Improving communication to increase uptake of high-risk breast cancer prevention appointments: Building a better letter.

Objective: Mailed letters to women identified as being at high-risk for developing breast cancer were not having the desired effect for encouraging appointments with prevention-focused providers at a large Midwest healthcare system. A partnership with communication scholars sought to revise the letter to increase awareness, intentions, and appointments.

Methods: Guided by the Extended Parallel Process Model, survey responses were collected from letter recipients over the course of two years, both pre and post letter revision.

Genomic identification, evolutionary analysis, and transcript profiling of protein phosphatase 2C in Solanum lycopersicum.

Protein phosphatases (PPs) are a class of enzymes that play a critical role in cellular regulation by catalyzing the removal of phosphate groups from proteins. This dephosphorylation process is essential for controlling and modulating various cellular functions, including signal transduction, cell cycle progression, metabolic regulation, and stress responses. This study focuses on the comprehensive genomic identification, evolutionary analysis, and transcript profiling of the PP2C gene family within Solanum lycopersicum, an economically significant crop with substantial agricultural and nutritional importance.

Maxillary protraction anchored on miniplates versus miniscrews: three-dimensional dentoskeletal comparison.

Objective: This retrospective study aimed to compare the three-dimensional (3D) outcomes of the novel miniscrew-anchored maxillary protraction (MAMP) therapy and the bone-anchored maxillary protraction (BAMP) therapy.

Methods: The sample comprised growing patients with skeletal Class III malocclusion treated with two skeletal anchored maxillary protraction protocols. The MAMP group comprised 22 patients (9 female, 13 male; 10.

Upconversion-Linked Immunosorbent Assay for the Biomimetic Detection of the Mycotoxin Cyclopiazonic Acid.

The neurotoxin α-cyclopiazonic acid (CPA) is an emerging mycotoxin produced as a secondary metabolite by several fungi species (., spp. and spp.

Bioactive glasses for bone tissue engineering: a bibliometric study of the top 100-most cited papers.

Using bioactive glasses (BGs) for bone reconstruction is a promising and expanding field of investigation in regenerative medicine. Therefore, the aim of this study was to assess the key features of the 100 most cited papers on BG in bone tissue engineering through bibliometric measures. A search was conducted in the Web of Science citation indexing database until October 2023.

Biomechanical differences and variability during sustained motorized treadmill running versus outdoor overground running using wearable sensors.

This study aimed to compare running biomechanics and biomechanical variability across 3 run segments and between conditions for 5-km outdoor overground and indoor treadmill running. Seventy-one recreationally-active adults (31F, 40 M; age: 37 ± 11 years; body mass index: 22.9 ± 2.

The Role of Electron Transfer in Copper-Mediated C(sp)-H Trifluoromethylation.

We report copper(II) and copper(III) trifluoromethyl complexes supported by a pyridinedicarboxamide ligand (L) as a platform for investigating the role of electron transfer in C(sp)-H trifluoromethylation. While the copper(II) trifluoromethyl complex is unreactive towards (hetero)arenes, the formal copper(III) trifluoromethyl complex performs C(sp)-H trifluoromethylation of a wide range of (hetero)arenes. Mechanistic studies using the copper(III) trifluoromethyl complex suggest that the mechanism of arene trifluoromethylation is substrate-dependent.

Intestinal Biomarkers and Their Importance in Canine Enteropathies.

Enteropathies are prevalent in dog internal medicine, and their diagnosis involves a lengthy process. One of the tests requested is for biomarkers, which are important as they can provide data on intestinal functionality, intensity of inflammation, and response to treatment, and can help determine the prognosis. This study aimed to conduct a literature review on the main serum and fecal intestinal biomarkers in dogs and proposed to refine the correlations between these indicators and enteropathies.

, , and are emerging preharvest maize ear rot pathogens in Ethiopia.

Fusarium ear rot (FER) and Gibberella ear rot (GER) caused by Fusarium species are major diseases affecting maize production in Ethiopia. In addition to reducing quality and yield, these fungi can produce mycotoxins that contaminate maize kernels and, thereby, pose health hazards to humans and livestock. A survey was conducted in 10 administrative zones of Ethiopia within the major maize-growing regions of the country to identify the species of Fusarium associated with ear rot.

Harnessing network pharmacology in drug discovery: an integrated approach.

Traditional drug discovery approach is based on one drug-one target, that is associated with very lengthy timelines, high costs and very low success rates. Network pharmacology (NP) is a novel method of drug designing, that is based on a multiple-target approach. NP integrates systems such as biology, pharmacology and computational techniques to address the limitations of traditional methods of drug discovery.

The 100 most influential articles in mouth breathing. A bibliometric and altmetric analysis: 2002-2021.

Background: This study aimed to identify and analyze the most influential Mouth Breathing (MB) articles in children and adolescents with the highest relative citation rates (RCRs), through bibliometric and altmetric analysis, from 2002 to 2021.

