Gluteus medius muscle activity in patellofemoral pain syndrome during squats: A Systematic Review.

Background: Pain around or behind the patella during activities like running, climbing stairs, jumping or squatting is termed as Patellofemoral pain syndrome (PFPS). The causes of PFPS are multifactorial. An improper gluteal muscle function may cause an increment in hip joint adduction and internal rotation movement during weight-bearing activities is one of the major causes of PFPS.

Aerosolized Harmful Algal Bloom Toxin Microcystin-LR Induces Type 1/Type 17 Inflammation of Murine Airways.

Harmful algal blooms are increasing globally and pose serious health concerns releasing cyanotoxins. Microcystin-LR (MC-LR), one of the most frequently produced cyanotoxins, has recently been detected in aerosols generated by the normal motions of affected bodies of water. MC-LR aerosol exposure has been linked to a pro-inflammatory influence on the airways of mice; however, little is understood about the underlying mechanism or the potential consequences.

Examining Working Memory Training for Healthy Adults-A Second-Order Meta-Analysis.

Background: Enhancing working memory performance in cognitively and physically healthy individuals is a popular area of research. The results from a large number of studies have now been summarized in multiple meta-analyses. In these reviews, various training methods have been examined, including mindfulness training, adaptive working memory training, physical activity training, and video game training, to examine whether working memory capacity can be improved.

Programmed Cell Death-Ligand 1 Expression and Clinical Outcomes Among Patients with Resected, Early-Stage Non-Small Cell Lung Cancer: A Real-World Study.

Treatment options for non-small cell lung cancer (NSCLC) are evolving, given recent and expected approvals of immune checkpoint inhibitors (ICIs) targeting programmed cell death-(ligand) 1 (PD-1/PD-L1). We retrospectively evaluated outcomes among patients with resected stage IB-IIIA NSCLC tumors expressing PD-L1 using PALEOS (Pan-cAnadian Lung cancEr Observational Study) data (2016-2019). Key outcomes included PD-L1 expression rate and treatment patterns, recurrence, and median overall (mOS) and disease-free survival (mDFS) among PD-L1+ patients.

Correction: Investigating the role of prognostic mitophagy-related genes in non-small cell lung cancer pathogenesis via multiomics and network-based approach.

[This corrects the article DOI: 10.1007/s13205-024-04127-y.].

Genomics of a sexually selected sperm ornament and female preference in Drosophila.

Our understanding of animal ornaments and the mating preferences driving their exaggeration is limited by knowledge of their genetics. Post-copulatory sexual selection is credited with the rapid evolution of female sperm-storage organ morphology and corresponding sperm quality traits across diverse taxa. In Drosophila, the mechanisms by which longer flagella convey an advantage in the competition among sperm for limited storage space in the female, and by which female sperm-storage organ morphology biases fertilization in favour of longer sperm have been resolved.

Bone Fracture History in Women With First Episode or With Persistent Anorexia Nervosa.

Objective: To investigate fractures history in women with first episode anorexia nervosa (AN) (FE-AN: ≤ 3 years duration) and those with persistent AN (P-AN: ≥ 7 years), compared to healthy controls (HC).

Method: One hundred nineteen women (FE-AN = 49, P-AN = 46 and HC = 24) completed online questionnaires on eating disorders symptoms, their menstrual and their fracture history.

Results: Average illness duration was 1.

Performance evaluation of TaqMan™ Arbovirus Triplex Kit (ZIKV/DENV/CHIKV) for detection and differentiation of dengue and chikungunya viral RNA in serum samples of symptomatic patients.

Introduction: Global outbreaks of mosquito-transmitted arbovirus infections, such as dengue (DENV) and chikungunya (CHIKV), are increasing. Differentiating these infections is challenging due to non-specific symptoms and serology limitations. PCR-based approaches offer higher sensitivity and specificity.

SARS-CoV-2 evolution balances conflicting roles of N protein phosphorylation.

All lineages of SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, contain mutations between amino acids 199 and 205 in the nucleocapsid (N) protein that are associated with increased infectivity. The effects of these mutations have been difficult to determine because N protein contributes to both viral replication and viral particle assembly during infection. Here, we used single-cycle infection and virus-like particle assays to show that N protein phosphorylation has opposing effects on viral assembly and genome replication.

Multisystem inflammatory syndrome in adults hospitalizations in the United States; evaluating patient characteristics, COVID-19 associations, and mortality.

