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2,303 results match your criteria: "Swiss Federal Institute of Technology (ETH)[Affiliation]"
Ecotoxicol Environ Saf
December 2024
State Key Laboratory of Environmental Criteria and Risk Assessment, and State Environmental Protection Key Laboratory of Simulation and Control of Groundwater Pollution, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. Electronic address:
Soil is the place where human beings, plants, and animals depend on for their survival and the link between the various ecological layers. Groundwater is an important component of water resources and is one of the most important sources of water for irrigated agriculture, industry, mining and cities because of its stable quantity and quality. Soil and groundwater are important strategic resources highly valued by countries around the world.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
December 2024
Department of Environmental Systems Science, Swiss Federal Institute of Technology (ETH) Zurich, Zurich 8006, Switzerland.
Resource availability dictates how fast and how much microbial populations grow. Quantifying the relationship between microbial growth and resource concentrations makes it possible to promote, inhibit, and predict microbial activity. Microbes require many resources, including macronutrients (e.
View Article and Find Full Text PDFEur J Cardiothorac Surg
November 2024
Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.
Objectives: This study investigates our enhanced recovery after minimally invasive cardiac surgery program "enhanced recovery after minimally invasive cardiac surgery" (ERMICS) following a 'Zero ICU' concept compared to standard-of-care treatment in terms of safety and clinical efficacy.
Methods: All patients who underwent minimally invasive mitral valve surgery for primary severe mitral valve regurgitation between 2021 and 2023 were included. Propensity score matching (2:1) was performed between patients who received standard-of-care treatment and those who underwent ERMICS.
Genet Med Open
April 2024
Department of Pediatrics, Boston Children's Hospital, Boston, MA.
Purpose: Limited knowledge about disease mechanisms, few published cases, and the lack of functional assessment of variants for neurodevelopmental genetic disorders challenge diagnostic classification for variants and increase the frequency of variants of uncertain significance (VUS). Because inheritance patterns aid in variant interpretation for neurodevelopmental conditions, genetic testing including only the proband leads to larger numbers of VUS than testing strategies that include the parents.
Methods: We reinterpreted genetic variants submitted to the Simons Searchlight research registry using American College of Medical Genetics and Genomics variant interpretation guidelines, familial cascade testing, and literature curation with annual VUS reevaluation.
Cell Death Differ
December 2024
Department of General Thoracic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland.
Ferroptosis is an oxidative, non-apoptotic cell death frequently inactivated in cancer, but the underlying mechanisms in oncogene-specific tumors remain poorly understood. Here, we discover that lactate dehydrogenase (LDH) B, but not the closely related LDHA, subunits of active LDH with a known function in glycolysis, noncanonically promotes ferroptosis defense in KRAS-driven lung cancer. Using murine models and human-derived tumor cell lines, we show that LDHB silencing impairs glutathione (GSH) levels and sensitizes cancer cells to blockade of either GSH biosynthesis or utilization by unleashing KRAS-specific, ferroptosis-catalyzed metabolic synthetic lethality, culminating in increased glutamine metabolism, oxidative phosphorylation (OXPHOS) and mitochondrial reactive oxygen species (mitoROS).
View Article and Find Full Text PDFChemSusChem
November 2024
Department for Knowledge and Communication Management, University for Continuing Education Krems - Danube University, Dr.-Karl-Dorrek-Straße 30, 3500, Krems a. d. Donau, Austria.
This paper examines the need for innovation in phosphorus fertilizer production. An important area requiring action is the use of sulfuric acid in the wet chemical process (WCP), which is the dominant process in phosphate fertilizer production. About 50 % of the sulfuric acid produced worldwide is used for fertilizers, and ~95 % of the world's fertilizers are based on sulfuric acid.
View Article and Find Full Text PDFNat Commun
November 2024
Conservation Science Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Tidal marshes are threatened coastal ecosystems known for their capacity to store large amounts of carbon in their water-logged soils. Accurate quantification and mapping of global tidal marshes soil organic carbon (SOC) stocks is of considerable value to conservation efforts. Here, we used training data from 3710 unique locations, landscape-level environmental drivers and a global tidal marsh extent map to produce a global, spatially explicit map of SOC storage in tidal marshes at 30 m resolution.
View Article and Find Full Text PDFAcute myeloid leukemia (AML) derives from hematopoietic stem and progenitor cells (HSPCs). To date, no AML-exclusive, non-HSPC-expressed cell-surface target molecules for AML selective immunotherapy have been identified. Therefore, to still apply surface-directed immunotherapy in this disease setting, time-limited combined immune-targeting of AML cells and healthy HSPCs, followed by hematopoietic stem cell transplantation (HSCT), might be a viable therapeutic approach.
View Article and Find Full Text PDFSci Total Environ
December 2024
State Key Laboratory of Environmental Criteria and Risk Assessment, and State Environmental Protection Key Laboratory of Simulation and Control of Groundwater Pollution, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. Electronic address:
Dissolved organic matter (DOM) regulates plant behavior in both agricultural and environmental fields. However, the regulatory mechanisms by which DOM influences soil-plant system interactions during the phytoremediation of Cd-contaminated soils remain unclear. Therefore, this study investigated the enhanced effect of kitchen compost-derived DOM on the Cd remediation capability of ryegrass across three phases of phytoremediation.
