Coastal vulnerability to extreme weather events: An integrated analysis of erosion, sediment movement, and land subsidence based on multi-temporal optical and SAR satellite data.

Coastal areas undergo continuous transformations, altering their geometry under the influence of external forces like tides, waves, and extreme events. Thus, monitoring the impact of extreme weather events on coastal regions is crucial to prevent potential cascading hazards. Here, we utilized time-series optical and SAR satellite data and tide records, coupled with sophisticated analytical techniques, to analyze erosion processes, sediment transport, and vertical land movement (VLM) at an embayed sandy beach (i.

Multiple burr hole and erythropoietin combination therapy: optimal early surgical intervention for patients with acute stroke episode of moyamoya disease or moyamoya syndrome.

Objective: The optimal timing of bypass surgery for patients with moyamoya disease (MMD) or moyamoya syndrome (MMS) following an acute stroke episode remains unclear, mainly owing to the risk of postoperative complications. In this study, we aim to validate the safety and efficacy of early intervention using multiple burr hole (MBH) and erythropoietin (EPO) therapy, thereby refining the management strategy for patients with acute stroke episode of MMD or MMS.

Methods: We retrospectively analyzed data from 70 patients with MMD or MMS who underwent MBH and EPO therapy.

The association between residing in regions with population decline and receiving management education or treatment in patients with hypertension.

Background: Many districts in rural areas of Korea are facing population decline due to the aging population phenomenon. This study examined the associations of rural residency with the likelihood of receiving hypertension management education and nonpharmacological and pharmacological treatment.

Methods: Data from the 2022 Korea Community Health Survey were used to identify individuals aged 19 years or above diagnosed with hypertension.

Freestanding Wide-Bandgap Semiconductors Nanomembrane from 2D to 3D Materials and Their Applications.

Wide-bandgap semiconductors (WBGS) with energy bandgaps larger than 3.4 eV for GaN and 3.2 eV for SiC have gained attention for their superior electrical and thermal properties, which enable high-power, high-frequency, and harsh-environment devices beyond the capabilities of conventional semiconductors.

COVID-19 Vaccination Recommendations for 2024-2025 in Korea.

The Korean Society of Infectious Diseases has been regularly publishing guidelines for adult immunization since 2007. Following the release of coronavirus disease 2019 (COVID-19) vaccination recommendations in 2023, significant changes have occurred due to the emergence of new variant strains and the waning immunity from previous vaccinations. This article provides a comprehensive update as of November 2024, incorporating the latest evidence and guidelines.

Ion-Induced Phase Changes in 2D MoTe Films for Neuromorphic Synaptic Device Applications.

Two-dimensional molybdenum ditelluride (2D MoTe) is an interesting material for artificial synapses due to its unique electronic properties and phase tunability in different polymorphs 2H/1T'. However, the growth of stable and large-scale 2D MoTe on a CMOS-compatible Si/SiO substrate remains challenging because of the high growth temperature and impurity-involved transfer process. We developed a large-scale MoTe film on a Si/SiO wafer by simple sputtering followed by lithium-ion intercalation and applied it to artificial synaptic devices.

Crystallization control of Cu(I)-halide thermal evaporation for improving resistive switching memory performance.

CsCuI is considered a promising material for lead-free resistive switching (RS) memory devices due to its low operating voltage, high on/off ratio, and excellent thermal and environmental stability. However, conventional lead-free halide-based RS memory devices typically require solvent-based thin-film formation processes that involve toxic organic and acidic solvents, and the effects of process conditions on device performance are often not fully understood. This study investigates the effect of crystallinity on CsCuI-based RS memory devices fabricated thermal evaporation.

Unveiling the Diverse Principles for Developing Sprayable Hydrogels for Biomedical Applications.

Sprayable hydrogels have emerged as a transformative innovation in biomedical technology, offering a versatile, efficient, and minimally invasive platform for various clinical applications. They form gels upon tissue contact, enabling seamless application on even complex surfaces. This property is especially useful in wound care, drug delivery, and tissue engineering, where localized and sustained release of therapeutics is essential.

Kinetically Tailored Chemical Vapor Deposition Approach for Synthesizing High-Quality Large-Area Non-Layered 2D Materials.

Non-layered 2D materials offer unique and more advantageous physicochemical properties than those of conventional 2D layered materials. However, the isotropic chemical bonding nature of non-layered materials hinders their lateral growth, making the synthesis of large-area continuous thin films challenging. Herein, a facile kinetically tailored chemical vapor deposition (KT-CVD) approach is introduced for the synthesis of 2D molybdenum nitride (MoN), a representative non-layered material.

Serum markers for beef meat quality: Potential media supplement for cell-cultured meat production.

As the global population continues to grow and food demands increase, the food industry faces mounting pressure to develop innovative solutions. Cell-cultured meat involves cultivating cells from live animals through self-renewal methods or scaffolding and presents a promising alternative to traditional meat production by generating nutritionally rich biomass. However, significant research is still needed to overcome challenges such as developing serum-free media, identifying suitable additives to support cell growth, and ensuring the quality of cell-cultured meat closely resembles that of traditional meat.

