Genetic Analysis of Psychosis Biotypes: Shared Ancestry-Adjusted Polygenic Risk and Unique Genomic Associations.

The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) created psychosis Biotypes based on neurobiological measurements in a multi-ancestry sample. These Biotypes cut across DSM diagnoses of schizophrenia, schizoaffective disorder and bipolar disorder with psychosis. Two recently developed ancestry adjustment methods of Polygenic Risk Scores (PRSs) generate Ancestry-Adjusted PRSs (AAPRSs), which allow for PRS analysis of multi-ancestry samples.

Optimizing Drug Delivery to the Brain for Breast Metastasis: A Novel Method for Tumor Targeting.

Introduction: Brain metastases are difficult to treat due to the blood-brain barrier limiting the delivery of therapeutic agents to the brain effectively. Intraventricular drug delivery has not been well studied for intra-axial pathologies. However, our prior work demonstrated that intraventricular drug delivery in a hyperosmolar vehicle showed preferential accumulation of drug within breast cancer tissue compared to surrounding brain parenchyma.

PFAS in landfill leachate: Practical considerations for treatment and characterization.

Per- and polyfluoroalkyl substances (PFAS) are widely used in consumer products and are particularly high in landfill leachate. The practice of sending leachate to wastewater treatment plants (WWTPs) is an issue for utilities that have biosolids land application limits based on PFAS concentrations. Moreover, landfills may face their own effluent limit guidelines for PFAS.

Prevalence of Tobacco and Poly-Tobacco Use as a Function of Sexual Orientation Identity and Sex.

Introduction: Limited research has characterized poly-tobacco use (i.e., use of at least two nicotine/tobacco products) among adults with sexual minoritized (SM) identities (i.

Interleukin-13 Receptor Subunit Alpha 2 Induces Chemokine Expression and Macrophage Polarization to Promote Inflammation and Fibrosis.

Purpose: Interleukin-13 (IL-13) is a known mediator of radiation-induced lung injury (RILI). IL-13Rα2 has an accepted role in antagonizing IL-13 signaling by acting as a decoy receptor. We sought to understand the role of IL-13Rα2 in the progression of RILI.

Expectancies for Alcohol Analgesia Among Emerging Adults: Confirmatory Factor Analysis, Reliability, and Validity.

Background: Alcohol and pain frequently co-occur and interact in a positive feedback loop that maintains and exacerbates both conditions. The Expectancies for Alcohol Analgesia (EAA) is a recently developed, single-factor measure that assesses the extent to which individuals expect alcohol will reduce their pain. Alcohol-related outcome expectancies motivate drinking and predict drinking trajectories among emerging adults (18-24).

Effects of soil bulk density and corresponding soil infiltration rate on the migration and transformation of gibberellic acid.

High intensity agricultural activities can lead to a decrease in soil fertility and an increase in soil bulk density, which may significantly impact the migration and transformation of pesticides in soil. As a new widely-used micro-toxic pesticide, gibberellic acid (GA) is more soluble and hydrophilic than most pesticides, which could readily migrate throughout the soil during water infiltration and impact groundwater quality. In this study, the leaching of GA in saturated soils with different bulk densities (1.

Blood IL-1α and IL-6 predict specific breast cancer-induced increases in hippocampal pro-inflammatory cytokines in mice.

Neuroinflammation is a key factor in cognitive and behavioral changes seen in patients with non-CNS cancers, and cytokine levels in the blood are often used as a proxy for brain inflammation. However, this approach has yielded inconsistent results, and a common inflammatory signature remains elusive. To explore whether a blood-to-brain inflammatory signature exists across breast cancer types, we assessed cytokine and glial protein responses in the hippocampus, prefrontal cortex (PFC), and their relationship to serum cytokines in mice bearing three different mammary cancers (n = 40).

Associations supporting items gained and maintained across recall tests.

When performing successive recall tests without restudy, subjects' recalls exhibit intriguing variability across tests, including gaining or losing items across tests. To examine the cognitive mechanisms underlying this variability, research has focused primarily on hypermnesia, the finding that recall performance increases across tests (Erdelyi & Becker, 1974). Hypermnesia studies commonly consider conditions that impact recall levels of items gained across tests versus items maintained across tests.

A meta-analytic review of cognitive behavior therapy and motivational interviewing for adolescent and young adult sleep concerns.

Cognitive behavioral therapy (CBT) is an evidenced-based treatment for sleep concerns but may be insufficient on its own to resolve adolescent sleep problems - combining this treatment with motivational interviewing may result in more robust improvements to sleep in adolescents and young adults (AYA). This study aimed to conduct the first meta-analysis of integrated CBT and motivational interviewing (MI) for AYA sleep concerns. Following PRISMA guidelines, PsycINFO, PubMed, and Google Scholar were searched through January 2024.

Validating social reinforcer classes for low-severity challenging behavior identified by sensitivity tests.

Behavior analysts typically assess and treat challenging behavior after it occurs regularly and at high severity. Although effective, this reactive approach is quite costly and resource intensive. A growing literature supports an alternative preventive approach; the first step involves conducting sensitivity tests to screen the topographies and functions of low-severity behavior evoked by establishing operations commonly included in challenging behavior research (e.

