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Evaluation of Curcumin Capped Copper Nanoparticles as Possible Inhibitors of Human Breast Cancer Cells and Angiogenesis: a Comparative Study with Native Curcumin.
AAPS PharmSciTech
October 2016
School of Life Sciences, Swami Ramanad Teerth Marathwada University, Nanded, 431 606, MS, India.
Article Synopsis
- Researchers are exploring the synthesis of metal nanoparticles, specifically curcumin-capped copper nanoparticles (CU-NPs), to enhance cancer treatment and drug delivery.
- The study evaluated CU-NPs for their effects on angiogenesis, cell proliferation, and migration in the MDA-MB-231 breast cancer cell line, using assays like the chorioallantoic membrane (CAM) model and the MTT cytotoxicity assay.
- Results indicated that CU-NPs did not show significant antiangiogenic or anticancer activity compared to native curcumin, and the study discusses potential reasons based on nanoparticle synthesis methods.