13,045 results match your criteria: "Surgical Treatment of Parkinson Disease"
Foot-Floor Contact Sequences: A Metric for Gait Assessment in Parkinson's Disease after Deep Brain Stimulation.
Sensors (Basel)
October 2024
Department of Neuroscience "Rita Levi Montalcini", University of Turin, 10126 Turin, Italy.
Digital gait monitoring is increasingly used to assess locomotion and fall risk. The aim of this work is to analyze the changes in the foot-floor contact sequences of Parkinson's Disease (PD) patients in the year following the implantation of Deep Brain Stimulation (DBS). During their best-ON condition, 30 PD patients underwent gait analysis at baseline (T0), at 3 months after subthalamic nucleus DBS neurosurgery (T1), and at 12 months (T2) after subthalamic nucleus DBS neurosurgery.
View Article and Find Full Text PDFComparison of the Burdens and Attitudes Between Standard and Web-Based Remote Programming for Deep Brain Stimulation in Parkinson Disease: Survey Study.
JMIR Aging
October 2024
Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No. 197 Ruijin Second Road, Shanghai (Yongjia Intersection), Shanghai, 200025, China, 86 021-64370045.
Article Synopsis
- Remote programming for implantable pulse generators allows online adjustments for Parkinson patients post-DBS surgery, but patient attitudes and needs regarding this method remain unclear.
- A web-based survey was conducted with 463 Parkinson patients, revealing that many faced logistical burdens with standard programming but a significant portion favored remote programming despite some challenges.
- Results showed that 62% of those who tried remote programming preferred it, highlighting the need for clinicians to address issues such as prescription access and insurance coverage to fully benefit from this technology.*
BMI and deep brain stimulation: A comprehensive review and future directions with AI integration.
Neurosurg Rev
October 2024
Fatima Jinnah Medical University, Lahore, Punjab, 54000, Pakistan.
Deep brain stimulation (DBS) has revolutionized the treatment of movement disorders, including Parkinson's disease (PD), essential tremors, dystonia, and treatment-refractory obsessive-compulsive disorder (OCD). This systematic review and meta-analysis aimed to assess the impact of DBS on Body Mass Index (BMI). Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines, data from 49 studies were reviewed, with 46 studies specifically focusing on BMI and DBS.
View Article and Find Full Text PDFProspective Connectomic-Based Deep Brain Stimulation Programming for Parkinson's Disease.
Mov Disord
December 2024
Department of Neurosurgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Background: Efficacy of deep brain stimulation (DBS) relies on accurate lead placement as well as optimization of the stimulation parameters. Although clinical software tools are now available, programming still largely relies on a monopolar review, a tedious process for both patients and programmers.
Objective: This study investigates the safety and feasibility of prospective automated connectomic DBS programming (automated connectomic programming [ACP]), focusing on the recruitment of specific white matter pathways.
Multiomics approach discloses lipids and metabolites profiles associated to Parkinson's disease stages and applied therapies.
Neurobiol Dis
November 2024
Institute of Genetics and Biophysics "Adriano Buzzati-Traverso", National Research Council, Naples, Italy; IRCCS INM Neuromed, Pozzilli, IS, Italy. Electronic address:
Article Synopsis
- The study investigates the lipid and metabolite profiles in Parkinson's disease (PD) patients to uncover new pathways and potential biomarkers for early detection and treatment.* -
- It highlights significant differences in lipid profiles among three groups (No L-Dopa, L-Dopa, and DBS) with findings that show increases in specific lipid species, particularly with deep brain stimulation (DBS) treatment.* -
- The research also reveals dysregulation in amino acid metabolism, especially L-glutamic acid, suggesting that DBS may positively influence glutamate levels, offering insights for future PD diagnosis and therapies.*
Mesenchymal stromal cells deliver HS-enhanced Nrf2 via extracellular vesicles to mediate mitochondrial homeostasis for repairing hypoxia-ischemia brain damage.
Free Radic Biol Med
November 2024
Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, PR China. Electronic address:
Article Synopsis
- Mesenchymal stromal cells (MSCs) are being investigated for their potential to treat neurological diseases through their extracellular vesicles (EVs), particularly in conditions of hypoxia-ischemia (HI) brain damage.
- In this study, modified EVs from MSCs preconditioned with NaHS reduced oxidative stress and improved mitochondrial function in HI mice when delivered intranasally, compared to regular EVs.
