88 results match your criteria: "T.A.D.; University of Texas M.D. Anderson Cancer Center[Affiliation]"
Targeted deep sequencing reveals no definitive evidence for somatic mosaicism in atrial fibrillation.
Circ Cardiovasc Genet
February 2015
From the Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine (J.D.R., T.A.D., J.E.O., G.M.M.), Cardiovascular Research Institute (A.P., P.-Y.K., R.C.D.), and Department of Medicine, California Institute for Quantitative Biosciences, Institute for Human Genetics (R.C.D.), University of California San Francisco; Division of Cardiovascular Surgery, Sutter Health, Sacramento, CA (J.L.); and Arrhythmia Research Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada (M.H.G.).
Background: Studies of ≤15 atrial fibrillation (AF) patients have identified atrial-specific mutations within connexin genes, suggesting that somatic mutations may account for sporadic cases of the arrhythmia. We sought to identify atrial somatic mutations among patients with and without AF using targeted deep next-generation sequencing of 560 genes, including genetic culprits implicated in AF, the Mendelian cardiomyopathies and channelopathies, and all ion channels within the genome.
Methods And Results: Targeted gene capture and next-generation sequencing were performed on DNA from lymphocytes and left atrial appendages of 34 patients (25 with AF).
Telomere length and the risk of atrial fibrillation: insights into the role of biological versus chronological aging.
Circ Arrhythm Electrophysiol
December 2014
From the Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine (J.D.R., T.A.D., J.E.O., G.M.M.), Institute of Human Genetics and Department of Medicine (E.Z., D.H.), Department of Biochemistry and Biophysics (J.L., E.H.B.), Department of Epidemiology and Biostatistics (D.V.G.), Department of Medicine (E.G.B.), and Department of Bioengineering and Therapeutic Sciences (E.G.B.), University of California, San Francisco; Division of Cardiovascular Surgery, Sutter Health, Sacramento, CA (J.L.); Department of Epidemiology (A.L.F., S.R.H.) and Cardiovascular Health Research Unit (B.M.P., S.R.H.), University of Washington, Seattle; and Departments of Medicine and Health Services, University of Washington and Group Health Research Institute, Group Health, Seattle (B.M.P., S.R.H.).
Background: Advanced age is the most important risk factor for atrial fibrillation (AF); however, the mechanism remains unknown. Telomeres, regions of DNA that shorten with cell division, are considered reliable markers of biological aging. We sought to examine the association between leukocyte telomere length (LTL) and incident AF in a large population-based cohort using direct LTL measurements and genetic data.
View Article and Find Full Text PDFReduction in perceived stress as a migraine trigger: testing the "let-down headache" hypothesis.
Neurology
April 2014
From the Saul B. Korey Department of Neurology (R.B.L., D.C.B., C.B.H., T.A.D., T.M.B., B.M.G., S.R.H.) and Department of Epidemiology and Population Health (R.B.L., C.B.H.), Albert Einstein College of Medicine, Bronx; Montefiore Headache Center (R.B.L., D.C.B., T.A.D., B.M.G.), Bronx, NY; and Department of Community Medicine (H.T.), University of Connecticut School of Medicine, Farmington, CT.
Objective: To test whether level of perceived stress and reductions in levels of perceived stress (i.e., "let-down") are associated with the onset of migraine attacks in persons with migraine.
View Article and Find Full Text PDFInitial symptoms in patients with HPV-positive and HPV-negative oropharyngeal cancer.
JAMA Otolaryngol Head Neck Surg
May 2014
IMPORTANCE This study addresses the most common initial symptoms of oropharyngeal squamous cell carcinoma (OPSCC) and investigates differences between human papillomavirus (HPV)–positive vs HPV-negative tumors. OBJECTIVES To analyze the most common initial symptoms in patients with OPSCC and to determine if any differences in initial symptoms occur between HPV-positive and HPV-negative tumors. DESIGN, SETTING, AND PATIENTS Retrospective single-institution review of medical records of previously untreated patients with OPSCC diagnosed from January 1, 2008, toMay 20, 2013, who were evaluated by 1 physician (the senior author, T.
View Article and Find Full Text PDFSurvey of ethical issues reported by Indian medical students: basis for design of a new curriculum.
Indian J Med Ethics
April 2015
Department of Gastrointestinal Sciences, Christian Medical College, Vellore 632 004, Tamil Nadu INDIA.
Education in ethics is now a formal part of the undergraduate medical curriculum. However, most courses are structured around principles and case studies more appropriate to western countries. The cultures and practices of countries like India differ from those of western countries.
