428 results match your criteria: "Surgical Research Center[Affiliation]"

The accurate staging of liver fibrosis is crucial for managing chronic liver disease (CLD). Although magnetic resonance elastography (MRE) is the reference standard for noninvasive fibrosis assessment, its cost, specialized hardware, and operational demands restrict accessibility. In contrast, two-dimensional shear-wave elastography (2D-SWE) is more affordable, accessible, and widely integrated into routine ultrasound systems.

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The article presents a clinical case of secondary cardiomyopathy in an HIV patient with plasmablastic lymphoma due to the combined pathology (HIV infection with ongoing antiretroviral therapy in combination with antitumor therapy), in which the use of multimodal imaging contributed to establishing the correct diagnosis and excluding the unjustified use of invasive methods for diagnosing ischemic heart disease.

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Purpose: This study aimed to compare the treatment outcomes of the closure methods between pre and post-eras of bedside wound retractor silo placement technique (BSC).

Methods: This retrospective cohort study included infants diagnosed with gastroschisis from 2006-2013, pre-BSC era, and from 2014-2021, BSC era. Infants who had fetal anomalies did not survive before receiving treatment and were treated with the delayed closure method were excluded.

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A comparison of walking performance between individuals with and without asymptomatic peripheral artery disease using the six-minute walk test and the incremental shuttle walk test.

Sci Prog

December 2024

Neuro-Musculoskeletal, Chronic Disease, and Aging Research Engagement Center (I-CARE center), Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.

Objective: Two walking tests including the six-minute walk test (6MWT) and the incremental shuttle walk test (ISWT) are widely used to evaluate functional ability in individuals with disease conditions. However, it remains unclear whether these walking tests effectively manifest clinical impairment in individuals with asymptomatic peripheral artery disease (PAD). We aimed (i) to compare the walking performance of individuals with and without asymptomatic PAD using the 6MWT and ISWT, and (ii) to investigate the correlation between ankle-brachial index and toe-brachial index (ABI-TBI) and the walking distance.

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Article Synopsis
  • * Data from 356 patients were analyzed, revealing that the 30-day amputation rates were comparable between PF (12.5%) and NPF (10%) groups, but PF patients had significantly lower overall survival rates within 30 days and long-term (1 and 5 years) compared to NPF.
  • * Additionally, wound infection rates were higher in the PF group (5.5%) than in the NPF group (1.7%), suggesting
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Article Synopsis
  • The study assessed how the COVID-19 pandemic affected the head injury fast-track system and surgical outcomes by comparing patient data before and during the pandemic.
  • A total of 128 patients were analyzed from the prepandemic period and 119 from the pandemic period, showing longer emergency room processing times during COVID but no significant changes in mortality or functional outcomes.
  • Though there were delays in treatment during the pandemic, the overall health outcomes for head injury patients remained comparable to the prepandemic period.
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Background:  Aggressive surgical methods for acute type A aortic dissection (ATAD) can cause extended operating times and postoperative complications. less extensive techniques may increase the risk of needing further aortic reintervention. To prevent the need for extensive aortic arch surgery and subsequent re-sternotomy, hemiarch replacement (HAR) with innominate artery (a.

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Advances in sarcopenia and urologic disorders.

Front Nutr

November 2024

Department of Urology, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University School of Medicine, Nanjing, China.

Article Synopsis
  • Sarcopenia is the decline in muscle strength, mass, and function, increasing the risk of injury and chronic health issues, which can severely affect a person's quality of life and longevity.
  • New research shows a strong connection between sarcopenia and urinary tract disorders, indicating that each condition can exacerbate the other, creating a harmful cycle.
  • This review aims to define sarcopenia, outline diagnostic methods, and explore its relationship with both benign and malignant urinary diseases, highlighting its significance for effective management and prognosis.
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Background/aims: Endoscopic sphincterotomy (EST) is a standard treatment for common bile duct (CBD) stones. Endoscopic sphincterotomy combined with endoscopic papillary large balloon dilation (EST-EPLBD) is an effective treatment for difficult CBD stones. This study aims to evaluate and compare the effectiveness and adverse effects of EST-EPLBD and EST in treating large CBD stones.

