3,979 results match your criteria: "Syndrome of Inappropriate Antidiuretic Hormone Secretion"
[Systemic lupus erythematosus involving the fornix column leading to hyponatremia: A case report].
Beijing Da Xue Xue Bao Yi Xue Ban
December 2024
Department of Rheumatology, Peking University Third Hospital, Beijing 100191, China.
We reported the diagnostic and therapeutic process of a young male patient with systemic lupus erythematosus (SLE) who presented with severe hyponatremia as the main manifestation upon admission, and analyzed and discussed the case. The patient was a 19-year-old young male with a subacute course of disease, fever ≥38.3 ℃ that could not be explained by other causes, acute and subacute cutaneous lupus erythematosus, oral ulcers, arthritis, leukopenia (< 4×10/L), low C3+low C4, and positive anti-double-stranded DNA (anti-dsDNA).
View Article and Find Full Text PDFEctopic olfactory neuroblastoma is associated with increased frequency of syndrome of inappropriate antidiuretic hormone secretion and reduced disease control: Case series with systematic review and pooled analysis.
Int Forum Allergy Rhinol
December 2024
Section of Otorhinolaryngology-Head and Neck Surgery, Department of Neuroscience, University of Padova, Padova, Italy.
Introduction: Olfactory neuroblastoma (ONB) is a rare malignant tumor originating from the olfactory neuroepithelium, typically within the sinonasal cavity. Cases of ONB originating outside of the olfactory cleft area are extremely rare and are referred to as "ectopic" (eONB), in contrast to "orthotopic" tumors (oONB). ONB has been associated with paraneoplastic syndromes (PNSs), including the syndrome of inappropriate antidiuretic hormone secretion (SIADH).
View Article and Find Full Text PDFLong-Term Persistence of Inappropriate Antidiuretic Hormone Secretion Following Minor Head Injury.
Eur J Case Rep Intern Med
November 2024
Department of Internal Medicine, Iris Hospitals South (Molière), Brussels, Belgium.
Unlabelled: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common cause of euvolemic hyponatremia, resulting from non-osmotic release of antidiuretic hormone (ADH). SIADH is frequently associated with neurological conditions, including traumatic brain injury (TBI). TBI-associated SIADH usually develops within days to weeks and resolves within a few weeks.
View Article and Find Full Text PDFComparative study of the effectiveness of tolvaptan versus urea in patients with hyponatremia caused by SIADH.
Rev Clin Esp (Barc)
December 2024
Unidad de Medicina Oral, Cirugía Oral e Implantología, Facultad de Medicina y Odontología, Universidad de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain.
Background And Objectives: Hyponatraemia is common in elderly and hospitalised patients, often caused by the syndrome of inappropriate antidiuretic hormone secretion (SIADH). This study evaluates the efficacy and safety of tolvaptan and urea in patients with hyponatraemia and SIADH.
Materials And Methods: An observational cohort study was conducted on 198 patients with SIADH and hyponatraemia (Na+ <135 mmol/L) at the Complejo Hospitalario Universitario de Pontevedra from January 2015 to May 2022.
Unraveling the Mystery of Rathke's Cleft Cyst Presenting with Hyponatremia: A Case Report with a Comprehensive Review of Literature.
Asian J Neurosurg
December 2024
Department of Neurosurgery, Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, New York, United States.
Article Synopsis
- Rathke's cleft cyst (RCC) is a benign cyst that usually goes unnoticed but can be associated with rare cases of hyponatremia due to inappropriate antidiuretic hormone (SIADH) secretion.
- The case study discusses a 56-year-old woman who experienced symptoms like blurry vision and headaches, ultimately diagnosed with euvolemic hyponatremia linked to RCC, which was treated effectively via endoscopic surgery.
- The article emphasizes the need for careful evaluation and a multidisciplinary approach in managing such rare instances, while calling for more research to enhance understanding and treatment strategies for RCC related to SIADH.
Coronavirus Disease 2019 (COVID-19)-Induced Hyponatremia: A Challenging Geriatric Case.
Cureus
October 2024
Family Medicine, Beckley Appalachian Regional Healthcare (ARH) Hospital, Beckley, USA.
Article Synopsis
- * Initial thoughts about her condition pointed to improper regulation of water in the body, but further investigation indicated that her symptoms might be due to poor fluid intake and a misdiagnosed kidney issue.
- * The patient's liver enzyme levels improved with supportive treatment, allowing for the use of remdesivir, and her sodium levels gradually stabilized, underscoring the need for tailored patient management during COVID-19 recovery.
A case of hyponatraemia cured by delivery.