View Article and Find Full Text PDFIndividualized current-shaping reduces DBS-induced dysarthria in patients with essential tremor.
Neurology
February 2014
From the Departments of Neurology (M.T.B., T.A.D., J.B., I.G.M., G.R.F., L.T.) and Stereotaxy and Functional Neurosurgery (M.R., M.M.), University Hospital Cologne; Cognitive Neuroscience (INM3) (M.T.B., G.R.F.), Institute of Neuroscience and Medicine, Research Centre Jülich; Department of Neurology (J.R.), University Hospital Kiel; and IB-Hochschule Berlin (M.H.), Germany.
Objective: To investigate in patients with essential tremor (ET) treated with thalamic/subthalamic deep brain stimulation (DBS) whether stimulation-induced dysarthria (SID) can be diminished by individualized current-shaping with interleaving stimulation (cs-ILS) while maintaining tremor suppression (TS).
Methods: Of 26 patients screened, 10 reported SID and were invited for testing. TS was assessed by the Tremor Rating Scale and kinematic analysis of postural and action tremor.
Distracted driving and risk of road crashes among novice and experienced drivers.
N Engl J Med
January 2014
From the Virginia Tech Transportation Institute (S.G.K., F.G., S.E.L., T.A.D.) and the Department of Statistics, Virginia Polytechnic Institute and State University (F.G.) - both in Blacksburg; the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (B.G.S.-M.); and the University of Sherbrooke, Sherbrooke, QC, Canada (M.C.O.).
Background: Distracted driving attributable to the performance of secondary tasks is a major cause of motor vehicle crashes both among teenagers who are novice drivers and among adults who are experienced drivers.
Methods: We conducted two studies on the relationship between the performance of secondary tasks, including cell-phone use, and the risk of crashes and near-crashes. To facilitate objective assessment, accelerometers, cameras, global positioning systems, and other sensors were installed in the vehicles of 42 newly licensed drivers (16.
Incident atrial fibrillation among Asians, Hispanics, blacks, and whites.
Circulation
December 2013
Department of Medicine, Division of Cardiology, Electrophysiology Section (T.A.D., J.E.O., G.M.M.) and the Department of Epidemiology and Biostatistics (E.V.), University of California, San Francisco, CA.
Background: Because the association between atrial fibrillation (AF) and race has only been rigorously compared in population-based studies that dichotomized participants as white or black, it is unclear whether white race confers elevated AF risk or black race affords AF protection.
Methods And Results: The Healthcare Cost and Utilization Project was used to identify patients receiving hospital-based care in California between January 1, 2005 and December 31, 2009. The association between race and incident AF was examined using Cox proportional hazards models.
Consensus statement on the classification and terminology of neck dissection.
Arch Otolaryngol Head Neck Surg
May 2008
Division of Otolaryngology, Southern Illinois University School of Medicine, Springfield, IL 62794-9677, USA.
Objective: To update the guidelines for neck dissection terminology, as previously recommended by the American Head and Neck Society.
Participants: Committee for Neck Dissection Classification, American Head and Neck Society; representation from the Committee for Head and Neck Surgery and Oncology, American Academy of Otolaryngology-Head and Neck Surgery (T.A.
Sister chromatid exchange (SCE) in cattle: a comparison between normal and rob (1;29)-carrying karyotypes.
Hereditas
April 1996
Dept. de Zootecnia, U.T.A.D., Vila Real, Portugal.
Fifty-one phenotypically normal Maronesa cattle (28 males and 23 females) from North-Portugal were studied to ascertain the frequency of SCEs in normal karyotypes and in karyotypes carrying rob (1;29). In the 1852 examined cells, the mean value of SCEs was 7.1 +/- 3.
View Article and Find Full Text PDFFrequency and distribution of rob (1;29) in three Portuguese cattle breeds.
Hereditas
May 1994
Departamento de Zootecnia, U.T.A.D., Vila Real, Portugal.
Representative samples of Portuguese cattle from Barrosã, Maronesa, and Mirandesa breeds underwent cytogenetic investigation. Banding showed that 134 (65.0%) Barrosas, 74 (40.
View Article and Find Full Text PDFLiving conditions of serious chronic respiratory insufficiency patients treated at home on oxygen therapy or assisted ventilation.
Lung
September 1990
A.N.T.A.D.I.R., Paris, France.
A study on the living conditions of patients on long-term oxygen therapy or assisted ventilation at home was conducted in France in January 1988. At that date, 13,500 patients had been handled by 30 regional associations. Twenty-four regional associations (80%) representing 11,079 patients (82%) participated in the study.
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