Material And Methods: On March 27, 2023 a PubMed search was conducted to detect papers published about MB. From a total of 826 documents, the article data were downloaded from iCite database.

Regulation of miR-206 in denervated and dystrophic muscles, and its effect on acetylcholine receptor clustering.

The muscle-specific microRNA miR-206 has recently emerged as a potential regulator of genes involved in the formation and regeneration of the neuromuscular junction (NMJ). This study investigated miR-206-3p (miR-206) expression in synaptic and non-synaptic regions of denervated mice and α-dystrobrevin (Dtna)-knockout mice, as well as its impact on the formation and/or maintenance of agrin-induced acetylcholine receptor (AChR) clusters. In denervated, Dtna-deficient and crushed muscles, miR-206 expression significantly increased compared to what was seen for innervated muscles.

A criterion for sequential Cohen-Macaulayness.

The purpose of this note is to show that a finitely generated graded module over , a field, is sequentially Cohen-Macaulay if and only if its arithmetic degree agrees with , where is a graded free -module and . This answers positively a conjecture of Lu and Yu from 2016.

Oomycete communities in lowland tropical forest soils vary in species abundance and comprise saprophytes and pathogens of seeds and seedlings of multiple plant species.

Premise: The soils in lowland tropics are teeming with microbial life, which can impact plant community structure and diversity through plant-soil feedbacks. While bacteria and fungi have been the focus of most studies in the tropics, oomycetes may have an outsized effect on seed and seedling health and survival, given their affinity for moister, warmer environments.

Methods: We assessed the diversity and pathogenicity of oomycete species present in a lowland tropical forest in Panama.

Caregiver restrictions on child access to tobacco in the home and home Smoking/Vaping bans among Black/African American women caregivers who smoke and live in Resource-limited, rural areas.

Objective: This study examined relationships between home smoking/vaping bans and caregiver restrictions on child access to tobacco in the home among rural, Black/African American caregivers who smoke.

Methods: Data were from the baseline survey of a randomized trial conducted in 2020-2022 among caregivers who smoke cigarettes and/or little cigars/cigarillos (N = 188). Logistic regressions examined associations between independent variables (tobacco product-specific and comprehensive home smoking/vaping bans) and dependent variables (caregiver keeps tobacco in the home; among caregivers with tobacco at home, caregiver restricts child tobacco access at home) Models were adjusted for caregiver tobacco use, income, and additional covariates based on stepwise selection.

Behavioral syndromes in paper wasps: Links between social and non-social personality in .

Although much work has focused on non-social personality traits such as activity, exploration, and neophobia, there is a growing appreciation that social personality traits play an important role in group dynamics, disease transmission, and fitness and that social personality traits may be linked to non-social personality traits. These relationships are important because behavioral syndromes, defined here as correlated behavioral phenotypes, can constrain evolutionary responses. However, the strength and direction of relationships between social and non-social personality traits remain unclear.

Desorption efficiency and holding capacity of acid-treated filters for nicotine sampling in vape shops.

Efficient sampling materials are essential for assessing nicotine levels in vape shops and other settings where nicotine exposures may exist. Two different treatments of Whatman glass fiber type A (GF/A) filters (sodium bisulfate treated and citric acid treated) were evaluated for nicotine capture, desorption efficiency, and holding capacity using Gas Chromatography-Mass Spectrometry (GC-MS). The Filters were treated with 0.

Bicyclo[2.1.1]hexanes via Intramolecular Formal (3+2)-Cycloaddition.

We report a synthesis of bicyclo[2.1.1]hexanes via an intramolecular formal (3+2) cycloaddition of allylated cyclopropanes bearing a 4-nitrobenzimine substituent.

Tissue nonspecific alkaline phosphatase deficiency impairs Purkinje cell development and survival in a mouse model of infantile hypophosphatasia.

Loss-of-function mutations in the tissue-nonspecific alkaline phosphatase (TNAP) gene can result in hypophosphatasia (HPP), an inherited multi-systemic metabolic disorder that is well-known for skeletal and dental hypomineralization. However, emerging evidence shows that both adult and pediatric patients with HPP suffer from cognitive deficits, higher measures of depression and anxiety, and impaired sensorimotor skills. The cerebellum plays an important role in sensorimotor coordination, cognition, and emotion.

L-Cysteine-Catalysed Hydration of Activated Alkynes.

Hydration reactions consist of the introduction of a molecule of water into a chemical compound and are particularly useful to transform alkynes into carbonyls, which are strategic intermediates in the synthesis of a plethora of compounds. Herein we demonstrate that L-cysteine can catalyse the hydration of activated alkynes in a very effective and fully regioselective manner to access important building blocks in synthetic chemistry such as β-ketosulfones, amides and esters, in aqueous media. The mild reaction conditions facilitated the integration with enzyme catalysis to access chiral β-hydroxy sulfones from the corresponding alkynes in a one-pot cascade process in good yields and excellent enantiomeric ratios.