflammatory, Antibacterial, and Antibiofilm Efficacies.

The use of metal nanoparticles is gaining popularity owing to their low cost and high efficacy. We focused on green synthesis of silver nanoparticles (AgNPs) using (Tc) leaf extracts. The structural characteristics of Tc nanoparticles (TcAgNPs) were determined using several advanced techniques.

Low-Crystallized Carbon as an Electron Mediator in g-CN/C/TiO for Enhancing Photocatalytic Degradation of Antibiotics.

Photodegradation of antibiotics based on photocatalytic semiconductors is a promising option to alleviate water pollution. Despite its limitations, TiO-based photocatalysts are still the most widely studied materials for pollutant degradation. In this work, a pomegranate-like g-CN/C/TiO nano-heterojunction was constructed using the hydrothermal-calcination method, consisting of interconnected small crystals with a dense structure and closely contacted interface.

The Dual Role of cGAS-STING Signaling in COVID-19: Implications for Therapy.

The progression of COVID-19 involves a sophisticated and intricate interplay between the SARS-CoV-2 virus and the host's immune response. The immune system employs both innate and adaptive mechanisms to combat infection. Innate immunity initiates the release of interferons (IFNs) and pro-inflammatory cytokines, while the adaptive immune response involves CD4+ Th lymphocytes, B lymphocytes, and CD8+ Tc cells.

Docetaxel-loaded, dipeptide-functionalized γ-Fe2O3 magnetic nanoparticles: Synthesis, characterization and targeting to prostate cancer.

A new delivery system was designed and synthesized to increase the efficiency of Docetaxel. For this aim, γ-Fe2O3 was synthesized in order to give the nanoparticle the ability to be magnetic targeted. It was functionalized with citric acid to prevent clumping and maintain stability.

Obstructive Sleep Apnea Syndrome: Prediction of Lipid Panel in Relation to Apnea- Hypopnea Index.

The research was designed to predict the relationship between the apnea-hypopnea index (AHI) as the main indicator of severity of obstructive sleep apnea syndrome (OSAS), and lipid panel test results. A cross-sectional observational study was done on 90 patients with suspected sleep-related breathing disorders as assumed by polysomnography. Patients were categorized into three equal groups depending on AHI: mild degree (5-15 events/hour), moderate degree (15-30 events/hour), and severe degree (> 30 events/hour).

Investigation of TLR4 Polymorphism in Children with Vesicoureteral Reflux and Renal Scarring.

Vesicoureteral reflux (VUR) is an important factor in the etiology of recurrent urinary tract infections (UTIs). Permanent kidney damage may develop in children with high-grade VUR in the long term. This damage may progress with the development of scar tissue in some patients.

and Gene Polymorphisms in Systemic Sclerosis.

The complex cytokine network plays an important role in disease susceptibility and development, therefore single-nucleotide polymorphisms (SNPs) in or near cytokine genes may be relevant to development of systemic sclerosis (SSc). We in this study investigated 22 SNPs in 13 cytokine genes of SSc patients, and their association with disease susceptibility. Twenty-three clinically diagnosed SSc patients were enrolled for this purpose along with 80 healthy volunteers for comparisons.

Unveiling Lipid Metabolic Shifts in Different Stages of Oral Submucous Fibrosis: A New Horizon in Predicting Malignant Transformation.

Background: Oral Submucous Fibrosis (OSMF) is a chronic, progressive condition linked to areca nut consumption, with a high potential for malignant transformation into oral squamous cell carcinoma (OSCC). Changes in lipid metabolism have been implicated in cancer biology, yet the relationship between lipid profiles and OSMF progression remains underexplored. This study investigates the alterations in serum lipid parameters across different clinical stages of OSMF and their association with malignant transformation.

Jianpi Yangzheng Xiaozheng granule induced ferroptosis to suppress gastric cancer progression through reprogramming lipid metabolism via SCD1/Wnt/β-catenin axis.

The incidence of Poorly cohesive carcinoma (PCC) has steadily risen in recent years, posing a significant clinical challenge. To reveal the anti-tumor effects of Jianpi Yangzheng Xiaozheng granule (JPYZXZ) in PCC, an initial investigation was performed using CCK-8, colony formation, scratch, and transwell assays. This was followed by network pharmacology studies to gain a deeper understanding of JPYZXZ's impact on gastric cancer (GC).

Traumatic stress-enhanced ethanol drinking: Sex, but not stress responsivity, alters sensitivity to the effects of a CRF-R1 antagonist and a GPR39 agonist in mice.

Background: Predator stress (PS) is used to model trauma leading to post-traumatic stress disorder, and it increases ethanol drinking in a proportion of male and female rodents. The goals of the present studies were to identify male and female mice with prior binge drinking experience that exhibited sensitivity and resilience to PS-enhanced drinking and then to test two target molecules (corticotropin releasing factor receptor 1 [CRF-R1] antagonist NBI-27914 [NBI] and G-protein coupled receptor 39 [GPR39] agonist TC-G 1008 [TC-G]) for their ability to selectively reduce PS-enhanced drinking.

Methods: Adult male and female C57BL/6J mice received seven binge ethanol sessions, a period of abstinence, and acclimation to lickometer chambers to examine the effects of NBI or TC-G on stress-associated drinking.

Newborn screening of primary carnitine deficiency: clinical and molecular genetic characteristics.

