Prognosis prediction of α-FAtE score for locoregional immunotherapy in hepatocellular carcinoma.

Purpose: The α-FAtE score, composed of alpha-fetoprotein, alkaline phosphatase, and eosinophil levels, has been reported as a predictor of prognosis in hepatocellular carcinoma (HCC) patients treated with atezolizumab plus bevacizumab. This study aimed to investigate the predictive ability of α-FAtE score for the efficacy and safety of locoregional immunotherapy as the treatment of HCC patients.

Methods And Patients: We conducted a retrospective study of 446 HCC patients at Sun Yat-sen University Cancer Center from January 1 2019 to January 1 2023.

Tumor-Stroma Ratio is a Critical Indicator of Peritoneal Metastasis in Gastric Cancer.

Objective: This study aims to investigate the correlation between the tumor-stroma ratio (TSR) and peritoneal metastasis (PM) in gastric cancer (GC) and constructs a diagnostic model based on preoperative examination data.

Methods: To determine the feasibility of obtaining TSR in GC patients through preoperative examinations, the consistency of TSR between endoscopic biopsy tissues and postoperative histopathological tissues was evaluated. Additionally, the correlation between TSR and PM in GC was analyzed using Gene Expression Omnibus (GEO) datasets.

GBR assisted Onlay bone grafting for the posterior maxillary horizontal ridge augmentation: a case report and literature review.

The posterior mandible is the primary area for occlusal function. However, long-term tooth loss in the posterior mandible often leads to rapid absorption of both buccal and lingual trabecular bone plates and subsequent atrophy of the alveolar ridge. This ultimately results in horizontal bone deficiencies that complicate achieving an optimal three-dimensional placement for dental implants.

iRGD-Targeted Biosynthetic Nanobubbles for Ultrasound Molecular Imaging of Osteosarcoma.

Purpose: Osteosarcoma is the most common primary malignant tumor of the bone. However, there is a lack of effective means for early diagnosis due to the heterogeneity of tumors and the complexity of tumor microenvironment. αvβ3 integrin, a crucial role in the growth and spread of tumors, is not only an effective biomarker for cancer angiogenesis, but also highly expressed in many tumor cells.

Utilization of Cardiac Magnetic Resonance Imaging for Assessing Myocardial Fibrosis in Prognosis Evaluation and Risk Stratification of Patients with Dilated Cardiomyopathy.

Dilated cardiomyopathy (DCM) is the ultimate manifestation of the myocardial response to various genetic and environmental changes and is characterized mainly by impaired left ventricular systolic and diastolic function. DCM can ultimately lead to heart failure, ventricular arrhythmia (VA), and sudden cardiac death (SCD), making it a primary indication for heart transplantation. With advancements in modern medicine, several novel techniques for evaluating myocardial involvement and disease severity from diverse perspectives have been developed.

Reappraisal of Variants in Cardiovascular Diseases: Uncovering Mechanisms and Future Directions.

Inherited cardiac arrhythmias, which may lead to sudden cardiac death, represent a significant health risk, with genetic factors playing a key role in their development. The ankyrin 2 () gene, encoding ankyrin-B, is implicated in several heritable arrhythmia syndromes. variants have been linked to an inherited condition known as "ankyrin-B syndrome", which manifests as a spectrum of cardiac arrhythmias and cardiomyopathy.

Impact of Obstructive Sleep Apnea on In-Stent Restenosis in Coronary Heart Disease Patients after Elective Drug-Eluting Stenting.

Background: Extensive research has established obstructive sleep apnea (OSA) as a contributing factor to numerous cardiovascular and cerebrovascular diseases. However, whether OSA affects in-stent restenosis (ISR) after elective drug-eluting stenting is unclear. Therefore, the objective of this study was to examine the impact of OSA on ISR in patients with coronary heart disease (CHD) who underwent successful elective drug-eluting stent (DES) implantation.

Clinical features and treatment of hypophosphatemia and associated complications induced by Phosphaturic mesenchymal tumors: A case series of six patients.