Comparison of antioxidant and antimicrobial activities of submerged culture mycelium and basidioma extracts of .

Unlabelled: This research aimed to assess the biological characteristics of both submerged culture mycelium and artificial basidioma of NTH-PL4. The extraction yield from the basidioma surpassed that of the mycelium. The use of hot water extract resulted in the highest total carbohydrate content, predominantly found in the basidioma.

Contact-Engineered Oxide Memtransistors for Homeostasis-Based High-Linearity and Precision Neuromorphic Computing.

Homeostasis is essential in biological neural networks, optimizing information processing and experience-dependent learning by maintaining the balance of neuronal activity. However, conventional two-terminal memristors have limitations in implementing homeostatic functions due to the absence of global regulation ability. Here, three-terminal oxide memtransistor-based homeostatic synapses are demonstrated to perform highly linear synaptic weight update and enhanced accuracy in neuromorphic computing.

Efficient Functional Compensation Layer Integrated with HTL for Improved Stability and Performance in Perovskite Solar Cells.

Improving the interface characteristics between the hole-transport layer (HTL) and perovskite absorber layer is crucial for achieving maximum efficiency in inverted perovskite solar cells (PSCs). This paper presents an effective functional compensation layer (FCL) composed of benzothiophene derivatives, particularly 5-(trifluoromethyl)-1-benzothiophene-2-carboxylic acid (TFMBTA); this layer is introduced between the MeO-2PACz HTL and perovskite absorber layer to improve the interfacial characteristics between them. This FCL improves charge transfer, hole extraction, and perovskite deposition by improving the surface morphology of the HTL and optimizing the energy level alignment.

Study Protocol of the Korean EGFR Registry: A Multicenter Prospective and Retrospective Cohort Study in Nonsmall Cell Lung Cancer Patients With EGFR Mutation.

Introduction: The provision of treatment for epidermal growth factor receptor (EGFR)-mutated nonsmall cell lung cancer (NSCLC) patients has increased in Korea. However, multicenter studies on the clinicopathologic dataset and treatment outcomes, using a large-scale dataset, have not been conducted. The current study is a prospective and retrospective multicenter observational cohort study that registers all stages of EGFR-mutated NSCLC patients.

Piezocatalysis-combined advanced oxidation processes for organic pollutant degradation in water system.

The piezoelectric catalyst process has emerged as a promising technology for energy harvesting, effectively converting natural mechanical energies, such as wind, water flow, and waves, into usable electrical energy using piezoelectric materials. In recent years, there has been a growing interest in applying this technology to water treatment to address environmental challenges. Concurrently, research efforts have focused on enhancing the efficiency of piezoelectric catalysis by integrating it with advanced oxidation processes (AOPs).

Flower-like tailored carbon nitride oligomer as an excellent aggregation-induced electrochemiluminescence emitter for sensitive immunoassay of neuron-specific enolase via dual quenching by bimetallic phenolic networks.

The adjustment of the electrochemiluminescence (ECL) of polymeric carbon nitride (CN) is essential for its application in sensitive immunoassays. However, such modification through aggregation-induced emission (AIE) has not yet been reported. Herein, aggregation-induced ECL in CN oligomer (CNO) was induced through the introduction of a rotatable imine moiety, with the resulting material exhibiting excellent performance in the targeted immunodetection of neuron-specific enolase.

Rational design and therapeutic potential of MyD88 inhibitory peptide in psoriasis.

Myeloid differentiation primary-response 88 (MyD88) is a crucial adaptor protein for initiating immune responses via Toll-like receptors (TLRs). This study employed a rational peptide design approach to develop MyD88 inhibitory peptides targeting the MyD88 interaction interface. The designed peptide, MyDIP2-4, was evaluated for its efficacy in inhibiting MyD88-dependent signaling in human and mouse cell lines.

A Novel RAGE Modulator Induces Soluble RAGE to Reduce BACE1 Expression in Alzheimer's Disease.

β-secretase (BACE1) is instrumental in amyloid-β (Aβ) production, with overexpression noted in Alzheimer's disease (AD) neuropathology. The interaction of Aβ with the receptor for advanced glycation endproducts (RAGE) facilitates cerebral uptake of Aβ and exacerbates its neurotoxicity and neuroinflammation, further augmenting BACE1 expression. Given the limitations of previous BACE1 inhibition efforts, the study explores reducing BACE1 expression to mitigate AD pathology.

The degradation mechanism of multi-resonance thermally activated delayed fluorescence materials.

1,4-Azaborine-based arenes are promising electroluminescent emitters with thermally activated delayed fluorescence (TADF), offering narrow emission spectra and high quantum yields due to a multi-resonance (MR) effect. However, their practical application is constrained by their limited operational stability. This study investigates the degradation mechanism of MR-TADF molecules.