1,105 results match your criteria: "T.N. Medical College & Nair Hospital[Affiliation]"
Role of Polyunsaturated Fat in Modifying Cardiovascular Risk Associated With Family History of Cardiovascular Disease: Pooled De Novo Results From 15 Observational Studies.
Circulation
January 2024
Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine (F.L., A.A., U.D.F., K.L.), Karolinska Institutet, Stockholm, Sweden.
Background: It is unknown whether dietary intake of polyunsaturated fatty acids (PUFA) modifies the cardiovascular disease (CVD) risk associated with a family history of CVD. We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large consortium.
Methods: Blood and tissue PUFA data from 40 885 CVD-free adults were assessed.
A Comprehensive Assessment of Tear-Film-Oriented Diagnosis (TFOD) in a Dacryoadenectomy Dry Eye Model.
Int J Mol Sci
November 2023
Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Tear film instability is a major cause of dry eye disease. In order to treat patients with short tear film breakup time (TBUT)-type dry eye, the development of tear film stabilizing agents is essential. However, the lack of an appropriate animal model of tear film instability has made drug development difficult.
View Article and Find Full Text PDFAgreement among high-sensitivity cardiac troponin assays and non-invasive testing, clinical outcomes, and quality-of-care outcomes based on the 2020 European Society of Cardiology Guidelines.
Eur Heart J Acute Cardiovasc Care
February 2024
Cardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, 165 Cambridge St Suite 400, Boston, MA 02114, USA.
Article Synopsis
- The study aimed to analyze how different high-sensitivity cardiac troponin (hs-cTn) assays impact the risk stratification and management of patients suspected of having acute coronary syndrome (ACS) based on the 2020 European Society of Cardiology guidelines.
- Blood samples from 238 patients were tested using four different hs-cTn assays, and results showed a 74% overall concordance in classifying patients, with significant variations in rule-out and observe strata but not in rule-in strata.
- Findings revealed that management decisions and quality of care varied significantly among assays, suggesting that patient outcomes could be influenced by the specific assay used, indicating a need for more research to standardize practices.
Caffeine administration to treat oversedation after general anesthesia: A retrospective analysis.
J Clin Anesth
February 2024
Department of Anesthesiology and Perioperative Medicine, United States of America.
Study Objective: Our institution has adopted an informal practice of administering postoperative caffeine to expedite anesthesia recovery for patients with excessive sedation. This study aimed to determine whether caffeine administration was associated with improved sedation recovery and reduced risk of respiratory complications.
Design: Single-center, retrospective, observational study.
Priorities for Advancements in Neuroimaging in the Diagnostic Workup of Acute Stroke.
Stroke
December 2023
Departments of Neurology (G.W.A., M.G.L.), Stanford University, CA.
Article Synopsis
- The STAIR XII workshop focused on improving neuroimaging techniques for diagnosing acute ischemic stroke, bringing together experts from academia, industry, and government to identify key priorities.
- Ten critical areas were outlined for advancements, including enhancing imaging at stroke centers, refining clot analysis, and establishing criteria to predict treatment response.
- Despite progress in imaging for stroke treatment, significant challenges persist, highlighting the need for collaboration among academics, industry, and regulators to enhance technologies and improve patient outcomes.
HLA allele-calling using multi-ancestry whole-exome sequencing from the UK Biobank identifies 129 novel associations in 11 autoimmune diseases.
Commun Biol
November 2023
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, QC, Canada.
The human leukocyte antigen (HLA) region on chromosome 6 is strongly associated with many immune-mediated and infection-related diseases. Due to its highly polymorphic nature and complex linkage disequilibrium patterns, traditional genetic association studies of single nucleotide polymorphisms do not perform well in this region. Instead, the field has adopted the assessment of the association of HLA alleles (i.
View Article and Find Full Text PDFCardiovascular Testing in the United States during the COVID-19 Pandemic: Volume Recovery and Worldwide Comparison.
