460,751 results match your criteria: "Switzerland; Swiss Centre for Applied Human Toxicology[Affiliation]"

Italy was among the first countries in Europe to be heavily impacted by the outbreak of COVID-19. Northern Italy and Lombardy, in particular, were the most affected areas. In September 2021, the team of "AIS, the digital turn" (AISdt), a project whose objectives include collecting data in 50 locations in Italy, across Lombardy and Piedmont, resumed in-person data collection.

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Introduction: Use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is still in the focus of research, in which pigs are commonly involved. During VA-ECMO, cardiovascular parameters are artificially manipulated and therefore not reliable indicators of nociception. Nociceptive withdrawal reflex (NWR) thresholds can be a suitable alternative in such a context.

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CSF concentrations of β-amyloid 42 (Aβ42) and phosphorylated tau (p-tau) are well-established biomarkers of Alzheimer's disease and have been studied in relation to several neuropathological features both in patients and in cognitively unimpaired individuals. The CSF p-tau/Aβ42 ratio, a biomarker combining information from both pathophysiological processes, has emerged as a promising tool for monitoring disease progression, even at pre-clinical stages. Here, we studied the association between the CSF p-tau/Aβ42 ratio with downstream markers of pre-clinical Alzheimer's disease progression including brain structure, glucose metabolism, fibrillary Aβ deposition and cognitive performance in 234 cognitively unimpaired individuals, who underwent cognitive testing, a lumbar puncture, MRI, 18F-fluorodeoxyglucose and 18F-flutemetamol PET scanning.

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Background: Telemedicine provides a means to deliver healthcare across distances, enhancing efficiency and accessibility, especially in low- and middle-income countries. The COVID-19 pandemic highlighted its importance by reducing the risk of virus transmission while maintaining healthcare delivery. This study evaluates the telemedicine program implemented at B.

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Introduction: Improving the quality of teaching placements in family medicine practice (FMP) could help to address the shortage of primary care physicians. This study aims to investigate students' evaluations of first-exposure FMP placements, to identify clusters of FMPs that might need to improve their placement quality, and to analyze students' perceptions of the FMP as a learning environment.

Methods: The design was a cross-sectional survey study, including all fourth-year undergraduate medical students at the University of Zurich, Switzerland, who completed a mandatory placement in FMP during 2019-2022.

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Look before you leap: Are increased recycling efforts accelerating microplastic pollution?

J Ind Ecol

December 2024

Group for Sustainability and Technology ETH Zurich Zurich Switzerland.

To fight plastic pollution and reach net-zero ambitions, policy and industry set goals to increase the recycling of plastics and the recycled content in products. While this ideally reduces demand for virgin material, it also increases pressure on recyclers to find suitable endmarkets for the recyclate. This may lead to two effects: a multiplication of recycled content in applications already made of plastic and a substitution of non-plastic materials with cheap, low-quality recyclate.

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Despite the many benefits of greenhouses, it is challenging to meet their heating demand, as greenhouses belong to the most energy-intensive production systems in the agriculture sector. Industrial symbiosis can bring an effective solution by utilizing waste heat from other industries to meet the greenhouse heat demand. This study proposes an optimization framework by which optimum symbiotic relationships can be identified.

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This work presents the PULPO (ython-based ser-defined ifecycle roduct ptimization) framework, developed to efficiently integrate life cycle inventory (LCI) models into life cycle product optimization. Life cycle optimization (LCO), which has found interest in both the process systems engineering and life cycle assessment (LCA) communities, leverages LCA data to go beyond simple assessments of a limited number of alternatives and identify the best possible product systems configuration subject to a manifold of choices, constraints, and objectives. However, typically, aggregated inventories are used to build the optimization problems.

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Interactions between magma oceans and overlying atmospheres on young rocky planets leads to an evolving feedback of outgassing, greenhouse forcing, and mantle melt fraction. Previous studies have predominantly focused on the solidification of oxidized Earth-similar planets, but the diversity in mean density and irradiation observed in the low-mass exoplanet census motivate exploration of strongly varying geochemical scenarios. We aim to explore how variable redox properties alter the duration of magma ocean solidification, the equilibrium thermodynamic state, melt fraction of the mantle, and atmospheric composition.

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This work explores the use of a cross-shaped organic framework that is used as a template for the investigation of multi-functionalized chromophores. We report the design and synthesis of a universal cross-shaped building block bearing two bromines and two iodines on its peripheral positions. The template can be synthesized on a gram scale in a five-step reaction comprising an oxidative homo-coupling macro-cyclization.

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The Burden of Pain Symptoms in Individuals with Uterine Fibroids-Results from a Prospective Observational Study in the USA.

Int J Womens Health

December 2024

Department of Obstetrics and Gynecology, University of California, San Diego, San Diego, CA, USA; Department of Obstetrics and Gynecology, The George Washington University, Washington, DC, USA.

Purpose: To characterize the burden of uterine fibroids (UF) in individuals experiencing heavy menstrual bleeding (HMB) and moderate-to-severe UF-associated pain in terms of symptoms experienced, impact on work and activities, and pain medication use both on menstrual and non-menstrual days.

Patients And Methods: This prospective, real-world, observational study enrolled 350 participants in the USA with a self-reported UF diagnosis, HMB, and moderate-to-severe pain due to UF. Data collection took place from February 9 to July 19, 2021.

