Managing Pregnancies of Unknown Location With the M4 Prediction Model or the NICE Algorithm: A Randomised Controlled Trial With Cross-Sectional Diagnostic Accuracy Data.

Objective: To determine the diagnostic performance and clinical utility of the M4 prediction model and the NICE algorithm managing women with pregnancy of unknown location (PUL).

Design: The study has a superiority design regarding specificity for non-ectopic pregnancy for M4, given that the primary outcome of sensitivity for ectopic pregnancy (EP) is non-inferior in comparison with the NICE algorithm.

Setting: Emergency gynaecology units in Sweden.

Universal Hydrogel Carrier Enhances Bone Graft Success: Preclinical and Clinical Evaluation.

Orthopedic, maxillofacial, and complex dentoalveolar bone grafting procedures that require donor-site bone harvesting can be associated with post-surgical complications. There has been widespread adoption of exogenously sourced particulate bone graft materials (BGM) for bone regenerative procedures; however, the particulate nature of these materials may lead to compromised healing outcomes, mainly attributed to structural collapse of the BGM, prolonged tissue healing. In this study, a fully synthetic thermoresponsive hydrogel-based universal carrier matrix (TX) that forms flowable and shapable putties with different BGMs while spatially preserving the particles in a 3D scaffold at the implantation site is introduced.

Toxicity and Quality of Life After Locoregional Radiotherapy in Patients With Thyroid Cancer.

Background: Locoregional external beam radiotherapy (EBRT) is selectively used in thyroid cancer patients to induce locoregional control. However, despite technological advances, EBRT remains associated with toxicities. We evaluated thyroid-cancer specific toxicities and long-term Quality of Life (QoL) post-EBRT.

Sphingosine-1-Phosphate, a Marker of Endothelial Injury and Disease Severity in Preeclampsia.

Background: Preeclampsia is a hypertensive pregnancy disorder marked by endothelial damage. Healthy endothelium is covered by a protective glycocalyx layer, which, when degraded, releases detectable products into the blood. Sphingosine-1-phosphate (S1P) is a cardiovascular biomarker involved in glycocalyx preservation, linked to placentation and preeclampsia development.

Detection of clinically relevant variants in the gene below 10% allelic frequency: A multicenter study by ERIC, the European Research Initiative on CLL.

In chronic lymphocytic leukemia, the reliability of next-generation sequencing (NGS) to detect variants ≤10% allelic frequency (low-VAF) is debated. We tested the ability to detect 23 such variants in 41 different laboratories using their NGS method of choice. The sensitivity was 85.

Knockout of caused significant sinapine reduction in transgene-free rapeseed mutants generated by protoplast-based CRISPR RNP editing.

Rapeseed ( L.) is known for its high-quality seed oil and protein content. However, its use in animal feed is restricted due to antinutritional factors present in the seedcake, with sinapine being one of the main compounds that reduces palatability.

Domesticated chickens interact more with humans and are more explorative than Red Junglefowl.

Domesticated species are adapted to thrive in an environment with regular human interaction, and these interactions influence the development of a human-animal relationship. Chickens are the most abundant domesticated species, but their relationship with humans is poorly understood. A more comprehensive analysis of this relationship would provide valuable insight into their welfare needs.

Global trends in surgical approach to neonatal brachial plexus palsy: a systematic review.

Background: We analyzed trends in age at surgery and surgical approach over time and geography.

Methods: We performed a systematic review according to PRISMA-IPD guidelines to include individual patient data. Collected data included age at surgery, location of surgery, and surgical approach.

Eye reactions under the influence of drugs of abuse as measured by smartphones: a controlled clinical study in healthy volunteers.

Background: It is known that illicit and prescribed drugs impact pupil size, eye movement and function. Still, comprehensive quantitative evaluations under known ambient light conditions are lacking, when smartphones are used for monitoring.

Methods: In this clinical study (NCT05731999), four medicinal products with addiction risks were administered to 48 subjects (18-70 years old, all with informed consent, 12 subjects per drug).

Comparing synthetic mammograms based on wide-angle digital breast tomosynthesis with digital mammograms.

Purpose: We aim to investigate the characteristics and evaluate the performance of synthetic mammograms (SMs) based on wide-angle digital breast tomosynthesis (DBT) compared with digital mammography (DM).

Approach: Fifty cases with both synthetic and digital mammograms were selected from the Malmö Breast Tomosynthesis Screening Trial. They were categorized into five groups consisting of normal cases and recalled cases with false-positive and true-positive findings from DM and DBT only.

Polygenic risk scores for atrial fibrillation and heart failure and the risk of stroke and dementia.

Atrial fibrillation and heart failure have both been suggested to increase stroke and dementia risk. However, in observational studies, reversed causation and unmeasured confounding may occur. To mitigate these issues, this study aims to investigate if higher genetic risk for atrial fibrillation and heart failure increases dementia and stroke risk.

Recommendations for reporting and evaluating proton therapy beyond dose and constant relative biological effectiveness.

Background And Purpose: In proton therapy, a relative biological effectiveness (RBE) of 1.1 is used to convert proton dose into an equivalent photon dose. However, RBE varies with tissue type, fraction dose, and beam quality parameters beyond dose such as linear energy transfer (LET) raising concerns about increased local effectiveness and potential toxicity.

Current practices in prevention, screening, and treatment of diabetes in kidney transplant recipients: European survey highlights from the ERA DESCARTES Working Group.

Background: Although post-transplant diabetes mellitus (PTDM) is a common complication after kidney transplantation, there are few data on prevention, optimal screening, and treatment strategies.

Methods: The European Renal Association's DESCARTES working group distributed a web-based survey to European transplant centres to gather information on risk assessment, screening procedures, and management practices for preventing and treating PTDM in kidney transplant recipients.

