Inhibition of HDAC6 elicits anticancer effects on head and neck cancer cells through Sp1/SOD3/MKP1 signaling axis to downregulate ERK phosphorylation.

Oxidative stress caused by reactive oxygen species (ROS) and superoxides is linked to various cancer-related biological events. Extracellular superoxide dismutase (SOD3), an antioxidant enzyme that removes superoxides, contributes to redox homeostasis and has the potential to regulate tumorigenesis. Histone deacetylase 6 (HDAC6), a major HDAC isoform responsible for mediating the deacetylation of non-histone protein substrates, also plays a role in cancer progression.

Thermal sensitivity and niche plasticity of generalist and specialist leaf-endophytic bacteria in Mangrove Kandelia obovata.

Leaf endospheres harbor diverse bacterial communities, comprising generalists and specialists, that profoundly affect ecosystem functions. However, the ecological dynamics of generalist and specialist leaf-endophytic bacteria and their responses to climate change remain poorly understood. We investigated the diversity and environmental responses of generalist and specialist bacteria within the leaf endosphere of mangroves across China.

Exponentially Enhanced Scheme for the Heralded Qudit Greenberger-Horne-Zeilinger State in Linear Optics.

High-dimensional multipartite entanglement plays a crucial role in quantum information science. However, existing schemes for generating such entanglement become complex and costly as the dimension of quantum units increases. In this Letter, we overcome the limitation by proposing a significantly enhanced linear optical heralded scheme that generates the d-level N-partite Greenberger-Horne-Zeilinger (GHZ) state with single-photon sources and linear operations.

Risk of malignant lymphoma in patients with previous tuberculosis infection: a cohort study.

Tuberculosis (TB) is associated with chronic inflammation, which has been implicated in the pathogenesis of various malignancies, including lung cancer. However, the relationship between TB and hematological malignancies like lymphoma remains less understood. This study aimed to investigate risks of incident malignant lymphoma according to previous TB infection in a large prospective cohort of 347,204 individuals.

Stretchable impedance electrode array with high durability for monitoring of cells under mechanical and chemical stimulations.

Electrochemical impedance spectroscopy (EIS) serves as a non-invasive technique for assessing cell status, while mechanical stretching plays a pivotal role in stimulating cells to emulate their natural environment. Integrating these two domains enables the concurrent application of mechanical stimulation and EIS in a stretchable cell culture system. However, challenges arise from the difficulty in creating a durable and stable stretchable impedance electrode array.

Understanding mechanical failure behaviours and protocol optimization for fast charging applications in Co-free Ni-based cathodes for lithium-ion batteries.

Currently, it is a significant challenge to achieve long-term cyclability and fast chargeability in lithium-ion batteries, especially for the Ni-based oxide cathode, due to severe chemo-mechanical degradation. Despite its importance, the fast charging long-term cycling behaviour is not well understood. Therefore, we comprehensively evaluate the feasibility of fast charging applications for Co-free layered oxide cathodes, with a focus on the extractable capacity and cyclability.

Enhancing Mechanical Resilience in Li-Ion Battery Cathodes with Nanoscale Elastic Framework Coatings.

Lattice volume changes in Li-ion batteries active materials are unavoidable during electrochemical cycling, posing significant engineering challenges from the particle to the electrode level. In this study, we present an elastic framework coating designed to absorb and reversibly release strain energy associated with particle volume changes, thereby enhancing mechanical resilience at both the particle and electrode levels. This framework, composed of multiwalled carbon nanotubes (MWCNTs), is applied to nickel-rich LiNiCoMnO (NCM9055) cathodes at a low loading of 0.

Phyletic patterns of bacterial growth temperature in and reveal gradual and sporadic evolution towards cold adaptation.

Bacterial species adapt to cold environments with diverse molecular mechanisms enabling their growth under low ambient temperature. The emergence of cold-adapted species at macro-evolutionary scale, however, has not been systematically explored. In this study, we performed phylogenetic analysis on the growth temperature traits in the genera that occupy broad environmental and host niches and contain known cold-adapted species.

1.6-Inch Transparent Micro-Display with Pixel Circuit Integrated microLED Chip Array by Misalignment-Free Transfer.

Recent advances in mass transfer technology are expected to bring next-generation micro light-emitting diodes (µLED) displays into reality, although reliable integration of the active-matrix backplane with the transferred µLEDs remains as a challenge. Here, the µLED display technology is innovated by demonstrating pixel circuit-integrated micro-LEDs (PIMLEDs) and integrating them onto a transparent glass substrate. The PIMLED comprises of low-temperature poly-silicon transistors and GaN µLED.

Reactive Oxygen Species Resistive Redox Mediator in Lithium-Oxygen Batteries.

The utilization of redox mediators (RMs) in lithium-oxygen batteries (LOBs) has underscored their utility in high overpotential during the charging process. Among the currently known RMs, it is exceptionally challenging to identify those with a redox potential capable of attenuating singlet oxygen (O) generation while resisting degradation by reactive oxygen species (ROS), such as O and superoxide (O ). In this context, computational and experimental approaches for rational molecular design have led to the development of 7,7'-bi-7-azabicyclo[2.

A recent large-scale intraspecific IR expansion and evolutionary dynamics of the plastome of Peucedanum japonicum.

Peucedanum japonicum (PJ), a member of the Apiaceae family, is widely distributed and cultivated in East Asian countries for edible and functional foods. In this study, we compared the plastid genomes (plastomes) and 45S nuclear ribosomal DNA (45S nrDNA) simultaneously from 10 PJ collections. Plastome-based phylogenetic analysis showed that the PJ accessions were monophyletic within the genus Peucedanum.

