411 results match your criteria: "Suresh Gyan Vihar University.[Affiliation]"

Article Synopsis
  • - The Fast Melt Tablet (FMT) is a new type of quickly dissolving tablet that uses cocoa butter to melt at body temperature, enhancing its effectiveness when taken orally.
  • - The study aimed to improve the taste of FMT containing memantine hydrochloride by using artificial sweeteners like aspartame and acesulfame K; six formulations were tested to find the best flavor masking.
  • - Formulation T7, using 30mg of aspartame, was found to effectively mask the bitter taste and has desirable properties for commercialization, showing potential as an easy-to-take treatment for Alzheimer's disease.
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Chilli, one of the most popular vegetables in the world is infested by many insect-pests and diseases. Fipronil, a phenylpyrazole class insecticide is used to manage insect-pests on chilli. The present study aimed to analyze the dissipation patterns and residual concentrations of the fipronil and its metabolites in chilli fruits during the Kharif season of 2020-21, in semi-arid environment.

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Alzheimer's disease is an ailment that is linked with the degeneration of the brain cells, and this illness is the main cause of dementia. Metabolic stress affects the activity of the brain in AD via FOXO signaling. The occurrence of AD will significantly surge as the world's population ages, along with lifestyle changes perceived in current decades, indicating a main contributor to such augmented prevalence.

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Article Synopsis
  • This study explores the third-order fractional nonlinear Schrödinger equation (FNLSE) using a new analytical method (NEDAM) to identify optical soliton solutions in various forms.
  • The researchers focus on understanding nonlinear wave behavior relevant to plasma physics and optics, validating their results with stability assessments and analysis techniques like chaos and bifurcation.
  • The findings contribute to advancements in fields related to nonlinear wave propagation, including Bose-Einstein condensates and ultrafast fibre optics, by providing visual data through 2D, 3D, and contour plots.
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To evaluate the apoptosis-inducing properties of undoped and silver-doped-zinc-oxide nanoparticles (SDZONs) synthesized using against MCF-7 (Luminal-A) and MDA-MB-231 (Triple-negative) breast cancer cell lines. Nanostructures were developed by facile biohydrothermal method and characterized by x-ray diffraction (XRD), Fourier transform infrared (FTIR), and high resolution transmission electron microscopy (HR-TEM). The comparative effect of doping and dose concentration of nanostructures on cytotoxicity was measured using MTT and trypan-blue-exclusion assay.

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Design of in-situ implant for the brain-targeted drug delivery using cross-linked gellan gum polymer through response surface methodology.

Ann Pharm Fr

October 2024

Centre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India; Centre of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates.

Article Synopsis
  • * Various formulations were analyzed using advanced techniques like FTIR and DSC, while optimization was conducted with Design Expert® software.
  • * The final optimized implant showed excellent tissue compatibility, stable drug content, and appropriate viscosity for injections, demonstrating its effectiveness in drug delivery over an extended period.
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This work deals with the synthesis of SnO-modified sugarcane bagasse biochar (SnO-SBB) nanocomposites using an impregnation method. XRD, FTIR, SEM, and EDX analyses were used to characterize the produced nanocomposites. Several factors influencing the removal of malachite green from wastewater the adsorption process were explored to maximize the effectiveness of this process.

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Burnout experience among healthcare workers post third COVID-19 wave in India; findings of a cross-sectional study.

PeerJ

September 2024

Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Alkharj, AR Riyadh Province, Saudi Arabia.

Background: The pandemic exacerbated burnout experienced by healthcare personnel, whose mental health had long been a public health concern before COVID-19. This study used the Copenhagen burnout inventory (CBI) tool to assess burnout and identify predictors among Indian healthcare workers managing COVID-19.

Methods: A cross-sectional study was conducted from June to December 2022, after the third pandemic wave.

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Foodborne diseases triggered by various infectious micro-organisms are contributing significantly to the global disease burden as well as to increasing mortality rates. Salmonella enterica belongs to the most prevalent form of bacteria accountable for significant burden of foodborne illness across the globe. The conventional therapeutic approach to cater to Salmonella enterica-based infections relies on antibiotic therapy, but the rapid emergence of the antibiotic resistance strains of Salmonella sp.