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Impact of taxation on tobacco products prices in Bahrain, Saudi Arabia and United Arab Emirates.

East Mediterr Health J

December 2024

Universal Health Coverage/Noncommunicable Diseases and Mental Health, WHO Office for the Eastern Mediterranean, Cairo, Egypt.

Background: In 2016, the 6 Gulf Cooperation Council countries agreed to implement a harmonized excise tax on tobacco products, at a rate of 100% of the pre-tax price.

Aim: To assess the implementation of tobacco taxation in Bahrain, Saudi Arabia and United Arab Emirates and its impact on consumer prices, affordability and substitution possibilities.

Methods: This study conducted simple descriptive analysis of open-source secondary data reported to WHO by Bahrain, Saudi Arabia and United Arab Emirates on cigarette excise taxes, price levels, price dispersion, and affordability.

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Situation analysis of sugar‑sweetened beverages taxation in Eastern Mediterranean Region.

East Mediterr Health J

December 2024

World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt.

Background: Significant attention is being given to the role of sugar-sweetened beverages (SSBs) in the increasing rates of obesity and diet-related noncommunicable diseases in the Eastern Mediterranean Region (EMR).

Aim: To document the different approaches being used by EMR countries in implementing the sugar-sweetened beverages taxation.

Methods: This study used data on indirect taxes levied on SSBs by the 22 EMR countries and territories collected by WHO between July 2022 and June 2023.

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The human cortical inhibitory system is known to play a vital role for normal brain development, function, and plasticity. GABA is the most prominent inhibitory neurotransmitter in the CNS and is a key regulator not only for motor control and motor learning, but also for cognitive processes. With ageing and many neurodegenerative pathologies, a decline in GABAergic function in several cortical regions together with a reduced ability to task-specifically modulate and increase inhibition in the primary motor cortex has been observed.

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Background: Isolated fractures of the greater tuberosity represent up to 20% of all proximal humeral fractures. Conservative and surgical treatment strategies are reported. Fracture displacement on radiographs is a key factor in treatment decisions, but the accuracy of measurement methods can limit this process.

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Cough is one of the most common reasons patients seek medical care in the outpatient setting. Chronic cough (CC) in adults is defined as a cough lasting more than 8 weeks, with a global prevalence of approximately 10%. CC significantly impairs quality of life, affecting physical, social, and psychological well-being.

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Femoral or Radial Secondary Access in TAVR: A Subanalysis From the Multicenter PULSE Registry.

JACC Cardiovasc Interv

December 2024

Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Center for Population Health Innovation, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel, Lübeck, Germany; BG University Hospital Bergmannsheil, Bochum, Germany.

Background: Transradial secondary access (TR-SA) may serve as an alternative to the traditional femoral secondary access (TF-SA) for pigtail placement in transcatheter aortic valve replacement (TAVR).

Objectives: The aim of this study was to assess the incidence of secondary access-related vascular complications after TR-SA or TF-SA in TAVR.

Methods: The PULSE (Plug or sUture based vascuLar cloSurE after TAVR) registry retrospectively evaluated data of 10,120 patients who underwent transfemoral TAVR at 10 heart centers from 2016 to 2021.

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Improving digital study designs: better metrics, systematic reporting, and an engineering mindset.

Lancet Digit Health

January 2025

Institute for Implementation Science in Health Care, University of Zurich, 8006 Zurich, Switzerland; Epidemiology, Biostatistics & Prevention Institute, University of Zurich, Zurich, Switzerland; Swiss School of Public Health (SSPH+), Zurich, Switzerland. Electronic address:

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The thalamus is a collection of gray matter nuclei that play a crucial role in sensorimotor processing and modulation of cortical activity. Characterizing thalamic nuclei non-invasively with structural MRI is particularly relevant for patient populations with Parkinson's disease, epilepsy, dementia, and schizophrenia. However, severe head motion in these populations poses a significant challenge for in vivo mapping of thalamic nuclei.

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Introduction: Influenza burden (IB) estimates are crucial for monitoring disease trends, allocating limited resources, and promoting influenza vaccination. However, IB in Egypt is poorly understood. This study estimates the mean-seasonal IB in Egypt, across levels of severity by age and regions using sentinel surveillance data between 2016 and 2019.

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Wild chimpanzees drum on tree buttresses during dominance displays and travel, generating low-frequency sounds that are audible over distances of more than 1 km. Western chimpanzees (Pan troglodytes verus) in the Nimba Mountains of Guinea selectively choose trees and buttresses when drumming, potentially based on their resonant properties, suggesting that these chimpanzees are optimizing their drumming signals. We investigated whether male eastern chimpanzees (Pan troglodytes schweinfurthii) from the Waibira community in the Budongo Forest, Uganda, also show preferences in tree and buttress choice, exploring whether selectivity is a species-wide feature.

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In freshwater lakes and rivers, cyanobacteria belonging to the family Leptolyngbyaceae bore > 1 mm deep into limestone pebbles by dissolving carbonate at the tip of their 3-8 μm-thick filaments. The abundance of these borings decreases downward while it is so high at the rock surface that micrometric debris is formed. Moreover, the disintegrated material on the pebbles' surface can be easily removed, for instance, when pebbles are grinding against each other due to wave or current action or when insect larvae settle and scratch loosened grains from the surface while constructing their cases.

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