402 results match your criteria: "SungKyunKwan University College of Medicine[Affiliation]"

Extracorporeal cardiopulmonary resuscitation (ECPR) has the potential to improve neurological outcomes in patients with refractory out-of-hospital cardiac arrest (OHCA), offering an alternative to conventional cardiopulmonary resuscitation (CCPR). However, its effectiveness in OHCA remains controversial despite advancements in resuscitation techniques. This retrospective single-center study compared neurological outcomes and 30-day survival between ECPR and CCPR patients from January 2014 to January 2022.

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Background: Preoperative biliary drainage (PBD) is commonly performed in patients with bile duct cancer (BDC). However, data regarding the timing of pancreatoduodenectomy (PD) after PBD are insufficient. This study aimed to investigate the optimal timing for surgically and oncologically safe PD after PBD.

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Article Synopsis
  • Remimazolam is a new type of benzodiazepine that has rapid onset and short duration, making it great for sedation during endoscopy.
  • It presents a safer option compared to older sedatives like midazolam and propofol, with fewer side effects like low blood pressure, heart rate issues, and breathing problems.
  • The article highlights remimazolam's benefits, such as easy administration, fast recovery, and low residual sedation, which can enhance patient safety and efficiency in clinical endoscopy.
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Background: The prevalence and clinical implications of chronic cough (CC) in patients with severe asthma receiving asthma treatment remain relatively unknown.

Objective: This study aimed to evaluate the relationships between CC and asthma control and quality-of-life (QoL) in patients with severe asthma through longitudinal analysis.

Methods: Baseline and 6-month follow-up data from the Korean Severe Asthma Registry were analyzed.

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Background: Abdominal aortic aneurysm (AAA) is more common in Non-small cell lung cancer (NSCLC) patients. Considering that ruptured AAA is potentially fatal, timely management of AAA would result in long-term survival benefits. We assess the prevalence and characteristics of AAA in resectable NSCLC patients who would benefit from AAA surveillance.

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Background And Objectives: Cervical laminoplasty is commonly used to treat cervical spondylotic myelopathy (CSM) and ossification of the posterior longitudinal ligament (OPLL). Postoperative kyphotic changes can restrict spinal cord dorsal shift, leading to poor neurological outcomes. This study analyzes risk factors for loss of cervical lordosis (LCL) after laminoplasty in 3 groups: CSM, continuous OPLL, and other OPLL.

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Trends of Left Ventricular Assist Device Implantation and Heart Transplantation in Korea.

Int J Heart Fail

October 2024

Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Korea.

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The Korean Organ Transplant Registry (KOTRY): Third Official Adult Heart Transplant Report.

Korean Circ J

October 2024

Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background And Objectives: The Korean Organ Transplant Registry (KOTRY) provided data for this third official report on adult heart transplantation (HT), including information from 709 recipients.

Methods: Data from HTs performed at seven major centers in Korea between March 2014 and December 2020 were analyzed, focusing on immunosuppression, acute rejection, cardiac allograft vasculopathy (CAV), post-transplant survival, and mechanical circulatory support (MCS) usage.

Results: The median ages of the recipients and donors were 56.

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J-shaped relationship between serum creatinine and mortality in Korean patients with acute heart failure.

Clin Res Cardiol

August 2024

Cardiovascular Center, Division of Cardiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gumiro 166, Bundang, Seongnam, Gyeonggi-Do, Republic of Korea.

Article Synopsis
  • Cachexia and sarcopenia are prevalent in heart failure patients, negatively affecting their survival, prompting this study to explore how serum creatinine levels relate to mortality in acute heart failure patients.
  • The study included 5,198 acute heart failure patients, categorized by serum creatinine levels into five groups, with a focus on post-discharge all-cause mortality and finding a J-shaped relationship between creatinine levels and mortality rates.
  • Results revealed that both low (<0.6 mg/dL) and high creatinine levels increased mortality risk, with low levels raising the risk of all-cause mortality by 33% after accounting for various health factors.
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Objective: To evaluate the outcomes of drug-eluting bead transarterial chemoembolization (DEB-TACE) according to the size of the beads for the treatment of small hepatocellular carcinoma (HCC).