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Liquiritin (LIQ), a bioactive flavonoid from Glycyrrhiza species, has shown significant potential in cancer therapy. LIQ exhibits potent inhibitory effects on various cancer cell types, including breast, lung, liver, and colon cancers, while demonstrating low toxicity towards healthy cells. Its anticancer mechanisms include inducing cell cycle arrest, promoting apoptosis, and modulating inflammation-related pathways.

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Background Objectives: More than 1 million people die every year from vector-borne diseases, which constitute more than 17% of all infectious diseases. This study's primary focus is on the detailed evolutionary history and expression analysis of immune genes, one of the key gene families in the immune system of vectors that play a role in the regulation and interaction of parasites in vector bodies, particularly the mosquitoes that transmit malaria and dengue, significant vector borne disease.

Methods: The vector potentiality and participation of TLR genes in vector parasite interaction in the Indian context will be explained by the differential expression study of this potential gene family in Indian populations of vector species.

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Dengue fever (DF) is a pervasive public health concern in tropical climates, with densely populated regions, such as India, disproportionately affected. Addressing this issue requires a multifaceted understanding of the environmental and sociocultural factors that contribute to the risk of dengue infection. This study aimed to identify high-risk zones for DF in Jaipur, Rajasthan, India, by integrating physical, demographic, and epidemiological data in a comprehensive risk analysis framework.

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Assessment of carbonized himalayan chir pine biomass as an eco-friendly adsorbent for effective removal of industrial dyes.

Sci Rep

July 2024

Department of Theoretical Electrical Engineering and Diagnostics of Electrical Equipment, Institute of Electrodynamics, National Academy of Sciences of Ukraine, 56, Kyiv-57, Peremogy, 03680, Ukraine.

This study investigates the use of carbonized Himalayan Chir Pine Biomass, known as Chir Pine Activated Carbon (CPAC), as an eco-friendly and cost-effective adsorbent for efficient industrial dye removal, with a focus on environmental sustainability. By applying different additive treatments, four adsorbents (C1, C2, C3, and C4) were formulated. CPAC was synthesized through pyrolysis and characterized using various analytical techniques including FE-SEM, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC).

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In this study, we explore the mechanical treatment of two metal-organic frameworks (MOFs), HKUST-1 and MOF-76, applying various milling methods to assess their impact on stability, porosity, and CO adsorption capacity. The effects of different mechanical grinding techniques, such as high-energy ball milling and hand grinding, on these MOFs were compared. The impact of milling time, milling speed and ball size during high-energy ball milling was assessed via the Design of Experiments methodology, namely using a 3 Taguchi orthogonal array.

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Article Synopsis
  • Brucellosis, although primarily affecting various organs, rarely leads to cardiovascular issues, typically appearing as endocarditis in under 2% of cases.
  • A 50-year-old male patient experienced severe symptoms over six months, including fever, weight loss, and heart murmurs, leading to a diagnosis of cardiac involvement due to Brucellosis.
  • The case highlights the importance of early detection and treatment to reduce the risks of complications like heart block and improve patient outcomes.
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Background: The therapeutic effect of NS oil in mild to moderate psoriasis is limited owing to low play load of thymoquinone (<15 %w/w), irritation, dripping, low viscosity and thus, less contact time on the lesions.

Aims: This study aimed at developing and characterizing the ethanolic vesicular hydrogel system of Nigella sativa (NS) oil (NS EV hydrogel) for the enhancement of anti-psoriatic activity.

Objective: The objective of this study was to develop NS EV hydrogel and evaluate its anti-psoriatic activity.

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Objective: Skin cancer refers to the pathological condition characterized by the proliferation of atypical skin cells in an uncontrolled manner. Plant-based products such as bixin although show promising anticancer properties, but maintaining their stability in a formulation is a difficult task. The objective of the research is to formulate a silver nanoparticle gel preparation of bixin and evaluate its anticancer properties.

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Endophytic Fungi: Cellular factories of novel medicinal chemistries.