- The mechanism involved the upregulation of the Nrf2 protein, which was loaded into EVs, leading to enhanced delivery of this antioxidant to neurons, and the research shows that knocking down Nrf2 in MSCs weakened the therapeutic effects of HS-EVs.
Lineage tracing of stem cell-derived dopamine grafts in a Parkinson's model reveals shared origin of all graft-derived cells.
Sci Adv
October 2024
Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, Lund Stem Cell Center, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Article Synopsis
- Stem cell therapies for Parkinson's disease are progressing, with new clinical trials starting to test human pluripotent stem cells for creating transplantable dopamine-producing cells.
- These dopamine progenitor cells initially appear uniform but develop into a mix of different cell types after being transplanted into patients.
- Research using advanced techniques like RNA-seq has revealed that key components of these grafts, including dopamine neurons and astrocytes, originate from a single type of precursor cell that can become multiple cell types.
Stem Cell Interventions in Neurology: From Bench to Bedside.
J Alzheimers Dis
October 2024
Department of Neuroscience, Developmental and Regenerative Biology, University of Texas at San Antonio, San Antonio, TX, USA.
Article Synopsis
- - Stem cell therapies are changing how we treat various neurological and age-related disorders, focusing on neural and mesenchymal stem cells for diseases like stroke, Alzheimer's, and Parkinson's.
- - The review highlights the fundamental features of stem cells, such as their ability to self-renew and differentiate, and discusses advancements like induced pluripotent stem cells that enhance treatment possibilities.
- - Despite promising results, the research faces challenges in translating findings from animal studies to human applications and calls for further exploration of new areas like stem cell-derived exosomes.
Parkinson's Disease Treatment: A Bibliometric Analysis.
Cureus
September 2024
Neurosurgery, Fluminense Federal University, Niterói, BRA.
Article Synopsis
- - Parkinson's disease (PD) is a progressive neurological condition leading to both motor symptoms (like tremors and stiffness) and non-motor symptoms that affect daily living, with an increasing prevalence, especially in older populations.
- - A review of treatment options for PD shows an uptick in research since 2000, peaking from 2011 to 2016, with significant contributions from the U.S., China, Canada, and the U.K.
- - The study used a bibliometric analysis of over 3,700 PD publications to identify key researchers, trends in pharmacological therapies, and the impact of major institutions on current research and treatment methodologies.
Application of multimodal deep learning and multi-instance learning fusion techniques in predicting STN-DBS outcomes for Parkinson's disease patients.
Neurotherapeutics
October 2024
Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui Province, PR China; Anhui Province Key Laboratory of Brain Function and Brain Disease, Hefei, Anhui Province, PR China. Electronic address:
Parkinson's Disease (PD) is a progressive neurodegenerative disorder with substantial impact on patients' quality of life. Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for advanced PD, but patient responses vary, necessitating predictive models for personalized care. Recent advancements in medical imaging and machine learning offer opportunities to enhance predictive accuracy, particularly through deep learning and multi-instance learning (MIL) techniques.
View Article and Find Full Text PDFArticle Synopsis
- Thiocolchicoside (THC) is a semi-synthetic muscle relaxant derived from the plant colchicoside, used to treat various conditions like arthritis, trauma, and muscle spasms.
- It possesses anti-inflammatory properties but has usage restrictions due to potential negative effects, including risks during pregnancy and male infertility.
- The study aims to evaluate THC's muscle relaxant effects in Wistar rats, comparing its efficacy against diazepam using a rotarod apparatus to measure retention time.
Does Surgical Treatment for Benign Prostate Enlargement (BPE)-Related Bladder Outlet Obstruction (BOO) Benefit Patients with Central Nervous System Diseases? A Systematic Review.
J Clin Med
September 2024
Department of Urology, Hippokrateion Hospital of Thessaloniki, 54642 Thessaloniki, Greece.
Article Synopsis
- * This study aimed to determine the benefits of prostate surgery for men with CNS diseases experiencing BPE-related BOO, using a systematic review of relevant literature spanning from 1946 to July 2023.
- * Out of 1572 abstracts, 13 studies on 1144 patients were included, with the highest success rate for surgery observed in spinal cord injury (81.4%), followed by multiple systemic atrophy (66.7%) and the lowest in Parkinson's disease (27
Functional and postoperative outcomes in ideal pouch-anal anastomosis in patients with parkinson disease and multiple sclerosis.
Langenbecks Arch Surg
October 2024
Department for Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic Main Campus, 9500 Euclid Ave, A30, Cleveland, OH, 44122, USA.
