463,278 results match your criteria: "Switzerland; and University of Massachusetts Medical School P.N.[Affiliation]"

Intraoperative goal-directed haemodynamic therapy: a systematic review and meta-analysis stratified by trial size.

Br J Anaesth

January 2025

Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Outcomes Research Consortium®, Houston, TX, USA. Electronic address:

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Background: We have previously demonstrated that an extrafascial injection of 20 ml of local anaesthetic for interscalene brachial plexus block (ISB) reduces the rate of hemidiaphragmatic paralysis by 70% compared with an intrafascial injection, with similar efficacy. In this double-blind trial, we tested the hypothesis that a local anaesthetic volume of 10 ml injected extrafascially would reduce the rate of hemidiaphragmatic paralysis vs a volume of 20 ml, while providing similar analgesia.

Methods: Sixty ASA physical status 1-3 patients scheduled for elective shoulder surgery under general anaesthesia were randomised to receive ultrasound-guided extrafascial ISB using ropivacaine 0.

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A step towards understanding plastic complexity: Antimony speciation in consumer plastics and synthetic textiles revealed by XAS.

J Environ Sci (China)

July 2025

Department F.-A. Forel, University of Geneva, Boulevard Carl-Vogt 66, CH-1205 Geneva, Switzerland. Electronic address:

We identified the antimony species present in a wide variety of plastic samples by X ray absorption spectroscopy (XAS) at the Sb L-edge. The samples contained different concentrations of antimony (Sb), ranging from PET bottles in which Sb compounds are used as catalysts, with concentrations around 300 mg/kg, to electrical equipment in which the element is used as a flame retardant, with concentrations of several tens of thousands of mg/kg. Although the shape of the spectra at the L-edge is quite similar for all Sb reference materials, we were able to identify antimony glycolate or acetate in PET bottles, bound organic Sb in c-PET trays and senarmontite in electrical materials as the main Sb components.

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Interdisciplinary examination of test materials requires careful consideration of how forensic routines can influence each other. This influence can be direct and obvious, or indirect and subtle. A multidisciplinary collaborative exercise (MdCE) should test a forensic laboratory's ability to account for these difficulties.

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International benchmarking of stage at diagnosis for six childhood solid tumours (the BENCHISTA project): a population-based, retrospective cohort study.

Lancet Child Adolesc Health

February 2025

Developmental Biology and Cancer Research & Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London, London, UK. Electronic address:

Background: International variation in childhood cancer survival might be explained by differences in stage at diagnosis, among other factors. As part of the BENCHISTA project, we aimed to assess geographical variation in tumour stage at diagnosis through the application, by population-based cancer registries working with clinicians, of the international consensus Toronto Childhood Cancer Stage Guidelines.

Methods: This population-based, retrospective cohort study involved 67 cancer registries from 23 European countries, Australia, Brazil, Japan, and Canada.

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Background: There are few data on the treatment of children and adolescents with multidrug-resistant (MDR) or rifampicin-resistant (RR) tuberculosis, especially with more recently available drugs and regimens. We aimed to describe the clinical and treatment characteristics and their associations with treatment outcomes in this susceptible population.

Methods: We conducted a systematic review and individual participant data meta-analysis.

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Background: The elderly population (≥80 years) were underrepresented in recent trials of endovascular thrombectomy (EVT) for anterior circulation large vessel occlusion acute ischemic stroke (LVO-AIS) with low Alberta Stroke Program Early CT Score (ASPECTS) (≤5).

Methods: This study analyzed data from a prospectively maintained database of 37 thrombectomy centers. The primary cohort of the study comprised patients with LVO-AIS aged ≥80 who underwent EVT with ASPECTS≤5 from 2013 to 2023.

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Inhibition of the adenosine 2A receptor (AR) is recognized as a promising immunotherapeutic strategy but is challenged by the ubiquity of AR function in the immune system. To develop a safe yet efficacious immunotherapy, the discovery of a novel negative allosteric modulator (NAM) was preferred. Leveraging an in-house, sensitive, high-throughput screening cellular assay, novel AR NAM scaffolds were identified, followed by an extensive structure-activity relationship (SAR) study, leading to the discovery of potent 2-amino-3,5-dicyanopyridine derivatives.

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Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) are more prevalent in males than females. Furthermore, they typically showed abnormally high delta (< 4 Hz) and low alpha (8-10 Hz) rhythms from resting-state electroencephalographic (rsEEG) activity. Here, we hypothesized that those abnormalities may depend on the patient's sex.

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Editorial Commentary on the Article "Latarjet Procedure: Open with Screws or Arthroscopic with Cortical-Buttons".

J Shoulder Elbow Surg

January 2025

Division of Orthopaedics and Trauma Surgery, Hôpital de La Tour, Meyrin, Switzerland; Division of Orthopaedics and Trauma Surgery, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland; Faculty of Medicine, University of Geneva, Geneva, Switzerland; FORE (Foundation for Research and Teaching in Orthopedics, Sports Medicine, Trauma, and Imaging in the Musculoskeletal System), Meyrin, Switzerland. Electronic address:

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Nonlinear homogenised finite element (hFE) models can accurately predict stiffness and strength of ultra-distal sections of the radius and tibia using in vivo HR-pQCT images. Recent findings showed good stiffness prediction at these distal sections but a limited ability to reproduce experimental strain localisation. The coarseness of voxel-based meshes reduces the computational effort at the cost of heavily simplifying the underlying geometry of the cortex, the gradient of material properties, and the resulting strain distribution.

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Post-growth: the science of wellbeing within planetary boundaries.

Lancet Planet Health

January 2025

Department of Environmental Sciences and Policy, Central European University, Vienna, Austria.

