A Macromolecule Reversing Antibiotic Resistance Phenotype and Repurposing Drugs as Potent Antibiotics.

In order to mitigate antibiotic resistance, a new strategy to increase antibiotic potency and reverse drug resistance is needed. Herein, the translocation mechanism of an antimicrobial guanidinium-functionalized polycarbonate is leveraged in combination with traditional antibiotics to afford a potent treatment for drug-resistant bacteria. Particularly, this polymer-antibiotic combination approach reverses rifampicin resistance phenotype in demonstrating a 2.

Gastrointestinal endoscopy nurse assistance during colonoscopy and polyp detection: A PRISMA-compliant meta-analysis of randomized control trials.

Background: Previous studies showed difference results about the effect of nurse in improvement of the colonoscopy detection rate. This meta-analysis aims to investigate whether nurse participation during colonoscopy can help in improving the detection rate of polyps and adenomas.

Methods: Original studies in English were searched from the MEDLINE database, PubMed, Web of Science, and the Cochrane Library database.

Protocatechuic acid supplement alleviates allergic airway inflammation by inhibiting the IL-4Rα-STAT6 and Jagged 1/Jagged2-Notch1/Notch2 pathways in allergic asthmatic mice.

Objective And Design: To clarify the effects of dietary supplementation of protocatechuic acid (PCA) and in-depth mechanisms on allergic asthma in ovalbumin (OVA)-induced mice.

Materials: Female BALB/c mice were randomly divided into three groups (n = 10 in each group): control group, OVA-induced allergic asthma group, and OVA plus PCA group.

Treatment: Dietary supplementation of PCA was achieved by adding 50 mg/kg PCA to AIN 93G diet for 25 days.

A novel artificial intelligence protocol to investigate potential leads for Parkinson's disease.

Previous studies have shown that small molecule inhibitors of NLRP3 may be a potential treatment for Parkinson's disease (PD). NACHT, LRR and PYD domains-containing protein 3 (NLRP3), heat shock protein HSP 90-beta (HSP90AB1), caspase-1 (CASP1) and cellular tumor antigen p53 (TP53) have significant involvement in the pathogenesis pathway of PD. Molecular docking was used to screen the traditional Chinese medicine database TCM Database@Taiwan.

Fundamental properties of TEMPO-based catholytes for aqueous redox flow batteries: effects of substituent groups and electrolytes on electrochemical properties, solubilities and battery performance.

Water-soluble 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) derivatives have been frequently utilized as catholytes for aqueous redox flow batteries to achieve cost-effective renewable energy storage. However, fundamental knowledge of TEMPO derivatives is still largely underdeveloped. Herein, a comprehensive study on the properties of TEMPO derivatives has been conducted in aqueous electrolytes.

Primary small cell neuroendocrine carcinoma combined with squamous carcinoma of the ureter after renal transplantation: a rare case report.

A 47-year-old female presented with a 1-month history of painless gross hematuria after undergoing kidney transplant 4 years. Computed tomography revealed mass-like soft tissue density in the middle-lower portion of the right autologous ureter, which was up to the upper margin of the fourth lumbar vertebra, down to the distal ureter near the entrance of the bladder. The patient underwent right autologous nephroureterectomy resection.

Diffuse large B cell lymphoma-derived extracellular vesicles educate macrophages to promote tumours progression by increasing PGC-1β.

Tumour-associated macrophages (TAMs) comprise an important part of the tumour microenvironment and play a key role in malignant tumours progression. Tumour-derived extracellular vesicles (EVs) modulated TAMs polarization and reprogrammed TAMs to influence the progression of various tumours. Here, we hypothesized that diffuse large B cell lymphoma (DLBCL)-derived EVs can regulate macrophages polarization and thus contribute to tumour progression.

Chloroplast population genetics reveals low levels of genetic variation and conformation to the central-marginal hypothesis in var. , an endangered conifer endemic to China.

The central-marginal hypothesis predicts that geographically peripheral populations should exhibit reduced genetic diversity and increased genetic differentiation than central populations due to smaller effective population size and stronger geographical isolation. We evaluated these predictions in the endangered conifer var. Eight plastid simple sequence repeats (cpSSRs) were used to investigate plastid genetic variation in 22 populations of var.

[Performance verification of direct chemiluminescence immunoassay to detect the serum 25-hydroxyvitamin D concentration].

Objective: To test the performance of direct chemiluminescence immunoassay(CLIA) in the determination of serum 25-hydroxyvitamin D [25(OH)D] concentration.

Methods: The CLIA analyzer of Italy DiaSorin was used to measure the 25(OH)D concentrations in the Standard Reference Material 972 a of National Institute of Standards and Technology, DiaSorin control materials, blind samples of Vitamin D External Quality Assessment Scheme(DEAQS), and outpatient serum samples. The functional sensitivity, precision, accuracy, recovery, and linearity were evaluated, and the samples of mild hemolysis, 5 days' storage at 4 ₿ and >1 year's storage at-80 ₿were tested for 25(OH)D.

Aggregation-Free Organic Dyes Featuring Spiro[dibenzo[3,4:6,7]cyclohepta[1,2-]quinoxaline-10,9'-fluorene] (SDBQX) for Dye-Sensitized Solar Cells.

Three novel organic dyes coded as , , and featuring spiro[dibenzo[3,4:6,7]cyclohepta[1,2-]quinoxaline-10,9'-fluorene] () moieties are designed to inhibit dye aggregation to improve the performance of dye-sensitized solar cells (DSSCs). The consistent absorption onsets of , , and in solutions and adsorbed on TiO films indicate that these dyes are aggregation-free dyes. Therefore, coadsorption with chenodeoxycholic acid (CDCA) of these three dyes reduces the performance of DSSCs because no inhibition effect for dye aggregation is needed, but, on the contrary, the dye loading amount is reduced after addition of CDCA.