Introduction: Patients with multiple sclerosis and Parkinson's disease may experience pelvic floor dysfunction and constipation which can affect ileoanal pouch emptying. This can lead to complications such as pouchitis, pouch dysfunction, and failure. We hypothesized that patients with neurological diseases have a higher rate of pouch failure and complications than healthy controls.
View Article and Find Full Text PDFThe zona incerta system: Involvement in Parkinson's disease.
Exp Neurol
December 2024
Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, School of Basic Medicine, Institute of Brain Science and Disease, Qingdao University, Qingdao, China. Electronic address:
Article Synopsis
- Parkinson's disease involves the degeneration of dopamine systems, leading to worsening motor and nonmotor symptoms, primarily affecting the basal ganglia.
- Recent research highlights the zona incerta (ZI) as a significant target for therapies like subthalamotomy and deep brain stimulation (DBS), which have shown promise in improving symptoms like rigidity, tremors, and even nonmotor issues like pain and anxiety.
- Animal studies utilizing advanced techniques reveal the critical roles of different neuron types in the ZI and their effects on movement and coordination, indicating a need for further exploration and discussion of controversies in the field.
Letter to the Editor: "Efficacy of subthalamic deep brain stimulation programming strategies for gait disorders in Parkinson's disease: A systematic review and meta-analysis".
Neurosurg Rev
October 2024
Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, India.
Article Synopsis
- The letter praises a recent systematic review on deep brain stimulation (DBS) for gait disorders in Parkinson's disease, emphasizing its thoroughness.
- It suggests that future research should aim to standardize classifications of gait disorders and include long-term studies to better understand the lasting effects of DBS.
- The author also recommends exploring adaptive DBS systems and using advanced neuroimaging techniques to deepen insights into neural changes after DBS, which could enhance treatment for patients.
Exploring adverse effects of deep brain stimulation: the need for personalized care and long-term monitoring.
Neurosurg Rev
October 2024
MBBS, Islamic International Medical College, Rawalpindi, Pakistan.
Article Synopsis
- Deep Brain Stimulation (DBS) is an FDA-approved treatment mainly for movement disorders like Parkinson's Disease, but it's being used more for other neurological and psychiatric issues.
- A recent meta-analysis showed that patients, particularly those with Parkinson's, experienced a significant increase in Body Mass Index (BMI) after DBS, but the study's varied results and lack of diversity raise questions about its broader applicability.
- DBS treatment may lead to several side effects, including motor complications, cognitive decline, and psychiatric issues, highlighting the need for tailored treatment plans and thorough patient evaluations before and after the procedure.
Evaluating a motor progression connectivity model across Parkinson's disease stages.
J Neurol
November 2024
Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt- Universität Zu Berlin, Berlin, Germany.
Background: Stimulation of a specific site in the dorsolateral subthalamic nucleus (STN) was recently associated with slower motor progression in Parkinson's Disease (PD), based on the deep brain stimulation (DBS) in early-stage PD pilot clinical trial. Here, subject-level visualizations are presented of this early-stage PD dataset to further describe the relationship between active contacts and motor progression. This study also evaluates whether stimulation of the sweet spot and connectivity model associated with slower motor progression is also associated with improvements in long-term motor outcomes in patients with advanced-stage PD.
View Article and Find Full Text PDFLow-beta versus high-beta band cortico-subcortical coherence in movement inhibition and expectation.
Neurobiol Dis
October 2024
Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK; Department of Human Movement Sciences, Vrije Universiteit Amsterdam, 1081, BT, Amsterdam, the Netherlands; Department of Neurology, Amsterdam University Medical Centers, Amsterdam Neuroscience, University of Amsterdam, 1105, AZ, Amsterdam, the Netherlands. Electronic address:
Article Synopsis
- Beta band oscillations in the sensorimotor cortex and subthalamic structures are important for controlling movement, with low-beta and high-beta frequencies potentially reflecting different neural pathways.
- A study with Parkinson's patients used deep brain stimulation and magnetoencephalography to investigate these frequency bands during a go/nogo task, revealing that low-beta coherence is more associated with executing movements, while high-beta coherence was linked to unexpected inhibitory responses.
- The findings suggest that low-beta coherence plays a critical role in facilitating motor function, whereas high-beta coherence needs more research to determine its exact role in movement inhibition.
Letter to the editor: "Deep brain stimulation of the subthalamic nucleus under general anesthesia versus local anesthesia in the treatment of Parkinson's disease: a meta-analysis of randomized clinical trials".
