The efficacy, tolerability and safety of diethylcarbamazine-fortified salt in the treatment of the microfilaraemias of brugian filariasis: an open, hospital-based study.

Cooking salt fortified with diethylcarbamazine (DEC) has been successfully used to control lymphatic filariasis in several parts of the world. The kinetics and efficacy of DEC-fortified salt in clearing microfilaraemias of Brugia malayi and the salt's tolerability and safety are examined in this study. Twenty individuals with B.

Investigation of the outbreak of cholera in Alleppey & Palghat districts, south India.

In May 1996, a massive outbreak of cholera occurred in Alleppey district of Kerala which spread to Palghat district by July 1996. Of the 575 patients hospitalized at the Alleppey Medical College hospital between May 1 and August 2, 1996, 30 deaths occurred with a case fatality rate of 5.2 per cent while of the 638 diarrhoea patients admitted at Agali PHC of Attapadi area in Palghat district, 30 (4.

The sheath of the microfilaria of Brugia malayi from human infections has IgG on its surface.

Microfilariae (mf) of Brugia malayi from microfilaraemic people had human IgG on their sheath. Fluorescent antibody studies showed that the predominant IgG isotype was IgG3, with IgG4 and IgG1 being present in lower quantities. Human albumin could not be detected.

Expert surrogate system. A new approach in clinical research in cervical carcinoma.

This study reports on the result of a detailed questionnaire given to a group of disinterested experts (Gynaecologists in this case), asking what type of treatment they would choose for themselves, between Radical Radiotherapy and Wertheim's Hysterectomy, if they themselves happened to be patients with Carcinoma of the Cervix Stage Ib (Non bulky). Out of 90 gynaecologists who were given the questionnaire, 71 had returned it duly filled in thirty eight out of seventy one (53.5%) of the gynaecologists had opted for radical radiotherapy while 33/71 (46.

A comparative study of the efficacy and tolerability of single and split doses of ivermectin and diethylcarbamazine in periodic brugian filariasis.

The use of ivermectin in lymphatic filariasis (both bancroftian and brugian) has been recently explored in several studies. We report in this paper, for the first time, a direct comparison of the efficacy and tolerability of single doses of ivermectin and diethylcarbamazine (DEC) in brugian filariasis. We also present our findings on the use of split doses of ivermectin and DEC on microfilaraemia levels and the occurrence of adverse reactions.

Ivermectin for the treatment of periodic malayan filariasis: a study of efficacy and side effects following a single oral dose and retreatment at six months.

Ivermectin, a new antifilarial drug and currently the drug of choice for the treatment of onchocerciasis, has been shown to be effective in bancroftian filariasis. We report here, for the first time, the efficacy and safety of the drug in the treatment of filariasis caused by periodic Brugia malayi. Sixty male, asymptomatic microfilaraemics of Alleppey district, Kerala, South India, received single oral doses of ivermectin in a double blind study.