View Article and Find Full Text PDFJ Am Chem Soc
October 2024
Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology, Barcelona 08028, Spain.
Gamma aminobutyric acid type A receptors (GABARs) play a key role in the mammalian central nervous system (CNS) as drivers of neuroinhibitory circuits, which are commonly targeted for therapeutic purposes with potentiator drugs. However, due to their widespread expression and strong inhibitory action, systemic pharmaceutical potentiation of GABARs inevitably causes adverse effects regardless of the drug selectivity. Therefore, therapeutic guidelines must often limit or exclude clinically available GABAR potentiators, despite their high efficacy, good biodistribution, and favorable molecular properties.
View Article and Find Full Text PDFJ Environ Manage
November 2024
College of Urban and Environmental Science, Northwest University, Xi'an, 710127, China. Electronic address:
Chrysene, as a high molecular weight polycyclic aromatic hydrocarbon (PAH), has become an important factor in degrading soil quality and constraining the safe production of food crops. Compost has been widely used to amend contaminated soil. However, to date, the main components of kitchen compost that enhance the biodegradation of chrysene in the soil remain unidentified.
View Article and Find Full Text PDFJ Environ Manage
November 2024
College of Urban and Environmental Science, Northwest University, Xi'an, 710127, China. Electronic address:
Sci Rep
October 2024
Department of Environmental Systems Science, Swiss Federal Institute of Technology ETH, Universitätstrasse 16, Zürich, CH-8092, Switzerland.
Commonly comprised of cyanobacteria, algae, bacteria and fungi, hypolithic communities inhabit the underside of cobblestones and pebbles in diverse desert biomes. Notwithstanding their abundance and widespread geographic distribution and their growth in the driest regions on Earth, the source of water supporting these communities remains puzzling. Adding to the puzzle is the presence of cyanobacteria that require liquid water for net photosynthesis.
View Article and Find Full Text PDFEur J Cardiothorac Surg
October 2024
Department of Cardiovascular Surgery and Complex Cardiovascular Center, Motol University Hospital V Úvalu, Prague, Czech Republic.
Sci Rep
September 2024
Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Forchstrasse 340, 8008, Zurich, Switzerland.
Eur Heart J Imaging Methods Pract
July 2024
Department of Cardiology, Deutsches Herzzentrum der Charité, Angiology and Intensive Care Medicine, Augustenburger Platz 1, Berlin 13353, Germany.
Brain
September 2024
Nuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, UK.
Neuronal hyperexcitability is a key driver of persistent pain states including neuropathic pain. Leucine-rich, glioma inactivated 1 (LGI1), is a secreted protein known to regulate excitability within the nervous system and is the target of autoantibodies from neuropathic pain patients. Therapies that block or reduce antibody levels are effective at relieving pain in these patients, suggesting that LGI1 has an important role in clinical pain.
View Article and Find Full Text PDFAging (Albany NY)
September 2024
Energy Metabolism Laboratory, Institute of Translational Medicine, Swiss Federal Institute of Technology (ETH) Zürich, Schwerzenbach CH-8603, Switzerland.
Eur J Neurosci
October 2024
Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, Canada.
Over the past decades, the focus of brain research has expanded from using strictly controlled stimuli towards understanding brain functioning in complex naturalistic contexts. Interest has increased in measuring brain processes in natural interaction, including classrooms, theatres, concerts and museums to understand the brain functions in the real world. Here, we examined how watching a live dance performance with music in a real-world dance performance setting engages the brains of the spectators.
View Article and Find Full Text PDFJ Hazard Mater
December 2024
State Key Laboratory of Environmental Criteria and Risk Assessment, and State Environmental Protection Key Laboratory of Simulation and Control of Groundwater Pollution, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
The emission of microplastics and heavy metals in landfills has attracted widespread attention for its stabilization process. Microplastics have become carriers of heavy metals due to their adsorption properties, affecting their environmental behavior. However, the effects of landfill stabilization on the interaction between microplastics and heavy metals in leachate are ambiguous.
View Article and Find Full Text PDFCell Metab
November 2024
Laboratory of Exercise and Health, Department of Health Sciences and Technology, Swiss Federal Institute of Technology (ETH Zürich), Zürich, Switzerland. Electronic address:
Proc Biol Sci
January 2024
Waldrappteam Research and Conservation, Schulgasse 28 , Mutters 6162, Austria.
During long-distance migrations, some bird species make use of in-wake flying, which should allow them to profit from the upwash produced by another bird. While indirect evidence supports energy saving as the primary benefit of in-wake flying, measurements are still missing. We equipped migrating northern bald ibises () with high-precision global navigation satellite system data loggers to track their position in the flock.
View Article and Find Full Text PDFJ Exp Biol
September 2024
School of Marine and Atmospheric Sciences, Stony Brook University, NY 11794-5000, USA.
Onco Targets Ther
August 2024
Philochem AG, Otelfingen, 8112, Switzerland.
Recombinant cytokine products have emerged as a promising avenue in cancer therapy due to their capacity to modulate and enhance the immune response against tumors. However, their clinical application is significantly hindered by systemic toxicities already at low doses, thus preventing escalation to therapeutically active regimens. One promising approach to overcoming these limitations is using antibody-cytokine fusion proteins (also called immunocytokines).
View Article and Find Full Text PDFBMB Rep
November 2024
Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH Zurich), Zurich 8093, Switzerland.