Materials And Methods: This retrospective study included 212 patients with a single HCC ≤5 cm from five tertiary institutions. One hundred and nine patients were treated with 70-150-µm doxorubicin DEBs (group A), and 103 patients received 100-300-µm doxorubicin DEBs (group B).

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Sleep Inertia and Its Associates in Shift and Non-Shift Workers.

Psychiatry Investig

August 2024

Department of Psychiatry, Sungkyunkwan University College of Medicine, Samsung Medical Center, Seoul, Republic of Korea.

Article Synopsis
  • The study aimed to compare sleep inertia, which is the grogginess felt after waking, between shift workers (SWs) and non-shift workers (NSWs) and to analyze how factors like depression, sleepiness, insomnia, and chronotype (sleep patterns) affect this grogginess.
  • A total of 4,561 SWs and 2,093 NSWs participated, completing surveys that assessed sleep inertia, depressive symptoms, sleepiness, and sleep patterns.
  • Results showed that SWs experienced greater sleep inertia than NSWs, with depressive symptoms affecting sleep inertia more significantly in SWs, while chronotypes had a stronger impact on NSWs; additionally, sleepiness mediated the relationship between these factors and sleep inertia
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Neuron-Specific Enolase as a Predictor of Neurologic Outcomes in Extracorporeal Cardiopulmonary Resuscitation Patients.

J Clin Med

July 2024

Department of Thoracic and Cardiovascular Surgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul 02841, Republic of Korea.

Article Synopsis
  • Neuron-specific enolase (NSE) is a biomarker that has been used to predict neurologic outcomes after cardiac arrest, and this study specifically evaluates its effectiveness in patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR).
  • The study included 47 adult ECPR patients, revealing that 46.8% experienced poor neurologic outcomes and 25.5% had abnormal brain CT findings.
  • NSE levels measured 72 hours after ECPR were found to be the most predictive of poor outcomes and 30-day mortality, with cutoff values indicating significant predictive power.
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Purpose: Zoledronic acid can inhibit the activity of osteoclasts, and thus, may slow or inhibit bone loss. The purpose of this study was to systematically evaluate the efficacy and safety of zoledronic acid in the treatment of osteoporosis.

Methods: Four databases, PubMed, Embase, Cochrane Library, and Web of Science, were systematically searched up to December 26, 2022.

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Article Synopsis
  • The study systematically reviewed and analyzed randomized controlled trials comparing unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) for treating unicompartmental knee osteoarthritis (KOA).
  • It included 13 publications with a total of 683 patients for each procedure, finding that UKA generally resulted in better knee recovery, function, less pain, and improved health status compared to TKA, but these differences were not clinically significant.
  • UKA also had fewer complications and shorter hospital stays, but there were no significant differences in ranges of motion, revision rates, operation time, or patient satisfaction between the two procedures.
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Article Synopsis
  • Current guidelines advise against routine imaging for asymptomatic breast cancer patients, yet advancements in treatments prompt a reevaluation of intensive imaging's role in survival outcomes.
  • A study of 4,130 patients from 11 Korean hospitals found that high-intensity imaging was linked to shorter distant metastasis-free survival, particularly for bone or lung metastases, while overall 5-year breast cancer-specific survival rates were high.
  • Despite earlier metastasis detection from frequent imaging, there was no significant correlation between screening intensity and breast cancer-specific survival, indicating that current treatments may diminish the benefits of intensive surveillance.
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The aim of this nationwide longitudinal cohort study is to determine the risk of congestive heart failure (CHF) associated with a seropositive rheumatoid arthritis (RA) population in Korea. In this study, National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) data from 2002 to 2003 were used. The cohort was followed up with for 12 years until December of 2015.