Phosphaturic mesenchymal tumor (PMT) is a rare benign mesenchymal tumor characterized by excessive secretion of fibroblast growth factor 23 (FGF23), leading to phosphate loss and systemic osteomalacia. Despite recent progress in PMT research, no consensus on diagnosis and treatment guidelines has been established. This case series describes the clinical and pathological features of six pathologically confirmed PMT patients treated at the Third Affiliated Hospital of Sun Yat-sen University from 2010 to 2024, aiming to provide new insights for the management of this condition.

Synthesis of Cr-doped AlO in nanoscale for bio-labels in myocardial cells.

The AlO: Cr light-converting materials were successfully synthesized via co-precipitation, resulting in a grain size ranging from 100 to 400 nm. Under excitation wavelengths spanning from 360 to 650 nm, a distinct near-infrared (NIR) emission at 695 nm was observed. Through optimization, it has been established that a Cr doping concentration of 1.

Accuracy of the Self-Administered Rapid HIV Urine Test in a Real-World Setting and Individual Preferences for HIV Self-Testing - Guangzhou City, Guangdong Province, China, July 2020-February 2021.

What Is Already Known About This Topic?: Human immunodeficiency virus (HIV) self-testing serves as a crucial strategy for overcoming testing barriers, with urine-based self-testing emerging as a potential novel approach.

What Is Added By This Report?: In a real-world setting, this study demonstrated that the urine rapid test exhibited lower diagnostic accuracy compared to the blood rapid test. Study participants expressed stronger preferences for HIV self-testing methods utilizing finger prick samples, accompanied by standard written instructions and lower costs.

Syncope secondary to arrhythmogenic left ventricular cardiomyopathy: a case report.

Background: Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disease characterized by fibrofatty replacement of ventricular myocardium. Ventricular arrhythmia and sudden cardiac death (SCD) are the main clinical manifestations. ACM was previously called arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D).

circ-1584 selectively promotes the antitumor activity of the oncolytic virus M1 on pancreatic cancer.

Pancreatic cancer is among the most challenging tumors to treat, and due to its immune tolerance characteristics, existing immunotherapy methods are not effective in alleviating the disease. Oncolytic virus therapy, a potential new strategy for treating pancreatic cancer, also faces the limitation of being ineffective when used alone. Elucidating the key host endogenous circular RNAs (circRNAs) involved in M1 virus-mediated killing of pancreatic ductal adenocarcinoma (PDAC) cells may help overcome this limitation.

KHSRP promotes cancer stem cell maintenance, tumorigenesis, and suppresses anti-tumor immunity in gastric cancer.

Objectives: KH-type splicing regulatory protein (KHSRP) is an RNA-binding protein involved in several cellular processes, including nuclear splicing, mRNA localization, and cytoplasmic degradation. While KHSRP's role has been studied in other cancers, its specific involvement in gastric cancer remains poorly understood. This study aims to explore KHSRP expression in gastric cancer and its potential effects on tumor progression and immune response.

Highly Crystalline and Flexible Covalent Organic Frameworks: Advancing Efficient Iodine Adsorption.

Flexible covalent organic frameworks (COFs) offer distinct advantages in elasticity and adaptability over rigid COFs, but these benefits often come at the expense of crystallinity due to challenges in polymerization, complicating both synthesis and structural characterization. Current research primarily employs single flexible monomers, which limits the tunability of these frameworks. In this study, we introduce two highly crystalline, flexible COFs, ZCST-102 and ZCST-103, constructed from dual flexible monomers.

Broadband and large surface enhancements of the local electric field enabled by cross-etched hyperbolic metamaterials.

Hyperbolic metamaterials (HMMs) have recently attracted significant research attention due to their hyperbolic wavevector iso-frequency contour, which leads to substantial local electric field (EF) enhancements that benefit optical processes, such as the nonlinear generation, quantum science, biomedical sensing, and more. However, three main challenges hinder their practical implementation: the difficulty in exciting their resonant modes using free-space incidence, the weak enhancement of surface EF, and the narrow spectral range of EF enhancements. Herein, we proposed cross-etched HMMs (CeHMMs) as a novel type of HMM, addressing these issues.

LiF Artifacts in XPS Analysis of the SEI for Lithium Metal Batteries.

