Prognostic value of CT-based skeletal muscle and adipose tissue mass and quality parameters in patients with liver metastases and intrahepatic cholangiocarcinoma undergoing Yttrium-90 radioembolization.

Objectives: To investigate baseline patient characteristics associated with the risk of computed tomography (CT)-based sarcopenia and assess whether sarcopenia and other morphometric parameters influence survival outcomes in patients with liver metastases and cholangiocarcinoma after Yttrium-90 radioembolization.

Materials And Methods: We retrospectively analyzed 120 cancer patients (mean age, 62 ± 13.3 years, 61 men) who underwent preprocedural CT.

Molecular epidemiology and genetic diversity of disappearing Plasmodium vivax in southern Thailand.

The evolution of genetic diversity and population structure of Plasmodium vivax as malaria elimination approaches remains unclear. This study analyzed the genetic variation and molecular epidemiology of P. vivax from Yala Province in southern Thailand, an area in the pre-elimination phase.

Vital signs-based healthcare kiosks for screening chronic and infectious diseases: a systematic review.

Background: Increasing demands, such as the COVID-19 pandemic, have presented substantial challenges to global healthcare systems, resulting in staff shortages and overcrowded emergency rooms. Health kiosks have emerged as a promising solution to improve overall efficiency and healthcare accessibility. However, although kiosks are commonly used worldwide for access to information and financial services, the health kiosk industry, valued at $800 million, accounts for just 1.

Insights from a century of data reveal global trends in ex situ living plant collections.

Ex situ living plant collections play a crucial role in providing nature-based solutions to twenty-first century global challenges. However, the complex dynamics of these artificial ecosystems are poorly quantified and understood, affecting biodiversity storage, conservation and utilization. To evaluate the management of ex situ plant diversity, we analysed a century of data comprising 2.

One carbon metabolism supplementation in maturation medium but not embryo culture medium improves the yield of blastocysts from bovine oocytes.

Optimizing oocyte maturation and embryo culture media could enhance in vitro embryo production. The purpose of the present study was to investigate the role of supplementing one carbon metabolism (OCM) substrates and its cofactors (Cystine, Zinc, Betaine, B2, B3, B6, B12 and 5-methyltetrahydrofolate) in maturation and/or embryo culture media on the rate of blastocyst formation and pregnancy outcomes following the transfer of the resulting blastocysts in bovines. In the first experiment, 2537 bovine oocytes were recovered from slaughterhouse ovaries and then matured either in conventional maturation medium (IVM) or IVM supplemented with OCM substrates (Sup-IVM).

The association of origin and environmental conditions with performance in professional IRONMAN triathletes.

We have (i) little knowledge about where the fastest professional IRONMAN triathletes originate from and where the fastest races take place and (ii) we have no knowledge of the optimal weather conditions for an IRONMAN triathlon. The aims of the present study were, therefore, (i) to investigate the origin and the fastest IRONMAN race courses for professional triathletes and (ii) to evaluate the best environmental conditions (i.e.

Development of a 3D cephalometric index to grade severity of dentofacial deformity in patients with juvenile idiopathic arthritis.

This investigation aimed to develop a radiographic 3D cephalometric index to grade severity of dentofacial deformity in patients with juvenile idiopathic arthritis (JIA), and to perform a validation against expert evaluations. Data were collected from a population-based Nordic JIA cohort of 240 patients that received a cone-beam computed tomography (CBCT) scan approximately 17 years after onset of JIA. The cohort was randomized into two groups: A baseline group for establishing the index (n = 210) and a test group (n = 30).

Taming large-scale genomic analyses via sparsified genomics.

Searching for similar genomic sequences is an essential and fundamental step in biomedical research. State-of-the-art computational methods performing such comparisons fail to cope with the exponential growth of genomic sequencing data. We introduce the concept of sparsified genomics where we systematically exclude a large number of bases from genomic sequences and enable faster and memory-efficient processing of the sparsified, shorter genomic sequences, while providing comparable accuracy to processing non-sparsified sequences.

Declining precipitation frequency may drive earlier leaf senescence by intensifying drought stress and enhancing drought acclimation.

Precipitation is an important factor influencing the date of foliar senescence, which in turn affects carbon uptake of terrestrial ecosystems. However, the temporal patterns of precipitation frequency and its impact on foliar senescence date remain largely unknown. Using both long-term carbon flux data and satellite observations across the Northern Hemisphere, we show that, after excluding impacts from of temperature, radiation and total precipitation by partial correlation analysis, declining precipitation frequency may drive earlier foliar senescence date from 1982 to 2022.

The Co-IMPACT Consortium: Integrating Prostate-specific Membrane Antigen Positron Emission Tomography and Radiotherapy in Prostate Cancer Care.

The Co-IMPACT consortium addresses knowledge gaps in prostate-specific membrane antigen positron emission tomography-guided radiotherapy for prostate cancer by establishing a global database (46 centres from 16 countries) to standardise and analyse data across four distinguished clinical scenarios. A collaborative model with the Advanced Prostate Cancer Consensus Conference aligns urgent clinical needs with actionable research insights.

Verification report: A critical reanalysis of Vahey et al. (2015) "A meta-analysis of criterion effects for the Implicit Relational Assessment Procedure (IRAP) in the clinical domain".

The meta-analysis reported in Vahey et al. (2015) concluded that the Implicit Relational Assessment Procedure (IRAP) has high clinical criterion validity (meta-analytic r‾ = .45) and therefore "the potential of the IRAP as a tool for clinical assessment" (p.

