3,759 results match your criteria: "Suny Downstate Medical Center[Affiliation]"

Optimization of Existing RNA Visualization Methods Reveals Novel Dendritic mRNA Dynamics.

Front Biosci (Landmark Ed)

December 2024

Department of Biological Sciences, Hunter College, City University of New York, New York, NY 10065, USA.

Background: Spatial-temporal control of mRNA translation in dendrites is important for synaptic plasticity. In response to pre-synaptic stimuli, local mRNA translation can be rapidly triggered near stimulated synapses to supply the necessary proteins for synapse maturation or elimination, and 3' untranslated regions (UTRs) are responsible for proper localization of mRNAs in dendrites. Although is a robust technique for analyzing RNA localization in fixed neurons, live-cell imaging of RNA dynamics remains challenging.

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How Ideas About Context and Remapping Developed in Brooklyn.

Hippocampus

January 2025

Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, New York, USA.

In 1979, I joined Jim Ranck's group in Brooklyn and began recording hippocampal neurons. The first project was to record single neurons across three behaviors in different chambers: pellet retrieval on a radial-arm maze, bar-pressing for food reward in an operant chamber, and maternal pup-retrieval in a large home box. We found spatial firing in all three chambers, with a single-neuron's firing pattern unpredictable from one chamber to the next.

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Purpose: To study the effects of anti-VEGF injections on the prevalence of ocular hypertension (OHT), sustained elevated intraocular pressure (SE-IOP), and primary open-angle glaucoma (POAG) with age-matched controls.

Methods: A retrospective case-control study was performed with neovascular age-related macular degeneration (AMD) or diabetic macular edema (DME) against a control group involving atrophic AMD or diabetic retinopathy (DR) without DME. Bevacizumab, ranibizumab, or a combination of both were used in the treatment group.

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We sought to conduct a systematic review of the literature and a meta-analysis of post-operative outcomes following TKA with an all-polyethylene tibial (APT) or a metal-backed tibial component (MBT). A systematic review of the literature was conducted to identify all studies comparing APT and MBT for TKA based upon rates of complications, revisions, reoperation, and patient-reported outcomes. Data was pooled and relative risk of each outcome measure at short (< 5 year), mid (5-10 year), and long (> 10 year) follow-up was calculated.

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Purpose: To identify factors that are associated with no-shows and cancellations in a glaucoma clinic.

Methods: Retrospective observational study of patients seen at a glaucoma clinic over a two-year period (6/2017-5/2019). Demographics and clinic information were recorded from the electronic medical record.

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Objectives: Hurricane Ida delivered record rainfall to the northeast, resulting in 11 deaths in New York City. We review these deaths, identify risk factors, and discuss solutions to prevent recurrence.

Methods: Deaths were confirmed by multiple sources.

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Scholarly activity is a key component of most residency programmes. To establish fundamental research skills and fill gaps within training curricula, we developed an online, asynchronous set of modules called to introduce trainees to various topics that are germane to the conduct of research and evaluated its effectiveness in resident research education. was utilised by residents at One Brooklyn Health in Brooklyn, NY.

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Article Synopsis
  • Late-onset psychosis (LOP) is a complex and poorly understood condition that could stem from late-onset schizophrenia or Alzheimer's disease, making accurate diagnosis crucial for effective treatment.
  • * This study used structural MRI data from 699 healthy individuals and 469 patients with schizophrenia or Alzheimer's to employ data-driven techniques, specifically K-means clustering, to differentiate between these conditions.
  • * Findings indicated that structural differences, such as larger right putamen volumes in schizophrenia patients, could help in distinguishing between AD and SCZ, highlighting the need for better diagnostic tools for LOP.
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A community-based analysis of security practices regarding over-the-counter skincare products in nationwide retail drug stores.

Arch Dermatol Res

December 2024

Dermatology Service, Veterans Affairs New York Harbor Healthcare System Brooklyn Campus, Brooklyn, NY, USA.

Access to over-the-counter (OTC) skincare products is critical for managing a wide range of dermatologic conditions, yet recent trends in urban retail stores may jeopardize this accessibility and exacerbate healthcare disparities. However, the emerging trend of securing skincare products behind security glass in urban retail environments poses significant risks to healthcare equity and accessibility. Herein, we aim to quantify the prevalence of skincare products behind security glass in pharmacies within a 25-mile radius of Times Square, New York City.

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Article Synopsis
  • - The study investigates the optimal timing for starting direct oral anticoagulants (DOACs) for stroke prevention in patients with atrial fibrillation and acute ischaemic stroke, comparing early initiation (around 3.5 days) to later initiation (about 5.7 days) due to concerns about bleeding risks.
  • - An analysis of 11 studies, including 13,020 participants, found that early initiation of DOACs resulted in significantly lower rates of recurrent ischaemic stroke and intracranial hemorrhage compared to the late group.
  • - While key outcomes like major hemorrhage and all-cause mortality showed no significant differences between the groups, the variability in the study designs and limited number of RCT
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Purpose: The National Institute of Health Toolbox Cognition Battery (NIHTB-CB) is increasingly used in Alzheimer disease (AD) research. We examined the relation of AD biomarkers with performance in the NIHTB-CB in late middle age.

Methods: This is a cross-sectional analysis of 334 Hispanic participants aged 64.