The solid electrolyte interphase (SEI) is considered to be the key to the performance of lithium metal batteries (LMBs). The analysis of the SEI and cathode electrolyte interphase (CEI) composition (especially F 1s spectra) by X-ray photoelectron spectroscopy (XPS) has become a consensus among researchers. However, the surface-sensitive XPS characterization is susceptible to LiF artifacts due to several factors, leading to the overexaggerated role of LiF in the analysis of the SEI and CEI.

Semaphorin-4D signaling in recruiting dental stem cells for vascular stabilization.

Background: Achieving a stable vasculature is crucial for tissue regeneration. Endothelial cells initiate vascular morphogenesis, followed by mural cells that stabilize new vessels. This study investigated the in vivo effects of Sema4D-Plexin-B1 signaling on stem cells from human exfoliated deciduous teeth (SHED)-supported angiogenesis, focusing on its mechanism in PDGF-BB secretion.

Sleep characteristics and intervertebral disc degeneration risk: an observational and Mendelian randomization study.

Objectives: Sleep disorders are considered a risk factor for aging and skeletal degeneration, but their impact on intervertebral disc degeneration (IDD) remains unclear. The aim of this study was to assess associations between sleep characteristics and IDD, and to identify potential causal relationships.

Methods: Exposure factors included six unhealthy sleep characteristics: insomnia, short sleep duration (< 7 h), long sleep duration (≥ 9 h), evening chronotype, daytime sleepiness, and snoring.

Warming-driven migration of enterotypes mediates host health and disease statuses in ectotherm Litopenaeus vannamei.

Global warming has threatened all-rounded hierarchical biosphere by reconstructing eco-structure and bringing biodiversity variations. Pacific white shrimp, a successful model of worldwide utilizing marine ectothermic resources, is facing huge losses due to multiple diseases relevant to intestinal microbiota (IM) dysbiosis during temperature fluctuation. However, how warming mediates shrimp health remains poorly understood.

Chain-mediated effect of physical activity between Chinese language-based L2 motivational self-system and intended effort.

The L2 Motivational Self System (L2MSS) determines an individual's motivation in second language learning and influences the learning experience and intended effort. Although physical activity (PA) has been shown to enhance academic efficacy, the role of PA in whether it promotes second language learning efficacy has not been elucidated. Therefore, the present study examined PA as a mediator and explored its ameliorative effects in L2MSS.

Fully automated in vivo screening system for multi-organ imaging and pharmaceutical evaluation.

Advancements in screening technologies employing small organisms have enabled deep profiling of compounds in vivo. However, current strategies for phenotyping of behaving animals, such as zebrafish, typically involve tedious manipulations. Here, we develop and validate a fully automated in vivo screening system (AISS) that integrates microfluidic technology and computer-vision-based control methods to enable rapid evaluation of biological responses of non-anesthetized zebrafish to molecular gradients.

Recovery of nearly 3,000 archaeal genomes from 152 terrestrial geothermal spring metagenomes.

Terrestrial geothermal springs, reminiscent of early Earth conditions, host diverse and abundant populations of Archaea. In this study, we reconstructed 2,949 metagenome-assembled genomes (MAGs) from 152 metagenomes collected over six years from 48 geothermal springs in Tengchong, China. Among these MAGs, 1,431 (49%) were classified as high-quality, while 1,518 (51%) were considered as medium-quality.

The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis.

Emerging evidence demonstrates that cryptic translation from RNAs previously annotated as noncoding might generate microproteins with oncogenic functions. However, the importance and underlying mechanisms of these microproteins in alternative splicing-driven tumor progression have rarely been studied. Here, we show that the novel protein TPM3P9, encoded by the lncRNA tropomyosin 3 pseudogene 9, exhibits oncogenic activity in clear cell renal cell carcinoma (ccRCC) by enhancing oncogenic RNA splicing.

Long-term reconstructed vegetation index dataset in China from fused MODIS and Landsat data.

The vegetation index is a key satellite-based variable used to monitor global vegetation distribution and growth. However, existing vegetation index datasets face limitations in achieving both high spatial and temporal resolution, restricting their application potential. This study revised a machine learning spatiotemporal fusion model (InENVI) to produce a high-resolution NDVI dataset with 8-day temporal and 30 m spatial resolution, covering China from 2001 to 2020.