Anti-angiogenic effects of cationic zinc (II) phthalocyanine derivatives through photodynamic therapy.

In this study, the in vitro photodynamic therapy (PDT) activity of two zinc phthalocyanines (ZnPc1 and ZnPc2) was systematically examined in human umbilical vein endothelial cells, focusing on PDT-induced cytotoxicity, reactive oxygen species (ROS) generation, and inhibition of angiogenic processes. Both the ZnPcs demonstrated minimal cytotoxicity in the absence of light, confirming their safety as photosensitizers. ZnPc-PDT led to significant cell death via apoptosis.

Modification of Gene Expression Involved in Alkaloid Production in Opium Poppy by VIGS Combined With Pretreatment of Macerozyme Enzyme.

L., a medicinal plant renowned for its pharmaceutical alkaloids, has captivated scientific interest due to its rich secondary metabolite profile. This study explores a novel approach to manipulating alkaloid biosynthesis pathways by integrating virus-induced gene silencing (VIGS) with macerozyme enzyme pretreatment.

Serum NMR Metabolomics in Distinct Subtypes of Hematologic Malignancies.

Hematological malignancies encompass a diverse array of subtypes, contributing to substantial heterogeneity that poses challenges in predicting clinical outcomes. Leveraging the capabilities of nuclear magnetic resonance holds substantial promise in the detection of serum biomarkers and individual metabolic alterations in patients. The study involved the analysis of the sera from patients with acute myeloid leukemia, chronic lymphocytic leukemia, and non-Hodgkin lymphoma to investigate the impacted metabolites and their associated pathways.

MXene as SERS-Active Substrate: Impact of Intrinsic Properties and Performance Analysis.

A new member is incorporated into the SERS active materials family daily as a consequence of advances in materials science. Furthermore, it has been demonstrated that MXenes, which display remarkable physicochemical characteristics, are also encompassed within this family. This Review offers a comprehensive and systematic assessment of the potential of MXene structures in the context of SERS applications.

Design of immunoassay based biosensor platforms for SARS-CoV-2 detection using highly specific monoclonal antibodies.

The global expand of SARS-CoV-2 has highlighted the importance of early and rapid detection to control the spread of a pandemic. In this study, specific and high-affinity monoclonal antibodies (mAbs) were developed against the conserved nucleocapsid protein of the virus among variants. Appropriate antibody pairs were selected to develop a lateral flow immunoassay (LFIA) and an unconventional application of an amperometric biosensor using unmodified screen-printed electrodes and external magnetic bead preparation.

Upcycling commercial nut byproducts for food, nutraceutical, and pharmaceutical applications: A comprehensive review.

This article presents a comprehensive overview of upcycling commercial nut byproducts (such as Brazil nut, cashew, hazelnut, macadamia, peanut (also known as a legume), pecan, pine nut, pistachio, and walnut) for food, nutraceutical, and pharmaceutical applications. Upcycling nut byproducts, namely husk/hull, hard shell, brown skin, defatted flour/meal/cake, pine cone, cashew nut shell liquid, cashew apple, walnut septum, and dreg/okara, has great potential, not only to reduce/minimise waste, but also to fit within the circular economy concept. Each byproduct has its own unique functional properties, which can bring significant value.

Enhanced Cycling Stability of Al-Doped LiMn Al NiCoO as a Cathode Material for Li-Ion Batteries by a Supercritical-CO-Assisted Method.

Lithium-rich layered oxide materials (Li-NMC) are considered a potential cathode material for next-generation batteries, thanks to their high theoretical specific capacity. Large potential drop and capacity loss after long cycles are the main obstacles to expanding commercial utilization of Li-NMC. In the past decade, great efforts have been made to overcome those issues of Li-NMCs.

A Novel PCR-Free Ultrasensitive GQD-Based Label-Free Electrochemical DNA Sensor for Sensitive and Rapid Detection of .

Biological warfare agents are infectious microorganisms or toxins capable of harming or killing humans. is a potential bioterrorism agent that is highly infectious, even at very low doses. Biosensors for biological warfare agents are simple yet reliable point-of-care analytical tools.