There are increasing concerns that continued economic growth in high-income countries might not be environmentally sustainable, socially beneficial, or economically achievable. In this Review, we explore the rapidly advancing field of post-growth research, which has evolved in response to these concerns. The central idea of post-growth is to replace the goal of increasing GDP with the goal of improving human wellbeing within planetary boundaries.

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Sand and dust storms: a growing global health threat calls for international health studies to support policy action.

Lancet Planet Health

January 2025

Chinese Center for Disease Control and Prevention, Beijing, China; Department of Epidemiology, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.

Sand and dust storms increasingly threaten global environmental and public health. To date, 150 countries are directly affected, with more than 100 classified as non-dust source regions. With climate change, these storms are expected to become more frequent and severe.

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Enzyme immobilization is an efficient and cost-effective approach to recovering, stabilizing, and enhancing enzyme catalytic properties. It is a challenge, however, for coimmobilized multiple enzymes to perform consecutive reactions without being inactivated under similar conditions. Here, we present a facile enzyme immobilization platform using β-lactoglobulin amyloid fibril hydrogels.

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Technical and clinical reasons for negative skin test results following intradermal testing of contrast media.

Eur J Radiol

January 2025

Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University of Bern, Freiburgstrasse, Bern 3010 Switzerland. Electronic address:

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Letter to the Editor regarding "A comparison and methodological proposal for hybrid approaches to quantify environmental impacts: A case study for renewable energies".

Sci Total Environ

January 2025

Laboratory for Energy Systems Analysis, PSI Centers for Nuclear Engineering & Sciences and Energy & Environmental Sciences, Villigen, Switzerland; Chair of Energy Systems Analysis, Institute of Energy and Process Engineering, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland. Electronic address:

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Abies alba Mill. is a prominent European tree species predominantly inhabiting cool and humid montane environments. However, paleoecological evidence reveals that during the Eemian and mid-Holocene, A.

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Controlling the stability of monodisperse phospholipid-coated microbubbles by tuning their buckling pressure.

J Colloid Interface Sci

January 2025

BIOS/Lab on a Chip Group, Max Planck Center Twente for Complex Fluid Dynamics, MESA+ Institute for Nanotechnology, Faculty of Electrical Engineering, Mathematics and Computer Science, University of Twente, P.O. Box 217, Enschede, 7500 AE, the Netherlands. Electronic address:

Hypothesis: Monodisperse phospholipid-coated microbubbles, with a size and resonance frequency tuned to the ultrasound driving frequency, have strong potential to enhance sensitivity, efficiency, and control in emerging diagnostic and therapeutic applications involving bubbles and ultrasound. A key requirement is that they retain their gas volume and shell material during physiologic pressure changes and withstand the overpressure during intravenous injection. The shell typically comprises a mixture of a phospholipid (e.

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Computational forensic identification of deceased using 3D bone segmentation and registration.

Forensic Sci Int

January 2025

Institute of Forensic Medicine, Department of Biomedical Engineering, University of Basel, Basel, Switzerland; Institute of Forensic Medicine, Health Department Basel-Stadt, Basel, Switzerland. Electronic address:

The identification of deceased with unknown identity is a key task in forensic investigations. Current radiologic identification approaches are often elaborative, lack statistical evidence, and are dependent on the examiner's experience and expertise. Thus, the aim of this work was to develop a 3D computational and thus, more objective identification approach.

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Print-Light-Synthesis of ruthenium oxide thin film electrodes for electrochemical sensing applications.

Bioelectrochemistry

January 2025

University of Bologna, Department of Industrial Chemistry "Toso Montanari", Center of Chemical Catalysis-C(3), Via Piero Gobetti 85, 40129 Bologna, Italy. Electronic address:

Print-Light-Synthesis (PLS) combines the inkjet printing of a ruthenium precursor ink with the simultaneous photo-induced generation of ruthenium oxide films. During PLS, inkjet-printing generates on conductive as well as insulating substrates micrometer-thin reaction volumes that contain with high precision defined precursor loadings. Upon direct UV light irradiation, the Ru precursor converts to RuO while all other ink components escape in the gas phase.

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Fewer than 10 % of children with diffuse midline glioma (DMG) survive 2 years from diagnosis. Radiation therapy remains the cornerstone of treatment and there are no medicinal products with regulatory approval. Although the biology of DMG is better characterized, this has not yet translated into effective treatments.

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Importance: Endocrine treatments, such as Tamoxifen (TAM) and/or Aromatase inhibitors (AI), are the adjuvant therapy of choice for hormone-receptor positive breast cancer. These agents are associated with menopausal symptoms, adversely affecting drug compliance. Topical estrogen (TE) has been proposed for symptom management, given its' local application and presumed reduced bioavailability, however its oncological safety remains uncertain.

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One hundred thirty-four germ line PU.1 variants and the agammaglobulinemic patients carrying them.

Blood

January 2025

Division of Immunology and Allergy, Children's Hospital of Philadelphia; Department of Pediatrics, Perelman School of Medicine; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.

Leukopoiesis is lethally arrested in mice lacking the master transcriptional regulator PU.1. Depending on the animal model, subtotal PU.

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Opportunities and Challenges of a Cap-and-Trade System for Plastics.

Environ Sci Technol

January 2025

Wageningen University and Research, Hydrology and Environmental Hydraulics Group, 6700 AA Wageningen, The Netherlands.

Recently, the rapid increase in global plastics production has caused various ecological and economic issues, worsened by poor material and waste management. Among the market-based instruments that could help mitigate the environmental impacts of plastics throughout their life-cycle, we evaluate the advantages and limitations of incorporating a cap-and-trade (CAT) system into future policy mixes. Our aim is to inspire further investigation of CAT's feasibility rather than presenting it as the ultimate solution.

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