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Article Synopsis
  • This study investigates the link between vitamin D levels and sudden cardiac arrest (SCA) in out-of-hospital cardiac arrest patients compared to healthy individuals.
  • Using data from the CAPTURES II registry, researchers compared vitamin D levels in 454 OHCA cases and 454 matched controls, revealing lower levels in the OHCA group.
  • The findings suggest vitamin D deficiency significantly increases the risk of SCA, independent of other health factors, with severe deficiency showing a particularly high association with SCA incidence.
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Optimal Dose of Edoxaban for Very Elderly Atrial Fibrillation Patients at High Risk of Bleeding: The LEDIOS Registry.

Korean Circ J

July 2024

Division of Cardiology, Department of Internal Medicine, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background And Objectives: Optimal anticoagulation in very elderly patients is challenging due to the high risk of anticoagulant-induced bleeding. The aim of this study was to assess outcomes of on-label reduced-dose edoxaban (30 mg) in very elderly patients who had additional risk factors for bleeding.

Methods: This was a multi-center, prospective, non-interventional observational study to evaluate the efficacy and safety of on-label reduced-dose edoxaban in atrial fibrillation (AF) patients 80 years of age or older and who had more than 1 risk factor for bleeding.

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Association of Cough Severity with Asthma Control and Quality of Life in Patients with Severe Asthma.

Lung

August 2024

Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea.

Purpose: Symptoms are important components in determining asthma control and in the adjustment of treatment levels. However, clinical relevance of cough in severe asthma is not well-understood. This study aimed to evaluate the severity and association of cough with patient-reported outcomes (PROs) in patients with severe asthma.

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Waking qEEG in older adults with insomnia and its associations with sleep reactivity and dysfunctional beliefs about sleep.

Int J Psychophysiol

August 2024

Department of Psychiatry, Sungkyunkwan University College of Medicine, Samsung Medical Center, Seoul, Republic of Korea. Electronic address:

Sleep quality often deteriorates with age, and insomnia among the elderly increases the risks of both physical and psychiatric disorders. To elucidate the mechanisms and identify useful diagnostic biomarkers for insomnia in the elderly, the current study investigated the associations of waking brain activity patterns with susceptibility to stress-induced insomnia (sleep reactivity) and dysfunctional beliefs about sleep, major factors precipitating and maintaining insomnia, respectively. Forty-five participants aged 60 years or older with insomnia completed self-reported measures assessing depression, anxiety, sleep quality, dysfunctional beliefs about sleep, and sleep reactivity.

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Effects of therapeutic ultrasound in patients with knee osteoarthritis: A systematic review and meta-analysis.

Heliyon

May 2024

Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Republic of Korea.

Article Synopsis
  • Therapeutic ultrasound (US) has potential benefits for relieving pain and improving function in patients with knee osteoarthritis (KOA), but its effectiveness and safety have been uncertain until now.
  • A systematic review included 21 randomized controlled trials (RCTs) with 1,315 patients and found that US significantly reduced pain levels as measured by visual analog scales (VAS) and patient function scores.
  • Results suggest that pulsed US treatments with lower intensity and longer sessions (around 24 sessions for 4-8 weeks) are particularly effective without any reported adverse events, indicating US could be a safe and beneficial option for KOA.
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Moderating effect of shift work on sleep and depression in individuals at high risk of bipolar disorder.

J Affect Disord

August 2024

Department of Psychiatry, Sungkyunkwan University College of Medicine, Samsung Medical Center, Seoul, Republic of Korea. Electronic address:

Article Synopsis
  • Social Zeitgeber Theory suggests that irregular social rhythms, often caused by shift work, may heighten the risk of bipolar disorder (BD) and related sleep issues.
  • A study involving 6,665 participants found that individuals with high mood disorder scores experienced significant sleep disturbances and depressive symptoms, particularly those in non-daytime shifts.
  • The research underscores the benefits of maintaining a regular daytime work schedule for those at risk of BD, advocating for consistent sleep interventions.
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Object: We explored the circadian preferences of non-shift workers (non-SWs) and various types of shift workers (SWs), and the associations of these preferences with sleep and mood.

Methods: In total, 4,561 SWs (2,419 women and 2,142 men aged 37.00 ± 9.

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