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Clinical evaluation of a block sequential regularized expectation maximization reconstruction algorithm in 18F-FDG PET/CT studies.

Nucl Med Commun

January 2017

Departments of aNuclear Medicine bDiagnostic and Interventional Radiology cNeuroradiology, University Hospital Zurich dUniversity of Zurich, Zurich, Switzerland ePET Clinical Science, GE Healthcare, Waukesha, Wisconsin, USA.

Purpose: To investigate the clinical performance of a block sequential regularized expectation maximization (BSREM) penalized likelihood reconstruction algorithm in oncologic PET/computed tomography (CT) studies.

Methods: A total of 410 reconstructions of 41 fluorine-18 fluorodeoxyglucose-PET/CT studies of 41 patients with a total of 2010 lesions were analyzed by two experienced nuclear medicine physicians. Images were reconstructed with BSREM (with four different β values) or ordered subset expectation maximization (OSEM) algorithm with/without time-of-flight (TOF/non-TOF) corrections.

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