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Objective: The aim of this study was to assess the seroconversion rate and percent inhibition of neutralizing antibodies against the wild-type and Omicron variants of SARS-CoV-2 in patients with solid cancer who received two COVID-19 vaccine doses by comparing chemotherapy and nonchemotherapy groups.

Methods: This prospective cohort study enrolled 115 cancer patients from Maharaj Nakorn Chiang Mai Hospital, Sriphat Medical Center, Faculty of Medicine, Chiang Mai University, and Chiang Mai Klaimor Hospital, Chiang Mai, Thailand, between August 2021 and February 2022, with data from 91 patients who received two COVID-19 vaccine doses analyzed. Participants received vaccines as part of their personal vaccination programs, including various mRNA and non-mRNA vaccine combinations.

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Outcomes of fenestration versus none in extracardiac total cavopulmonary connection.

Asian Cardiovasc Thorac Ann

November 2024

Division of Cardiovascular and Thoracic Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Background: Fenestrated total cavopulmonary connection has gained popularity due to its capacity to reduce systemic venous pressure and enhance cardiac output. However, there is ongoing debate about the immediate and long-term advantages of fenestration in this context.

Method: A retrospective cohort study was conducted involving 97 patients who underwent extracardiac total cavopulmonary connection at Chiang Mai University Hospital between January 1999 and December 2019.

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This study aimed to explore the impact of PM 2.5 exposure on survival, post-operative outcomes, and tumor recurrence in resectable non-small cell lung cancer (NSCLC) patients. The study cohort comprised 587 patients at Chiang Mai University Hospital between January 1, 2010, and December 31, 2017.

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Background: Bone Morphogenetic Proteins and the related Growth and Differentiation Factors (GDFs) are much conserved signaling proteins. GDF5 is pivotal for skeletal development. Several skeletal dysplasia and malformation syndromes are known as a result of mutations in .

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Article Synopsis
  • A study in rural Northern Thailand explored how arterial stiffness affects health-related quality of life (HRQoL) in older adults with HIV, highlighting elevated cardiovascular risks among this group.
  • 338 participants aged 50 and over were tracked over five years, with findings indicating that higher arterial stiffness (CAVI ≥8) was linked to lower physical and mental health scores compared to those with normal levels (CAVI <8).
  • The study emphasizes the need for regular screening and comprehensive care strategies to address cardiovascular risks in older adults with HIV, although its findings may not be widely applicable due to regional limitations and participant dropout.
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Alterations of senescence-associated markers in patients with non-syndromic cleft lip and palate.

Sci Rep

September 2024

Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.

Article Synopsis
  • Non-syndromic cleft lip with or without palate (NSCL/P) is a common birth defect, potentially influenced by abnormal DNA methylation in pregnant mothers.
  • The study involved 39 NSCL/P patients and 33 mothers, analyzing Alu methylation and cellular aging markers in blood and tissue samples.
  • Findings showed specific patterns of Alu methylation changes in patients with cleft lip and palate, indicating the mother's methylation status may contribute to the severity of the child's cleft condition.
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Background: There is growing evidence that local recurrence after radiotherapy often occurs within the dominant intraprostatic lesions (DILs) in prostate cancer. This study aimed to evaluate the dose difference between DILs defined by Magnetic Resonance-guided and arc-based Intensity Modulated Radiation Therapy (IMRT) and to assess the association between the dose difference and biochemical recurrence-free survival.

Materials And Methods: Between 2015 and 2019, 48 prostate cancer patients with DILs visible from multiparametric Magnetic Resonance Imaging (mpMRI) underwent arc-based IMRT with 70 Gy (2.

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Background: This study aims at investigating and evaluating the categorical knowledge of residency using an internet-based examination.

Methods: All in-training examinees from 32 Thailand's general surgery residency training institutions participating in the online examination. One hundred fifty Multiple Choice questions (MCQs) were selected for this examination from a pool of previous MCQs used for board certification examinations.

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Introduction: Sepsis is a significant and common cause of death and burden among critically ill patients, which has increasing incidence and mortality in adults over 60 and advanced age. This study aimed to develop an easy-to-use clinical tool for assessing 28-day mortality risk in older sepsis patients upon their initial assessment in the emergency department (ED).