Obstet Med
April 2024
Obstetric Medicine, Mater Health, Raymond Terrace, South Brisbane, Australia.
Article Synopsis
- * It occurs in about 0.27% of pregnant women, usually caused by conditions like hyperemesis gravidarum early on and preeclampsia later in the pregnancy.
- * Factors like prolonged labor, cesarean sections, and excessive water intake can worsen hyponatraemia by increasing antidiuretic hormone levels, but cases can resolve quickly after childbirth.
Real-time intraoperative ultrasound imaging of the posterior pituitary gland during endoscopic endonasal approach.
Acta Neurochir (Wien)
November 2024
Department of Neurosurgery, The Ohio State University Wexner Medical Center, Doan Hall N 1049, 460 W 10th Ave, Columbus, OH, 43210, USA.
Article Synopsis
- Pituitary adenomas are common benign tumors that often require surgical removal via an endoscopic endonasal approach, with potential complications like central diabetes insipidus and SIADH stemming from manipulation of the posterior pituitary gland.
- This study investigates the intraoperative endoscopic endonasal ultrasound (IEUS) to visualize and describe the characteristics of the posterior pituitary gland during surgery, collecting data from surgeries between January 2022 and December 2023.
- Results show that the posterior pituitary gland is consistently hypoechoic and is most commonly elliptical in shape, providing critical information for surgeons to better identify and preserve this structure during operations.
Hyponatremia Associated with the Use of Common Antidepressants in the All of Us Research Program.
Clin Pharmacol Ther
November 2024
Precision Health Informatics Section, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Article Synopsis
- This study investigates the risk of hyponatremia (low sodium levels) associated with various antidepressants, including SSRIs, SNRIs, and NRIs, through examination of health records in the All of Us Research Program.
- The overall incidence of hyponatremia was found to be 0.87% within the first 30 days and 10.5% over three years among participants taking these medications.
- Among the antidepressants studied, duloxetine and escitalopram had the highest risk for hyponatremia, while bupropion and paroxetine were linked to the lowest risk, helping providers make informed treatment decisions.
Severe Hyponatremia Caused by the Syndrome of Inappropriate Antidiuresis Due to Urinary Retention.
Cureus
November 2024
Department of Internal Medicine, Municipal Omori Hospital, Yokote, JPN.
Article Synopsis
- A 90-year-old woman experienced severe low sodium levels (hyponatremia) due to syndrome of inappropriate antidiuresis (SIAD) caused by urinary retention.
- Her symptoms included worsening fatigue over 10 days, and treatment with hypertonic saline and bladder catheterization improved her condition.
- The case emphasizes that urinary retention can trigger SIAD in patients with unexplained low sodium levels, and highlights the need for careful sodium monitoring to avoid serious complications.
Article Synopsis
- SIADH causes low sodium levels (hyponatremia) and decreased uric acid in the body.
- A patient with small-cell lung cancer experienced SIADH and low uric acid (hypouricemia) after taking duloxetine, a medication used for depression and anxiety.
- The patient's condition improved when duloxetine was replaced with mirogabalin, suggesting a link between the medications and these side effects.
The Complexity of Managing Antipsychotic-Induced Hyponatremia: A Case Series.
Cureus
October 2024
Psychiatry, Al Amal Psychiatric Hospital, Emirates Health Services, Dubai, ARE.
Article Synopsis
- This case series explores hyponatremia (low sodium levels) that developed in three patients after starting antipsychotic medications, highlighting the challenges in managing both psychiatric conditions and electrolyte balance.
- The patients showed fluctuating sodium levels, necessitating close monitoring and interventions like adding lithium and aripiprazole to stabilize both their sodium and psychiatric symptoms.
- The findings emphasize the need for a tailored, interdisciplinary approach to effectively manage the relationship between psychiatric treatment and electrolyte disturbances, ensuring the safety and stability of patients.
Delayed Emergence of Isolated Secondary Adrenal Insufficiency: A Case Report.
Cureus
October 2024
Family Medicine, Baptist Health of South Florida, Miami, USA.
Article Synopsis
- Secondary adrenal insufficiency (SAI) is a rare condition caused by a deficiency in the adrenocorticotropic hormone (ACTH) from the pituitary gland, leading to symptoms like chronic low sodium levels (hyponatremia), and can present a diagnostic challenge, particularly when there are no identifiable triggers.
- An 80-year-old woman with a history of multiple health issues was diagnosed with isolated adrenal insufficiency after presenting with weakness and fatigue, leading to complications that required specific treatments including corticosteroids.