Introduction: Multisystem inflammatory syndrome in adults (MIS-A) is thought to be closely linked with COVID-19 infection. This study aims to elucidate the demographics and clinical characteristics of MIS-A, aiding in timely diagnosis and management.

Methods: Utilizing the National Inpatient Sample (NIS) database (2021), patients were stratified into MIS-A and non-MIS-A groups.

Design and Synthesis of Various Aryl Amide Derivatives of Imidazo[1,5-a] Pyridine-1,2,4-Thiadiazoles: In Vitro Cytotoxicity Evaluation and In Silico Molecular Docking Studies.

A new series of various aryl amide derivatives of imidazo[1,5-a]pyridine-1,2,4-thiadiazoles (15a-j) were designed, synthesized, and evaluated for their cytotoxic profiles against four human cancer cell lines such as breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205), and ovarian cancer (A2780), via the MTT assay, with etoposide as the standard known chemotherapeutic agent. Five compounds, 15a, 15b, 15c, 15f, and 15j, exhibited more potent cytotoxic effects than did etoposide. Among them, compound 15a exhibited potent cytotoxic effects against the MCF-7, A549, Colo-205, and A2780 cell lines, with IC values of 0.

Comparison of Surgery test scores using Concept Maps and Interactive Lectures among the Undergraduate Medical Students.

Objective: Concept Maps (CM) aid in the acquisition of new information, and comprehend prior knowledge with better retention. Their use is not explored in undergraduate surgical education in our country, hence this study aimed to compare the surgery test scores of undergraduate medical students taught by concept maps and interactive lectures.

Methods: This quasi-experimental study was carried out at the Department of Surgery, at a Private University Hospital among 60 students of fourth year MBBS from 2017-2018.

CELF2 promotes tau exon 10 inclusion via hinge domain-mediated nuclear condensation.

Alternative splicing is a fundamental process that contributes to the functional diversity and complexity of proteins. The regulation of each alternative splicing event involves the coordinated action of multiple RNA-binding proteins, creating a diverse array of alternatively spliced products. Dysregulation of alternative splicing is associated with various diseases, including neurodegeneration.

Integrated care for chronic diseases: An evolutionary step for emerging primary health care systems.

Globally, people are living longer, and many will have multiple, complex chronic diseases. These chronic diseases are often a leading cause of death and disability particularly in emerging developed countries. For these emerging nations, the current trajectory of gradual health system change is likely to lag changing population needs and escalating cost pressures.

Green synthesis of nickel-integrated chitosan-modified CeO nanocatalyst for the efficient hydrogenation of 4-NP and azo dyes.

This paper reports the green synthesis and characterization of nickel-integrated chitosan-modified cerium oxide (CHS-CeO@Ni) nanocatalyst aimed at the efficient hydrogenation of 4-nitrophenol (4-NP) and the reduction of azo dyes such as methyl orange (MO) and Congo red (CR). The CHS-CeO@Ni nanocatalyst was synthesized via a green method, where Arnebia benthamii plant extract was used as a reducing agent to deposit nickel nanoparticles onto the CHS-CeO nanocomposite. Results confirmed the successful integration of Ni into the CHS-CeO matrix, resulting in a highly crystalline, mesoporous structure with a substantial surface area of 78.

Preparation of amorphous Nd/Dy-based metal organic framework@MXene for solar driven selective photocatalytic and serving as sensor for fluorescence quenching detection, and biological activity.

The development of a new Neodymium/Dysprosium metal-organic framework, referred to as Nd/Dy-BTC MOF, based on benzene-1,2,4-tricarboxylic acid, has been achieved through an in situ growth process on 2D transition metal carbides (MXene) surfaces. This synthesis was conducted via a solvothermal method utilizing a solvent mixture of water, ethanol, and dimethylformamide. The primary objective of this research is to investigate the framework's efficacy as a photocatalyst for the degradation of anionic dye, as well as its potential for sensing certain explosives.

Preclinical evaluation of the CD38-targeting engineered toxin body MT-0169 against multiple myeloma.

Despite significant progress in the treatment of multiple myeloma (MM), relapsed/refractory patients urgently require more effective therapies. We here describe the discovery, mechanism of action, and preclinical anti-MM activity of engineered toxin body MT-0169, a next-generation immunotoxin comprising a CD38-specific antibody fragment linked to a de-immunized Shiga-like toxin A subunit (SLTA) payload. We show that specific binding of MT-0169 to CD38 on MM cell lines triggers rapid internalization of SLTA, causing cell death via irreversible ribosome inhibition, protein synthesis blockade, and caspase 3/7 activation.