Radiol Cardiothorac Imaging
October 2023
From the Division of Cardiology, Weill Cornell Medicine and NewYork-Presbyterian Hospital, New York, NY (C.B.H.); Departments of Medicine and Radiology, Brigham and Women's Hospital, Boston, Mass (S.D.); Blavatnik Family Women's Health Research Institute, Mount Sinai Medical Center, New York, NY (L.J.S.); Division of Cardiovascular Medicine, Department of Medicine, University of Virginia, Charlottesville, Va (T.C.V.); The George Washington University School of Medicine, Washington, DC (A.D.C.); Cabrini Health, Royal Melbourne Hospital and University of Melbourne, Melbourne, Australia (N.B.); Quanta Diagnostico por Imagem, Curitiba, Brazil (R.J.C., J.V.V.); Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India (G.K.); BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland (M.C.W.); Houston Methodist DeBakey Heart and Vascular Center, Houston, Tex (M.A.M.); Departments of Imaging, Medicine, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, Calif (D.S.B.); Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.B.); Division of Cardiology, Centre for Cardiac MRI, Allegheny Health Network, Allegheny General Hospital, Pittsburgh, Pa (R.W.B.); Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (P.E.B.); Lundquist Institute at Harbor-UCLA, Torrance, Calif (M.J.B.); Department of Cardiology, Deborah Heart and Lung Center, Browns Mills, NJ (R.P.B.P.); National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (M.Y.C.); Division of Cardiology, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian Morgan Stanley Children's Hospital, New York, NY (M.P.D., A.S.); Division of Cardiology, Cook County Health, Chicago, Ill (R.D.); Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Ore (M.F.); Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minn (J.B.G.); University of Alabama at Birmingham and Birmingham Veterans Affairs Medical Center, Birmingham, Ala (F.G.H.); Section of Cardiology, Deming Department of Medicine, Tulane University School of Medicine, New Orleans, La (R.C.H.); Duke University Medical Center, Durham, NC (L.K.); Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Mich (V.L.M.); Division of Cardiology, Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, NY (J.N.); Department of Medicine, Cardiovascular Division, University of Virginia Health System, Charlottesville, Va (P.F.R.L.); Division of Cardiology, Department of Medicine, Brown University Alpert Medical School, Providence, RI (N.R.S.); Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, Pa (P.S.); St Luke's Mid America Heart Institute, Kansas City, Mo (R.C.T.); Cleveland Clinic Florida, Weston, Fla (D.W.); Technion Israel Institute of Technology, Haifa, Israel (Y.A.C., A.J.E.); Seymour, Paul, and Gloria Milstein Division of Cardiology, Columbia University Irving Medical Center and New York-Presbyterian Hospital, 622 W 168th St, PH 10-203, New York, NY 10032 (E.M., A.J.E.); Department of Medicine, Columbia University Irving Medical Center and New York-Presbyterian Hospital, New York, NY (M.J.R.); Lee Health Heart & Vascular Institute, Fort Myers, Fla (J.L.M.); Department of Cardiology, Loma Linda University Health, Loma Linda, Calif (P.P.); University of Chicago (NorthShore), NorthShore University Health System, Evanston, Ill (M.S.); Department of Science and Technology, Philippine Nuclear Research Institute, Quezon City, Philippines (T.N.B.P.); International Atomic Energy Agency, Vienna, Austria (Y.P., M.D., D.P.); and Department of Radiology, Columbia University Irving Medical Center and New York-Presbyterian Hospital, New York, NY (A.J.E.).
Article Synopsis
- The study aimed to assess how diagnostic cardiovascular procedure volumes rebounded in the U.S. and abroad during the year after COVID-19 hit, relying on data from 669 facilities worldwide.
- In the early pandemic (April 2020), procedure volumes dropped significantly but showed a better recovery in U.S. facilities by April 2021 compared to non-U.S. facilities, although high-income non-U.S. countries showed similar recovery rates as the U.S.
- Regional variations within the U.S. were noted, with the Midwest having the highest recovery rate, but no specific factors were found to predict recovery levels from the initial drop in procedure volumes.
Detection of brain lesions after catheter ablation depends on imaging criteria: insights from AXAFA-AFNET 5 trial.
Europace
December 2023
Atrial Fibrillation NETwork association (AFNET), Mendelstr. 11, 48149 Münster, Germany.
Article Synopsis
- The study focuses on the effects of left atrial catheter ablation in patients with symptomatic atrial fibrillation, particularly the risk of embolism to the brain and how MRI imaging parameters impact lesion detection.
- Participants in the AXAFA-AFNET 5 trial underwent MRI using two different slice thicknesses of diffusion-weighted imaging (DWI), revealing that high-resolution DWI detected more brain lesions than standard DWI.
- The findings suggest that using high-resolution DWI in future studies is beneficial for accurately assessing ablation-related brain lesions, while the strength of the MRI (1.5T vs. 3T) did not significantly affect the results.
Efficacy of the Geriatric Nutritional Risk Index for Predicting Overall Survival in Patients with Head and Neck Cancer: A Meta-Analysis.