- This case highlights the importance of recognizing atypical presentations of adrenal insufficiency, as well as the effectiveness of corticosteroid replacement therapy in resolving symptoms and normalizing sodium levels.
Severe Hyponatremia Caused by Sertraline-Induced Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Complication With Critical Implications for Patient Safety.
Cureus
October 2024
Internal Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, USA.
Article Synopsis
- * Hyponatremia, although rare, can lead to critical health problems and was observed in a 68-year-old woman after she started taking sertraline.
- * Healthcare providers should carefully monitor patients on SSRIs for electrolyte levels and adjust treatment plans as needed to prioritize safety in psychiatric care.
[Effectiveness of the administration of a dietary supplement (oral urea) for the treatment of hyponatremia in SIADH].
Nutr Hosp
November 2024
HosServicio de Medicina Familiar y Comunitaria. Área Sanitaria Pontevedra e O Salnés.
Article Synopsis
- The study focuses on comparing the effectiveness and safety of urea versus fluid restriction for treating hyponatraemia caused by SIADH in hospital patients.
- An observational cohort study involving 212 patients showed that urea significantly increased sodium levels more than fluid restriction, with faster normalization of sodium levels (6 days vs. 8 days).
- Additionally, the urea group had a lower 60-day mortality rate (16.1%) compared to the fluid restriction group (32.8%), highlighting urea’s better safety profile.
Long-term Outcome of a Chihuahua With Idiopathic Syndrome of Inappropriate Antidiuretic Hormone Secretion.
J Am Anim Hosp Assoc
November 2024
From the Department of Small Animal Clinical Sciences (D.B.A., A.H.), University of Florida, Gainesville, Florida.
Article Synopsis
- A 3-year-old female Chihuahua was found to have excessive thirst and urination after being adopted; tests showed low sodium, chloride, and osmolality levels.
- Elevated levels of antidiuretic hormone (ADH) indicated an inappropriate response given the dog's serum osmolality, leading to a diagnosis of idiopathic syndrome of inappropriate antidiuretic hormone secretion.
- The dog has remained healthy for 2 years post-diagnosis with no treatment required except for slight dietary salt supplementation, highlighting a unique case with a positive outcome and innovative testing methods.
An adolescent girl with syndrome of inappropriate antidiuretic hormone secretion preceding the diagnosis of olfactory neuroblastoma - a case report.
Front Endocrinol (Lausanne)
October 2024
Division of Pediatric Endocrinology, Department of Pediatrics, Hasbro Children's Hospital, Providence, RI, United States.
Article Synopsis
- - A 13-year-old girl diagnosed with SIADH (Syndrome of Inappropriate Antidiuretic Hormone) after restrictive eating had normal initial brain MRIs, later revealing olfactory neuroblastoma (ONB) 2.5 years post-diagnosis.
- - Initial treatments for SIADH included fluid restriction, which was somewhat effective, but the condition recurred post-surgery for ONB, indicating persistence of SIADH even after successful tumor removal.
- - The case emphasizes the need for healthcare providers to consider the possibility of ONB when evaluating children with unexplained SIADH, recommending earlier imaging and endoscopy if no clear cause is found.
Acute Intermittent Porphyria: A Diagnostic Conundrum.
Cureus
October 2024
Internal Medicine, ABLE Charitable Hospital, Bahrola, IND.
Article Synopsis
- A 20-year-old female presented with severe abdominal pain, nausea, and discolored urine, and was diagnosed with acute intermittent porphyria (AIP) after initial tests showed no abnormalities but later revealed elevated urinary porphobilinogen.
- Her medical history included recurrent urinary tract infections, a past episode of SIADH, and psychiatric issues like anxiety and depression.
- The patient received targeted treatment, including intravenous Haem arginate, leading to improvement, but she required further hospitalization due to symptom recurrence, emphasizing the need for better awareness and education regarding AIP in Acute Medicine.
Cutaneous Herpes Zoster Infection as a Rare Etiology of Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH): A Case Report.
Cureus
September 2024
Internal Medicine, Temple University Hospital, Lewis Katz School of Medicine at Temple University, Philadelphia, USA.
Article Synopsis
- - Herpes zoster occurs when the varicella-zoster virus reactivates after causing chicken pox in childhood, mainly affecting older adults and those with weakened immune systems.
- - SIADH is characterized by the excessive release of antidiuretic hormone, leading to difficulty in excreting water and resulting in low sodium levels (hyponatremia).
- - This case is unique because the patient displayed signs of hypovolemic hyponatremia alongside SIADH, suggesting that herpes zoster might disrupt the normal regulation of ADH in the nerve roots.