CBS promoter hypermethylation increases the risk of hypertension and stroke.

Objectives: Cystathionine β-synthase is a major enzyme in the metabolism of plasma homocysteine. Hyperhomocysteinemia is positively associated with hypertension and stroke. The present study was performed to examine the possible effects of Cystathionine β-synthase promoter methylation on the development of hypertension and stroke.

Significant Association of Promoter Hypomethylation with Stroke in a Chinese Population with Primary Hypertension.

Objective: Hypertension and hyperhomocysteinemia are both stroke risk factors. plays a vital role in one-carbon metabolism via encoding a protein with three distinct enzymatic activities (methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase, and formate-tetrahydrofolate ligase). We aimed to elucidate the association between promoter methylation and stroke in a Chinese population with primary hypertension.

Inositol 1,4,5-Trisphosphate Receptors in Endothelial Cells Play an Essential Role in Vasodilation and Blood Pressure Regulation.

Background Endothelial NO synthase plays a central role in regulating vasodilation and blood pressure. Intracellular Ca mobilization is a critical modulator of endothelial NO synthase function, and increased cytosolic Ca concentration in endothelial cells is able to induce endothelial NO synthase phosphorylation. Ca release mediated by 3 subtypes of inositol 1,4,5-trisphosphate receptors ( IP Rs) from the endoplasmic reticulum and subsequent Ca entry after endoplasmic reticulum Ca store depletion has been proposed to be the major pathway to mobilize Ca in endothelial cells.

Intrathyroid thymic carcinoma: report of two cases with pathologic and immunohistochemical studies.

Intrathyroid thymic carcinoma (ITCA) is a rare neoplasm of the thyroid gland, that is difficult to diagnose because of its complex pathologic and immunohistochemical characteristics. Here, we report two cases that may provide a better understanding of this disease. Case 1 is a 30-year-old man, and Case 2 is a 42-year-old man.

CREB5 promotes cell proliferation and correlates with poor prognosis in hepatocellular carcinoma.

CAMP responsive element binding protein 5 (CREB5) has been reported to be overexpressed in several types of human cancers and has crucial roles in regulating cell growth, proliferation, differentiation, and the cell cycle. However, the expression and function of CREB5 in hepatocellular carcinoma (HCC) remains unclear. The purpose of this study was to investigate the role of CREB5 in HCC, and its prognostic significance.

Exosome-related lncRNAs as predictors of HCC patient survival: a prognostic model.

Objectives: Accumulating evidence suggests that long non-coding RNA (lncRNA) may affect hepatocellular carcinoma (HCC) progression. However, the mechanism remains unclear. Previous studies have shown that exosomes may promote tumor progression by transporting proteins.

Serum miR-126-3p level is down-regulated in sepsis patients.

Background: Endothelial injury is part of the pathogenesis of sepsis. The microRNA-126 (miR-126) was previously identified as an endothelial biomarker and is known to play a critical role in preserving endothelial cell integrity. However, the role of miRNA-126 in sepsis is unclear.

NRP1 promotes cell migration and invasion and serves as a therapeutic target in nasopharyngeal carcinoma.

Neuropilin 1 (NRP1) promotes tumor growth, angiogenesis, tumor migration, and invasion. Its higher expression is closely related to the metastasis and poor outcome of many cancers. We have reported that NRP1 was expressed at higher levels in highly metastatic cells in comparison to minimally metastatic cells in nasopharyngeal carcinoma (NPC).

A novel compound heterozygous GAA mutation in a Chinese family with juvenile onset form of Pompe disease with cardiomyopathy.

Pompe disease is an autosomal recessive disorder resulting from a deficiency of acid α-glucosidase (GAA). It is uncommon in the mainland of China, due to rare mutations in the gene. The aim of this work was to elucidate the causative role of a novel compound heterozygous mutation of juvenile onset Pompe disease.

Sclerosing thymoma with extensive ossification and myasthenia gravis: an extremely rare case in the anterior mediastinum.

Sclerosing thymoma is a rare variant of thymomas, recently recognized in pathology. Since its first description in 1994, only 15 cases have been reported. Furthermore, osseous metaplasia in sclerosing thymoma is an even unusual characteristic.

De novo SCN2A mutation in a Chinese infant with severe early-onset epileptic encephalopathy, bronchopulmonary dysplasia, and adrenal hypofunction.

Early-onset epileptic encephalopathies (EOEEs) are a group of phenotypically and genetically heterogeneous neurodevelopmental disorders. Mutations of , the gene encoding the aII subunit of the voltage-gated sodium channel (Nav1.2), have been detected in some EOEE patients.

7,8-Dihydroxyflavone Ameliorates Cognitive Impairment by Inhibiting Expression of Tau Pathology in ApoE-Knockout Mice.

7,8-Dihydroxyflavone (7,8-DHF), a tyrosine kinase B agonist that mimics the neuroprotective properties of brain-derived neurotrophic factor, which can not efficiently deliver into the brain, has been reported to be useful in ameliorating cognitive impairment in many diseases. Researches have indicated that apolipoprotein E-knockout (ApoE-KO) mouse was associated with cognitive alteration via various mechanisms. Our present study investigated the possible mechanisms of cognitive impairment of ApoE-KO mouse fed with western type diet and the protective effects of 7,8-DHF in improving spatial learning and memory in ApoE-KO mouse.