Nutrients
October 2023
Department of Anesthesiology, Chi Mei Medical Center, Tainan City 71004, Taiwan.
Head and neck cancer (HNC) is a prevalent malignancy with a poor prognosis, necessitating the identification of prognostic biomarkers to guide management. The geriatric nutritional risk index (GNRI), calculated from serum albumin and body weight, may predict survival in patients with HNC. We performed a systematic review and meta-analysis to clarify this relationship.
View Article and Find Full Text PDFThe Stroke Treatment Academic Industry Roundtable XII included a workshop to discuss the most promising approaches to improve outcome from acute stroke. The workshop brought together representatives from academia, industry, and government representatives. The discussion examined approaches in 4 epochs: pre-reperfusion, reperfusion, post-reperfusion, and access to acute stroke interventions.
View Article and Find Full Text PDFMicrobiome-based risk prediction in incident heart failure: a community challenge.
medRxiv
October 2023
Department of Computing, Faculty of Technology, University of Turku, Turku, Finland.
Heart failure (HF) is a major public health problem. Early identification of at-risk individuals could allow for interventions that reduce morbidity or mortality. The community-based FINRISK Microbiome DREAM challenge (synapse.
View Article and Find Full Text PDFA transdermal drug delivery system based on dissolving microneedles for boron neutron capture therapy of melanoma.
Biomater Sci
November 2023
The 10th Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Dongguan, 523059, China.
Boron neutron capture therapy (BNCT) is a promising therapy for malignant tumors that requires selective and high concentrations of B accumulation in tumor cells. Despite ongoing developments in novel boron agents and delivery carriers, the progress and clinical application of BNCT is still restricted by the low B accumulation and tumor-to-normal tissue (T/N) ratio. Herein, a dissolving microneedle-based transdermal drug delivery system was specifically designed for BNCT in a mouse model of melanoma.
View Article and Find Full Text PDFRepeatability of MRI Biomarkers in Nonalcoholic Fatty Liver Disease: The NIMBLE Consortium.
Radiology
October 2023
From the Liver Imaging Group (K.J.F., M.S.M., D.B., W.C.H., C.B.S.) and Department of Hepatology (R.L.), University of California-San Diego, 6206 Lakewood St, San Diego, CA 92122; Department of Radiology, Mayo Clinic, Rochester, Minn (S.K.V., J.C., K.P., J.M., K.J.B., R.E.); Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio (N.O.); Pfizer Research and Development, Pfizer, Inc, Sacramento, Calif (S.S.S.); Foundation for the National Institutes of Health, North Bethesda, Md (T.N.K., A.P.); Regeneron Pharmaceuticals, Inc, Tarrytown, NY (R.A.C.); Department of Gastroenterology, Virginia Commonwealth University, Richmond, Va (A.J.S.); Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.E.S.); and Department of Imaging Alliances, Pfizer, Inc, New York, NY (S.P.S.).
Background There is a need for reliable noninvasive methods for diagnosing and monitoring nonalcoholic fatty liver disease (NAFLD). Thus, the multidisciplinary Non-invasive Biomarkers of Metabolic Liver disease (NIMBLE) consortium was formed to identify and advance the regulatory qualification of NAFLD imaging biomarkers. Purpose To determine the different-day same-scanner repeatability coefficient of liver MRI biomarkers in patients with NAFLD at risk for steatohepatitis.
View Article and Find Full Text PDFCardiovascular Disease Knowledge Portal: A Community Resource for Cardiovascular Disease Research.
Circ Genom Precis Med
December 2023
Programs in Metabolism and Medical and Population Genetics (M.C.C., M.B., M.D., Q.H., D.J., R.K., A.M., T.N., O.R., P.S., J.F., N.P.B.), The Broad Institute of MIT and Harvard, Cambridge, MA.
Alternative splicing in lung influences COVID-19 severity and respiratory diseases.
Nat Commun
October 2023
Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, QC, Canada.
Alternative splicing generates functional diversity in isoforms, impacting immune response to infection. Here, we evaluate the causal role of alternative splicing in COVID-19 severity and susceptibility by applying two-sample Mendelian randomization to cis-splicing quantitative trait loci and the results from COVID-19 Host Genetics Initiative. We identify that alternative splicing in lung, rather than total expression of OAS1, ATP11A, DPP9 and NPNT, is associated with COVID-19 severity.
