Trace amine-associated receptor 1 agonist reduces aggression in brain serotonin-deficient tryptophan hydroxylase 2 knockout rats.

Introduction: Aggression and self-harm disproportionately occur in youths preoccupied with social status tracking. These pathological conditions are linked to a serotonin (5-HT) deficit in the brain. Ablation of 5-HT biosynthesis by tryptophan hydroxylase 2 knockout (TPH2-KO) increases aggression in rodents.

Early allelopathic input and later nutrient addition mediated by litter decomposition of invasive affect native plant and facilitate its invasion.

Litter decomposition is essential for nutrient and chemical cycling in terrestrial ecosystems. Previous research on litter decomposition has often underestimated its impact on soil nutrient dynamics and allelopathy. To address this gap, we conducted a comprehensive study involving both field and greenhouse experiments to examine the decomposition and allelopathic effects of the invasive L.

Efficient Electrosynthesis of Hydrogen Peroxide Enabled by a Hierarchical Hollow RE-P-O (RE = Sm, La, Gd) Architecture with Open Channels.

The electrochemical two-electron oxygen reduction reaction (2e ORR) offers a sustainable pathway for the production of HO; however, the development of electrocatalysts with exceptional activity, selectivity, and long-term stability remains a challenging task. Herein, a novel approach is presented to addressing this challenge by synthesizing hierarchical hollow SmPO nanospheres with open channels via a two-step hydrothermal treatment. The produced compound demonstrates remarkable 2e selectivity, exceeding 93% across a wide potential range of 0.

Intravenous anesthesia with high-flow nasal cannula improves recovery in elderly undergoing ureteroscopic lithotripsy: a prospective controlled study.

Background: Intravenous anesthesia with high-flow nasal cannula (HFNC) has been reported to benefit oxygen reserves and enhance postoperative recovery in surgeries requiring low neuromuscular blockade. This study investigated whether HFNC improves recovery quality in elderly undergoing ureteroscopic holmium laser lithotripsy (UHLL).

Methods: We enrolled 106 elderly patients undergoing UHLL, with 96 patients (48 per group) included in the final analysis.

Wearable electrodriven switch actively delivers macromolecular drugs to fundus in non-invasive and controllable manners.

Current treatments for fundus disorders, such as intravitreal injections, pose risks, including infection and retinal detachment, and are limited in their ability to deliver macromolecular drugs across the blood‒retinal barrier. Although non-invasive methods are safer, their delivery efficiency remains suboptimal (<5%). We have developed a wearable electrodriven switch (WES) that improves the non-invasive delivery of macromolecules to the fundus.

Virtual Frisch grid perovskite CsPbBr semiconductor with 2.2-centimeter thickness for high energy resolution gamma-ray spectrometer.

High intrinsic detection efficiency is as decisive as high energy resolution. Scaling up detector volume has presented great challenges, preventing perovskite semiconductors from reaching sufficient detection efficiency. We report a hole-only virtual-Frisch-grid CsPbBr detector up to 2.

Construction of Linear Tetramer-Type Acceptors for High-Efficiency and High-Stability Organic Solar Cells.

Thanks to the development of non-fullerene acceptor (NFA) materials, the photovoltaic conversion efficiency (PCE) of organic solar cells (OSCs) has exceeded 20 %, which has met the requirements for commercialisation. In the current stage, the main focus is to balance the performance and stability. It has been shown that all-polymer formulation can improve device stability, however, PCE is not in satifsfaction, and the batch-to-batch variation leads to quality control issues.

Effects of a self-efficacy-centered self-management program on neurogenic bladder after spinal cord injury: A randomized controlled trial.

Purpose: The present research aimed to investigate the effects of a self-efficacy-centered self-management program on persons with neurogenic bladder (NGB) after spinal cord injury (SCI).

Design: A randomized controlled trial.

Materials And Methods: Eighty-two individuals with NGB after spinal cord injury (SCI) were randomized into either the control or intervention group.

Roles of waste iron scraps in anammox system treating sulfide-containing wastewater: Alleviating sulfide inhibition, promoting novel anammox bacteria enrichment, and enhancing nitrogen removal capacity.

In this study, waste iron scraps (WIS) were exerted to alleviate sulfide inhibition on anammox bacteria and promote anammox nitrogen removal from sulfide-containing wastewater.Short-term batch experiments showed that WIS-addition led to the anammox bacteria activity increasing by 124.8 % at an initial sulfide concentration of 40 mgS/L.

Innovative Heating for the Nano Age: Exploring the Potentials of Carbothermal Shock.

Heating techniques have underpinned the progress of the material and manufacturing industries. However, the explosive development of nanomaterials and micro/nanodevices has raised more requirements for the heating technique, including but not limited to high efficiency, low cost, high controllability, good usability, scalability, universality, and eco-friendliness. Carbothermal shock (CTS), a heating technique derived from traditional electrical heating, meets these requirements and is advancing at a high rate.

Visual dominance of the congruency sequence effect in a cross-modal context.

The congruency sequence effect (CSE) refers to the reduction in the congruency effect in the current trial after an incongruent trial compared with a congruent trial. Although previous studies widely suggested that CSE was observed only in the modality repeat condition, few studies have reported that CSE could also appear in the modality switch condition. However, it remains unclear whether these conflicting findings were caused by partial repetition effects under modality transition conditions.

RePaIR: Repaired pruning at initialization resilience.

Over the past decade, the size of neural network models has gradually increased in both breadth and depth, leading to a growing interest in the application of neural network pruning. Unstructured pruning provides fine-grained sparsity and achieves better inference acceleration under specific hardware support. Unstructured Pruning at Initialization (PaI) optimizes the iterative pruning pipeline, but sparse weights increase the risk of underfitting during training.

