3,500 results match your criteria: "Surgical Treatment of Vulvar Cancer"
Prevalence and impact of vulvar lesions diagnosed prior to vulvar squamous cell carcinoma: A population-based cohort study.
Gynecol Oncol
December 2024
Amsterdam UMC location Vrije Universiteit Amsterdam, Pathology, De Boelelaan 1117, Amsterdam, the Netherlands; Cancer Centre Amsterdam, Imaging and Biomarkers, Amsterdam, the Netherlands. Electronic address:
Objective: To systematically explore vulvar pathology diagnosed prior to vulvar squamous cell carcinoma (VSCC), as well as the association with tumor characteristics, stage and survival outcome, with the aim of improving vulvar cancer prevention strategies.
Methods: VSCC diagnosed between 2005 and 2019 were identified from a population-based cohort provided by the Dutch Nationwide Pathology Databank. Pathology reports were reviewed to identify vulvar pathology diagnosed before primary VSCC.
Article Synopsis
- An 82-year-old woman with a history of bladder cancer had a cystectomy and developed a ureteral fistula in 2012, showing no cancer spread at that time.
- In 2020, she experienced vulvar itching, diagnosed as vulvovaginitis, but the symptoms persisted, leading to a biopsy in 2023 that revealed Paget cells and secondary extramammary Paget's disease linked to urothelial carcinoma.
- After detecting a mass in the pelvic floor and confirming local recurrence of cancer, she underwent surgery in October 2023 and is currently recovering well without signs of recurrence.
Well-differentiated squamous cell carcinoma of the clitoris: a rare case report.
Pan Afr Med J
December 2024
Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha, Maharashtra, India.
Article Synopsis
- Squamous cell carcinoma (SCC) can affect various organs, including the vagina and vulva, with vulvar carcinoma being a rare occurrence, typically seen in those over 70 years old, with a low prevalence of 2.6 per 100,000 people.
- This case study focuses on a 65-year-old woman diagnosed with well-differentiated squamous cell carcinoma (WDSCC) of the clitoris, highlighting an increasing trend of diagnoses in women aged 35 to 45.
- Current treatment approaches are shifting from radical surgeries, such as vulvectomy and lymph node removal, to more personalized and less invasive strategies for managing vulvar carcinomas.
Impact of age on surgical excision margins for vulvar squamous cell carcinomas: A multicenter study by the francogyn group.
Surg Oncol
November 2024
ECEVE U1123, National Institute of Health and Medical Research, Paris Cité University, Paris, France; Department of Obstetrics and Gynaecology, Lariboisiere University Hospital, University Paris Cité, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France.
Article Synopsis
- Vulvar cancer primarily affects older women and requires surgical treatment, with guidelines emphasizing the importance of negative histological margins.
- A study analyzed the impact of patient age on surgical outcomes, finding that older patients (≥65 years) had larger tumors but similar rates of negative excision margins compared to younger patients (<65 years).
- Results indicated that younger patients experienced better recurrence-free survival and were more likely to undergo revision surgery despite the older group receiving more radical surgery.
Treatment Outcomes of Vulvar Cancer: Our Experience From a Tertiary Care Center in Eastern India.
Cureus
November 2024
Surgical Oncology, All India Institute of Medical Sciences, Patna, Patna, IND.
Article Synopsis
- Vulvar carcinoma, primarily squamous cell carcinoma, is a rare form of cancer occurring in the external female genitalia, necessitating a multidisciplinary treatment approach often involving surgery and adjuvant therapy based on stage and other factors.
- A retrospective study conducted in India over eight years included 21 patients with vulvar cancer, analyzing disease stages, treatment methods, and outcomes, revealing a five-year survival rate of about 71%.
- The study highlighted the importance of individualized treatment plans and the need for strict protocols and regular follow-ups, especially in low-resource settings, to improve patient outcomes in this rare disease.
The prognostic value of tumor-infiltrating lymphocytes in vulvovaginal melanoma.
