1,037 results match your criteria: "Sunnybrook Health Sciences Center.[Affiliation]"

Background: Some prior studies have found that patients treated by female physicians may experience better outcomes, as well as lower healthcare costs than those treated by male physicians. Physician-patient sex concordance may also contribute to better patient outcomes. However, other studies have not identified a significant difference.

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Objective: Spinal cord injury (SCI) trials have historically underrepresented pediatric patients. There are limited pediatric data examining the influence of surgical timing on complications and mortality for children and adolescents who have sustained complete traumatic SCI.

Methods: The following multicenter cohort study used Trauma Quality Improvement Program data from 2010 to 2020.

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Background And Objectives: Current virtual care guidance lacks specialty-specific considerations. Neurological care is unique due to its reliance on physical examination and complex patient population. Our aim was to determine which factors impact virtual care suitability in neurology, virtual care adoption patterns, and satisfaction with virtual care among neurologists.

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Background And Objective: Breast cancer is the most prevalent cancer among women worldwide, with 45% of them over 65 years old. Older breast cancer patients tend to be underrepresented and understudied in major clinical trials. This narrative review provides a comprehensive overview of the current evidence regarding treatment decision-making, treatment toxicities, and proposed survivorship management recommendations for geriatric cancer patients.

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Objective: To determine the association between residence in racialized neighborhoods with direct healthcare expenditure and days at home (DAH) after moderate to severe traumatic brain injury (TBI).

Summary Background Data: Differences in ethno-racial background have been associated with health outcome disparities. Much of this prior research was conducted in settings without universal healthcare coverage.

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This study aims to estimate real-world clinical practice trends in time to surgery following thoracolumbar spinal cord injury (SCI) in trauma centers across North America over the last decade (2010-2020). A multi-center retrospective observational study was conducted using Trauma Quality Improvement Program data from 2010 to 2020. All surgically treated patients with thoracic and lumbar SCI were included.

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Article Synopsis
  • This study analyzes the time to surgery for patients with complete traumatic cervical spinal cord injuries in North America from 2010 to 2020, using data from trauma centers and focusing on the period post-hospital arrival.
  • Over the decade, the median time to spine surgery decreased by an average of 0.6 hours per year, indicating a trend towards quicker surgical intervention.
  • The research involved 6855 patients and showed a significant annual reduction of 5% in time to surgery, emphasizing the improvement in response time across accredited trauma centers.
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This column is intended to address the kinds of knotty problems and dilemmas with which many scholars grapple in studying health professions education. In this article, we address the dilemma of engaging with foundational works versus depending on summary articles. We argue that an over-dependence on secondary sources can lead to prejudices and unquestioned assumptions, and limit the constructive development of our field.

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Long-Term Impact of Regionalization of Thoracic Oncology Surgery.

Ann Thorac Surg

February 2025

Department of Surgery, University of Ottawa, Ottawa, Ontario, Canada; Division of Thoracic Surgery, The Ottawa Hospital, Ottawa, Ontario, Canada. Electronic address:

Background: In 2007, Cancer Care Ontario created Thoracic Surgical Oncology Standards for the delivery of surgery, including lobectomy, esophagectomy, and pneumonectomy. These standards regionalized thoracic surgery into designated centers and mandated physical and human resources. This analysis sought to identify the impact of these standards, hereafter referred to as "regionalization," on outcomes after thoracic oncology surgery in Ontario, Canada.

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Adolescents and young adults (AYAs; ages 15-39 years) are a vulnerable population facing challenges in oncological care, including access to specialized care, transition of care, unique tumor biology, and poor representation in clinical trials. Brain tumors are the second most common tumor type in AYA, with malignant brain tumors being the most common cause of cancer-related death. The 2021 WHO Classification for central nervous system (CNS) Tumors highlights the importance of integrated molecular characterization with histologic diagnosis in several tumors relevant to the AYA population.

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Article Synopsis
  • The article focuses on a clinical case that highlights the importance of early identification of cerebral palsy (CP) and the challenges of communicating this diagnosis to parents and providers.
  • It reviews literature on effective communication strategies and discusses findings from thirteen relevant studies that involve parent experiences and interdisciplinary team perspectives.
  • Key recommendations for successful communication include engaging families and therapy teams, ensuring individualized approaches, and using inclusive language to avoid ableism.
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Article Synopsis
  • * Methods: Researchers conducted a retrospective cohort study at a tertiary care institution, examining data from patients with high-grade endometrial cancer who underwent related surgeries between 2015 and 2020, focusing on demographics, surgical management, and outcomes.
  • * Results: Out of 110 patients, a notable percentage had different cancer grades and stages. About 5.8% with pelvic SLNs negative still had positive PA nodes, and among 75
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Unemployment and Personal Income Loss After Traumatic Brain Injury.

JAMA Surg

December 2024

Division of Neurosurgery, Unity Health Toronto, Toronto Ontario, Canada.