Improving robustness by action correction via multi-step maximum risk estimation.

Certifying robustness against external uncertainties throughout the control process to reduce the risk of instability is very important. Most existing approaches based on adversarial learning use a fixed parameter to adjust the intensity of adversarial perturbations and design these perturbations in a greedy manner without considering future implications. However, they often lead to severe vulnerabilities when attack budgets vary dynamically or under foresighted attacks.

Ancestral Nitrilase Mining and Semi-Rational Engineering for Enhanced Thermal Stability in Rapeseed Meals-Derived Nitriles Degradation.

Rapeseed meal (RSM), a protein-rich byproduct, holds potential as a high-quality animal feed, but nitrile compounds derived from glucosinolates (GSLs) in RSM pose a toxicity risk. Nitrilases, enzymes that hydrolyze toxic nitriles to carboxylic acids, offer a potential solution for detoxification. However, the low thermal stability of nitrilases restricts their industrial applicability.

Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health.

The Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and Social media - form a synergistic ecosystem. Advanced technologies drive biological research, which generates novel insights that are disseminated through academic journals.

Aberrant resting-state functional network centrality and cognitive impairment in unmedicated, euthymic bipolar patients.

Background: Cognitive impairment is prevalent in bipolar disorder (BD), and has negative impacts on functional impairments and quality of life, despite euthymic states in most individuals. The underlying neurobiological basis of cognitive impairment in BD is still unclear.

Methods: To further explore potential connectivity abnormalities and their associations with cognitive impairment, we conducted a degree centrality (DC) analysis and DC (seed)-based functional connectivity (FC) approach in unmedicated, euthymic individuals with BD.

Optical sectioning methods in three-dimensional bioimaging.

In recent advancements in life sciences, optical microscopy has played a crucial role in acquiring high-quality three-dimensional structural and functional information. However, the quality of 3D images is often compromised due to the intense scattering effect in biological tissues, compounded by several issues such as limited spatiotemporal resolution, low signal-to-noise ratio, inadequate depth of penetration, and high phototoxicity. Although various optical sectioning techniques have been developed to address these challenges, each method adheres to distinct imaging principles for specific applications.

Morusin regulates the migration of M2 macrophages and GBM cells through the CCL4-CCR5 axis.

Background: Glioblastoma (GBM) is the most aggressive tumor in the central nervous system. Tumor-associated macrophage (TAMs) represent a major immune cell population in tumor microenvironment (TME) and exert immunosuppressive effects that impede GBM treatment. Morusin is a flavonoid extracted from mulberry trees and has anti-tumor properties against various cancers, including glioma.

Recent Advances in Wide-Range Temperature Metal-CO Batteries: A Mini Review.

The metal-carbon dioxide batteries, emerging as high-energy-density energy storage devices, enable direct CO utilization, offering promising prospects for CO capture and utilization, energy conversion, and storage. However, the electrochemical performance of M-CO batteries faces significant challenges, particularly at extreme temperatures. Issues such as high overpotential, poor charge reversibility, and cycling capacity decay arise from complex reaction interfaces, sluggish oxidation kinetics, inefficient catalysts, dendrite growth, and unstable electrolytes.

Chirality-Induced Hydroxyapatite Manipulates Enantioselective Bone-Implant Interactions Toward Ameliorative Osteoporotic Osseointegration.

Inspired by the fundamental attribute of chirality in nature, chiral-engineered biomaterials now represent a groundbreaking frontier in biomedical fields. However, the integration of chirality within inorganic materials remains a critical challenge and developments of chirality-induced bionic bone implants are still in infancy. In this view, novel chiral hydroxyapatite (CHA) coated Ti alloys are successfully synthesized by a sophisticated chiral molecule-induced self-assembly method for the first time.

Low-frequency bladder vibration for the treatment of urinary tract infections in spinal cord injury patients with neurogenic bladder.

Purpose: Evaluate if low-frequency bladder vibration (LFBV) combined with clean intermittent catheterization (CIC) alleviated urinary tract infections (UTIs) in spinal cord injury (SCI) patients with neurogenic bladder (NB).

Methods: A single-blind randomized controlled trial was conducted. Patients who developed UTIs while rehabilitating from SCI were enrolled continuously between January 2021 and March 2023 and randomly assigned to the control or the intervention group.

A fast-modeling framework for personalized human body models based on a single image.

Finite element human body models (HBMs) are the primary method for predicting human biological responses in vehicle collisions, especially personalized HBMs that allow accounting for diverse populations. Yet, creating personalized HBMs from a single image is a challenging task. This study addresses this challenge by providing a framework for HBM personalization, starting from a single image used to estimate the subject's skin point cloud, the skeletal point cloud, and the relative positions of the skeletons.

A general strategy to achieve see-through devices through the micro-structuring of colored functional materials.

Irrespective of the specific see-through device, obtaining optimal transparency remains the primary goal. In this work, we introduce a general strategy to enhance the transparency of various see-through devices. We achieve this by structuring the colored functional materials into imperceptible three-dimensional mesh lines, addressing a common challenge in multi-layer structures where each layer causes a reduction in transparency due to their color or opacity.

Ultrahigh concentration exfoliation and aqueous dispersion of few-layer graphene by excluded volume effect.

Colloidal properties of nanoparticles are intricately linked to their morphology. Traditionally, achieving high-concentration dispersions of two-dimensional (2D) nanosheets has proven challenging as they tend to agglomerate or re-stack under increased surface contact and Van der Waals attraction. Here, we unveil an excluded volume effect enabled by 2D morphology, which can be coupled with electrostatic repulsion to synthesize high-concentration aqueous graphene dispersions.