1 results match your criteria: "Sunway University College[Affiliation]"
Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease.
Bioorg Med Chem Lett
June 2006
Sunway University College, Bandar Sunway, 46150, P.J. Selangor, Malaysia.
Article Synopsis
- Boesenbergia rotunda derivatives, specifically 4-hydroxypanduratin A and panduratin A, effectively inhibit the dengue 2 virus NS3 protease with Ki values of 21 and 25 microM.
- Pinostrobin and cardamonin demonstrated non-competitive inhibition against the same protease.
- The structures of the six isolated compounds were determined using NMR and GCMS spectroscopy techniques.