6 results match your criteria: "Sweden National Veterinary Institute[Affiliation]"
Amiodarone increases positive-strand RNA virus replication in vitro: implications for its use in patients with viral infections.
J Antimicrob Chemother
January 2016
Department of Molecular Medicine, University of Padova, Padova, Italy
Amiodarone and metabolite MDEA inhibit Ebola virus infection by interfering with the viral entry process.
Pathog Dis
July 2015
Department of Microbiology, The Public Health Agency of Sweden, Solna 171 82, Sweden Department for Laboratory Medicine, Karolinska Institute, Huddinge/Stockholm 141 83, Sweden National Veterinary Institute, Uppsala 751 89, Sweden.
Ebola virus disease (EVD) is one of the most lethal transmissible infections characterized by a high fatality rate, and a treatment has not been developed yet. Recently, it has been shown that cationic amphiphiles, among them the antiarrhythmic drug amiodarone, inhibit filovirus infection. In the present work, we investigated how amiodarone interferes with Ebola virus infection.
View Article and Find Full Text PDFA virus-like particle system identifies the endonuclease domain of Crimean-Congo hemorrhagic fever virus.
J Virol
June 2015
Institute for Virology, Philipps University Marburg, Marburg, Germany
Unlabelled: Crimean-Congo hemorrhagic fever virus (CCHFV; genus Nairovirus) is an extremely pathogenic member of the Bunyaviridae family. Since handling of the virus requires a biosafety level 4 (BSL-4) facility, little is known about pathomechanisms and host interactions. Here, we describe the establishment of a transcriptionally competent virus-like particle (tc-VLP) system for CCHFV.
View Article and Find Full Text PDFMolecular typing of Escherichia coli O157:H7 isolates from Swedish cattle and human cases: population dynamics and virulence.
J Clin Microbiol
November 2014
National Veterinary Institute (SVA), Uppsala, Sweden.
While all verotoxin-producing Escherichia coli O157:H7 bacteria are considered potential pathogens, their genetic subtypes appear to differ in their levels of virulence. The aim of this study was to compare the distribution of subtypes of E. coli O157:H7 in the cattle reservoir and in human cases with and without severe complications in order to gain clues about the relationship between subtype and relative virulence.
View Article and Find Full Text PDFCharacterization of an experimental vaccine for bovine respiratory syncytial virus.
Clin Vaccine Immunol
July 2014
INRA, Unité de Virologie et Immunologie Moléculaires, Jouy-en-Josas, France.
Article Synopsis
- Bovine respiratory syncytial virus (BRSV) and human respiratory syncytial virus (HRSV) are significant causes of respiratory diseases in calves and children, respectively, highlighting the need for effective vaccines.
- The study evaluated an experimental BRSV vaccine called ISCOM, confirming the presence of several proteins (F, G, N, M, P, SH) critical for targeting and designing new subunit vaccines, with protein F being the most abundant.
- Results showed that while antibodies were produced against several proteins in immunized calves, some proteins were not detected, suggesting further investigation is needed to understand their potential roles in immunity and vaccine development.
Phenotypic and molecular characterization of Brachyspira spp. isolated from wild rodents.
Environ Microbiol Rep
December 2010
Departments of Clinical Sciences and Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden. National Veterinary Institute, Department of Bacteriology, Uppsala, Sweden.
The occurrence of intestinal spirochaetes of genus Brachyspira in wild rodents was studied by cultivating 209 caecal samples. Spirochaetal cultures were obtained from 83% of rats and 33% of house mice. Biochemical characterization and six different species-specific PCR methods were applied to 101 of 118 isolates and a selection of 34 brachyspiras were further studied by sequencing of the 16S rRNA gene.
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