View Article and Find Full Text PDFAllogeneic hematopoietic cell transplantation for blastic plasmacytoid dendritic cell neoplasm: a CIBMTR analysis.
Blood Adv
November 2023
Division of Hematology-Oncology, Blood and Marrow Transplantation Program, Mayo Clinic, Jacksonville, FL.
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy with a poor prognosis and considered incurable with conventional chemotherapy. Small observational studies reported allogeneic hematopoietic cell transplantation (allo-HCT) offers durable remissions in patients with BPDCN. We report an analysis of patients with BPDCN who received an allo-HCT, using data reported to the Center for International Blood and Marrow Transplant Research (CIBMTR).
View Article and Find Full Text PDFChoroidal Changes in Rhesus Macaques in Aging and Age-Related Drusen.
Invest Ophthalmol Vis Sci
September 2023
Department of Ophthalmology & Vision Science, University of California, Davis, Sacramento, California, United States.
Article Synopsis
- The study investigates choroidal thickness and vascularity in aged rhesus macaques to understand changes related to aging and age-related macular degeneration (AMD).
- Using optical coherence tomography, researchers analyzed 244 eyes from 122 macaques, measuring various parameters including choroidal thickness (CT) and choroidal vascularity index (CVI), and assessing the impact of soft drusen.
- Findings show that choroidal thickness and vascularity decrease with age, but eyes with soft drusen are thicker and more vascular, displaying similarities to pachydrusen seen in human AMD patients.
Perinatal Outcomes Associated With Management of Stage 1 Hypertension.
Obstet Gynecol
December 2023
Departments of Obstetrics and Gynecology, University of Wisconsin, Madison, and Medical College of Wisconsin, Milwaukee, Wisconsin, University of Alabama at Birmingham, Birmingham, and University of South Alabama, Mobile, Alabama, University of North Carolina at Chapel Hill, Chapel Hill, and Duke University, Durham, North Carolina, University of Pennsylvania and Drexel University College of Medicine, Philadelphia, St. Luke's University Health Network, Fountain Hill, and Magee Women's Hospital and University of Pittsburgh, Pittsburgh, Pennsylvania, University of Texas at Houston, Baylor College of Medicine, and Texas Children's Hospital, Houston, UTSouthwestern Medical Center, Dallas, and University of Texas Medical Branch, Galveston, Texas, Columbia University, New York, NYU Langone Hospital-Long Island, Mineola, and NewYork-Presbyterian Queens Hospital, Queens, New York, University of Oklahoma Health Sciences, Oklahoma City, Oklahoma, Indiana University, Indianapolis, Indiana, University of Utah Health, Salt Lake City, Utah, Washington University in St. Louis, St. Louis, Missouri, University of Mississippi Medical Center, Jackson, Mississippi, The Ohio State University, Columbus, Ohio, Rutgers University-Robert Wood Johnson Medical School, New Brunswick, New Jersey, Yale University, New Haven, Connecticut, University of Colorado, Aurora, and Denver Health, Denver, Colorado, Emory University, Atlanta, Georgia, University of California, San Francisco, San Francisco, Stanford University, Palo Alto, and Arrowhead Regional Medical Center, Colton, California, and Beaumont Hospital, Royal Oak, Michigan; the Department of Biostatistics, the Division of Neonatology, Department of Pediatrics, the Division of Cardiovascular Disease, Department of Medicine, and the Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama; MetroHealth System, Cleveland, Ohio; Intermountain Healthcare, Salt Lake City, Utah; Ochsner Baptist Medical Center, New Orleans, Louisiana; Christiana Care Health Services, Newark, Delaware; St. Peter's University Hospital, New Brunswick, New Jersey; Weill Cornell Medicine, New York, New York; Zuckerberg San Francisco General Hospital, San Francisco, California; the Division of Cardiovascular Sciences, NHLBI, Bethesda, Maryland; and the Department of Women's Health, University of Texas at Austin, Austin, Texas.
Objective: To evaluate the association between maternal blood pressure (BP) below 130/80 mm Hg compared with 130-139/80-89 mm Hg and pregnancy outcomes.
Methods: We conducted a planned secondary analysis of CHAP (Chronic Hypertension and Pregnancy), an open label, multicenter, randomized controlled trial. Participants with mean BP below 140/90 mm Hg were grouped as below 130/80 mm Hg compared with 130-139/80-89 mm Hg by averaging postrandomization clinic BP throughout pregnancy.