Dynamic tracking of objects in the macaque dorsomedial frontal cortex.

A central tenet of cognitive neuroscience is that humans build an internal model of the external world and use mental simulation of the model to perform physical inferences. Decades of human experiments have shown that behaviors in many physical reasoning tasks are consistent with predictions from the mental simulation theory. However, evidence for the defining feature of mental simulation - that neural population dynamics reflect simulations of physical states in the environment - is limited.

Reconfigurable Sequential-Logic-in-Memory Implementation Utilizing Ferroelectric Field-Effect Transistors.

In modern digital systems, sequential logic circuits store and process information over time, whereas combinational logic circuits process only the current inputs. Conventional sequential systems, however, are complex and energy-inefficient due to the separation of volatile and nonvolatile memory components. This study proposes a compact, nonvolatile, and reconfigurable van der Waals (vdW) ferroelectric field-effect transistor (FeFET)-based sequential logic-in-memory (S-LiM) unit that performs sequential logic operations in two nonvolatile states.

Surface conduction and reduced electrical resistivity in ultrathin noncrystalline NbP semimetal.

The electrical resistivity of conventional metals such as copper is known to increase in thin films as a result of electron-surface scattering, thus limiting the performance of metals in nanoscale electronics. Here, we find an unusual reduction of resistivity with decreasing film thickness in niobium phosphide (NbP) semimetal deposited at relatively low temperatures of 400°C. In films thinner than 5 nanometers, the room temperature resistivity (~34 microhm centimeters for 1.

Landscape profiling of PET depolymerases using a natural sequence cluster framework.

Enzymes capable of breaking down polymers have been identified from natural sources and developed for industrial use in plastic recycling. However, there are many potential starting points for enzyme optimization that remain unexplored. We generated a landscape of 170 lineages of 1894 polyethylene terephthalate depolymerase (PETase) candidates and performed profiling using sampling approaches with features associated with PET-degrading capabilities.

Clinical and microbiological analyses of colistin-resistant strains among carbapenem-resistant complex clinical isolates.

Carbapenem-resistant complex (CR-ECC), which is rapidly increasing as the cause of nosocomial infections, has limited treatment options. The aim of this study is to investigate the microbiological and clinical traits and molecular epidemiology of isolates of CR-ECC and provide guidance for antibiotic selection in clinical practice. Clinical CR-ECC isolates (ertapenem MIC ≥ 2 mg/L) were collected from 2021 to 2022.

Assessment of oral health status in intensive care unit patients using quantitative light-induced fluorescence: a multicenter cross-sectional study.

Objectives: The aim of this study was to evaluate oral hygiene using quantitative light-induced fluorescence (QLF) and to compare its results with those of oral examination to determine the applicability of QLF technology for assessing oral health status and oral hygiene in intensive care unit (ICU) patients.

Materials And Methods: We analyzed oral health status, oral examination findings, oral hygiene evaluations using QLF technology, and dry mouth in a sample of 70 hospitalized ICU patients. The relationship between oral hygiene assessments using QLF technology and oral examinations was analyzed using Pearson correlation coefficients.

Protein engineering of an oxidative cleavage-free pathway for crocetin-dialdehyde production in Escherichia coli.

The growing depletion of petroleum resources and the increasing demand for sustainable alternatives have spurred advancements in microorganism-based biofactories. Among high-value compounds, carotenoids are widely sought after in pharmaceuticals, cosmetics, and nutrition, making them prime candidates for microbial production. In this study, we engineered an efficient biosynthetic pathway in Escherichia coli for the production of the C-carotenoid crocetin-dialdehyde.

Smoking Experience before Adulthood Is Associated with an Increased Risk of Developing Ulcerative Colitis in Adult Ex-Smokers.

Purpose: Smoking may have a protective role in developing ulcerative colitis (UC) but have the opposite effect on Crohn's disease (CD). This study aimed to determine the risk of developing inflammatory bowel disease (IBD) according to smoking status and onset age of smoking.

Materials And Methods: We collected data on the smoking experiences of participants aged 20-39 years who underwent biannual examinations provided by the Korean National Health Screening Program from 2009 to 2012.

Ultrafast hot carrier extraction and diffusion at the MoS/Au van der Waals electrode interface.

Metal electrode deposition is universally adopted in the community for optoelectronic device fabrication, inducing hybridization at electrode interfaces, and allows efficient extraction or injection of photocarriers. However, hybridization-induced midgap states increase photocarrier recombination pathways, creating a paradoxical trade-off. Here, we discovered that efficient photocarrier extraction and a long photocarrier lifetime can be achieved simultaneously in MoS/van der Waals Au contact, minimizing photocarrier loss at the interface.

High Efficiency and Narrow Emissions in Deep-Blue Pt(II) Emitters in Organic Light-Emitting Diodes via Anchor-Shaped Substituent Design.

In this study, a tetradentate Pt(II) complex designed to have -heterocyclic carbene ligands modified with an anchor-shaped 2,6-diisopropylphenyl (dip) group is described to enhance molecular rigidity for narrow emission and high efficiency. The tetradentate ligand with the dip group significantly hinders steric interactions and restricts π-conjugation from benzocarbene, leading to shallow lowest unoccupied molecular orbital levels and a consequent reduction in the triplet metal-to-ligand charge transfer character. These structural modifications result in narrow emission spectra and enhanced efficiency for blue organic light-emitting diodes (OLEDs) over wide doping concentration ranges.