Neurosurg Rev
October 2024
Department of Dental Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 602105, Tamil Nadu, India.
Cognitive phenotyping of GBA1-Parkinson's disease: A study on deep brain stimulation outcomes.
Parkinsonism Relat Disord
November 2024
Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Movement Disorders Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Spain; Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED, Carlos III Health Institute (ISCIII), Madrid, Spain; Department of Medicine Autonomous University of Barcelona, Barcelona, Spain; Faculty of Health Sciences, Universitat Oberta de Catalunya (UOC), Barcelona, Spain.
Background: Heterozygous variants in the glucocerebrosidase (GBA1) gene are the most common genetic risk factor for Parkinson's Disease (PD). GBA1-PD patients exhibit earlier disease onset, severe motor impairment, and heightened cognitive decline. Deep Brain Stimulation (DBS) offers motor improvement for PD patients, but its cognitive effects, particularly in GBA1-PD, are debated.
View Article and Find Full Text PDFEffect of deep brain stimulation on sexual dysfunction among patients who had Parkinson's disease: a systematic review and meta-analysis.
Neurol Res
December 2024
Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Background: Patients who have Parkinson's disease (PD) present several non-motor issues, such as sexual dysfunction. Deep brain stimulation (DBS) is a great treatment for PD and could affect both motor and non-motor symptoms of patients.
Aim: The main goal of the current study is to evaluate the impact of DBS on the sexual dysfunction among patients with PD.
Enhancements in Parkinson's Disease Management: Leveraging Levodopa Optimization and Surgical Breakthroughs.
Curr Drug Targets
September 2024
University Institute of Pharma Sciences (UIPS), Chandigarh University NH-95, Chandigarh Ludhiana Highway, Mohali Punjab, India.
Article Synopsis
- Parkinson's disease (PD) is a complex neurological disorder influenced by genetics, environment, and behavior, with focus on its onset, diagnosis, therapy, and progression.
- The review highlights key pathogenic mechanisms, including reactive microgliosis and the role of protein aggregation in dopaminergic cell function due to mutations in genes like UCH-L1, parkin, and α-synuclein.
- It discusses promising therapeutic developments such as neuroprotective drugs and techniques like Deep Brain Stimulation (DBS), while also addressing non-motor symptoms that significantly affect patients’ quality of life.
Current and future applications of local field potential-guided programming for Parkinson's disease with the Percept™ rechargeable neurostimulator.
Neurodegener Dis Manag
October 2024
Icahn School of Medicine at Mount Sinai, Mount Sinai West, 1000 10th Avenue, Suite 10C, New York, NY 10019, USA.
Deep brain stimulation (DBS) has been established as an effective neuromodulatory treatment for Parkinson's disease (PD) with motor complications or refractory tremor. Various DBS devices with unique technology platforms are commercially available and deliver continuous, open-loop stimulation. The Percept™ family of neurostimulators use BrainSense™ technology with five key features to sense local field potentials while stimulating, enabling integration of physiologic data into the routine practice of DBS programming.
View Article and Find Full Text PDFNeuropsychology and Movement Disorders.
Neurol Clin
November 2024
Department of Clinical Neuropsychology, Barrow Neurological Institute, 222 West Thomas Road, Suite 315, Phoenix, AZ 85013, USA. Electronic address:
Article Synopsis
- - Neuropsychology plays a crucial role in diagnosing and planning treatment for patients with movement disorders, as well as in their surgical assessments and providing support for their families.
- - The text examines the cognitive profiles associated with various movement disorders, highlighting how these profiles can affect patient care.
- - It also discusses relevant research on neurosurgery and cognitive-enhancing medications that may benefit individuals suffering from movement disorders.
Direct conversion of human umbilical cord mesenchymal stem cells into dopaminergic neurons for Parkinson's disease treatment.
Neurobiol Dis
October 2024
Department of Cell Biology, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China. Electronic address:
Article Synopsis
- Parkinson's disease is a neurodegenerative disorder caused by a lack of dopamine, and stem cell differentiation therapy shows promise for treating its symptoms by generating functional neurons.
- Researchers developed a one-step system using a cocktail of chemicals (YFBP) to convert human umbilical cord stem cells into dopaminergic neurons without altering their genes, achieving over 80% successful differentiation.
- After being implanted in mice with Parkinson's, these chemically induced neurons not only survived and demonstrated typical neuronal activity but also improved movement disorders by increasing dopamine levels in the brain.