When Designs Became Interventions in Hospitals.

Design is and always has been interventional and clinically relevant. Modern evidence-based designers' lineage was prominently shaped between 1800 and 1970. This article investigates hospital designs during this period that were correlated with patients' health outcomes and suggests how this history influenced our present-day understanding of evidence-based design.

Social validity of Research Ethics for All: Social-behavioral research ethics education for community research partners with developmental disabilities.

Background: Training in research ethics supports community research partners with developmental disabilities to take on additional research responsibilities. We worked with an academic-community partnership to develop an accessible research ethics training tailored to the roles of community research partners with developmental disabilities that leads to certification: Research Ethics for All.

Objective: We evaluated the social validity of the educational activities and certification process.

Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus.

The gene inositol polyphosphate-5-phosphatase D (INPP5D), which encodes the lipid phosphatase SH2-containing inositol polyphosphate 5-phosphatase 1 (SHIP1), is associated with the risk of Alzheimer's disease (AD). How it influences microglial function and brain physiology is unclear. Here, we showed that SHIP1 was enriched in early stages of healthy brain development.

Driving under the influence of allergies: the effect of seasonal pollen on traffic fatalities.

Traffic fatalities are the leading cause of mortality in the United States despite being preventable. While several policies have been introduced to improve traffic safety and their effects have been well documented, the role of transitory health shocks or situational factors at explaining variations in fatal traffic accidents has been understudied. Exploring daily variation in city-specific pollen counts, this study finds novel evidence that traffic fatalities increase on days in which the local pollen count is particularly high.

The effective multiplicity of infection for HCMV depends on the activity of the cellular 20S proteasome.

Human cytomegalovirus (HCMV) is a betaherpesvirus capable of infecting numerous cell types and persisting throughout an infected individual's life. Disease usually occurs in individuals with compromised or underdeveloped immune systems. Several antivirals exist but have limitations relating to toxicity and resistance.

Response Rates, Reliability, and Convergent Validity in Experience Sampling Data.

This study examined associations of compliance rate with the reliability and convergent validity of intoxication and negative affect assessments in experience sampling method (ESM) data in three samples (Veterans, Sexual Minority Men, and College Students). Convergent validity was operationalized as within-person associations between daily aggregates of random in situ assessments and retrospective daily assessments or transdermal alcohol assessments. Measures with lower ICC require more assessments for a reliable aggregate (e.

Taurine stimulation of planarian motility: a role for the dopamine receptor pathway.

Taurine, a normal dietary component that is found in many tissues, is considered important for a number of physiological processes. It is thought to play a particular role in eye development and in the maturation of both the muscular and nervous systems, leading to its suggested use as a therapeutic for Alzheimer's and Parkinson's diseases. Taurine increases metabolism and has also been touted as a weight loss aid.

Early experience with the Aristotle Colossus 0.035' macrowire for mechanical thrombectomy in 30 consecutive cases.

Introduction: Recent literature continues to demonstrate the successful role of large-bore aspiration catheters in thrombus ingestion during mechanical thrombectomy. However catheter-to-microwire step-off and distal navigation are ongoing challenges in thrombectomy. A new to market 0.

Role of Momentary Alcohol Cognitions in Event-Level Relations Between PTSD Symptoms and Alcohol Outcomes: Le rôle des cognitions momentanées liées à l'alcool au niveau de l'événement entre les symptômes du TSPT et la consommation d'alcool.

Objective: Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) commonly co-occur. Momentary alcohol cognitions may represent in-the-moment, modifiable risk factors to target in interventions for comorbid PTSD and AUD. However, the role of such cognitions in risk for problematic drinking as it emerges in response to individuals' fluctuating PTSD symptoms across their daily lives remains unknown.

Thermogenic adipose tissues: Promising therapeutic targets for metabolic diseases.

The ongoing increase in the prevalence of obesity and its comorbidities such as cardiovascular disease, type 2 diabetes (T2D) and dyslipidemia warrants discovery of novel therapeutic options for these metabolic diseases. Obesity is characterized by white adipose tissue expansion due to chronic positive energy balance as a result of excessive energy intake and/or reduced energy expenditure. Despite various efforts to prevent or reduce obesity including lifestyle and behavioral interventions, surgical weight reduction approaches and pharmacological methods, there has been limited success in significantly reducing obesity prevalence.

An Alkyne-Containing Isoprenoid Analogue Based on a Farnesyl Diphosphate Scaffold Is a Biologically Functional Universal Probe for Proteomic Analysis.

Prenylation consists of the modification of proteins with either farnesyl diphosphate (FPP) or geranylgeranyl diphosphate (GGPP) at a cysteine near the C-terminus of target proteins to generate thioether-linked lipidated proteins. In recent work, metabolic labeling with alkyne-containing isoprenoid analogues including C15AlkOPP has been used to identify prenylated proteins and track their levels in different diseases. Here, a systematic study of the impact of isoprenoid length on proteins labeled with these probes was performed.