Acute Urinary Retention and Severe Hyponatremia in a Patient With a Large Intramural Uterine Fibroid.
Cureus
September 2024
Internal Medicine/Malignant Hematology, Westchester Medical Center, Valhalla, USA.
Article Synopsis
- Acute urinary retention (AUR) is the inability to urinate voluntarily, with a higher occurrence in males, particularly due to benign prostatic hyperplasia in older men and pelvic issues in women.
- Timely diagnosis and treatment are crucial to prevent complications from AUR, such as pain and acute kidney injury, and can also lead to less common issues like acute hyponatremia.
- A unique case involved a patient with a large uterine fibroid who was asymptomatic but experienced abdominal distention, ultimately diagnosed with AUR and severe hyponatremia, which was managed conservatively.
Urea to Treat Hyponatremia Due to Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Systematic Review and Meta-Analysis.
Am J Kidney Dis
October 2024
Department of Medicine Aga Khan University Hospital, Karachi, Pakistan.
Article Synopsis
- The systematic review and meta-analysis aimed to evaluate the effectiveness, safety, and tolerability of using urea to treat hyponatremia caused by SIADH, addressing previously raised concerns in the medical community.
- The study analyzed existing observational research from multiple databases, focusing on patients with SIADH-related low sodium levels and including trials that measured outcomes like serum sodium concentration and any adverse effects from urea administration.
- Results showed that urea treatment led to a significant improvement in serum sodium levels, particularly in more severe cases of hyponatremia, indicating it may be an effective treatment option despite some variability in outcomes.
Takotsubo syndrome induced by severe hyponatraemia in mineralocorticoid-responsive hyponatraemia of the elderly: a case report.
Eur Heart J Case Rep
October 2024
Division of Cardiology, Department of Internal Medicine, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama, Kanagawa 227-8501, Japan.
Article Synopsis
- An 85-year-old woman's severe hyponatraemia (low sodium levels) led to transient loss of consciousness and subsequent cardiac dysfunction, ultimately diagnosed as Takotsubo syndrome, indicating a heart condition triggered by stress.
- The patient was treated with hypertonic saline to gradually correct her low sodium levels, which required careful monitoring to avoid complications, and her condition improved over 14 days.
- This case highlights the importance of promptly treating severe hyponatraemia in elderly patients, raises concerns about current treatment protocols for mineralocorticoid-responsive hyponatraemia (MRHE), and suggests a possible link between MRHE and acute cardiomyopathy.
Encephalopathy with cerebellar deficits in a context of hyponatremia.
Acta Neurol Belg
December 2024
Department of Neurology, Agios Pavlos General Hospital of Thessaloniki, Leoforos Ethnikis Antistaseos 161, 55134, Kalamaria, Thessaloniki, Greece.
Article Synopsis
- A 53-year-old male with a history of diabetes and anxiety was admitted with confusion and coordination issues, linked to low sodium levels due to sepsis.
- Laboratory tests showed high urine osmolarity and imaging revealed cerebral edema, leading to treatment with antibiotics and sodium supplements.
- The case emphasizes that cerebellar ataxia can be a rare but reversible symptom of hyponatremia, necessitating thorough diagnostic procedures to rule out other conditions.
A real-world pharmacovigilance study using disproportionality analysis of United States Food and Drug Administration Adverse Event Reporting System events for vinca alkaloids: comparing vinorelbine and Vincristine.
Expert Opin Drug Saf
November 2024
Department of Respiratory and Clinical Care Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Article Synopsis
- Vinca alkaloids, like vinorelbine and vincristine, are important cancer treatments known for affecting microtubule dynamics, but there's still much to learn about their potential side effects.
- A detailed analysis of adverse events (AEs) was conducted using data from the FDA, employing different statistical methods to assess the risks associated with these medications, particularly focusing on blood and lymphatic system related issues.
- The study found significant AEs linked to both drugs and identified new, previously unreported side effects, underscoring the importance of continued research into the safety profile of these cancer treatments.
Neuroinflammation-Induced SIADH in West Nile Virus Infection: An Uncommon Neurological and Endocrine Manifestation.
Am J Case Rep
September 2024
Department of Graduate Medical Education, Internal Medicine Residency, Sutter Roseville Medical Center, Roseville, CA, USA.
Article Synopsis
- A case involving a 75-year-old man showed severe hyponatremia (sodium at 117 mmol/L) alongside symptoms of viral meningitis, leading to confusion and lethargy, ultimately diagnosed as a WNV infection.
- The case highlights the challenges in diagnosing WNV, particularly its link to hyponatremia, emphasizing the importance of supportive care, as there are no established specific treatments.