1 results match your criteria: "Sydney and Ingham Institute Liverpool Hospital[Affiliation]"
Cytokines affecting CD4T regulatory cells in transplant tolerance. II. Interferon gamma (IFN-γ) promotes survival of alloantigen-specific CD4T regulatory cells.
Transpl Immunol
June 2017
Immune Tolerance Group, Faculty of Medicine, UNSW Australia, Sydney and Ingham Institute Liverpool Hospital, NSW, Australia. Electronic address:
Article Synopsis
- CD4T cells responsible for transferring transplant tolerance are short-lived without specific stimulation, but their survival can be enhanced by cytokines like IFN-γ.
- In a study involving DA rats and PVG heart transplants, CD4T cells maintained their tolerance-transfer ability when cultured with IFN-γ and specific-donor alloantigens, preventing graft rejection.
- The presence of IFN-γ in culture inhibited the proliferation of tolerant CD4T cells while sustaining their expression of IFN-γ receptors, indicating it plays a crucial role in maintaining their tolerance function.