Int J Gynecol Cancer
December 2024
Department of Surgical Oncology, Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, France
Article Synopsis
- The study aimed to investigate the relationship between the immune microenvironment and survival outcomes in patients with vulvovaginal melanoma.
- It involved a retrospective analysis of 42 patients, examining tumor-infiltrating lymphocytes and genetic mutations, with significant findings on immune cell presence related to better disease-free survival.
- The researchers concluded that specific types of tumor-infiltrating lymphocytes could indicate disease progression and response to treatments, suggesting the need for further multicenter studies to confirm these results.
Vulvar Skin Metastasis From Cervical Adenocarcinoma.
Am J Dermatopathol
December 2024
Institute of Dermatology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China; and.
Article Synopsis
- Cervical cancer is a prevalent type of cancer affecting women's reproductive systems, especially in developing nations, but skin metastasis from it is rare.
- The study discusses a case of a 44-year-old woman with stage IIA gastric-type endocervical adenocarcinoma.
- After treatment involving a radical hysterectomy and chemoradiation, the patient developed skin metastasis in the vulvar area two years later.
Systemic hormone therapy after breast and gynecological cancers: an Italian expert group consensus opinion.
Climacteric
November 2024
Coordinator of the Italian Group of Special Interest on Menopause of the Italian Society of Obstetrics and Gynecology, Women's Wellness Foundation, Cagliari, Italy.
Article Synopsis
- * ET/HT can be cautiously used after vulvar cancers, melanoma, and certain endometrial cancers, while more caution is needed with adenocarcinomas and uterine sarcomas.
- * For breast cancer survivors, ET/HT is likely safe after ER/PR-negative cancers but should be applied carefully after ER/PR-positive cases.
[Staged operations of acquired lymphangiectasia of the vulva: 10 cases clinical analysis].
Zhonghua Fu Chan Ke Za Zhi
October 2024
Department of Lymph Surgery, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing 100038, China.
Article Synopsis
- This study examined acquired lymphangiectasia of the vulva (ALV) by retrospectively analyzing clinical data from patients treated at a hospital over 14 years, focusing on their characteristics, diagnosis, and treatment outcomes.* -
- Out of 48 patients with ALV, 10 underwent staged surgical operations, including labiectomy and lymphatic procedures, with evaluations conducted to track improvements in symptoms like swelling and fluid leakage.* -
- The findings indicated a median age of 60 years among patients, most having a history of pelvic malignancies and radiotherapy, with common symptoms like blisters and lymphatic obstruction observed through imaging studies.*
Cystic Angiomyofibroblastoma of the Uterus Mimicking Ovarian Cancer.
Medicina (Kaunas)
October 2024
Institute of Medical Science, Gyeongsang National University, Jinju 52727, Republic of Korea.
Article Synopsis
- - Angiomyofibroblastoma (AMFB) is a very rare benign tumor found in the lower genital tract, mainly affecting premenopausal women and usually requires surgical removal.
- - A unique case involved a 51-year-old woman with breast cancer who had a large pelvic mass, which turned out to be AMFB in the uterus, confirmed through histopathology and immunohistochemical analysis.
- - This case emphasizes the need for accurate diagnosis of AMFB, as it can mimic other tumors like aggressive angiomyxoma, and suggests potential connections with uterine myomas that need further research.
The value of a multimodal approach combining radical surgery and intraoperative radiotherapy in the recurrence treatment of gynecological malignancies - analysis of a large patient cohort in a tertiary care center.
Radiat Oncol
October 2024
Department of Obstetrics and Gynecology, Medical Center, University of Freiburg, Freiburg, Germany.
Article Synopsis
- Recurrent gynecological cancers often have a poor prognosis, especially when complications like pelvic local recurrence occur after treatment; therefore, locoregional control is crucial for improving patient outcomes.
- This study analyzed 40 patients who underwent surgery and intraoperative radiotherapy (IORT) from 2010 to 2022, measuring outcomes such as locoregional control, overall survival, and time without distant metastases.