Multifunctional PAMAM Dendrimers Carrying SAHA, 5-FU, and a Therapeutic Gene for Targeted Co-Delivery Toward Colorectal Cancer Cells.

A promising approach to treat colorectal cancer (CRC) involves combining chemotherapy, epigenetics, and gene therapy to combat drug resistance. Multifunctional nanocarriers have emerged as a valuable tool for targeted CRC therapy. By delivering multiple treatments directly to cancer cells, these nanocarriers offer the potential for improved outcomes and reduced side effects.

Synthesis of Co/CoO Heterostructure in N-Doped Porous, Amorphous Carbon: A Superior Electrochemical Sensor for Sensitive Determination of Alectinib in Various Fluids.

Highly crystallized Co and CoO nanoparticles embedded in an N-doped amorphous carbon matrix have been successfully fabricated by the molten-salt-assisted method using KClO and zeolitic imidazolate framework-12 (ZIF-12). Pyrolysis of ZIF-12 with different concentrations of KClO leads to embedded Co and CoO nanoparticles in a conductive amorphous carbon network. The impact of salt concentration on the morphology and electrochemical performance of these composites was investigated for electrochemical sensor applications.

Cationic first-row transition metal saccharinate complexes with tris(2-pyridylmethyl)amine: synthesis, structures and anticancer studies.

A series of new cationic first-row transition metal complexes of [Mn(sac)(HO)(tpma)](sac)·HO (Mn), [(μ-O){FeCl(tpma)}](sac)·3HO (Fe), [Co(sac)(HO)(tpma)](sac)·HO (Co), [Ni(HO)(tpma)](sac)·2HO (Ni), [Cu(sac)(tpma)](sac) (Cu) and [Zn(sac)(HO)(tpma)](sac) (Zn), where sac = saccharinate and tpma = tris(2-pyridylmethyl)amine, were synthesized and structurally characterized by elemental analysis, UV-Vis, IR, ESI-MS, NMR, X-ray diffraction and conductivity measurements. The cytotoxic activity of the metal complexes was evaluated against lung carcinoma (A549), breast adenocarcinoma (MCF7), colon (HT29), and normal BEAS-2B cell lines. Mn and Fe displayed potent cytotoxic activity in all cell lines with IC values between 1.

The development of a novel, green, efficient, and eco-friendly GC-MS/MS analytical method for the reliable and rapid determination of dl-PCBs, and PCDD/Fs using hydrogen as a carrier gas and a modified ion source.

The polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) are worldwide contaminants, and they tend to accumulate in wide variety of matrices. Therefore, due to the highest accumulation rate and recalcitrancy, their precise quantification makes significant concern about their toxicological effects on both humans and organisms. The objective of the study is that using hydrogen carrier gas instead of helium in gas chromatography with triple quadrupole (GC-MS/MS) systems could contribute to improvements on the analysis of dl-PCBs and PCDD/Fs in environmental matrices.

Enhancement of methane production by electrohydrolysis pretreatment for anaerobic digestion of OFMSW.

Hydrolysis is the most critical rate-limiting step in the anaerobic digestion (AD) process for most types of substrates. The organic fraction of municipal solid waste (OFMSW) is a rich source for the AD process because of its high degradability. In this study, electrohydrolysis pretreatment was investigated for the OFMSW to overcome the rate-limiting step of hydrolysis.

Delivery of proapoptotic gene in Peptide-18-targeted Poly(2-oxazoline)-DOPE nanoliposomes for breast cancer models.

Breast cancer is one of the most common cancers and a significant cause of death in females worldwide. For effective breast cancer treatment, using systems with a promising delivery of anticancer agents is an important strategy. Peptide 18 (P18), a tumor-homing peptide, shows a high binding affinity toward breast cancer cells.

Unveiling the Potential of Protein-Based Sustainable Antibacterial Materials.

