Whole-exome profiles of inflammatory breast cancer and pathological response to neoadjuvant chemotherapy.

Background: Neoadjuvant chemotherapy (NACT) became a standard treatment strategy for patients with inflammatory breast cancer (IBC) because of high disease aggressiveness. However, given the heterogeneity of IBC, no molecular feature reliably predicts the response to chemotherapy. Whole-exome sequencing (WES) of clinical tumor samples provides an opportunity to identify genomic alterations associated with chemosensitivity.

Ganglion Impar Neurolysis to Treat Refractory Chronic Pain From Vulvar Cancer: A Case Report.

Cancer pain treatment currently consists of the administration of pain medications, radiation therapy, tumor ablation as well as neurolytic plexus blocks. Neurolytic plexus blocks target both sensory afferent fibers and sympathetic fibers innervating visceral organs. Finding the right block for a specific type and location of cancer-related pain is crucial for the successful control of pain.

Marco Deiana.

"My long-term goal is to popularize biocatalysis in India so that more and more people work in this area and invent new-to-nature chemistry… If I could have dinner with a well-known historic figure, I would invite Nikola Tesla and I would ask him how I can get rid of all the wires on my table…" Find out more about Syed Masood Husain in his Introducing… Profile.

Syed Masood Husain.

"A turning point in my career was when I realized that I was running a marathon, not a 100-meter dash… When I was a kid I wanted to be an inventor - and I think I did not end up too far from that...

ViTDroid: Vision Transformers for Efficient, Explainable Attention to Malicious Behavior in Android Binaries.

Smartphones are intricately connected to the modern society. The two widely used mobile phone operating systems, iOS and Android, profoundly affect the lives of millions of people. Android presently holds a market share of close to 71% among these two.

The Impact of Infliximab on Hyperinflammation State in Hospitalized COVID-19 Patients: A Retrospective Study.

Elevated levels of pro-inflammatory cytokines have been linked to increased mortality in COVID-19 patients. Infliximab, a tumor necrosis factor inhibitor, has been reported to improve outcomes in COVID-19 patients by targeting the hyperinflammatory response. Our objective was to evaluate the effectiveness of incorporating Infliximab into standard care guidelines for the management of COVID-19.

Defects in Exosome Biogenesis Are Associated with Sensorimotor Defects in Zebrafish Mutants.

Mutations in human are associated with neurodevelopmental defects, including motor delays and defective muscle tone. encodes a AAA-ATPase required for membrane scission, but how mutations in lead to impaired control of motor function is not known. Here we identified a mutation in zebrafish , T248I, that affects sensorimotor transformation.

Design, synthesis, and evaluation of a pyrazole-based corrosion inhibitor: a computational and experimental study.

By employing a synergistic blend of experimental and theoretical methodologies, we investigated the corrosion inhibition efficacy of a synthesized pyrazole derivative (BM-01) in a solution of hydrochloric acid (1 M). We utilized molecular dynamics (MD) simulations, scanning electron microscopy (SEM), density functional theory (DFT), complexation, plus electrochemical impedance spectroscopy (EIS). We conducted weight loss (WL) measurements from 298 to 328 K.

Protocol to induce cell labeling in vivo and to trace labeled hematopoietic cells using mouse models.

A combination of hematopoietic stem cell (HSC)- and endothelial cell (EC)-lineage-tracing mouse models enables us to determine blood cell origins. We present a protocol to induce cell labeling in vivo and to trace labeled hematopoietic cells to segregate their origins. We describe the steps for harvesting various hematopoietic tissues, antibody staining, and analyzing the Tomato+ percentages within each immune cell population.

Advancements in the Treatment of Diuretic Resistance in Congestive Heart Failure.

This narrative evaluates the dynamic developments that have significantly transformed treatment strategies in the constantly evolving domain of diuretic resistance (DR) management in congestive heart failure (CHF). The discourse explores historical challenges and the current state of therapeutic approaches as it investigates the crucial matter of DR in patients with CHF. An introduction provides a synopsis of the pivotal function diuretics performed in the management of fluid excess and the intricacies associated with CHF.

Comparative evaluation of data imbalance addressing techniques for CNN-based insider threat detection.

Insider threats pose a significant challenge in cybersecurity, demanding advanced detection methods for effective risk mitigation. This paper presents a comparative evaluation of data imbalance addressing techniques for CNN-based insider threat detection. Specifically, we integrate Convolutional Neural Networks (CNN) with three popular data imbalance addressing techniques: Synthetic Minority Over-sampling Technique (SMOTE), Borderline-SMOTE, and Adaptive Synthetic Sampling (ADASYN).

Pre-Emptive Pharmacogenetic Testing in the Acute Hospital Setting: A Cross-Sectional Study.

Background: Pharmacogenetic guided prescribing can be used to improve the safety and effectiveness of medicines. There are several approaches by which this intervention might be implemented in clinical practice, which will vary depending on the health system and clinical context.

Aim: To understand the clinical utility of panel-based pharmacogenetic testing in patients admitted acutely to hospital and to establish variables which predict if an individual might benefit from the intervention.

Diagnostic accuracy of low dose CT-Scan abdomen in patients with clinical features of acute appendicitis.

Background & Objective: Acute appendicitis is one of the commonest causes of acute abdominal pain presenting to emergency department (ED) and Computerized Tomography scan (CT) is considered gold standard for its diagnosis. Internationally Low Dose Computerized Tomography scan (LDCT) in emergency department is recommended as a beneficial tool to diagnose acute appendicitis with less exposure to radiation and reduction in the rate of negative laparotomy. Local trials are needed to determine the diagnostic accuracy of LDCT as the first line imaging test for acute appendicitis.

Discovering down's syndrome: An account from A low middle income country.

Objective: This study aims to establish the frequency of Down's syndrome which will enhance the knowledge of our local population as well to understand our genotypic patterns and variations.

Methods: Electronic Medical Records of inborn babies at the Department of Neonatology, Sheikh Saeed Memorial Campus of The Indus Hospital Karachi during the study period from 1 January 2021 to 31 December 2022 were retrieved. Chromosomal karyotyping was done for all babies with suspicious clinical features identified on routine new born examination by consultant neonatologists, trainee doctors and experienced nurses.

Impact of complete dentures treatment on Oral health-related quality of Life (OHRQoL) in edentulous patients: A descriptive case series study.

Objectives: To evaluate the changes in oral health-related quality of life [OHRQoL] before and three months after complete denture oral rehabilitation using the Geriatric oral health assessment index [GOHAI] in Pakistani elderly edentulous patients.

Methods: In this descriptive case series study a total of 80 edentulous patients were recruited from Islamic International Dental Hospital, Islamabad, Pakistan from November 2021 to April 2022. The OHRQoL was evaluated twice by using the GOHAI- Urdu version.

Role of Ginger in management of nausea among patients receiving chemotherapy.

Objective: Cancer patients treated with chemotherapy often face variety of side effects, with nausea and vomiting being the most frequent. Ginger (), contains natural compounds that can speed up the metabolism and increase intestinal motility. It is traditionally used to treat gastrointestinal disorders.