- Results indicated that cervical carcinoma was the most common, with 60% of patients having no residual tumor after treatment, while factors like age, disease-free intervals, and IORT techniques were assessed for their impact on survival outcomes.
Surgical outcomes and morbidity in open and videoendoscopic inguinal lymphadenectomy in vulvar cancer: A systematic review and metanalysis".
Eur J Surg Oncol
October 2024
Unit of Gynecologic Oncology, National Cancer Institute, IRCCS - Fondazione "G. Pascale", Naples, Italy.
Article Synopsis
- * The meta-analysis included data from 17 studies, revealing that VEIL had significantly lower rates of major complications compared to OIL (12.6% vs. 41.1%), though other factors like blood loss and hospital stay were similar between the two methods.
- * While VEIL appears to be a safer option, OIL is quicker, making it a valid alternative; further randomized trials are needed to better assess these outcomes.
Non-surgical management of recurrent Paget's disease of the vulva: A case report.
Gynecol Oncol Rep
October 2024
Division of Gynecologic Oncology, The Ohio State University Wexner Medical Center and James Cancer Hospital, United States.
Article Synopsis
- Paget's Disease of the Vulva is a rare condition that can recur and may indicate more serious health issues, requiring thorough investigation and treatment.
- Surgery is typically the first line of treatment, but some patients may opt for non-surgical methods like topical imiquimod, which can be poorly tolerated due to side effects.
- This case report highlights a successful treatment approach using a combination of imiquimod and Silver Sulfadiazine for a patient with extensive, recurrent Paget's disease who preferred to avoid surgery.
Recurrent multisystem Langerhans cell histiocytosis involving the female genitalia: A case report.
World J Clin Cases
October 2024
Department of Gynecologic Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing Cancer Institute, Chongqing Cancer Hospital, Chongqing 400030, China.
Article Synopsis
- * A 52-year-old woman was diagnosed with recurrent multisystem LCH after presenting with bilateral vulvar masses, following a previous diagnosis of a single-system LCH treated surgically in 2021.
- * The patient's treatment included six cycles of chemotherapy leading to partial remission, highlighting the need for thorough imaging and a collaborative approach to diagnosis and treatment in managing recurrent LCH cases.
Lymph node ratio as an indicator of nodal status in the assessment of survival and recurrence in vulvar cancer: A cohort study.
Womens Health (Lond)
September 2024
Department of Surgical Oncology, Salah Azaiez Institute, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia.
Article Synopsis
- Inguinal lymph node metastasis and the number of metastatic lymph nodes (NMLN) are key prognostic factors in vulvar squamous cell carcinoma (VSCC), but the lymph node ratio (LNR) also reflects lymphadenectomy effectiveness.
- This study analyzed data from 192 VSCC patients to assess the impact of LNR and lymph node count on overall survival (OS) and recurrence-free survival (RFS).
- Results indicated significant findings with a 5-year OS of 52.5% and 5-year RFS of 55.8%, highlighting LNR, FIGO stage, and negative margins as critical independent prognostic factors.
Case report: Staged tension-reducing excision of giant acquired vulvar lymphangioma secondary to cervical cancer surgery.
Front Oncol
September 2024
State Key Laboratory of Traditional Chinese Medicine Syndrome/Department of Gynecology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Article Synopsis
- Acquired vulvar lymphangioma (AVL) is a rare condition resulting from damage to deep lymphatic vessels, causing swelling and discharge, often leading to misdiagnosis.
- A 53-year-old woman developed AVL seven years after cervical cancer surgery, showing significant vulvar enlargement and drainage, which was confirmed through biopsy.
- The case highlights the need for awareness of AVL post-surgery, and the successful staged excision approach could inform future treatment protocols for similar cases.
Clinical, radiological, and pathological features of mitotically active cellular fibroma of ovary: A review of cases with literature review.