Bioorg Chem

September 2024

Department of Biological Chemistry, Regional University of Cariri, Crato 63105-000, Brazil. Electronic address:

Inflammation and associated disorders have been a major contributing factor to mortality worldwide. The augmented mortality rate and emerging resistance against the approved therapeutics necessitate the discovery of novel chemistries destined for multiple clinical settings. Cellular factories including endophytic fungi have been tapped for chemical diversity with therapeutic potential.

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From diagnosis to therapy: The critical role of lncRNAs in hepatoblastoma.

Pathol Res Pract

August 2024

Department of Pharmaceutical Chemistry, College of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia. Electronic address:

Article Synopsis
  • Long non-coding RNAs (lncRNAs) play a crucial role in the development of various cancers, particularly in Hepatoblastoma (HB), a rare liver cancer primarily affecting young children, with symptoms like abdominal swelling and weight loss.
  • The study investigates how lncRNAs influence key cellular functions in HB, such as cell growth, death, movement, and treatment resistance, while also considering their potential as both diagnostic markers and therapeutic targets in cancer treatment.
  • Abnormal lncRNA expression has been linked to HB's progression, highlighting their potential roles in early cancer detection and offering new insights for innovative diagnostic and treatment strategies.
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Cancer poses intricate challenges to treatment due to its complexity and diversity. Ferroptosis and circular RNAs (circRNAs) are emerging as innovative therapeutic avenues amid the evolving landscape of cancer therapy. Extensive investigations into circRNAs reveal their diverse roles, ranging from molecular regulators to pivotal influencers of ferroptosis in cancer cell lines.

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The end-to-end process in the discovery of drugs involves therapeutic candidate identification, validation of identified targets, identification of hit compound series, lead identification and optimization, characterization, and formulation and development. The process is lengthy, expensive, tedious, and inefficient, with a large attrition rate for novel drug discovery. Today, the pharmaceutical industry is focused on improving the drug discovery process.

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Exploring the role of the ocular surface in the lung-eye axis: Insights into respiratory disease pathogenesis.

Life Sci

July 2024

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, P.O. Box 123, Broadway, Ultimo, NSW 2007, Australia; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia. Electronic address:

Chronic respiratory diseases (CRDs) represent a significant proportion of global health burden, with a wide spectrum of varying, heterogenic conditions largely affecting the pulmonary system. Recent advances in immunology and respiratory biology have highlighted the systemic impact of these diseases, notably through the elucidation of the lung-eye axis. The current review focusses on understanding the pivotal role of the lung-eye axis in the pathogenesis and progression of chronic respiratory infections and diseases.

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Oxidative Coupling and Self-Assembly of Polyphenols for the Development of Novel Biomaterials.

ACS Omega

May 2024

Pharmacology Unit, Jeffrey Cheah School of Medicine and Health Sciences, Monash University, Jalan Lagoon Selatan, Bandar Sunway, 47500 Selangor Darul Ehsan, Malaysia.

In recent years, the development of biomaterials from green organic sources with nontoxicity and hyposensitivity has been explored for a wide array of biotherapeutic applications. Polyphenolic compounds have unique structural features, and self-assembly by oxidative coupling allows molecular species to rearrange into complex biomaterial that can be used for multiple applications. Self-assembled polyphenolic structures, such as hollow spheres, can be designed to respond to various chemical and physical stimuli that can release therapeutic drugs smartly.

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ncRNAs and their impact on dopaminergic neurons: Autophagy pathways in Parkinson's disease.

Ageing Res Rev

July 2024

Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.

Parkinson's Disease (PD) is a complex neurological illness that causes severe motor and non-motor symptoms due to a gradual loss of dopaminergic neurons in the substantia nigra. The aetiology of PD is influenced by a variety of genetic, environmental, and cellular variables. One important aspect of this pathophysiology is autophagy, a crucial cellular homeostasis process that breaks down and recycles cytoplasmic components.

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Chilli is an indispensable food item in the daily life of humans but it is affected by many insects, so various pesticides, including spiromesifen, are applied to chilli crops to protect this crop from insect infestation. However, the use of pesticides poses environmental and health issues. These issues have raised the demand for pesticide-free chillies among consumers.

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