Background: Primary carnitine deficiency (PCD) is a rare autosomal recessive fatty acid oxidation disorder caused by variants in the SLC22A5 gene, with its prevalence and the spectrum of mutations in SLC22A5 varying across races and regions. This study aimed to analyze the clinical and genetic characteristics of PCD patients, including newborns and their mothers, identified by newborn screening (NBS) in Hefei, China.

Methods: The dried blood spot samples from newborns were analyzed using tandem mass spectrometry (MS/MS) from July 2015 to December 2024.

Clinical evidence of sesame (Sesamum indicum L.) products and its bioactive compounds on anthropometric measures, blood pressure, glycemic control, inflammatory biomarkers, lipid profile, and oxidative stress parameters in humans: a GRADE-assessed systematic review and dose-response meta-analysis.

This comprehensive systematic review and meta-analysis aimed to assess the impact of sesame (Sesamum indicum L.) supplementation on cardiovascular disease risk factors. Relevant research was discovered via PubMed, Scopus, Web of Science, CENTRAL, and EMBASE up to June 2024.

The core microbiomes and associated metabolic potential of water kefir as revealed by pan multi-omics.

Water kefir (WK) is an artisanal fermented beverage made from sugary water, optional fruits and WK grains. WK grains can be reused to start new fermentations. Here we investigate the microbial composition and function of 69 WK grains and their ferments by shotgun metagenomics.

Effluent quality-based ranking of sewage treatment plants using multicriteria decision making technique.

Water pollution control agencies worldwide face the complex challenge of ensuring the efficient operation of sewage treatment plants (STPs) to protect water bodies receiving their effluent as well as for reuse. However, evaluating the performance of these plants is difficult due to multiple criteria involved. Further, while previous studies have focused on evaluating the efficiency of individual plants, it remains unclear how the effluent quality of STPs affect the water quality of receiving bodies without relying on the complex simulation-optimization models (such as waste load allocation) to understand the cause-and-effect relationships.

Multi-omics reveal the effects and regulatory mechanism of dietary echinocystic acid supplementation on abdominal fat and liver steatosis in broiler chickens.

The accumulation of abdominal fat and the metabolic dysfunction-associated fatty liver disease (MAFLD) are prevalent problems in the poultry industry, and seriously compromise broiler health and reduce economic benefits. Echinocystic acid (EA), a natural product with anti-inflammatory and antioxidant effects, has been demonstrated to reduce abdominal fat deposition and improve intestinal inflammation in mice. However, it has not been reported in poultry research.

Unveiling the synergistic mechanism of Fe-Cu bimetallic catalysts for degradation of tetracycline antibiotic with ultralow peroxymonosulfate dosage consumption: Key contribution of electron transfer process.

Developing low-oxidant, high efficiency catalysts is critical to meet the green-circular goal in water treatments. Heteroatom-doped graphite-based carbon nitride carrier catalysts are among the most promising candidate materials in water purification catalysis. In this research, a bimetallic catalyst (Fe-Cu@SNC), featuring dual reaction centers, was prepared using a mass-producible co-precipitation method.

The bidirectional matter transfer in adsorption-promoted photocatalytic ozonation system derived by triazine nanosheets-heptazine nanotubes homojunction composite biochar.

Heterogeneous catalytic ozonation (HCO) process is an efficiency and eco-friendly solution to the growing challenge of water purification, yet is challenging by O utilization, pollutants selectivity, and matter transfer resistance. Herein, adsorption-promoted photocatalytic ozonation (HCO/PO) system was constructed derived by triazine nanosheets-heptazine nanotubes homojunction carbon nitride composite Enteromorpha prolifera derived biochar (CN/EpC) to provide a targeted solution for the refractory organic pollutants treatment. In the HCO/PO system, the adsorption sites predominantly reside on EpC, while the catalytic sites are primarily located on CN.

Do The Inflammatory Cells In The Blood And Tissues Have Predictive And Prognostic Value In Benign, Premalignant And Malignant Lesions Of The Larynx?

Objective: The aim of our study is to investigate the predictive and prognostic value of inflammatory cells in blood and tissues in laryngeal lesions.

Methods: The data of a total of 112 patients, of whom 36 had benign, 38 had premalignant and 38 had malignant laryngeal lesions, were analyzed retrospectively. Along with the demographic characteristics of the patients, hemogram parameters were also captured by hematoxylin-eosin staining performed on pathology preparation lymphocytes and neutrophils, and Langerhans cells count was carried out by immunohistochemical staining.

Association between RC/HDL-C and hyperuricemia in adults: evidence from NHANES 2005-2018.

Background: The incidence of hyperuricemia is growing in the world, with a significant influence on the survival and healthy condition of the patient. The connection between serum residual cholesterol (RC) to high-density lipoprotein cholesterol (HDL-C) ratio and hyperuricemia is uncertain. Consequently, we tried to elucidate the connection between the hyperuricemia and RC/HDL-C ratio.

Oncological and Survival Endpoints in Cancer Cachexia Clinical Trials: Systematic Review 6 of the Cachexia Endpoints Series.

Background: In patients receiving anti-cancer treatment, cachexia results in poorer oncological outcomes. However, there is limited understanding and no systematic review of oncological endpoints in cancer cachexia (CC) trials. This review examines oncological endpoints in CC clinical trials.