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Most physicians appreciate that practicing medicine is a commitment to continuous learning. However, "learning" can be mistakenly understood as simply the acquisition of facts and new knowledge. But learning also necessitates the constant re-examination and challenging of one's existing body of knowledge, as misinformation persists when one's beliefs are not challenged or questioned in the light of new information.

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Background: Peripheral nerve stimulation (PNS) has been used for over 50 years to treat chronic pain by delivering electrical pulses through small electrodes placed near targeted peripheral nerves those outside the brain and spinal cord. Early PNS systems often required invasive neurosurgical procedures. However, since 2015, the Food and Drug Administration (FDA) approved percutaneously implanted PNS leads and neurostimulators  offering a much less invasive, non-opioid option for managing recalcitrant chronic pain.

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Cardiac resynchronization therapy (CRT) has revolutionized heart failure (HF) management, offering benefits in morbidity, mortality, and symptom alleviation. However, optimal response rates are not universally achieved, necessitating enhanced patient-selection strategies. Myocardial scar patterns, quantified by delayed-enhancement cardiac magnetic resonance (DE-CMR), have been implicated in CRT outcomes.

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Carbapenem-resistant Enterobacterales in solid organ transplant recipients.

Am J Transplant

November 2024

Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA. Electronic address:

Carbapenem-resistant Enterobacterales (CRE) are an important threat to the health of solid organ transplant recipients (SOTr); data comparing outcomes of SOTr with CRE to non-SOTr with CRE are lacking. A matched cohort study was performed within 2 prospective, multicenter, cohort studies (Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacterales and Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacterales 2). The epidemiology, desirability of outcome rankings outcomes, and mortality of SOTr and non-SOTr hospitalized in the United States (December 2011-August 2017) with clinical isolates with Centers for Disease Control and Prevention-defined CRE were compared.

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Causal inference methods can be applied to estimate the effect of a point exposure or treatment on an outcome of interest using data from observational studies. For example, in the Women's Interagency HIV Study, it is of interest to understand the effects of incarceration on the number of sexual partners and the number of cigarettes smoked after incarceration. In settings like this where the outcome is a count, the estimand is often the causal mean ratio, i.

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Article Synopsis
  • Cangrelor, an intravenous P2Y12-receptor inhibitor, is compared to traditional antithrombotic medications like eptifibatide in patients undergoing endovascular thrombectomies (EVTs), with previous data being insufficient for direct comparison.
  • A study reviewed clinical data from 1010 EVT patients who received either cangrelor or eptifibatide to assess safety and efficacy, focusing on outcomes like hemorrhagic conversion and functional status using scales like the mRS and NIHSS.
  • Results showed that cangrelor was linked to a lower risk of hemorrhagic conversion and better functional outcomes at discharge and follow-up, indicating its potential benefits over GPIs in this specific medical context
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Liver fibrosis is the pathological deposition of extracellular matrix rich in fibrillar collagen within the hepatocytes in response to chronic liver injury due to various causes. As the condition advances, it can progress to cirrhosis, the late stages of which are irreversible. Multiple pathophysiological mechanisms and cell types are responsible for the progression of liver fibrosis and cirrhosis.

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Optimal treatment of locally advanced cancer of the larynx is controversial. In this study, we aim to compare outcomes in patients with T3-4N0-1 cancer of the larynx who underwent surgery alone versus surgery followed by radiation therapy (RT). A total of 1820 patients with advanced laryngeal cancer were identified from the national Surveillance, Epidemiology, and End Results Database and stratified based on postoperative RT status, and clinical outcomes were compared between these 2 groups.

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The COMPASS scale for the assessment of individuals with first episode psychotic disorders.

Schizophr Res

December 2024

The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Departments of Psychiatry and of Molecular Medicine, Hempstead, NY, USA; The Feinstein Institutes for Medical Research, Institute of Behavioral Science, Manhasset, NY, USA; The Zucker Hillside Hospital, Psychiatry Research, Northwell Health System, Glen Oaks, NY, USA. Electronic address:

Background: Psychosis symptom assessment instruments are rarely used in US mental health community clinical practice despite the advantages of measurement-based care. Barriers include the length of typical scales and that data for scale evaluation often come from researcher and not clinician raters.

Study Design: The 12-item COMPASS symptom assessment was designed for the RAISE-ETP study of early phase psychosis.

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Purpose: To investigate the impact of smartphone viewing distance and angle on reaction times.

Design: A prospective, self-controlled, single-center study.

Methods: Participants engaged in a driving simulation facing a large screen with a simulated brake pedal.

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Background: Coronary heart disease (CHD) is a leading cause of death for Hispanic/Latino populations in the United States. We evaluated polygenic risk scores (PRS) with incident myocardial infarction (MI) in a Hispanic/Latino study sample.

Methods: We leveraged data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) to assess four CHD-PRS from the PGS catalog, derived using multiple methods (LDpred, AnnoPred, stacked clumping and thresholding, and LDPred2).

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The role of aryl hydrocarbon receptor agonists in the treatment of vitiligo.

Arch Dermatol Res

October 2024

Dermatology Service, Veterans Affairs New York Harbor Healthcare System, Brooklyn Campus, Brooklyn, NY, US.

Article Synopsis
  • * Ruxolitinib is the only FDA-approved medication for vitiligo but has serious side effects, highlighting the need for safer alternatives like aryl hydrocarbon receptor (AhR) agonists.
  • * Recent research shows that AhR agonists, particularly tapinarof, promote skin repigmentation and have a better safety profile, but more clinical trials are needed to fully assess their potential in vitiligo treatment.
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