Comparing Functional Outcomes and Safety Profiles of First-Line Aspiration Thrombectomy Versus Stentriever for Acute Basilar Artery Occlusion: Propensity Analysis of the PC-SEARCH Thrombectomy Registry.
Stroke
October 2023
Department of Neurology, University of Toledo College of Medicine and Life Sciences, OH (A.T.M., N.A., K.G., E.A., S.Z., M.J.).
Background: Aspiration catheters (ASPs) and stentriever thrombectomy devices have comparable safety and efficacy in anterior circulation ischemic strokes. However, there is lack of high-quality comparative data in acute basilar artery occlusions. Our objective is to compare the outcomes and safety of ASPs and stentriever devices in acute basilar artery occlusions.
View Article and Find Full Text PDFComputational study on the mechanisms of inhibition of SARS-CoV-2 M by aldehyde warheads based on DFT.
Phys Chem Chem Phys
October 2023
School of Basic Medical Sciences and Forensic Medicine, North Sichuan Medical College, Sichuan, China.
SARS-CoV-2 main protease, M, plays a crucial role in the virus replication cycle, making it an important target for antiviral research. In this study, a simplified model obtained through truncation is used to explore the reaction mechanism of aldehyde warhead compounds inhibiting M at the level of density functional theory. According to the calculation results, proton transfer (P_T)-nucleophilic attack (N_A) is the rate-determining step in the entire reaction pathway.
View Article and Find Full Text PDFSugammadex and urinary retention after hysterectomy: A propensity-matched cohort study.
Biomol Biomed
March 2024
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.
Postoperative urinary retention (POUR) is a well-known complication after gynecologic surgery. Our objective was to investigate whether the choice of pharmacologic agent for reversing neuromuscular blockade at the end of a hysterectomy is a risk factor for POUR. Among adult patients undergoing hysterectomy with general anesthesia from 2012 to 2017, those who received aminosteroid nondepolarizing neuromuscular agents followed by pharmacologic reversal were identified, and electronic health records were reviewed.
View Article and Find Full Text PDFIntroduction: In 2014, a TNM-based system for thymic epithelial tumors was proposed. The TNM stage classification system was published as a result of a joint project from the International Association for the Study of Lung Cancer and the International Thymic Malignancy Interest Group for the eighth edition of the American Joint Commission on Cancer and the Union for International Cancer Control stage classification system. The Thymic Domain of the Staging and Prognostic Factors Committee of the International Association for the Study of Lung Cancer received the mandate to make proposals for the ninth edition of the TNM stage classification.
View Article and Find Full Text PDFAssociation of Bergmeister Papilla and Deep Optic Nerve Head Structures With Prelaminar Schisis of Normal and Glaucomatous Eyes.
Am J Ophthalmol
January 2024
Hamilton Glaucoma Center (L.M.Z., R.N.W.), Shiley Eye Institute, and the Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.
Purpose: To investigate factors associated with the severity of prelaminar schisis (PLS) in heathy subjects and glaucoma patients.
Design: Prospective cross-sectional study.
Methods: A total of 217 eyes of 217 subjects (110 normal eyes and 107 open angle glaucoma eyes) were studied.
The mid-term effect of intravascular ultrasound on endovascular interventions for lower extremity peripheral arterial disease: A systematic review and meta-analysis.
J Vasc Surg
April 2024
Department of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY; Department of Cardiology, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY. Electronic address:
Objective: Intravascular ultrasound (IVUS) is an important adjunctive tool for patients with lower extremity peripheral arterial disease (PAD) undergoing endovascular therapy (EVT). The evidence regarding the advantages of IVUS use is evolving, and recent studies have reported conflicting results. We aimed to perform a meta-analysis to evaluate the efficacy of IVUS during angiography-guided EVT for patients with PAD.
View Article and Find Full Text PDFLandscape of germline variants in breast and ovarian cancer in Peru.
Front Oncol
August 2023
Escuela Profesional de Medicina Humana-Filial Ica, Universidad Privada San Juan Bautista, Ica, Peru.
Background: There is an increasing amount of data from Latin America on the characterization of BRCA variants; however, there is limited information from Peru. We conducted a retrospective study to describe germline pathogenic/likely pathogenic(P/LP) variants and variants of uncertain/unknown significance (VUS) in the BRCA1 and BRCA2 genes in Peru, in patients with breast and ovarian cancer, candidates for treatment with poly (adenosine diphosphate-ribose) polymerase (PARP) inhibitors.
Methods: The patients were evaluated during the period 2019-2021.