Results: Answers were obtained from 121/241 transplant centres (50%) across 15 European countries.

Applying a sustainability perspective in the literature on physical therapy in relation to pharmaceuticals: a scoping review.

Introduction: Physical therapy encompasses a broad range of treatment options, often utilized in clinical settings where pharmaceutical interventions are standard. The potential for physical therapy to contribute to sustainable healthcare by reducing environmental impact, while maintaining the quality of care, remains underexplored. This study aimed to map existing research comparing physical therapy to pharmaceuticals, with a specific focus on whether these studies address aspects of sustainable development.

Vibrational and Electronic Spectroscopy of 2-Cyanoindene Cations.

2-Cyanoindene is one of the few specific aromatic or polycyclic aromatic hydrocarbon (PAH) molecules positively identified in Taurus molecular cloud-1 (TMC-1), a cold, dense molecular cloud that is considered the nearest star-forming region to Earth. We report cryogenic mid-infrared (550-3200 cm) and visible (16,500-20,000 cm, over the ← electronic transition) spectra of 2-cyanoindene radical cations (2CNI), measured using messenger tagging (He and Ne) photodissociation spectroscopy. The infrared spectra reveal the prominence of anharmonic couplings, particularly over the fingerprint region.

Towards a sustainable set of European Core Health Indicators (ECHI).

Background: The European Core Health Indicators (ECHI) are a set of 88 indicators that provide a compact overview of the extensive field of European public health and healthcare. The ECHI set adds value to European Union health information systems (HIS) for both Member States and EU-associated countries and the European Commission by providing a solid, comparable information base on national public health and healthcare trends and developments. The indicators allow for learning by comparison and the list supports the organisation of national health information systems.

The Role of Host-Range Expansion and Co-Speciation in Host-Parasite Associations With the Divergence of the Great Tit Species Complex.

During the evolution of parasites, co-speciation and host-range expansion are thought to play roles in establishing associations with hosts, while sorting events can lead to dissolution of those associations. To address the roles of these processes, we focus on avian haemosporidian parasites infecting hosts of the intensively studied great tit species complex. We estimated the phylogeography of lineages detected in the species complex, and quantified their transition probabilities among hosts.

Psychosocial wellbeing and risk perception of older adults during COVID-19 pandemic in Nigeria: perspectives on the role of social workers.

Background: The COVID-19 pandemic presented a 'double-edged sword' for older adults: not only were they more susceptible to the virus, but its broader consequences also exacerbated other challenges, particularly those related to psychosocial well-being. Limited evidence exists on how older adults perceive the pandemic and its impact on their well-being and the role of social workers in addressing these challenges, particularly in resource-limited settings like Nigeria.

Aim: This study explored older adults' perceived risks regarding COVID-19, its impact on their psychosocial well-being, and the role of social workers in addressing these challenges in Nigeria.

Unveiling the role of BON domain-containing proteins in antibiotic resistance.

The alarming rise of antibiotic-resistant Gram-negative bacteria poses a global health crisis. Their unique outer membrane restricts antibiotic access. While diffusion porins are well-studied, the role of BON domain-containing proteins (BDCPs) in resistance remains unexplored.

Acute Vestibular Syndrome Unmasking an -Spectrum Disorder.

Objectives: Since the discovery of biallelic pentanucleotide expansions in as the cause of cerebellar ataxia, neuropathy, vestibular areflexia syndrome, a wide and growing clinical spectrum has emerged. In this article, we report a man with acute vestibular syndrome that likely unmasked a -spectrum disorder.

Methods: Detailed clinical evaluation, neuroimaging, nerve conduction studies, evaluation of vestibular function, and short-read whole-genome sequencing and targeted long-read adaptive sequencing were performed.

Association of GLP1R locus with mental ill-health endophenotypes and cardiometabolic traits: A trans-ancestry study in UK Biobank.

Aims: Glucagon-like peptide 1 receptor agonists (GLP1RA), used to treat type 2 diabetes and obesity, have been associated with off-target behavioural effects. We systematically assessed genetic variation in the GLP1R locus for impact on mental ill-health (MIH) and cardiometabolic phenotypes across diverse populations within UK Biobank.

Materials And Methods: All genetic variants with minor allele frequency >1% in the GLP1R locus were investigated for associations with MIH phenotypes and cardiometabolic phenotypes.

The chemistry of halide-based solid electrolytes: unlocking advances in solid-state Li-ion batteries.

Solid-state batteries (SSBs) represent a transformative advancement in electrochemical energy storage, offering exceptional energy density, enhanced safety, and broad operational temperature ranges, making them ideal for next-generation applications. While liquid electrolytes dominate conventional lithium-ion batteries (LIBs) due to their high conductivity and efficient electrode interface wetting, their flammability and volatility pose significant safety risks, particularly in electric vehicles and portable electronics. Solid electrolytes, a cornerstone of SSB technology, offer a promising pathway to enhance LIB energy density and safety.

Global, Regional, and National Burden of Low Back Pain: Findings from the Global Burden of Disease Study 2021 and Projections to 2050.

Study Design: This was an observational study.

Objective: Assessing the global burden of disease for low back pain (LBP) using the 2021 GBD (Global Burden of Disease) database.

Summary Of Background Data: LBP is a leading cause of workforce loss and disability.

Priority effects can be explained by competitive traits.

Priority effects, the effects of early-arriving species on late-arriving species, are caused by niche preemption and/or niche modification. The strength of priority effects can be determined by the extent of niche preemption and/or modification by the early-arriving species; however, the strength of priority effects may also be influenced by the late-arriving species, as some species may be better adapted to deal with niche preemption and/or modification. Therefore, some combinations of species will likely lead to stronger priority effects than others.