Taiwan J Obstet Gynecol
September 2024
Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan, South Korea; Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea. Electronic address:
Article Synopsis
- The study focuses on mitotically active cellular fibroma (MACF) of the ovary, detailing its clinical, radiological, and pathological characteristics through the analysis of 11 cases between 2015 and 2022.
- The median patient age was 53.7 years, with most presenting symptoms being abdominal pain; tumor sizes varied, and preoperative imaging often misidentified the tumors.
- Results indicate that MACF generally has a benign outcome, and fertility-sparing surgical options are effective, with no disease relapses observed during follow-up, highlighting the importance of intraoperative frozen section for accurate diagnosis.
Article Synopsis
- The text provides a detailed overview of surgical treatment options for recurrent gynecological cancers, specifically focusing on malignancies affecting the ovaries, fallopian tubes, uterus, cervix, vagina, and vulva, excluding breast cancers.
- It emphasizes the importance of a multidisciplinary approach when determining the best surgical treatment, taking into account various individual prognostic factors.
- The decision-making process for treatment should involve discussions among a specialized oncogynecological commission to tailor strategies to each patient's unique situation.
Value of surgical lymph node assessment for patients with vulvar melanoma.
Eur J Cancer
October 2024
Division of Gynecologic Oncology, Stony Brook Medicine, Stony Brook, NY, USA. Electronic address:
Article Synopsis
- The study aimed to evaluate the impact and effectiveness of lymphadenectomy/sampling (LND) in patients diagnosed with vulvar melanoma, analyzing data from 2004-2015 to compare clinical characteristics and survival outcomes.
- Out of 1286 patients, 62.8% underwent LND, with those who had the procedure being generally younger, more likely to have private insurance, and presenting with more severe tumor characteristics.
- Results indicated that patients who underwent LND had significantly better overall survival (median of 49.08 months) compared to those who did not (35.91 months), suggesting that LND contributes positively to survival rates in vulvar melanoma cases.
Vulvar Paget's disease: A population-based cancer registry descriptive study.
J Gynecol Obstet Hum Reprod
December 2024
Department of Dermatology, University Hospital, Besançon, France; Inserm 1098 RIGHT, University of Franche Comté, Besançon, France. Electronic address:
Article Synopsis
- Vulvar Paget's Disease (VPD) is a rare skin cancer with good outcomes but high recurrence rates, affecting patients' quality of life.
- A study conducted in Franche Comté examined data from 21 patients diagnosed with VPD over 40 years, revealing that many experienced a delayed diagnosis and had a significant likelihood of recurrence, especially after surgical treatment.
- The use of postoperative adjuvant therapies notably improved patients' chances of remaining free from recurrence, highlighting the importance of thorough follow-up care.
Video-endoscopic inguinal sentinel lymph node biopsy with indocyanine green in vulvar cancer.
Int J Gynecol Cancer
August 2024
UOC Ginecologia Oncologica, Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Squamous Cell Carcinoma In Situ-The Importance of Early Diagnosis in Bowen Disease, Vulvar Intraepithelial Neoplasia, Penile Intraepithelial Neoplasia, and Erythroplasia of Queyrat.
Diagnostics (Basel)
August 2024
Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Article Synopsis
- - Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer, with early recognition being crucial as delayed diagnosis can lead to more aggressive forms and surgical complications.
- - Bowen's disease (BD) is an early stage of cSCC that shows specific skin features, but histopathology is essential for accurate diagnosis and treatment planning.
- - Diagnosing precancerous conditions like vulvar and penile intraepithelial neoplasia (VIN and PeIN) can be complex, often requiring multiple biopsies and utilizing techniques like immunostaining and HPV testing to guide treatment options.
An Unusual Vulvar Mass in a Middle-Aged Woman: Challenge.
Am J Dermatopathol
September 2024
The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
An Unusual Vulvar Mass in a Middle-Aged Woman: Answer.
Am J Dermatopathol
September 2024
Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Optimizing and harmonizing lymph node dissection and radiotherapy in advanced vulvar cancer.
Gynecol Oncol
August 2024
Department of Surgery, Division of Gynecologic Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA.