Matairesinol repolarizes M2 macrophages to M1 phenotype to induce apoptosis in triple-negative breast cancer cells.

Objective: Triple-Negative Breast Cancer (TNBC), the most challenging subtype of Breast Cancer (BC), currently lacks targeted therapy, presenting a significant therapeutic gap in its management. Tumor Associated Macrophages (TAMs) play a significant role in TNBC progression and could be targeted by repolarizing them from M2 to M1 phenotype. Matairesinol (MAT), a plant lignan, has been shown to exhibit anticancer, anti-inflammatory and immunomodulatory activities.

A 7-point evidence-based care discharge protocol for patients hospitalized for exacerbation of COPD: consensus strategy and expert recommendation.

Acute exacerbations of COPD (ECOPD) are an important event in the life of a COPD patient as it causes significant deterioration of physical, mental, and social health, hastens disease progression, increases the risk of dying and causes a huge economic loss. Preventing ECOPD is therefore one of the most important goals in the management of COPD. Before the patient is discharged after hospitalization for ECOPD, it is crucial to offer an evidence-based care bundle protocol that will help minimize the future risk of readmissions and death.

Unseen crisis: Revealing the hidden health impact of indoor air pollution-A scoping review.

Indoor air pollution presents a critical public health challenge, particularly in countries such as India, where millions are exposed to harmful pollutants within their homes and workplaces. This scoping review delves into the multifaceted impacts of indoor air pollution on health outcomes, synthesizing evidence from various study designs and geographical regions A scoping review was conducted. Drawing on a comprehensive search strategy, which yielded 320 records, wherein 120 in PubMed, 108 in Web of Science, and 92 in SCOPUS.

Effectiveness of video assisted teaching program of pranayama on selected physiological parameters among patients with COPD.

Background: According to research on the global burden of illness, chronic obstructive pulmonary disease (COPD) is expected to rank third globally in terms of cause of mortality in the first 20 years of the 20 century and fifth in terms of major cause of impairment. A thorough yoga program can enhance general well-being and respiratory function, which will improve a person's capacity to complete daily chores.

Materials And Methods: One group pretest and posttest design in a quasi-experimental study was applied.

Therapeutic potential of antibody-drug conjugates possessing bifunctional anti-inflammatory action in the pathogenies of rheumatoid arthritis.

In an age where there is a remarkable upsurge in developing precision medicines, antibody-drug conjugates (ADCs) have emerged as a progressive therapeutic strategy. ADCs typically consist of monoclonal antibodies (mAb) conjugated to the cytotoxic payloads by utilizing a linker, combining the benefits of definitive target specificity of mAbs and potent killing impact of payload to achieve precise and efficient elimination of target cells. In addition to their well-established role in oncology, ADCs are currently demonstrating encouraging potential in addressing the unmet requirements in the treatment of autoimmune conditions such as rheumatoid arthritis (RA).

Tri-Ponderal Mass Index-A reliable anthropometric index for early screening of adolescent obesity in a school-based setting: A cross-sectional study.

Objective: This study was designed to examine the reliability of the Tri-Ponderal Mass Index (TMI) for early screening of adolescent obesity compared with anthropometric measures such as hip circumference, neck circumference, waist circumference, waist-height ratio, waist-hip ratio, and body mass index.

Methods: A school-based, cross-sectional study was conducted between July and December 2019 among 1101 school-going adolescents (both sexes) aged 12 to 17 years, in Rudrapur, Uttarakhand, India. Anthropometric measurements were collected using well-calibrated equipment, and age- and sex-specific BMI percentile cutoff values recommended by the Indian Academy of Pediatrics were used to define overweight and obesity.

Multi-objective optimization of laser machining parameters for carbon-glass reinforced hybrid composites: Integrating gray relational analysis, regression, and ANN.