The surge in bacterial growth and the escalating resistance against a multitude of antibiotic drugs have burgeoned into an alarming global threat, necessitating urgent and innovative interventions. In response to this peril, scientists have embarked on the development of advanced biocompatible antibacterial materials, aiming to counteract not only bacterial infections but also the pervasive issue of food spoilage resulting from microbial proliferation. Protein-based biopolymers and their meticulously engineered composites are at the forefront of this endeavor.

Unexpected far-field deformation of the 2023 Kahramanmaraş earthquakes revealed by space geodesy.

The spatiotemporal pattern of surface displacements from large earthquakes provides crucial insights about the deformation of Earth's crust at various scales and the interactions among tectonic plates. However, the lack of extensive and large-scale geodetic networks near such seismic events hinders our thorough understanding of the large-scale crustal deformation resulting from earthquakes. Using Türkiye's extensive and continuous global navigation satellite system (GNSS) network during the moment magnitude 7.

Development of new sustainable pyridinium ionic liquids: From reactivity studies to mechanism-based activity predictions.

Context: This study addresses the development of sustainable pyridinium ionic liquids (ILs) because of their potential applications in agriculture and pharmaceuticals. Pyridinium-based ILs are known for their low melting points, high thermal stability, and moderate solvation properties. We synthesized three novel pyridinium-based ILs: 1-(2-(isopentyloxy)-2-oxoethyl)pyridin-1-ium chloride, 1-(2-(hexyloxy)-2-oxoethyl)pyridin-1-ium chloride, and 1-(2-(benzyloxy)-2-oxoethyl)pyridin-1-ium chloride.

Superior Electrochemical Sensor Application of CoO/C Heterostructure in Rapid Analysis of Anticancer Drug Palbociclib in Pharmaceutical Formulations and Biological Fluids.

In this work, we report a study examining how different salt concentrations affect the structure and electrochemical performance of two CoO/C materials designed for the fabrication of an easy, cheap, fast, safe, and useful electrochemical sensor for the detection of Palbociclib (PLB). CoO nanoparticles were successfully created by encapsulating them in N-doped amorphous carbon matrices by using the molten salt-assisted approach. In this process, different amounts of potassium iodate and zeolitic imidazolate framework-12 (ZIF-12) were used, followed by pyrolysis at 800 °C.

Antiviral effect of cannabidiol on K18-hACE2 transgenic mice infected with SARS-CoV-2.

The aim of this study was to determine the antiviral activity of cannabidiol (CBD) against SARS-CoV-2 infection. CBD is the second most studied cannabinoid obtained from Cannabis plants. We investigated the potential use of CBD, which has so far proven to have a positive effect on different diseases, in the SARS-CoV-2 infection.

Bacterial Membrane Vesicles as a Novel Vaccine Platform against SARS-CoV-2.

Throughout history, infectious diseases have plagued humanity, with outbreaks occurring regularly worldwide. Not every outbreak affects people globally; however, in the case of Coronavirus Disease 2019 (COVID-19), caused by a novel coronavirus (SARS-CoV-2), it reached a pandemic level within a remarkably short period. Fortunately, advancements in medicine and biotechnology have facilitated swift responses to the disease, resulting in the development of therapeutics and vaccines.

Field-applicable simultaneous multiplex LAMP assay for screening HBV and HCV co-infection in a single tube.

Background: Globally, around 7 to 20 million people are believed to be suffering from coinfection with both hepatitis B virus (HBV) and hepatitis C virus (HCV). The loop-mediated isothermal amplification (LAMP) approach, introduced by Notomi and colleagues, has undergone substantial advancements as an effective molecular tool that enables the simultaneous analysis of multiple samples in a single tube.

Methods: The present study examined the simultaneous detection of HBV and HCV in a single tube using melt curve analysis multiplex LAMP (mLAMP), which is based on the identification of unique melting peak temperatures.

PEtOx-DOPE nanoliposomes functionalized with peptide 563 in targeted delivery to prostate cancer.

Background: Nanocarrier-based systems have cultivated significant improvements in prostate cancer therapy. However, the efforts are still limited in clinical applicability, and more research is required for the development of effective strategies. Here, we describe a novel nanoliposomal system for targeted apoptotic gene delivery to prostate cancer.