Art of TIL immunotherapy: SITC's perspective on demystifying a complex treatment.

In a first for solid cancers, cellular immunotherapy has entered standard of care in the treatment of patients with metastatic melanoma. The infusion of autologous tumor-infiltrating T lymphocytes (TIL) is capable of mediating durable tumor regression and is now Food and Drug Administration-approved for patients with disease refractory to immune checkpoint inhibitors. Since the advent of chimeric antigen receptor (CAR) T cells for patients with hematological malignancies, a growing network of centers capable of delivering effector T cell products to patients has developed.

Stability study of topotecan in ophthalmic prefilled syringes for intravitreal delivery.

Background: Intravitreal and intracameral administration of melphalan and topotecan (TPT) has shown its efficacy in the treatment of retinoblastoma over the last few years. Due to rapid hydrolysis, melphalan must be administered within the hour following reconstitution. With improved stability at room temperature and reduced ocular toxicity, TPT seems to be a promising candidate for production of prefilled syringes in terms of safety and efficiency of preparation and treatment administration.

Coexistence of cardiac sarcoidosis and arrhythmogenic cardiomyopathy-associated genetic variants: a multicentre case-control study.

Background: Cardiac sarcoidosis (CS) is a chronic inflammatory disease characterised by non-caseating granulomas, while arrhythmogenic cardiomyopathy (ACM) is a genetic condition mainly affecting desmosomal proteins. The coexistence of CS and genetic variants associated with ACM is not well understood, creating challenges in diagnosis and management. This study aimed to describe the clinical, imaging and genetic features of patients with both conditions.

National Consensus on the Assessment of Visual Function for Driving in Switzerland.

Purpose: To establish a national consensus on assessing visual function for fitness to drive in Switzerland.

Methods: The minimum medical requirements for visual function for fitness to drive are regulated by Swiss Federal Law, namely, by the Traffic Licensing Ordinance (TLO). The medical examination techniques relevant in this context and their assessment are not further specified therein, which leads to legal inequality among drivers and uncertainty among examiners.

Small intra-tropical long-distance migratory birds track rainy seasons across hemispheres.

The main features of long-distance migration are derived from landbirds breeding in the Northern Hemisphere. Little is known about migration within the tropics, presumably because tropical species typically move opportunistically and over shorter distances. However, such generalizations are weakened by a lack of solid data on spatial, temporal and behavioural patterns of intra-tropical migrations.

Socio-ecological context modulates the significance of territorial contest competition in .

The intensity and direction of sexual selection are intricately linked to the social and ecological context. Both operational sex ratios (OSRs) and population densities can affect the ability of males to monopolize resources and mates, and thus the form and intensity of sexual selection on them. Here, we studied how the mating system of the promiscuous and strongly sexually dimorphic fruit fly responds to changes in the OSR and population density.

Continuous colonization of the Atlantic coastal rain forests of South America from Amazônia.

The two main extensions of rain forest in South America are the Amazon (Amazônia) and the Atlantic rain forest (Mata Atlântica), which are separated by a wide 'dry diagonal' of seasonal vegetation. We used the species-rich tree genus to test if Amazônia-Mata Atlântica dispersals have been clustered during specific time periods corresponding to past, humid climates. We performed hybrid capture DNA sequencing of 810 nuclear loci for 453 accessions representing 164 species that included 62% of Mata Atlântica species and estimated a dated phylogeny for all accessions using maximum likelihood, and a species-level tree using coalescent methods.

Animal behavior: Chimpanzee play and the evolutionary roots of cooperation.

Social play in adults is considered rare in non-human species. A new study has found that play among adult chimpanzees is common and linked to cooperation and social bond maintenance. The societal function of adult social play may thus have deep evolutionary roots.

Relationship between trait mindfulness and physical activity among emerging adults: The mediating roles of exercise-related cognitive errors and trait self-control.

Objective: Exercise-related cognitive errors (ECEs) is a significant factor that can negatively influence physical activity (PA) engagement among emerging adults, whereas mindfulness interventions may be beneficial for promoting PA. Against this background, we investigated the potential association between trait mindfulness and PA levels among emerging adults and determined whether trait self-control and ECEs serve as mediators.

Method: 328 Chinese participants (61.

The 2025 Motile Active Matter Roadmap.

Activity and autonomous motion are fundamental aspects of many living and engineering systems. Here, the scale of biological agents covers a wide range, from nanomotors, cytoskeleton, and cells, to insects, fish, birds, and people. Inspired by biological active systems, various types of autonomous synthetic nano- and micromachines have been designed, which provide the basis for multifunctional, highly responsive, intelligent active materials.

A review of predictive modelling and drone remote sensing technologies as a tool for detecting clandestine burials.

The search for missing people is a complex and intensive undertaking. Predictive models (such as RAG mapping and geographic profiling) in combination with drone-mounted technologies can improve these searches by driving down time and monetary costs, gathering new types of data and reducing the need for investigators to expose themselves to dangerous environments. Promising technologies to discover traces of clandestine burials in the landscape are LiDAR, RGB photography, multispectral and hyperspectral imaging, as well as infrared/thermal photography.

The association between neighbourhood socioeconomic status and parental mental health in the first years after birth - Cross-sectional results from the SKKIPPI project.

Background: The urban environment can influence mental health. However, research on neighbourhood influences on mental health of parents with young children is sparse. This study aimed to analyse the association between neighbourhood socioeconomic status (SES) and mental health outcomes in urban parents in the first years after birth.