Method: A retrospective cohort study was conducted using electronic medical records of older (≥60 years) ED patients with suspected sepsis from August 1, 2018, to December 31, 2018.

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Article Synopsis
  • The study examines how a multidisciplinary team (MDT) approach impacts the care and outcomes of non-small cell lung cancer (NSCLC) patients, specifically focusing on those who underwent pulmonary resection at a Thai hospital between 2009 and 2021.
  • It compares two groups of patients: those who received standard care before the implementation of the MDT and those who received care after its introduction in March 2018.
  • Results show that the MDT group had better survival rates, shorter waiting times for procedures, and a higher proportion of early-stage patients compared to the non-MDT group, indicating the potential benefits of a team-based approach in cancer care.
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Development of Prediction Model for Hirschsprung-Associated Enterocolitis (HAEC) in Postoperative Hirschsprung Patients.

J Pediatr Surg

December 2024

Division of Pediatric Surgery, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Clinical Surgical Research Center, Faculty of Medicine, Chiang Mai University, Thailand; Clinical Epidemiology and Statistical Statistic Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. Electronic address:

Article Synopsis
  • A study was conducted to create a clinical prediction model for determining the risk of postoperative Hirschsprung-associated enterocolitis (HAEC) within 5 years following surgery in children with Hirschsprung disease.
  • The research included 274 patients, revealing that 27.4% experienced HAEC, with eight significant predictors identified, like gender, weight at surgery, and the type of surgical approach.
  • The prediction model demonstrated promising accuracy (AuROC of 0.749) and established risk categories (low and high), aiding in patient management and follow-up; an online tool was also developed for calculating individual risk.
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Background: Open liver resection necessitates a substantial upper abdominal inverted-L incision, resulting in severe pain and compromising patient recovery. Despite the efficacy of epidural analgesia in providing adequate postoperative analgesia, the potential epidural-related adverse effects should be carefully considered. This study aims to compare the efficacy and safety of continuous epidural analgesia and intravenous analgesia in open liver resection.

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The efficacy of Aescin combined with MPFF for early control of bleeding from acute hemorrhoids, A randomized controlled trial.

Asian J Surg

August 2024

Division of Colorectal Surgery, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Clinical Surgical Research Center, Chiang Mai University, Chiang Mai, Thailand.

Background: Hemorrhoidal disease, affecting over 20 % of the population, presents management challenges due to its multifaceted nature. While treatments like Micronized Purified Flavonoid Fraction (MPFF) show promise, Aescin's efficacy remains uncertain. This study assesses the combined effectiveness of Aescin with MPFF against MPFF alone in treating Grades 1 and 2 hemorrhoids, focusing on halting bleeding and reducing mass effect.

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Association between clinical factors and mortality in older adult trauma patients: A systematic review and meta-analysis.

Am J Surg

October 2024

Department of Surgery, Faculty of Medicine, Chiang Mai University Hospital, Chiang Mai, 50200, Thailand; Clinical Surgical Research Center, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand. Electronic address:

Background: This study reviews and meta-analysis factors affecting mortality in older adult trauma patients, addressing previously unidentified heterogeneity and risk burden.

Methods: Databases (PubMed, Embase, Cochrane and Scopus) were searched for studies from January 1, 2000, to April 30, 2024. Inclusion criteria were patients aged ≥65 years with trauma, assessing survival or death outcomes.

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Clinical Prediction Rules for In-Hospital Mortality Outcome in Melioidosis Patients.

Trop Med Infect Dis

June 2024

Clinical Surgical Research Center, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.

Background: Melioidosis, a disease induced by , poses a significant health threat in tropical areas where it is endemic. Despite the availability of effective treatments, mortality rates remain notably elevated. Many risk factors are associated with mortality.

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Diabetes has a protective effect on abdominal aortic aneurysms (AAAs); however, there are contrasting reports on the impact of diabetes on endovascular aortic repair (EVAR) outcomes, endoleaks (ELs) being the major negative outcome. The present study characterizes ELs and their outcomes in AAA patients, diabetic or not. This single-center, retrospective, comparative study was carried out on 324 AAA patients who underwent elective EVARs between 2007 and 2016 at the University Hospital of Liège (Belgium).

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