1 results match your criteria: "Switzerland [2] Swiss Institute for Experimental Cancer Research (ISREC) at EPFL[Affiliation]"
Functional characterization of the TERRA transcriptome at damaged telomeres.
Nat Commun
October 2014
1] Ecole Polytechnique Fédérale de Lausanne (EPFL), School of Life Sciences, 1015 Lausanne, Switzerland [2] Swiss Institute for Experimental Cancer Research (ISREC) at EPFL, Station 19, CH-1015 Lausanne, Switzerland.
Telomere deprotection occurs during tumorigenesis and aging upon telomere shortening or loss of the telomeric shelterin component TRF2. Deprotected telomeres undergo changes in chromatin structure and elicit a DNA damage response (DDR) that leads to cellular senescence. The telomeric long noncoding RNA TERRA has been implicated in modulating the structure and processing of deprotected telomeres.
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