This research aims to improve the accuracy of cutting fiber-reinforced polymers (FRPs) utilizing CO2 laser processing techniques, with a particular focus on carbon-glass fiber-reinforced hybrid composites (CGFRP) using epoxy resin. Establishing CO laser machining as a dependable and effective process for creating superior CGFRP components is the main goal. This research intends to optimize laser machining parameters to enhance surface quality and machining efficiency for these composites by a thorough parametric analysis.

Assessing the efficacy of mind mapping as a learning technique to enhance information retrieval in nursing students.

Background: Nursing education, rooted in conventional methods like didactic lectures and clinical experiences, is evolving to incorporate innovative learning strategies. This study delves into the effectiveness of mind mapping, an interactive technique, in enhancing information retrieval skills among nursing students. Departing from linear note-taking, mind maps visually organize information, aligning with contemporary learning theories emphasizing visual and interactive modalities.

Comparison of Taxonomic Resolutions of Various Typing Methods for and Species Isolated from Landfill Leachate.

Anaerobic bacteria and methanogenic archaea at municipal landfill dumping sites play a vital role in the landfill ecology, waste degradation, global warming and climate change. Although landfill works as a cheap way of solid waste management, unmanaged landfill plays a significant role in spreading pollutants and pathogens in natural ecosystems. The genera and are important groups of anaerobic microbes from a public and environmental health perspective.

Automated crack localization for road safety using contextual u-net with spatial-channel feature integration.

Accurate and timely crack localization is crucial for road safety and maintenance, but image processing and hand-crafted feature engineering methods, often fail to distinguish cracks from background noise under diverse lighting and surface conditions. This paper proposes a framework utilizing contextual U-Net deep learning model to automatically localize cracks in road images. The framework design considers crack localization as a task of pixel-level segmenting, and analyzing each pixel in a road image to determine if it belongs to a crack or not.

Artificial intelligence and machine learning approaches in cerebral palsy diagnosis, prognosis, and management: a comprehensive review.

Cerebral palsy (CP) is a group of disorders that alters patients' muscle coordination, posture, and movement, resulting in a wide range of deformities. Cerebral palsy can be caused by various factors, both prenatal and postnatal, such as infections or injuries that damage different parts of the brain. As brain plasticity is more prevalent during childhood, early detection can help take the necessary course of management and treatments that would significantly benefit patients by improving their quality of life.

Effectiveness of neuro-feedback on Alzheimer's rehabilitation: a bibliometric analysis.

Background: Alzheimer's Disease (AD) is a neurodegenerative disorder with limited treatment options. Neurofeedback, a technique that trains brainwaves, has shown promise in addressing cognitive impairments.

Objectives: To conduct a bibliometric analysis to explore the current research on neurofeedback as a treatment for AD.

Accuracy of femoral tunnel placement using three different techniques in performing arthroscopic all-inside anterior Cruciate Ligament reconstruction; A randomized study.

Background: One of the key steps in arthroscopic Anterior Cruciate Ligament Reconstruction (ACLR) is getting the femoral tunnel at the right position to attach the graft. While the correct position has been described as a low and posterior position behind the bifurcate ridge on the medial surface of lateral femoral condyle, to reproducibly achieve it more than one technique is being used by surgeons. There are no randomized studies in literature which have evaluated the efficacy of these in a surgeon's hand.

Tuning fungal promoters for the expression of eukaryotic proteins.

Fungal systems, yeast as well as filamentous fungi, are effective platforms for producing recombinant eukaryotic proteins because of their efficient secretion, robust development features, and capacity for post-translational modification. However, to achieve optimum protein expression in fungal hosts, a precise regulation of gene expression levels is necessary. Promoters are critical cis-regulatory regions that drive gene expression.

Exploring the efficacy of various CNN architectures in diagnosing oral cancer from squamous cell carcinoma.

Unlabelled: Oral cancer can result from mutations in cells located in the lips or mouth. Diagnosing oral cavity squamous cell carcinoma (OCSCC) is particularly challenging, often occurring at advanced stages. To address this, computer-aided diagnosis methods are increasingly being used.