Article Synopsis
  • * Using health and tax data from 2007 to 2017 on 18,050 TBI patients, the research found significant income reductions—averaging CAD $7,635 in the first year and CAD $5,000 by the third year after injury—compared to uninjured individuals.
  • * Additionally, 7.8% of TBI survivors became newly unemployed each year after their injury, highlighting the ongoing socioeconomic challenges faced by these individuals.
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Impact of postpartum physical activity on cardiometabolic health, breastfeeding, injury and infant growth and development: a systematic review and meta-analysis.

Br J Sports Med

October 2024

Program for Pregnancy and Postpartum Health, Physical Activity and Diabetes Laboratory, Faculty of Kinesiology, Sport, and Recreation, Women and Children's Health Research Institute, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada

Objective: To examine the relationship between postpartum physical activity and maternal postnatal cardiometabolic health, breastfeeding, injury, and infant growth and development.

Design: Systematic review with random-effects meta-analysis and meta-regression.

Data Sources: Eight online databases were searched up until 12 January 2024.

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Detailed cellular and spatial characterization of chronic lung allograft dysfunction using imaging mass cytometry.

J Heart Lung Transplant

January 2025

Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, Toronto, Ontario, Canada; Toronto Lung Transplant Program, Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Article Synopsis
  • Long-term survival rates after lung transplantation are hindered by chronic lung allograft dysfunction (CLAD), primarily characterized by two conditions: bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS).
  • The study utilized imaging mass cytometry (IMC) to analyze lung samples from BOS, RAS, and control groups, identifying 50 distinct immune and non-immune cell clusters with notable differences.
  • Findings revealed that CLAD lungs had fewer club cells, a higher presence of Ki67-high basal cells near memory T cells in RAS, and an increased occurrence of memory CD8 T cells in CLAD lungs, along with more regulatory T cells in RAS, highlighting IMC
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Article Synopsis
  • Evidence-based treatment for advanced gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) requires personalized decisions that take into account individual patient and cancer characteristics. !* -
  • A multidisciplinary panel reviewed 131 publications to develop a guidance document with 24 recommendations and 5 good clinical practice statements focusing on diagnostic features and biomarkers for managing unresectable or metastatic GEP-NENs. !* -
  • The document emphasizes treatment strategies based on tumor characteristics and specific biomarkers, and it received endorsements from major neuroendocrine tumor organizations. !*
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Article Synopsis
  • The study systematically reviews evidence on cancer drug wastage and the effectiveness of various mitigation methods, assessing articles from databases like Scopus, PubMed, and EMBASE.
  • Out of 6298 articles, 94 were included, with most focusing on high-income countries and recent publications, revealing that a significant number report on mitigation methods like vial sharing and dose rounding.
  • Findings show that cancer drug wastage costs are notably higher in the US compared to other countries, emphasizing the need for better reporting standards for drug wastage in future research to improve healthcare expenditure efficiency.
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Article Synopsis
  • The study aimed to analyze the relationship between the sex of surgeons and the number of days patients spend alive and at home (DAH) after surgery.
  • It found that patients treated by female surgeons had significantly more DAH compared to those treated by male surgeons over all measured time frames (30, 90, and 365 days).
  • The findings suggest that higher DAH associated with female surgeons could lead to lower healthcare costs and better patient quality of life, indicating a need for further research in different healthcare settings.
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Metabolic phenotypes and vitamin D response in the critically ill: A metabolomic cohort study.

Clin Nutr

November 2024

Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, USA; Division of Renal Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, USA. Electronic address:

Background & Aims: Although vitamin D deficiency is common in critically ill patients, randomized controlled trials fail to demonstrate benefits of supplementation. We aimed to identify distinct vitamin D responsive metabolic phenotypes prior to trial intervention of high-dose vitamin D by applying machine learning clustering method to metabolomics data from the Correction of Vitamin D Deficiency in Critically Ill Patients (VITdAL-ICU) trial.

Methods: In the randomized, placebo-controlled VITdAL-ICU trial, critically ill adults received placebo or high-dose vitamin D.

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Association Between Inability to Stand at ICU Discharge and Readmission: A Historical Cohort Study.

Crit Care Med

December 2024

Department of Medicine, Division of Critical Care Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal, Montréal, QC, Canada.

Objectives: The aim of this study was to determine if being unable to stand at ICU discharge was associated with an increased probability of ICU readmission.

Design: A multicenter retrospective cohort study was conducted using the Toronto Intensive Care Observational Registry (iCORE) project.

Setting: Nine tertiary academic ICUs in Toronto, Canada, affiliated with the University of Toronto.

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The Impact of Location and Asset Type on the Success of Advanced Airway Management in a Critical Care Transport Environment.

Air Med J

September 2024

Ornge, Toronto, Canada; Department of Emergency Medicine, St. Michael's Hospital, Toronto, Canada; Division of Emergency Medicine, Department of Medicine, University of Toronto, Toronto, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada. Electronic address:

Objective: Advanced airway management (AAM) is a critical component of prehospital critical care. Airway management in flight can be more challenging because of spatial, ergonomic, and environmental factors. This study examines the frequency of in-flight intubation (IFI), first-pass success (FPS) rates, and definitive airway sans hypoxia/hypotension on first attempt (DASH-1A) across different locations of airway management.

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