Geographic information system mapping and predictors of glycemic control in children and youth with type 1 diabetes: a study from Western India.

Objectives: Geographic Information System (GIS) mapping, is a novel way to provide insights into spatial distribution of type 1 diabetes (T1D) and associations between T1D outcomes and potential predictors. We aimed to explore GIS in children with T1D, and identify predictors of poor glycemic control.

Methods: Design: Cross-sectional; Participants: 402 children and youth (187 boys) with T1D.

Exploring telemedicine and organizational challenges in the healthcare system: a qualitative analysis using Grounded Theory.

Purpose: Telemedicine is a context-specific intervention that implies significant procedural changes in a health organization. The objective of the study is to explore healthcare professionals' usage of and perceptions towards telemedicine technology and identify the perceived factors and related process change, influencing the effective adoption of telemedicine from an organizational perspective.

Design/methodology/approach: The study includes multi-disciplinary commentaries of a purposive sample of 31 healthcare professionals, conducted through semi-structured qualitative interviews and employs Grounded Theory and Thematic Analysis techniques to analyze the data.

Reliability and Accuracy of Portable Devices for Measuring Countermovement Jump Height in Physically Active Adults: A Comparison of Force Platforms, Contact Mats, and Video-Based Software.

Measuring countermovement jump (CMJ) height accurately is essential for evaluating lower-body explosive power in athletes and other active populations. With technological advancements, various portable tools have been developed for this purpose, including force platforms, contact mats, and video-based software. This study aimed to (a) investigate the test-retest reliability of the KINVENT K-Deltas force platform for CMJ height measurement and (b) compare its accuracy with a contact mat (Chronojump, Spain) and a video-based software (My Jump app, version 3).

Flexible four-port MIMO antenna for 5G NR-FR2 tri-band mmWave application with SAR analysis.

This paper introduces a compact, triband four-port Multiple Input Multiple Output (MIMO) antenna optimized for mmWave 5G and navigation services. The antenna is built on a Rogers RT Duroid 5880 substrate, with dimensions of 31 × 42 mm² and a thickness of 0.4 mm.

Dry promotions and positive psychology: striking a balance for employee well-being.

Purpose: We aim to address the evolving phenomenon of dry promotions and its impact on employee well-being in organizations. Dry promotion, its possible effects on employee well-being and some strategies to mitigate its adverse consequences are presented as a viewpoint paper.

Design/methodology/approach: The arguments in this viewpoint are built on theoretical insights drawn from various organizational theories, such as Maslow's hierarchy of needs, Herzberg's two-factor theory and self-determination theory.

A dataset revolutionizing Indian bay leaf analysis.

Indian bay leaf is a crucial spice in Indian cuisine. However, its quality and authenticity are often compromised. To address this, we introduce The Digital Indian Bay leaf dataset, a comprehensive collection of high-resolution 5696 images capturing diverse bay leaf samples under controlled conditions.

A Randomized Trial Assessing the Effectiveness of High-fidelity Simulation Training in Managing Maternal Cardiac Arrest among Emergency Medical Professionals in India.

Introduction: Maternal cardiac arrest is a rare but critical event that poses significant risks to both the mother and the fetus. As majority of population in India lives in the rural areas, Emergency Medical Professionals assist in childbirth in transit in ambulances. This timely assistance ensures the safe transportation of both mother and new born baby to the hospital.

Geographical health inequalities in India: the impact of the COVID-19 pandemic on healthcare access and healthcare inequality.

Purpose: With an emphasis on spatial health disparities, this study examines how COVID-19 has affected healthcare access and inequality in India. The study developed the Healthcare Access Index (HAI) and Healthcare Inequality Index (HII) to assess the pandemic's effects on healthcare. The study addresses spatial health disparities in healthcare access and inequality, filling gaps in the literature.